Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis. www.biorxiv.org/content/10.1...

Excited to share my PhD research, now on bioRxiv! We report a proteo-transcriptomic reprogramming and resource reallocation in the aging brain. Co–first author with Verena Kluever. Grateful to @forna.bsky.social‬ for mentorship, and to @tatjanat.bsky.social‬, Carlos López Otín & all collaborators🧠

New work from the lab! C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules - Bilican - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1002/...

Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells https://www.biorxiv.org/content/10.1101/2025.08.20.671247v1

🎉 We’re excited to share our very first preprint!! 🎉 "Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells" 👉 doi.org/10.1101/2025... #FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience

RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...

Our RAPPL purification of ribosomes and associated material is out. I am really proud of this study in collaboration primary with Pavlovic-Djuranovic lab, as well as Jovanovic and Hashem Labs. This method aims to replace 60 years old purification of ribosomes by sucrose cushions rdcu.be/ezlhg

Excited to announce our paper describing how allelic variants in ribosome biogenesis factors cause neurodevelopmental disorders. Congratulations to Chunyang Ni, Yudong Wei and Barbara Vona, our collaborators Jun Wu, Reza Maroofian, and Leqian Yu, and all the other authors from across the globe.

🚨 Happy to share our first pre-print 🎉 on the causes of ribosome-associated degradation of CFTR and other transmembrane proteins. We explore how protein folding, ER insertion, and elongation dynamics influence translation arrests in this new class of RQC targets.👇 www.biorxiv.org/content/10.1...

To all post-docs: The Genome Biology dept ‪@embl.org has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

I am happy to share our last preprint, where we identified FASN as an endogenous dsRNA-associated factor and demonstrated that its depletion triggers endodsRNA accumulation and a stronger antiviral response to exogenous dsRNAs,#RNA, #interferon,#immunometabolism www.biorxiv.org/cgi/content/...

🚨🚨🚨 Please RT! We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets. Deadline: 30/09/25👇

Postdoc positions in structural biology of RNA processing complexes. An ERC-funded position will dissect pre-mRNA processing pathways in the infective organism Trypanosoma brucei. An ANR-funded position will characterise large complexes in RNA modification. Details: tinyurl.com/postdoc-RNA-...

So shiny ✨I am so happy to be part of this amazing initiative!

Freshly launched! 🚀 Check out the new CRC 1678 website 🌐 👉 crc1678.uni-koeln.de

Proud to share our work where we resolved a longstanding question regarding the existence of a human telomerase dimer and provided insights into its function. Led by 3 amazing lab members in collaboration with @yiliangding.bsky.social and @rdaslab.bsky.social. www.science.org/doi/10.1126/...

Currently our Mercator Fellow Alice E. Lee from Harvard Medical School is visiting us. We very much welcome Alice in Cologne and we are looking forward to many stimulating discussions with her! 👉 labs.childrenshospital.org/lee-lab

We are very happy to invite you to our 9th Rhineland RNA Club at @dzne.science Bonn with great local speakers and Lena Steckelberg @lenasteckelberg.bsky.social as our invited speaker. All #RNA enthusiasts are welcome! Organized by @inahuppertz.bsky.social and @katleppek.bsky.social. #RNAsky

🚀 Big news for kidney research! CRC/TRR 422 ‘PodoSigN’ has been funded to explore podocyte signaling networks. Proud to see two of our CRC 1678 Group Leaders @muellerrom.bsky.social and @inahuppertz.bsky.social involved in this groundbreaking work! #KidneyResearch #PodoSigN #DFGFunding

Join the Hallegger Lab in Oxford! A post-doc position available to develop neuronal cell models to characterise how TDP-43 aggregation leads to its dysfunction in MND. Highly collaborative project funded by My Name'5 Doddie Foundation @MNDoddie5 Please repost and share widely!

The awesome Helene Kretzmer and I are looking to recruit a join computational PhD student. Applications will be evaluated on a rolling basis, so don't wait! Any questions get in touch. We are looking forward.

What an honour to be part of this initiative #RNA #RNAsky

Mind blown 🤯 rdcu.be/enTz2

CECAD receives renewed DFG funding! 🎉 We continue to unlock the biology of aging 🧬 and advance healthy aging for all! 👵👴 ➡️ uni.koeln/GAPGK #CECAD #AgingResearch #ExcellenceCluster #DFG #HealthyAging @unicologne.bsky.social

Ribosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decay

Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social, @marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social 🔗 Preprint here tinyurl.com/3a74uanv

It was such a great day #RNA #RNASky

Excited to share this one! We developed an in vivo model for specific manipulation of transfer RNA acetylation and found it serves as a sentinel modification whose loss causes ribosome stalling and stress signaling. Implications for a genetic disorder and cancer. www.science.org/doi/10.1126/...

The first paper from the Leppek lab is published today at @embojournal.org!! 🎉 We designed and evaluated a versatile toolbox for determining IRES activity in cells and embryonic tissues. www.embopress.org/doi/full/10....

ARGONAUTES 2025 The grassroot meeting of Argonaute afficionados is looking for afficionados! Full coverage of Argonautes from prokaryotes to #RNAi, #piRNA and #microRNA Join us in Prague at @imgprague.bsky.social during 27-30/8, 2025. Registration, program and more info here: argonautes.img.cas.cz

We are very happy to invite you to our 8th edition of the Rhineland RNA Club @mpiage.bsky.social with great local speakers and Julian König @koenig-lab.bsky.social as our invited speaker. All #RNA enthusiasts are welcome. Organized by @katleppek.bsky.social and @inahuppertz.bsky.social. #RNAsky

Excited to share the work of Jonathan Perr where he uncovered a surprisingly common feature of cell surfaces - the presentation and clustering of RNA binding proteins with #glycoRNA. Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...

Join our GBM Redox Meeting 2025 in Saarbrücken! We put together an exciting program covering diverse aspects of Redox Regulation in Life. Check out the Programm and register until Feb 28! redox-gbm-meeting-2025.uni-koeln.de #redox #redoxbiology #gbm @gbmev.bsky.social

Come and joint us at @mrclmb.bsky.social ! We have an opening for a new group leader in the Structural Studies Division. We are very interactive and collaborative with amazing facilities and generous core funding. Get in touch with myself or @sjorsscheres.bsky.social if you have any questions.

Very happy to share that my research group has launched at the German Diabetes Center (DDZ) in Düsseldorf! We're looking for a PhD student to study the effects of inter-tissue communication on energy balance and metabolic health. Interested? Get in touch! ddz.de/en/job/docto...

🦋 A starter pack of peer-reviewed journals in all fields of natural sciences 🔬🧪🧬🧠🧫⚛️ #biology #physics #astronomy #botany #chemistry #chemsky #chemisky #ChemBio #MicroSky #microbiology #MolBiol #genomics #neuroscience #PlantScience #PlantBiology #AcademicSky #Academia #research #science #PhDSky #PhD

Very proud of our first peer-reviewed paper from the lab: a review on the multifaceted role of RNA-binding proteins in the metabolic control of stem cells. Check it out! This is a truly amazing effort by my PhD student Ellie Koletsou @mpiage.bsky.social #proudPI doi.org/10.1038/s443...

Check out the latest Reviews and Perspectives from experts in RNA biology in this joint collection from @CellChemBiol and @MolecularCell http://dlvr.it/TGwFkr

Winter sunsets are the best. Did I mention that the Champalimaud PhD program just opened for applications and that the lab has an open postdoc position in metabolism?

First paper of our lab today @natureportfolio.bsky.social by Nussi! We provide a real-time movie on how #transcription and #translation cooperate using #single-molecule FM: we find long-range #ribosome/ RNAP communication mediated by #RNA looping! @embl.org #RNAbiology #RNASky t.co/a24Xxcxdo0

We are recruiting an associate or full Professor of Infection and/or Immunity to the school biological sciences in Cambridge. Full details here: www.jobs.cam.ac.uk/job/49381/ #immunology #virology

Today we celebrated the successful defense of Franz Reichel's master's thesis. Franz worked on the role of #RNA-binding proteins in #senescence as part of the @crc1678.bsky.social initiative. I could not be more proud to have such a great lab @mpiage.bsky.social

This week, the @crc1678 kick-off retreat brought all the project leaders together! 🚀 A fantastic opportunity to dive into projects, spark collaborations, and lay the groundwork for an exciting journey ahead. On our way to innovation, teamwork and impactful discoveries! 💡👩‍🔬🧑‍🔬 #Research #Collaboration

People working on #cancermetabolism, #mitochondrialbiology, #metabolism, please reach out! Share this so I can follow who is here! I will share paper on cancer metabolism, but anything else related to mitochondria and metabolism.

My first post on Blue Sky - moving over ! For all post-docs out there - fantastic opportunity @EMBL. Independent group leader position: Core funding, state-of-the-art core facilities, access to fantastic Ph.D. students, and of course amazing colleagues. Please apply www.embl.org/jobs/positio...

Fellow #RNA lovers, please repost 🙏: 2 ERC-funded Post-doc positions are available in our lab to investigate #RNA structural ensemble and their dynamics in living cells. Application link: t.co/pYJ3H3j705

First tweet of appreciation: I love my #lab. They prepared an #advent #calendar and everyone contributed little surprises for each other. I am grateful to have such a wonderful #team. Chrysa, Danae, Ellie, Julia, Lea, Musa, Niko, Norito, Viktoriia and Virginia🫶 #RNA #metabolism #stemcells