Thanks to Autoimmunity podcast @kevinbonham.bsky.social & @woodrufflab.bsky.social for discussing our glycoRNA paper w/ @raflynn5.bsky.social @vinnieviruses.bsky.social

In our latest episode, @woodrufflab.bsky.social and @kevinbonham.com talk about glycoRNAs, and the way they're shielded from the immune system in a new paper from the labs of @raflynn5.bsky.social and @vijayrathinam.bsky.social 🧪 audiommunity.org/episodes/epi...

Sugar coats shield immunogenic RNA modification:A new function for RNA glycosylation: Molecular Cell www.cell.com/molecular-ce... @raflynn5.bsky.social @vinnieviruses.bsky.social

Don’t trust the experts”? That’s not democracy, that’s recklessness. On a plane, I want a pilot. In a hospital, I want doctors and scientists who understand the evidence. Expertise isn’t religion or authoritarianism — it’s training, accountability, and data. Ignore it and we all pay the price.

🚨New Paper in Cell 🧵🔎 Happy to share our work led by the @camilahcoelho.bsky.social, on mAbs against mpox. We were very excited (and lucky!) to contribute to this collab. effort. 🦠“Human monoclonal antibodies targeting A35 protect from death caused by mpox”🦠 doi.org/10.1016/j.cell.2025.08.004

#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...

Another piece of the #glycoRNA puzzle revealed by @raflynn5.bsky.social and @vijayrathinam.bsky.social!! RNAs with modified base acp3U activate TLR3/7, but not when acp3U is N-glycosylated. This is how cell surface/secreted glycoRNAs avoid stimulating autoimmunity. www.nature.com/articles/s41...

4/5 The Glycobiology Significant Achievement Award: Dr. Ryan Flynn @raflynn5.bsky.social, Harvard University, 👏👏🥂

@vijayrathinam.bsky.social @vinnieviruses.bsky.social ‪@raflynn5.bsky.social‬ discovers why RNA undergoes glycosylation: N-glycans on glycoRNAs hide self-RNA from endosomal TLRs promoting ‘silent’ clearance of dead cells @nature.com www.nature.com/articles/s41...

Incredible discovery ! The first known role for sugar coated RNAs : immune evasion ! @raflynn5.bsky.social does it angain with @vinnieviruses.bsky.social @vijayrathinam.bsky.social and colleagues !

Check out this @nature.com paper from the brilliant scientist I get to call my husband!!!!

RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...

Big congrats to Vinnie Graziano @vinnieviruses.bsky.social who led the project and huge thanks to our great collaborators: Jennifer Porat, Thomas Carell, Franck Barrat, Beiyan Zhou, Sivapriya Kailasan Vanaja, Michael Wilson, and Penghua Wang!! #innate_immunity #interferon #celldeath

Hi everybody! I am super excited to share the work done during my PhD published in @nature today! We describe a new mechanism of self- vs. non-self RNA discrimination by showing how N-glycans shield glycoRNAs from stimulating endosomal RNA sensors www.nature.com/articles/s41...

Wow Karolinska Institutet is recruiting 20 outstanding early-career researchers for assistant professor positions ki.se/en/about-ki/...

The science being done in my lab right now is the best in my 20 years as a professor at UW. It's just incredible whiplash to flip between that the science funding situation here in the US, and to think about the societal abandonment of the brilliant young trainees who are pushing the work forward.

My next paper is going to be written like a Choose your own Adventure: To do a Western Blot from the pulldown, go to page 7 To CRISPR out the functional domains, go to page 46 To skip till the Acknowledgements, go to page 52

**US-CAN Doctoral Excellence Award @WesternU -$160,000 to 25 PhD students for up to 4 years. - Must've had offer rescinded/cancelled from US school. -Expedited admission process. -Feel free to reach out, if interested in a PhD in inorganic chem! www.forbes.com/sites/michae...

If you were too young in 2003 here is what Bush told the American people: 1) The Iraq War won’t cost a lot of money 3) We won’t need a lot of troops 4) We’ll bring peace and freedom to Iraq 5) We’ll find WMDs 6) We’ll be welcomed as liberators 7) It will be easy 8) It won’t take long All lies.

Can confirm: 60 Minutes will be worth watching tonight about #NIH.

Pope Francis lifted the world as he led the Church with his profound moral voice. As he returns to God, may his call to humility and concern for the least among us continue to resound.

From a source at NIH: “Right now NIH’s ability to buy things is dead. Nearly all people with the power to make an order — purchasing people — have been removed. The NIH hospital can’t buy medicines, the labs can’t buy petri dishes. X-Ray machine breaks? Too bad. Everything is stopped”

“This will go down as one of the darkest days in modern scientific history” 🧪 www.nature.com/articles/d41...

There is no other way to say this: Today is the day the CDC was essentially dissolved. What's left is a husk. People will die as a direct result. www.wired.com/story/cdc-gu...

F mechanisms (New and Competitive renewals) Oof! 3/n

Hearing that NIH has been ordered to cut $2.6B in contracts. NCI, which supports cancer research, to cut $900M. Fort Detrick might be on the chopping block.

A nearly 9 year effort to design and implement new CLIP-based technologies to define multimeric protein assemblies on RNA. Enables ‘watching’ of RNP assemblies inside living cells Special congrats to Luca Ducoli, Brian Zarnegar, and Paul Khavari @nature.com www.nature.com/articles/s41...

When your ideology denies climate change’s impact on public health, cutting research funding is the predictable next step. A devastating blow to a critical field—and to the people who rely on its findings www.propublica.org/article/nih-...

Whooo! Congrats @vijayrathinam.bsky.social

I have just eaten exactly one piece of pizza too many, i.e., the correct amount of pizza

Horrible news - The Adolescent Medicine Trials Networks for HIV/AIDS Interventions (ATN) funded by the NIH has just been terminated. Stopping a clinical trial mid-course like this is insane. www.nichd.nih.gov/research/sup...

RIP George Foreman 🙏…one of the best to ever do it….rest easy Champ!

NEW: Judge Boasberg issues a show-cause order (precedes contempt sanctions) on why he shouldn't find that the gov't defied his orders. "In an ex parte pleading delivered shortly after today’s deadline, the Government again evaded its obligations." storage.courtlistener.com/recap/gov.us...

Excited to share the work of Jonathan Perr where he uncovered a surprisingly common feature of cell surfaces - the presentation and clustering of RNA binding proteins with #glycoRNA. Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...

Check out the Insights piece from A Blumenthal & L Dominguez Cadena on our discovery of CCDC134’s role in Gp96 stability and TLR biogenesis. Many thanks to the authors for discussing our work broadly, integrating recent studies by Rohatgi and Locher/Kaelin labs, and highlighting key open questions.

Excited to share our latest paper out today in @naturecomms.bsky.social ! Great work led by postdoc Ales Drobek showing for the first time the critical role in vivo of the SLC15A4/TASL/IRF5 pathway that we discovered few years ago. #ImmunoSky #InterferoSky

Wooo! Congrats to all the authors! Skylar absolutely killed it with these critical experiments. It was such a privledge to watch this research be done in the @vijayrathinam.bsky.social and @kailasanvanaja.bsky.social lab

Noro is crazy contagious, so folks, if you do have it in your household…please: ramp up your hand hygiene (soap & water, as hand sanitizer is limited in efficacy for it), clean/disinfect like no one’s business (w/effective products! When in doubt, bleach it out), (1/2)

"I'm taking his bench!"

Hi everyone! New to Bluesky, but happy to share the final chapter of my PhD @uconnhealth.bsky.social out today in Nature Immunology! Here, we uncovered a noncanonical function of the glucose transporter GLUT4 in regulating RLR signaling in muscle and adipocytes www.nature.com/articles/s41...