Coordinating mRNA maturation: The U1 relay model

I love this portrait of a scientist so much. Portrait of Dr Bouchard, by Tamara de Lempicka, 1928

Journal: "Given your expertise in this area, we invite you to review the manuscript below." Scientists:

mRNA is a key polymer of life. While its sequence is linear, its function requires its 3D organization. Yet what does a mRNA look like in 3D? In collaboration with the fbzt.bsky.social, we developed a method to visualize mRNA in 3D and at the nanoscale inside human cells. tinyurl.com/r858t6ff 1/3

Thanks Julian! 😁

1️⃣7️⃣ Milo Aukerman is a molecular biologist as well as the lead singer of the punk-rock band Descendents www.asbmb.org/asbmb-today/...

New preprint led by Fan Cao & Giulio Tesei We present a data-driven “stickiness” scale for amino acids in intrinsically disordered proteins 🍝, learned from SAXS data on 115 proteins. The scale captures effective residue interactions without conflating size and strength doi.org/10.64898/202...

A new function for GlycoRNAs!! The GlycoRNA-Heparan sulfate complex on the cell surface controls VEGF-A signaling and angiogenesis. Superexciting findings from Ryan Flynn's lab. Congratulations to all authors!! @raflynn5.bsky.social www.nature.com/articles/s41...

Now online! Metabolically regulated proteasome supramolecular organization in situ

Now out in Nature! We visualize infection of the RNA virus RSV in real-time with single-vRNP resolution to understand how RSV establishes viral factories, biomolecular condensates that act as sites of viral replication. A huge collaborative effort led by Dhanushika Ratnayake! rdcu.be/e1bBW

A great read! link.springer.com/article/10.1...

📡🧵 Excited to release an updated version of our preprint: Zebrahub-Multiome: Uncovering Gene Regulatory Network Dynamics During Zebrafish Embryogenesis 🧪🧬🖥️🐠 doi.org/10.1101/2024... A tour-de-force by @yangjoonkim with an unexpected discovery!

This large-scale open dataset and the continued community development around it exemplify the spirit of #TeamTomo 🧪 🔬 👨‍🔬👩‍💻

So cool - someone finally hacked 'the vault'. www.science.org/doi/10.1126/...

Shocking news: Peer Bork passed away today. We lost a giant of computational biology! We will miss you Peer. www.embl.org/news/embl-an...

Knockdown of the fly spliceosome component Rbp1 (orthologue of SRSF1) extends lifespan #Drosophila

Short fatty acids, custom synthesized by engineered yeast 🧫 Here it is: doi.org/10.1038/s415... 🤝✨ Fantastic team effort — thanks to Yongjin Zhou! Science made possible at @goetheuni.bsky.social 🏛️🔬

Excited for this work by Michael Cortazar, an @JagannathanLab Postdoc, to be out as a preprint. So much hard work went into it, but it was well worth it 🤓

Online Now: Toward community-driven visual proteomics with large-scale cryo-electron tomography of Chlamydomonas reinhardtii Online now:

super cool story! Congratulations @helena-stafflinger.bsky.social and the Wöhnert Lab.

Two of the three latest Breakthrough papers in #NAR are from our department. Congrats to @schneian.bsky.social and his amazing team!

Intrigued by a long-standing conundrum in small RNA biology—how nuclear Argonaute proteins silence transposons when they *need* target transcription for their own recruitment—we studied the piRNA pathway. And found a hidden RNA-decay axis from Piwi to the RNA exosome.

Great work led by Yunqing Li @yunqingli.bsky.social & another great collaboration with Hartmut Niemann (Bielefeld). Funded by CRC1507 'Membrane-associated protein assemblies' @crc1507.bsky.social at @goetheuni.bsky.social 🙏

⏰Call for Applications - Join Our Team and Help Shape Our Cluster @goetheuni.bsky.social and the Cluster of Excellence SCALE - Subcellular Architecture of Life are seeking 3 highly motivated scientists to join a vibrant and innovative research community on Campus Riedberg. Share with your network!

Application deadline: 18 January 2026 For details and application instructions, visit: berufungsportal.uni-frankfurt.de Further information about SCALE can be found at: scale-frankfurt.org @mpibp.bsky.social @mpibrain.bsky.social @proloewe.bsky.social @unimainz.bsky.social @FIAS

Take advantage of this fantastic opportunity to become part of the SCALE community! Several professorships and group leader positions are available at Goethe University and FIAS. We are looking for professors in the fields of molecular microbiology, cellular biochemistry, and molecular biochemistry.

Interested in the group leader positions in Computational Sciences, please visit the FIAS webpage for details: fias.institute/de/das-fias/...

This opening statement made me actually open and read the paper. You all should, too. It's a wonderful piece of work. Thought-provoking in the best sense. It may very well be that Yamuna & team have found a proxy measurement for local metabolic activity. Which would be a game changer.

How liquid-like is the nuclear pore barrier?🍝𖣐 Our new preprint shows that FG-NUPs exhibit nanosecond-scale, liquid-like mobility in living cells. 💧⚡O-GlcNAcylation and an importin-β gradient keep the FG network liquid-like, reconciling nuclear pore complex models.

Before you decorate the tree, come decorate your RNA next Thursday, 4 pm, 18.12.2025 Our last RNA event before the holidays. Also:Glühwein&snacks Registration: rmu-rna-salon.idloom.events/2-rmu-rna-sa... Please share @mixmue.bsky.social @cpi-exstra.bsky.social @scale-cluster-ffm.bsky.social

We analyzed changes in physiology relative to menopause using two large scale studies that include millions of lab tests. Rather than align by age, we used statistical inference to align tests to final menstrual period. (1/2) arunamed.com/the-menopaus...

Exceptional work by Enya (TU Delft) and Laurell (Frankfurt) 💪 and a great team 👍 & great support by our Exc Cluster @scale-cluster-ffm.bsky.social @goetheuni.bsky.social & we thank our Editor and the Reviewers for their valuable input @natcomms.nature.com #FluorescenceFriday #smartmicroscopy #RNA

It’s out 🥳🥳. Amazing new insights into Paraspeckles by SMART 3D STED imaging. Paraspeckles can be polar and fuse and have an interesting loop that contacts the nucleoplasm. Kudos to @heilemannlab.bsky.social, Sjoerd Stallinga and Bernd Rieger.

Made the mistake of opening Twitter: the amount of AI in Life Sciences grifters in there is just insane.

It has simply become unusable.

"In particular, we show that, if it is true that some degree of talent is necessary to be successful in life, almost never the most talented people reach the highest peaks of success, being overtaken by mediocre but sensibly luckier individuals" arxiv.org/abs/1802.07068

🤯This is wow! Molecular mechanism of mRNA export. by @juliusbrennecke.bsky.social @plaschkalab.bsky.social www.nature.com/articles/s41...

It was a true pleasure.

Great work of @deglushk.bsky.social from my PhD lab @mpibp.bsky.social on how to get more information out of all the membranes you see in cryoET data!

1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...

Im Exzellenzcluster @cpi-exstra.bsky.social untersuchen #Forschende interdisziplinär das Zusammenspiel von Herz und Lunge, Ziel ist u.a. die Entwicklung neuartiger Therapeutika. Zum Interview mit Prof. Dr. Dr. h.c. Stefanie Dimmeler von der @goetheuni.bsky.social geht es hier: youtu.be/aik52E5AlXg

Our photoswitchable HaloTag is out in Angewandte Chemie @angewandtechemie.bsky.social ! We now also show that this system can be used to control emitter density in SMLM. Congrats to Franzi, Bego, and our amazing collaborators. Check it out: onlinelibrary.wiley.com/doi/full/10....

Thrilled to share our work on transcription initiation and termination being spatially coordinated out today in Science! www.science.org/doi/10.1126/...

SCALE is a pioneering research center in partnership with Max Planck Institute of Biophysics, Max Planck Institute for Brain Research, FIAS - Frankfurt Institute for Advanced Studies, Universität des Saarlandes, Johannes Gutenberg University Mainz, and EMBL. 👉 Learn more: scale-frankfurt.org

Join the SCALE Community!

Wow! Max Planck is coming to Würzburg! 🥳

Congrats Mandy 🥳🤩