Really interesting that a poly-glutamine substrate associated with neurodegenerative disease are efficiently degraded from one terminus but resist degradation when engaged from the opposite terminus, highlighting the importance of substrate engagement mode.

Researchers at the Crick, @cam.ac.uk and Sanquin Research Amsterdam have made a key discovery about how the immune system can switch from ‘on’ to ‘off’ so quickly. The findings could offer potential new avenues for treating cancer or autoimmune conditions. www.crick.ac.uk/news/2026-01...

I am recruiting postdoctoral fellows to develop new research directions in the lab. We study transcriptional regulation through biomolecular condensates in development and disease, with an emphasis on first-principles and mechanistic discovery. Please repost or share with colleagues.

Three years after our launch, we’ve worked tirelessly to understand how and why MND occurs, identify promising treatments, and test them in clinical trials. Read about what we've achieved, together, in our first three years here: ukmndri.org/2025/12/17/u...

We are pleased to be a media partner for the @embo.org @embl.org Symposium: Cellular mechanisms driven by phase separation Abstract submission: 10 Feb 2026 Registration (On-site): 7 Apr 2026 Registration (Virtual): 12 May 2026 bit.ly/3NaPXJX @events.embl.org #EESPhaseSeparation

Discuss #RNA 3' ends and their regulation at the EMBO Workshop "RNA 3' ends and beyond" in #Oxford, United Kingdom, 7–11 September 2026. Deadline: 4 May 2026 https://meetings.embo.org/event/26-rna3#RNA#Oxford#EMBORNA3EndsBeyond #RNAsky #LifeSciences #meeting #EMBOevents 🧪

The Michael J Fox Foundation is hosting an online town hall on endolysosomal targets in Parkinson disease on 25 March at 12.30pm EST. Registration now open. www.dementiaresearcher.nihr.ac.uk/event/mjff-t...

What's larger, a protein or its templating mRNA ? > The mRNA is much larger. ⬛ 𝐀 𝐬𝐞𝐧𝐬𝐞 𝐨𝐟 𝐬𝐜𝐚𝐥𝐞 -- 𝐪𝐮𝐚𝐧𝐭𝐢𝐭𝐚𝐭𝐢𝐯𝐞 𝐢𝐧𝐭𝐮𝐢𝐭𝐢𝐨𝐧 & 𝐜𝐨𝐧𝐬𝐭𝐫𝐚𝐢𝐧𝐭𝐬 -- 𝐢𝐬 𝐚 𝐩𝐨𝐰𝐞𝐫𝐟𝐮𝐥 𝐞𝐧𝐚𝐛𝐥𝐞𝐫 𝐨𝐟 𝐫𝐞𝐬𝐞𝐚𝐫𝐜𝐡. The figure shows myoglobin protein drawn to scale next to its mRNA template. The coding sequence of an mRNA ...

The Structured RNA-binding Domains and Condensation Capacity of FUS Shape its RNA-binding Landscape and Function. https://www.biorxiv.org/content/10.64898/2026.01.12.699057v1

Today we celebrate #ListerFellow @nickywhiffin.bsky.social 🤩She's on The Sunday Times Alternative Honours List 2025 for her role in discovering ReNU syndrome and the non-coding variants behind the disorder 👏 Read this fab story of discovery and rapid uptake👉 lister-institute.org.uk/renu-ed-hope...

My Name is Doddie Foundation Catalyst Awards 2026 are now open. Funding bold early stage MND research ideas with up to £100k to generate data and open new treatment pathways. www.dementiaresearcher.nihr.ac.uk/funding/my-n...

📣Excited to announce a new pre-print from the lab 📣 Led by my student @storiesofisobel.bsky.social in collab with Hemali Phatnani @nygenome.org We discovered a novel class of TDP-43 dependent cryptic gene-TE spliced transcripts: crypTEs #TEsky #RNAsky #ALS doi.org/10.64898/2026.01.09.698641

If successful, he will be the first UK Paralympian with MND in any sport. Whether you’re also hitting the slopes or just heading out for a walk, Davy is encouraging everybody to take part in Doddie Aid in their own way. Sign up for Doddie Aid today at doddieaid.com 🏂

Happy to share with you our work on how the interferon response impacts embryonic development 🦠Mammalian embryos contain endogenous dsRNAs that resemble viruses and can be misrecognised by the dsRNA sensor MDA5. Thanks to all collaborators, we could not have done it without you 🤩 rdcu.be/eWMfA

We introduce #ProxiCapture, an affinity-proteomics platform to map degrader-induced interactions in native cell & tissue lysates. We uncover a context-dependent “glueable” proteome and a scalable route to accelerate molecular glue discovery 🤗 @ibc2-gu.bsky.social @goetheuni.bsky.social

Latest research from my group. We activated BDNF protein expression by disrupting a repressive uORF using a CRISPR base editing strategy: www.sciencedirect.com/science/arti... #OxfordPaediatrics #IDRMOxford #BDNF #uORF #CRISPR #BaseEditing

These are great, but I'm worried that I'd have suspected AI for some of them, especially the rhino one. Are our mental AI detectors being calibrated too high? www.nature.com/immersive/d4...

Work from my Master’s year out now!

Nuclear speckle associated RRM-containing proteins are block copolymers. They make size-limited, ordered microphases, tens of nm in size comprising tens of molecules. Speckles are likely clusters or emulsions of distinct microphases and not macrophases www.sciencedirect.com/science/arti...

On my last day in the lab for 2025... Our work with @roylab-ucsd.bsky.social on the formation of the membrane-associated periodic skeleton during axon development via droplet formation and condensation is out in @cp-iscience.bsky.social! www.cell.com/iscience/ful...

⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...

Excited to share that this work is now published in its final form! link.springer.com/article/10.1...

It’s been two weeks since Kevin Sinfield’s epic 7 in 7 Challenge for the MND community 💪 We still can’t get over how fantastic the support was when we were in Dundee for the 6th day - everywhere Kev went, there was a sea of blue and yellow tartan cheering him on 💙💛

How liquid-like is the nuclear pore barrier?🍝𖣐 Our new preprint shows that FG-NUPs exhibit nanosecond-scale, liquid-like mobility in living cells. 💧⚡O-GlcNAcylation and an importin-β gradient keep the FG network liquid-like, reconciling nuclear pore complex models.

New preprint led by super🌟 PhD student @eloisewells.bsky.social! Here we explore using exon-skipping to remove upstream open reading frames (uORFs) and increase protein translation as a therapeutic approach for rare haploinsufficient disorders 🧬 To learn more see Eloise's 🧵 👇

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Excited to share the latest work from postdocs Ameya and Zach! We thought about how multinucleate cells are able to maintain N:C ratio, and found a condensate rheostat that regulates translation of cell cycle + growth mRNAs. Check it out! www.biorxiv.org/content/10.1...

We also have a range of posters today, so please come and check them out this evening! #alsmndsymp

🚨 NEW: One of the largest COVID-19 vaccine studies ever (28 MILLION people in France) just dropped. Results? • 74% lower risk of death from severe COVID-19 • 25% lower risk of all-cause mortality • No increase in 4-year mortality #BlueSky #MedSky #IDSky #SciSky #NewsSky #PedsSky #ObSky #NurseSky

Research Assistant Vacancy Oxford Centre for Human Genetics for iPSC dopamine neuron studies in the Lang Group exploring glial neuronal roles in Parkinsons disease. Closing date: 2nd January www.dementiaresearcher.nihr.ac.uk/job/research...

New pipeline to implant human chromosomes into mouse cells and back again signals first step in mammoth undertaking to synthesise the human genome. Read more about the achievement from LMB’s PNAC Division as part of the SynHG project: www2.mrc-lmb.cam.ac.uk/transplant-o... #LMBResearch

I am happy to share that my postdoctoral work in the @gerlichlab.bsky.social at @imbavienna.bsky.social is finally out 🎉! Our study reveals how cohesin guides focused and accurate homology search. Read more 👉 www.science.org/doi/10.1126/... Follow along for key insights and updates! 🧵

Very nice paper from Yi Liu's lab on how the CCR4-NOT and PAXT complexes repress expression of mRNAs with low codon usage values by promoting their nuclear decay. Many codon effects likely boil down to GC-content. www.nature.com/articles/s41...

To Oxford, to talk to the Biochemistry Society about DNA and Rosalind Franklin. Talk is at 19:00 in St Peter's College if you fancy coming along.

PolyA_DB v4: systematic polyA site identification and isoform annotation in human and mouse genomes using 3′ end and long-read sequencing data.#PolyA #IsoformAnnotation #Genomics #Bioinformatics #NAR @narjournal.bsky.social 🧪🧬 🖥️ academic.oup.com/nar/advance-...

Researchers at the Crick, @psich.bsky.social and @esrf.fr have developed a new way to look deeper into brain cell connections by using a particle accelerator and a kind of resin borrowed from the aerospace industry. www.crick.ac.uk/news/2025-11...

We show structural details of TDP-43's C-terminal helix assembly into functional multimers, explaining dysfunction caused by several disease mutations (in Nature Comm). Appropriate for Thanksgiving day, there is a critical tryptophan! with @mittalgrouptamu.bsky.social www.nature.com/articles/s41...

I wish I didn’t have to share this. But the BBC has decided to censor my first Reith Lecture. They deleted the line in which I describe Donald Trump as “the most openly corrupt president in American history.” /1

Exciting Symposium on Biopolymers coming up in Mainz in March 2026! Great lineup of speakers from both the polymer and life sciences 👇

Which TDP-43 regulated events go first? Very exciting to read this! No need for Angst on here!

Man do I miss the good ole days when I could tweet a new paper without thinking about the existential dread of feeding the algorithms. Anyway - on the off chance this still works in the way I remember, We've got a new preprint! www.biorxiv.org/content/10.1...

One week left to apply! Great Opportunity! Make sure to check out the joint project in the Hallegger and Fowler lab! Please, share and repost!

Registration is open for "The complex life of #RNA" 2026 @embl.org in Heidelberg! Excellent invited speakers and 30 short talks and even more flash talks selected from the abstracts!

(Part 2/2) The model uncovers how homotypic and heterotypic interactions shape condensate architecture and reveals how protein dynamics differ depending on whether they are DNA-bound, in the dense phase, or freely diffusing.

This work is now officially published @natsmb.nature.com with some fun new analyses included in the revised version. Congratulations to all the authors! @connyyu.bsky.social @rappsilber.bsky.social @lrsinn.bsky.social @fjoreilly.bsky.social www.nature.com/articles/s41...

Developing new treatments is essential for MND, but the process is lengthy and people with MND don’t have time to wait. Repurposing means we can quickly see if any already available treatments could be effective in MND and get them into clinical trials as soon as possible. Read more👇

Our story on GroEL/ES action during cotranslational folding is now published @natcomms.nature.com. Led by former-student Alzbeta Roeselova, and in collaboration with Rado Enchev's lab @crick.ac.uk. www.nature.com/articles/s41...

It's coming again!! Can't wait...

Latest #CDlab paper on nanopore protein sequencing on @biorxivpreprint.bsky.social: www.biorxiv.org/cgi/content/... Here, Justas Ritmejeris, @xiuqichen.bsky.social, collaborator @albadalab.bsky.social and me developed a conjugation chemistry strategy for nanopore sequencing of natural peptides!

Check out our work on RNA structure in introns! Testing >100k base pairing patterns, we found that RNA structure can predictably tune gene expression. Just by changing intron sequence, we see a dynamic range of regulation comparable to messing e.g. with promoters. @karlaneugebauer.bsky.social