I am very proud of @maraneuerburg.bsky.social with her excellent PhD defense today! Now up to the next adventure!

📣 Neue Podcast-Folge 📣 Prof. Dr. Joris Deelen erzählt, warum manche Menschen über 100 Jahre alt werden und was uns die Langlebigkeits-Gene APOE und FOXO3 über das Altern verraten. 🎧 Hier gehts zur Folge: codedeslebens.podigee.io/55-langlebig... #Genetik #Forschung #Podcast #Wissenschaft #GHGA

I am very happy to present you the latest preprint from my group at the @mpiage.bsky.social, which is the main outcome of the PhD project of Mara Neuerburg! 🧪🧬

🚨Excited to share our new medRxiv preprint spearheaded by Mengle Zhu in which we provide novel mechanistic insights into the biology of familial longevity and cardiometabolic resilience using metabolomic and proteomic profiling!🚨 @molepi.bsky.social 🧪 www.medrxiv.org/content/10.6...

Human whole-blood NAD+ levels do not vary with age or lifestyle interventions www.nature.com/articles/s42...

I’m hiring! We have a position for a scientist in our department Neurobiology & Aging. Check out the vacancy in Dutch & English in the links below 🧠

💥 New publication from the Demetriades and Nüchel groups– final version now online in EMBO reports! This Tour de force wouldn’t have worked out without the amazing support from our collaborators and core facilities!

🚨 Scholarship Alert! 🚨 🧬👩🏽‍🔬 Pursue your Master studies in Biology or Biochemistry in Cologne at @unicologne.bsky.social and get full funding with our CGA Master Fellowship programme.💰 📅 Apply by July 15! 🔗 Learn more: www.ageing-grad-school.de/master/maste...

🚨I am happy to share our new paper in collaboration with @haggsara.bsky.social, spearheaded by Larissa Smulders 🚨 We provide further evidence that MetaboHealth is moderately heritable (40%) and is likely modifiable through lifestyle, e.g., smoking cessation. 🧪🚭 link.springer.com/article/10.1...

🚨I am happy to share our new paper in collaboration with @haggsara.bsky.social, spearheaded by Larissa Smulders 🚨 We provide further evidence that MetaboHealth is moderately heritable (40%) and is likely modifiable through lifestyle, e.g., smoking cessation. 🧪🚭 link.springer.com/article/10.1...

📣#CECAD will host two exciting conferences 📆 11th - 14th October 2026 15th AHA Conference - “From mechanisms of age-associated diseases to healthy aging” uni.koeln/7X2K8 📆 14th - 16th October 2026 1stEFAR Conference - “On the Biology of Aging” uni.koeln/YGPMA 👉 Submit abstracts by May 31st

Epidemiological approaches to refine biomarkers of aging www.nature.com/articles/s43...

Personal-MetaboHealth, an actionable health check in middle age, is improved by an effective lifestyle intervention in those at risk https://www.medrxiv.org/content/10.64898/2026.02.15.26346369v1

What started as a student project from Gabriela Natalle Lopes together with Niels vd Berg has now become a fleshed out preprint in which we present Personal-MetaboHealth, a personalised version of MetaboHealth based on clinically validated metabolic biomarkers. 🧪 www.medrxiv.org/content/10.6...

Rethinking the heritability of aging www.science.org/doi/10.1126/...

🆕 @science.org Revising the heritability of lifespan, from 25% to ~50%, by correcting for extrinsic factors science.org/doi/10.1126/...

Rare longevity-associated variants, including a reduced-function mutation in cGAS, identified in multigenerational long-lived families www.biorxiv.org/content/10.6...

Ben je geïnteresseerd naar ons onderzoek naar gezonde veroudering binnen de sectie @molepi.bsky.social van de afdeling @bds-lumc.bsky.social bij het LUMC? Kijk dan naar dit item van het Belgische programma @terzake.bsky.social van @vrtnws.be waarvoor ik geïnterviewd ben. www.vrt.be/vrtnws/nl/ki...

Wat is de ideale methode als je wil beginnen met vasten? Zo pakken deze experts het aan. Voor meer tips, luister naar aflevering 3 van Leef als een Naakte Molrat: Spotify: lnkd.in/eyGeyybx Apple Podcasts: lnkd.in/e_JwiYvh #fasting #vasten #gezondheid #afvallen #wetenschap

Was erg leuk om bij te dragen aan de @naaktemolratpod.bsky.social podcast serie over veroudering en vasten van Leon Doedens!

🚨 Deadline Extended! 🙏 RT: Postdoc opening @ Babraham Institute, Cambridge to study extracellular #proteostasis and #aging. If you have #biochemistry expertise and want to join a world-class research environment, apply now! ✅ Global Talent Visa covered 📅 Apply by 09.01.26 👉 tinyurl.com/38rn6czz

Goede voornemens voor 2026? Luister vanaf 2 januari naar Leef als een Naakte Molrat voor de laatste lifestylehacks uit de wetenschap over voeding, vasten, sport en mentale gezondheid. #podcast #lifehack #health #nutrition #fasting #fitness #mentalhealth

Interested in metabolomics/systems biology and aging in Drosophila? We have a post-doc opening! And of course, there will be plenty of opportunities for side projects on the @dogagingproject.bsky.social. 🐶 promislowlab.org/wp-content/u...

🔬#Postdoc position available: We are looking for new lab member to join our team working on Protein #Aggregation and #Ageing in Cambridge. Please spread the word. tinyurl.com/38rn6czz

This includes a variant in cGAS, for which we subsequently showed it leads to a reduced function of the protein in cell lines from both humans and mice, which nicely complements earlier work on this protein in animal models. @molepi.bsky.social @marianbeekman.bsky.social @antebilab.bsky.social 🧬🧪

🚨Proud to present the latest preprint from our group, spearheaded by Pasquale Putter and the culmination of many years of work on the Leiden Longevity Study, in which we used multigenerational long-lived families to identify novel rare protein-altering genetic variants linked to ancestral longevity.

🚀 preprint alert: medrxiv.org/cgi/content/... 🧬 How important is genetic predisposition to chronic diseases for healthy survival up to later age?

🚨Proud to present the latest preprint from our group, spearheaded by Pasquale Putter and the culmination of many years of work on the Leiden Longevity Study, in which we used multigenerational long-lived families to identify novel rare protein-altering genetic variants linked to ancestral longevity.

Key takeaway: Absence of CAD disease risk alleles is one key-feature linked to longevity and alleles linked to cholesterol metabolism are a key component in healthy aging trajectories. @jorisdeelen.bsky.social @marianbeekman.bsky.social

I'm very happy to see this paper now out. We used early-life climbing ability to separate genetically identical short-lived and long-lived sub-cohorts of fruit flies, and to identify metabolites and metabolite modules that predict longevity. onlinelibrary.wiley.com/doi/10.1111/...

My lab is associated with two fantastic project opportunities - one on circadian genes led by Matt Jones and one on inflammation in ageing led by Chris Mahony - which you can find in the 'Fundamentals of Life' theme at the link above.

Calling on my #science network! TeamNDF is #hiring a postdoc to start in 2026! Are you fascinated by metabolism and the brain? Do you want to dig into life long impacts and the molecular cause? Learn more about the team and our research here: www.dife.de/en/research/... Please share! 🧠 🍔 💉

I'm delighted to share our curated list of 100 open problems in ageing science. This represents a collective, systematic effort to map the key challenges and knowledge gaps across biogerontology and offers a roadmap to guide future progress in geroscience. link.springer.com/article/10.1...

📰Weekend read! BSRA & Dutch Society for Research on Ageing sign collaboration agreement of 1. Mutural speaker exchange 2. Reciprocal meeting benefits 3. Joint policy work 4. Joint initiatives 5. Future plans, watch this space... Read more - bsra.org.uk/dusra-collab...

Back again after some inspiring trips to both the TWIN4EarLiStAge HorizonEU Twinning Project summer school in Heraklion and the Biomarkers of Aging Consortium meeting in Boston. Great to see so many young scientists getting interested in ageing research!

PhD studentship available in our lab to study ageing, longevity and cellular rejuvenation using computational methods and machine learning/AI. Applications are open to UK and international students. Deadline: 27 November 2025. www.findaphd.com/phds/project...

And that was the end of part 2, an inspiring G-JAM conference in Jena with many exciting talks! Next up the TWIN4EarLiStAge HorizonEU Twinning Project Training Course in the Biology of Aging in Crete and the Biomarkers of Aging Consortium meeting in Boston!

Phenomenal. In my 10 year update of A Brief History, I make the point that in the first edition, not one disease had been successfully treated using gene therapy. Today that number is at least 7.

🔬We have a fully funded Cambridge Biosciences DTP PhD postion to study #Proteostasis and #Aging in colloboration with @jrkumita.bsky.social @Pharmacology. Details on the project ▶️https://tinyurl.com/2zhkjjhs + bbsrcdtp.lifesci.cam.ac.uk/how-apply . Please RT.

Great to see this paper by Daniele Bizzarri now published in Immunity & Ageing! Here we show that a higher MetaboHealth score is associated with increased inflammatory/immune related proteins and decreased cholesterol transport related proteins. 🧪 immunityageing.biomedcentral.com/articles/10....

My new lab at the MPI Age is looking for a postdoc in skeletal muscle cell and molecular biology! If you’re a curious and motivated scientist and would like to apply, check the details below:

Conference season has officially started! I had a great time in Berlin last week @ComLab10 organised by the Alexander von Humboldt Foundation where I talked about our work on the genetics of human longevity. It was an inspiring meeting and I was really impressed by the pitches from the participants!

🎉 We’re excited to share our very first preprint!! 🎉 "Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells" 👉 doi.org/10.1101/2025... #FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience

Registration is now open! As one of the organizers, I am looking forward to meeting all the aging researchers in the Netherlands at our annual meeting! dusra.nl/annual-meeti... #DuSRA #AmsterdamUMC #Agingresearch #Netherlands

🚨 Happy to share our first pre-print 🎉 on the causes of ribosome-associated degradation of CFTR and other transmembrane proteins. We explore how protein folding, ER insertion, and elongation dynamics influence translation arrests in this new class of RQC targets.👇 www.biorxiv.org/content/10.1...

Grateful to @maxplanck.de ‬for featuring our recent paper in their amazing new video! 🎥🌟 Thank you for the wonderful spotlight on our work! 🙌😄

New preprint with our list of 100 open problems in ageing science. Our curated list captures both long-standing fundamental questions and emerging research frontiers. A massive team effort by >30 researchers from many disciplines in biogerontology. arxiv.org/abs/2507.18602

Very proud of Niels van den Berg who managed to secure a prestigious Veni grant from NWO! It is really great that he can now expand his research line on socioeconomic factors influencing health within families as part of our Ageing group within @molepi.bsky.social @bds-lumc.bsky.social!

The MolEpi group congratulates Niels van den Berg with his Veni grant! 👏🥂 📝 Title of the project: Spousal survival Advantage by Marrying into longevity Enriched families (SAME) 👉 www.nwo.nl/en/news/200-... #NWO #veni #grant #Causality #BDS-MOLEPI #LUMC #ODDISEI #DataScience #HealthCampustheHague

We are hiring a research assistant 👉 tinyurl.com/yxebtjbj to join our lab working on healthy #ageing and protein #aggregation in C. elegans 🪱. Deadline August 4th. 🙏 RT. #proteostasis @babrahaminst.bsky.social