A sex-adjusted 7-biomarker clinical aging clock for translational preventative medicine www.nature.com/articles/s41...

Happy to share that this is now out in Microbial Ecology 🥳 Huge thanks to the whole team, especially @sultanova.bsky.social 🙌 link.springer.com/article/10.1... @leibnizfli.bsky.social @uniofeastanglia.bsky.social

1/6 In a new preprint we ask a question: Why do males and females so often age and die at different rates? We argue that sex-specific mutation accumulation may be the most parsimonious evolutionary explanation for sex-biased ageing: ecoevorxiv.org/repository/v...

Happy to share our recent publication, which grew out of a consulting job I did last year: www.nature.com/articles/s41... 🧵

New study by our #CRC1678 members @bjornschumacher.bsky.social, @meyerdh.bsky.social and Walter Sandt showing that C. elegans dauer stage decelerates aging and even reverses biological age upon exit, revealing natural gene patterns of rejuvenation. Congratulations! 🎉 #AgingResearch #Longevity

🎥 Meet the 2025 SIB Bioinformatics Awards laureates: ⭐ David Meyer @meyerdh.bsky.social, PhD Paper Award ⭐ Michael Skinnider @skinnider.bsky.social Early Career Award ⭐ scverse @scverse.bsky.social, Innovative Resource Award, accepted by Ilan Gold Watch their award ceremony talks👇& congrats to all!

🚀 🚀 🚀 Our latest paper is out now: Age Deceleration and Reversal Gene Patterns in Dauer Diapause. We can learn from nature how aging of a whole organism with completely differentiated tissues can be slowed and how that organism can be completely rejuvenated. onlinelibrary.wiley.com/doi/10.1111/...

🚨🚨Job! 🚨🚨Permanent (75% time) job! We are a pretty awesome research group & seek a manager who deals with everything: personnel tasks, organizing retreats, preparing code for teaching / data structures for research... Fluency in German & English essential. stellenboerse.uni-mainz.de#/jgu/job/51527

Super grateful that our scETM work (from my summer internship with Dr. Yue Li, in collab. with Huiyu Cai and @tangjian.bsky.social) was recognized with an honourable mention at SIB PhD Paper Award competition. Many thanks to the jury and congrats to @meyerdh.bsky.social and Can Chen! #bc2basel

A fantastic few days of ageing talks, great people, and excellent food! Massive thanks to (Hanna!) @kokkonut.bsky.social, Margaux Bieuville, Victor Ronget, and the fantastic people at The Gutenberg Workshops in the Life Sciences

Ribonucleotide incorporation into mitochondrial DNA drives inflammation www.nature.com/articles/s41... Congratulations to the Langer lab @mpiage.bsky.social, Amir, and the rest of the team!

This review of our @crc1678.bsky.social member @bjornschumacher.bsky.social and @meyerdh.bsky.social is greatly summarizing fundamentals of the molecular biology of aging. What causes aging? Read the answer!

🔥🔥🔥Out now: our Perspectives article in @nataging.nature.com outlining how aging is driven by molecular damage leading to increasing molecular noise whose quantification could track aging with the precision of a clock @meyerdh.bsky.social @alexeimaklakov.bsky.social www.nature.com/articles/s43...

We argue that selection shadow - gradual decline in the force of selection after the onset of reproduction - is sufficient/parsimonious to explain why damage accumulates with age. 'Aging clocks' measure damage accumulation, they neither require nor support any kind of 'program'-based explanation.

👵🏻⏰👴🏻 Is aging a programmed process? Check out this perspective article in Nature Aging by our two #CRC1678 members @meyerdh.bsky.social and @bjornschumacher.bsky.social. Congratulations! 🥳

You can also read it here rdcu.be/eG1N7 👇

🕰️ Is aging driven by a programmed/programmatic mechanism, or by the unavoidable burden of imperfect maintenance? Our perspective argues that aging reflects finite maintenance and reduced evolutionary pressure🧵🧪 www.nature.com/articles/s43... @bjornschumacher.bsky.social @alexeimaklakov.bsky.social

💪🎉Congratulations to our #CRC1678 member @meyerdh.bsky.social for winning the SIB Bioinformatics PhD Paper Award 2025 for his work on Ageing Clocks ⏰ 👵🏻👴🏻

✨ I’m honored and grateful to have received the SIB Bioinformatics PhD Paper Award 2025 for part of my PhD work. Thank you for your guidance and inspiration @bjornschumacher.bsky.social #SIBAwards #bc2basel #Bioinformatics

Read David’s award winning article ‘Aging clocks based on accumulating stochastic variation’. www.nature.com/articles/s43... #bc2basel

💫 The PhD Paper Award goes to @meyerdh.bsky.social from Uni-Köln 💫 “David Meyer’s paper ‘Aging clocks based on accumulating stochastic variation’ presents a completely novel concept and a fresh way to address the problem”. #Bioinformatics #SIBawards #bc2basel

#bc2basel @SIB#bc2baselPhD Paper Award 👏 David Meyer: Aging clocks based on accumulating variation https://doi.org/10.1038/s43587-024-00619-x

🚨 New from our lab: Here we explored how aging contributes to harmful protein aggregation in diseases like Huntington’s & ALS. The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch 🧵 www.nature.com/articles/s43...

New work from the lab! C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules - Bilican - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1002/...

Can't wait to be at the #ARDD2025 next week! agingpharma.org I'm presenting "Aging by the clock and yet without a program" on Tuesday in the GeroPhysics session. If you're at the conference, let's grab a coffee and chat! 🧪 #AgingResearch #Longevity #Science

Congratulations to our new postdoc Domenico DiFraia for his amazing paper in @science.org! 🥂 A tour de force on brain aging in the killifish. 🐟 Transcriptomics, proteomics, including ribosome profiling, PTMs, etc... Translation is key for understanding brain aging!🧬🎉 www.science.org/doi/10.1126/...

🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town. Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag. 🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41... 🧵Let’s break down what makes DynaTag so powerful (1/7)

Thrilled to share that I’ve been selected for the Minerva Fast Track program to launch my research group at @mpiage.bsky.social as part of the @antebilab.bsky.social department! Huge thanks to @maxplanck.de, my mentors Dr. Demetriades & @antebilab.bsky.social, and all who supported me!

Join the GUTENBERG WORKSHOP on the Evolution of Ageing! Organizers: Margaux Bieuville, @kokkonut.bsky.social and Victor Ronget @unimainz.bsky.social, and eivimeycook.bsky.social @uofglasgow.bsky.social Info at gutenberg-workshops.uni-mainz.de/evolution-ag... #ageing #evolution #lifesciences

The deadline for short talk and poster submissions is in less than a week! (15th July!) Any questions - feel free to DM me!

I had a great time on The Sheekey Science Show! 🧪 It was fun discussing the stochasticity of aging and potential remedies. Watch the whole episode 👇 youtu.be/Buj07nWt7o0 #Aging #Longevity If you are interested in more details: 🧵 (1/7)

New paper! "Rapamycin, Not Metformin, Mirrors Dietary Restriction-Driven Lifespan Extension in Vertebrates: A Meta-Analysis" tinyurl.com/yc6pkmbe Using meta-analysis, we examined the average lifespan extension conferred by dietary restriction (DR), Metformin, and Rapamycin.

Last year's edition of this workshop got so much love by its participants that they simply wanted more. Here we will offer more! We'll force theoreticians to say (final slide of talk) what they wished empiricists would now do & vice versa. Isn't that a cool idea?

Join the Evolution of Ageing workshop led by Dr. Edward Ivimey-Cook. More info: https://gutenberg-workshops.uni-mainz.de/evolution-ageing/ Interested in SORTEE? Contact Edward for details! #workshop

Preprint alert @biorxivpreprint! We are excited to share our latest study led by @kkawamura13.bsky.social @annadiederich01.bsky.social in collaboration with & C. Demetriades Lab & @muellerrom.bsky.social Lab www.biorxiv.org/content/10.1...

We are looking for a postdoctoral researcher with bioinformatic expertise to join our research group @molepi.bsky.social @bds-lumc.bsky.social at the LUMC! More details, including the link to submit applications, are provided on the website below. 🖥️🧪 www.lumc.nl/en/about-lum...

I'm looking forward to this meeting! 🧪 Evolution of #Aging

🚨 Scholarship Alert! 🚨 Pursue your Master studies in Biology or Biochemistry with our #CGA Master Fellowship programme. 🧬👩🏽‍🔬💰 Explore ageing research at the Cologne Ageing Campus! Apply by July 15! 📅 🔗 Learn more: www.ageing-grad-school.de/master/maste...

Congratulations to #CECAD Prof. David Vilchez @thevilchezlab.bsky.social on securing #DFG funding for a new research group on organismal proteostasis! This project, involving also Prof. Hoppe, will explore how proteostasis regulates #aging and #disease. @dfg.de #Proteostasis uni.koeln/ZCFFX

We are experiencing an assault on science unparalleled by anything I’ve seen in my life. It’s not one issue or another anymore, the entire institution is under attack by the most powerful individuals in the country. This Friday, where will you be? standupforscience2025.org

"We’re witnessing the self-sabotage of the United States" from @davidfrum.bsky.social www.theatlantic.com/politics/arc...

This will be a fantastic thread👇 For the top aging preprints also see www.longevist.xyz/gallery #GeroSky 🧪

For those starting on BSKY and loving #metabolism and #mitochondria, the 2 starter packs have now been completed. 300 scientists working in this field are here to be followed! Happy Boxing Day Starter pack 1: go.bsky.app/VavECSX Starter pack 2: go.bsky.app/CH1MctZ

Many thanks to The Biochemist for the interview and opportunity to highlight the ongoing research in my group @mpiage.bsky.social! portlandpress.com/biochemist/a...

After 5 years, our team has a new telomere-to-telomere gap-free reference genome for C. elegans. We published our first results in 2019; I thought we'd have our loose ends wrapped up by spring 2020. That prediction was ... slightly off. But here's the genome now! www.biorxiv.org/content/10.1...

1/12 1. I’m very excited to share the first piece of my postdoc work! www.biorxiv.org/content/10.1...

Scared to share this after 10 freaking years of waiting, but here we go: We found that temperature *perception* can change the biology of the next generations, even when “it’s just in the parents' head”. Read how C. elegans neurons control epigenetic inheritance! www.biorxiv.org/content/10.1...

Very exciting preprint: could stress-induced mutagenesis be adaptive (as opposed to simply a malfunction)? The presence of a mechanism to trigger mutagenesis in response to environmental alterations might indicate that it is an evolutionarily beneficial process

Read our 2 new stories about how neurons 🧠 influence the germline and how their activity can even shape inheritable transposable element expansion 🧪 #Evolutionary_Biology 👇

Hello World! ⭐ We’re CECAD Cologne, a cutting-edge research center dedicated to unraveling the mysteries of #Aging and promoting healthier, longer lives! Follow us for the latest discoveries, insights, and events in #AgingResearch! 🧬🔬👩‍🔬 www.cecad.uni-koeln.de