Need to profile DNA replication genome-wide? TrAEL-seq reveals replication patterns and fork progression in unsynchronised, unlabelled and unsorted cells Our revised protocol: • Provides far better data from mammalian cells • Includes 6-way multiplexing academic.oup.com/nar/article/...

Exciting new project in our lab @babrahaminst.bsky.social! We are working with @alesdantas.bsky.social at @newcastleuni.bsky.social to understand how extrachromosomal circular DNA mediates drug resistance in fungal pathogens Funded by @wellcometrust.bsky.social #ecDNA #eccDNA #Candida #Zymoseptoria

Post-doc job alert! Only a week left to apply for this post doc role, joining our team at the Babraham Institute @babrahaminst.bsky.social to explore ageing metabolism and epigenetics. babrahaminstitute.livevacancies.co.uk#/job/details...

Post-doc job alert! We have an exciting opportunity for a post doc to join our team at the Babraham Institute, exploring ageing metabolism and epigenetics. babrahaminstitute.livevacancies.co.uk#/job/details...

Our new Preprint describes an improved TrAEL-seq protocol: • Provides far better data from mammalian cells • Includes multiplexing for higher throughput TrAEL-seq reveals replication patterns and fork progression in unsynchronised, unlabelled and unsorted cells www.biorxiv.org/content/10.1...

If you're at the AGE meeting don't miss the BSRA Korenchevsky Award talk from Hanane Hadj-Moussa! Hanane's work shows that we can acheive excellent healthy ageing through metabolic rewiring, even on an unrestricted diet Profile: whova.com/embedded/spe... Preprint: www.biorxiv.org/content/10.1...

Is healthy ageing possible on a normal diet? Our latest Preprint describes metabolic re-engineering of yeast to avoid senescence The A2A mutant we created is super-fit late in life even on a rich high glucose diet www.biorxiv.org/content/10.1...

Congratulations to our PhD student Amy Wolstenholme for winning the Poster Prize at the EMBL Drug Resistance meeting #EESDrugResistance this week Amy's poster showed that circular DNAs providing copper resistance can be stably transmitted for hundreds of generations in yeast