On my way, Clacton.

Due to alternative splicing that removes the TM–encoding exon, CD137 exists in both soluble and membrane forms, both expressed by Treg & critical for immunoregulation in #T1D @jem.org @medicalcollegeofwi.bsky.social rupress.org/jem/article/...

Congratulations to my final year PhD student Tahmid Hussain on winning a poster prize at Translation UK in Leeds #RNA

Why not just do both? Most 'green space' is grass fields for cows, which means methane farts plus CO2, methane and nitrous oxide greenhouse gas emissions from fertiliser. End animal farming and cover some fields in solar farms instead.

Really interesting and important suggestions marianamazzucato.substack.com/p/what-labou...

looks very useful

my Bluesky isn't showing pictures anymore and I have nt been able to remedy this. Help appreciated

very good news! www.bbc.co.uk/news/article...

Finally out in @Cellcellpress! Proteins with long IDRs are prone to misfolding during protein synthesis. This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones. www.cell.com/cell/fulltex...

What were the death tolls from pandemics in history? How many deaths were caused by different pandemics, and how have researchers estimated their death tolls? -by Saloni Dattani (12/7/2023 Our World In Data) Highly Informative article. Stunning data presentation. Follow ‪@scientificdiscovery.dev‬

Last night, I got to sit 5 rows away from a true force of nature, a woman who is the very definition of badass. Her performance was a benefit for the Centrum Arts organization. A force of nature, a badass, and a heart as big as all of us. Thank you, Ms. Raitt!

youtu.be/n0XSOKQDHTU?... longer and more intriguing than the studio version

from someone who knows www.economist.com/by-invitatio...

Life is wondrous!

very interesting and informative for the non-expert such as myself royalsociety.org/science-even...

Poly-ubiquitylated proteins proved trickier to purify for LC-MS than expected. Non-specific background swamped isolations: with histones and uncertainty! This led us to develop Ubi-SCAPE—for characterising the poly-ubiquitylome to unprecedented purity and depth. www.biorxiv.org/content/10.6...

Agree with this, Quality Journals can help here by publishing more theory and acting as conduit for discussion.

This evil happened in a highly technologically and culturally sophisticated society and today we day remember the camp was liberated by the Russians in 1945. And we will remember tomorrow and for ever.

Just out @natrevimmunol.nature.com RNA-binding proteins and ribonucleoproteins as determinants of immunity www.nature.com/articles/s41... gives our perspective on this growing area of research. Special thanks to the editor Alexandra, for streamlining the manuscript.

good to see this landmark work published www.theguardian.com/science/2025...

fascinating!

essential reading en.wikipedia.org/wiki/On_Bull...

I had no idea. www.theguardian.com/law/2025/nov...

Thanks Fiamma, Your work has been well-received. It's remarkable that these RNA binding proteins can regulate the cell cycle in proliferating B cells. But in Treg cells this does not seem to be the case, they are regulating responses to IL2, but proliferation was not obviously affected.

‘As new infections outpace new drugs, are we sleepwalking into a global health disaster?’ | Dr Manica Balasegaram

Fantastic team effort led by the rising star Dunja Capitan-Sobrino and many great scientists at Infinity - Toulouse, Inserm, CNRS !!!

The saxophone solo is wonderful www.youtube.com/watch?v=Ov4p...

Amazing, and really cool therapy. mRNA for the win! “The cells produce a small fragment of genetic material (called microRNA) that is designed to intercept and disable the instructions (called messenger RNA) being sent from the cells' DNA for building mutant huntingtin.”

An exceptional album. just saw the original cover photo sold for >300K...The music is for everyone. www.youtube.com/watch?v=CM3f...

Great album for dog walking on a sunny today morning www.youtube.com/watch?v=t2x1...

uplifting music for walking the dog on a surprisingly warm September day (Thanks to Bobby Friction for bringing this to my attention) www.youtube.com/watch?v=39VR...

www.youtube.com/watch?v=7HSr... check it out, covered by Joy Division on Unknown Pleasures.

Vivensa Academy is a growing membership (500+) of researchers, clinicians and community organisations, all dedicated to improving later life. Discover why you should apply to join, and the fantastic members-only exclusives you can access from day one: vivensafoundation.org.uk/news/three-g...

Great Opportunity

Great 5' video from >10 years ago explains where we still are today and why the government has to invest (which means spending more money, not austerity). www.youtube.com/watch?v=Fmsj...

In the new book Labwork to Leadership, chemist Jen Heemstra offers actionable leadership advice to principal investigators. Check out the #ScienceBooks Review on #ReadABookDay: https://scim.ag/46l2X6y

These projections for population changes over the century are fascinating! What will the age distribution look like esp in China?

🌟 We have funded five places for Academy members on Zinc's upcoming Inflection Fellowship Programme for mid-career professionals (10+ years of professional or research experience). More info and how to apply here: vivensafoundation.org.uk/news/five-fu... #midcareeropportunity #FundingForAgeingWell

very timely--mRNA vaccines for HIV trigger strong immune response in people www.nature.com/articles/d41...

& can be very rapidly produced and shared at scale in a crisis such as a pandemic!

Good news for molecular studies of the mechanisms of ageing.

A great moment for Women's football in England. I hope this leads to more investment at the community level in football and all other sports.

Read Hanane's blog for the @bsrageing.bsky.social describing her experience at #AGE2025 held in Alaska! * how her research @houseleylab.bsky.social has progressed since winning the 2024 Korenchevsky Award * conference highlights * sampling the Alaskan wilderness

An incredibly important contribution to humanity. observer.co.uk/news/interna...