I'm delighted to share our curated list of 100 open problems in ageing science. This represents a collective, systematic effort to map the key challenges and knowledge gaps across biogerontology and offers a roadmap to guide future progress in geroscience. link.springer.com/article/10.1...

📰Weekend read! BSRA & Dutch Society for Research on Ageing sign collaboration agreement of 1. Mutural speaker exchange 2. Reciprocal meeting benefits 3. Joint policy work 4. Joint initiatives 5. Future plans, watch this space... Read more - bsra.org.uk/dusra-collab...

Back again after some inspiring trips to both the TWIN4EarLiStAge HorizonEU Twinning Project summer school in Heraklion and the Biomarkers of Aging Consortium meeting in Boston. Great to see so many young scientists getting interested in ageing research!

PhD studentship available in our lab to study ageing, longevity and cellular rejuvenation using computational methods and machine learning/AI. Applications are open to UK and international students. Deadline: 27 November 2025. www.findaphd.com/phds/project...

And that was the end of part 2, an inspiring G-JAM conference in Jena with many exciting talks! Next up the TWIN4EarLiStAge HorizonEU Twinning Project Training Course in the Biology of Aging in Crete and the Biomarkers of Aging Consortium meeting in Boston!

Phenomenal. In my 10 year update of A Brief History, I make the point that in the first edition, not one disease had been successfully treated using gene therapy. Today that number is at least 7.

🔬We have a fully funded Cambridge Biosciences DTP PhD postion to study #Proteostasis and #Aging in colloboration with @jrkumita.bsky.social @Pharmacology. Details on the project ▶️https://tinyurl.com/2zhkjjhs + bbsrcdtp.lifesci.cam.ac.uk/how-apply . Please RT.

Great to see this paper by Daniele Bizzarri now published in Immunity & Ageing! Here we show that a higher MetaboHealth score is associated with increased inflammatory/immune related proteins and decreased cholesterol transport related proteins. 🧪 immunityageing.biomedcentral.com/articles/10....

My new lab at the MPI Age is looking for a postdoc in skeletal muscle cell and molecular biology! If you’re a curious and motivated scientist and would like to apply, check the details below:

Conference season has officially started! I had a great time in Berlin last week @ComLab10 organised by the Alexander von Humboldt Foundation where I talked about our work on the genetics of human longevity. It was an inspiring meeting and I was really impressed by the pitches from the participants!

🎉 We’re excited to share our very first preprint!! 🎉 "Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells" 👉 doi.org/10.1101/2025... #FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience

Registration is now open! As one of the organizers, I am looking forward to meeting all the aging researchers in the Netherlands at our annual meeting! dusra.nl/annual-meeti... #DuSRA #AmsterdamUMC #Agingresearch #Netherlands

🚨 Happy to share our first pre-print 🎉 on the causes of ribosome-associated degradation of CFTR and other transmembrane proteins. We explore how protein folding, ER insertion, and elongation dynamics influence translation arrests in this new class of RQC targets.👇 www.biorxiv.org/content/10.1...

Grateful to @maxplanck.de ‬for featuring our recent paper in their amazing new video! 🎥🌟 Thank you for the wonderful spotlight on our work! 🙌😄

New preprint with our list of 100 open problems in ageing science. Our curated list captures both long-standing fundamental questions and emerging research frontiers. A massive team effort by >30 researchers from many disciplines in biogerontology. arxiv.org/abs/2507.18602

Very proud of Niels van den Berg who managed to secure a prestigious Veni grant from NWO! It is really great that he can now expand his research line on socioeconomic factors influencing health within families as part of our Ageing group within @molepi.bsky.social @bds-lumc.bsky.social!

The MolEpi group congratulates Niels van den Berg with his Veni grant! 👏🥂 📝 Title of the project: Spousal survival Advantage by Marrying into longevity Enriched families (SAME) 👉 www.nwo.nl/en/news/200-... #NWO #veni #grant #Causality #BDS-MOLEPI #LUMC #ODDISEI #DataScience #HealthCampustheHague

We are hiring a research assistant 👉 tinyurl.com/yxebtjbj to join our lab working on healthy #ageing and protein #aggregation in C. elegans 🪱. Deadline August 4th. 🙏 RT. #proteostasis @babrahaminst.bsky.social

One week left until the abstract submission deadline. Excellent line-up of speakers discussing diverse topics on aging and longevity and 20+ slots for short talks selected from the abstracts. Don't miss your chance to join us in Jena in September!

Online now!✨RESEARCH: Gkioni et al @mpiage.bsky.social show that trametinib and rapamycin treatment combine additively to extend lifespan and healthspan in female and male mice, reducing tumor growth and inflammation www.nature.com/articles/s43... rdcu.be/eo3gS

We are excited to be recruiting 3 post-doctoral researchers to study glial cell dysfunction in #agingresearch and #neurodegeneration, including one position using #Drosophila models! If you are interested, please read more below to get in touch or apply (links in thread).

Sad to learn we lost Keith Blackwell, an unsung hero of the aging field. Keith showed rapamycin extends C. elegans lifespan, that mTORC2 has diet-dependent effects on aging, and linked together skn1 TOR splicing and aging. www.legacy.com/us/obituarie...

New publication from the Deelen Lab—don't miss out! 👇

I am very proud to present you the first paper from the main research line of my group at the @mpiage.bsky.social in collaboration with my current group @molepi.bsky.social @bds-lumc.bsky.social at the LUMC, which is now published in @geroscience.bsky.social! link.springer.com/article/10.1...

The combination of two cancer drugs, rapamycin and trametinib, can extend the lifespan of mice by 30%, according to a study co-led by Prof Dame Linda Partridge @ucllifesciences.bsky.social with @mpiage.bsky.social colleagues www.ucl.ac.uk/news/2025/ma...

🚨 New publication in Nature Aging 🚨 Combining the cancer drugs rapamycin and trametinib extends the lifespan of mice by about 30% and improves their health in old age 🐭✨ @cecad.bsky.social @maxplanck.de www.nature.com/articles/s43...

In mice, the additive effect of 2 drugs for extending lifespan and healthspan: rapamycin and trametinib, a MEK blocker used for cancer treatment @nataging.nature.com www.nature.com/articles/s43...

Interested in healthy aging - from fundamental mechanisms to advanced interventions? Join us September 24-26 for the Groningen-Jena Aging Meeting, featuring talks by leading experts and 20+ short talk slots selected from abstracts. Early bird registration ends on 30.06.25

We have a 4-year postdoc position open in our Research Unit on proteostasis! The project explores inter-tissue regulation using advanced proteomics approaches. Collaborative & interdisciplinary environment. More details & application here: jobs-uk-koeln.onlyfy.jobs/job/pktg6ivj...

Looking forward to attend the #GeneForum2025 at the Institute of Genomics, University of Tartu and present our work on metabolomics-based biomarkers of ageing!

We are looking for a postdoctoral researcher with bioinformatic expertise to join our research group @molepi.bsky.social @bds-lumc.bsky.social at the LUMC! More details, including the link to submit applications, are provided on the website below. 🖥️🧪 www.lumc.nl/en/about-lum...

Please check out this new publication by Daniel Kolbe from our ongoing collaboration between the @molepi.bsky.social @bds-lumc.bsky.social department at the Leiden University Medical Center and the IKMB at Kiel University! link.springer.com/article/10.1...

Apply now to the imAGEin #ErasmusMundus Master program to study the biology of aging @cecad.bsky.social @unicologne.bsky.social @sorbonne-universite.fr @unisevilla.bsky.social and Universities of Coimbra and @univcotedazur.bsky.social @ircan.bsky.social life.univ-cotedazur.eu/internationa...

🚨G-JAM2025 Registration Alert!🚨 Join us in September for an exciting #aging research meeting co-organized by FLI Jena and ERIBA Groningen! We're bringing together top experts to explore aging from mechanistic insights in model organisms to human aging and interventions 1/4

My lab at the Max Planck Institute for Molecular Biomedicine in Muenster, Germany offers postdoc positions in stem cell mechanobiology. www.mpi-muenster.mpg.de/departments/... drop me an email

Very happy to share that my research group has launched at the German Diabetes Center (DDZ) in Düsseldorf! We're looking for a PhD student to study the effects of inter-tissue communication on energy balance and metabolic health. Interested? Get in touch! ddz.de/en/job/docto...

I really enjoyed taking part in the retreat of the IMPRS of the @mpimicrobiomarburg.bsky.social today as invited speaker and by being part of a panel on science communication. The interactions with the PhD students is one of those things that makes my job so rewarding!

Very proud of our first peer-reviewed paper from the lab: a review on the multifaceted role of RNA-binding proteins in the metabolic control of stem cells. Check it out! This is a truly amazing effort by my PhD student Ellie Koletsou @mpiage.bsky.social #proudPI doi.org/10.1038/s443...

Many thanks to The Biochemist for the interview and opportunity to highlight the ongoing research in my group @mpiage.bsky.social! portlandpress.com/biochemist/a...

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I am very excited to officially announce that I will be starting my new position as associate professor ("Universitair Hoofddocent") in the section of Molecular Epidemiology, Department of Biomedical Data Sciences at the Leiden University Medical Center on the 1st of January! (1/4)

The CALERIE Genomic Data Resource is up www.nature.com/articles/s43...

We have created a starter pack with our researchers and alumni! Someone missing? Let us know! go.bsky.app/BjLT1RR

Game recognizes game x.com/rogerfederer...

I have moved to the HNRCA at #Tufts in #Boston. We have #postdoc openings in the #systemsbiology of #aging, using #Drosophila as a model. For more info, see promislowlab.org/wp-content/u...

Are you an RNA biologist or developmental biologist studying cardiac development? Join us at our new lab at the Vascular Research Center @UK_Frankfurt . We are expanding our team: Currently hiring 1 Postdoc and 2 PhD students to study mRNA translation @ERC_Research Please RT

Great to see that our MetaboHealth score (mentioned in the preprint as the Deelen et al. score) is doing so well regarding the prediction of both morbidity and mortality in independent cohorts! www.medrxiv.org/content/10.1...

Our review on the genetics of human longevity is now published in the Journal of Internal Medicine. I am very proud of my PhD student Larissa Smulders who managed to finalise the manuscript while enjoying her parental leave. I hope you will enjoy the read! onlinelibrary.wiley.com/doi/10.1111/...