🤯This is wow! Molecular mechanism of mRNA export. by @juliusbrennecke.bsky.social @plaschkalab.bsky.social www.nature.com/articles/s41...

It was a true pleasure.

Great work of @deglushk.bsky.social from my PhD lab @mpibp.bsky.social on how to get more information out of all the membranes you see in cryoET data!

1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...

Im Exzellenzcluster @cpi-exstra.bsky.social untersuchen #Forschende interdisziplinär das Zusammenspiel von Herz und Lunge, Ziel ist u.a. die Entwicklung neuartiger Therapeutika. Zum Interview mit Prof. Dr. Dr. h.c. Stefanie Dimmeler von der @goetheuni.bsky.social geht es hier: youtu.be/aik52E5AlXg

Our photoswitchable HaloTag is out in Angewandte Chemie @angewandtechemie.bsky.social ! We now also show that this system can be used to control emitter density in SMLM. Congrats to Franzi, Bego, and our amazing collaborators. Check it out: onlinelibrary.wiley.com/doi/full/10....

Thrilled to share our work on transcription initiation and termination being spatially coordinated out today in Science! www.science.org/doi/10.1126/...

SCALE is a pioneering research center in partnership with Max Planck Institute of Biophysics, Max Planck Institute for Brain Research, FIAS - Frankfurt Institute for Advanced Studies, Universität des Saarlandes, Johannes Gutenberg University Mainz, and EMBL. 👉 Learn more: scale-frankfurt.org

Join the SCALE Community!

Wow! Max Planck is coming to Würzburg! 🥳

Congrats Mandy 🥳🤩

❓What if you could peek between your tilt series ❓ We are proud to introduce cryoTIGER -- deep-learning based tilt interpolation for enhanced reconstruction in cryo-ET. A great collaboration between Turoňová lab, @becklab.bsky.social, @hummerlab.bsky.social #teamtomo www.nature.com/articles/s42...

Heartfelt congratulations to @ralfsteinhilper.bsky.social @bjmurphylab.bsky.social on successfully defending his PhD thesis with summa cum laude! 👏💪🏆 For his doctoral research, Ralf used anaerobic sample preparation to study redox enzymes by single-particle cryo-EM.🔬 #phdlife #biophysics #excellence

Q.E.D works amazingly well! I was a skeptic at the beginning and then just really really impressed. For change 🥂

Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.

For the attention of all the Organelle researchers in Germany, the Annual meeting of the @gbmev.bsky.social study section Cellular Organelles will be held in Düsseldorf …. Seats fast filling up … please submit your abstract … information below: gbm-online.de/de/tagungska...

Stress granules have a limited impact on global translation regulation but serve to protect small ribosomal subunits and preinitiation complexes from degradation

How are RNAs sorted for export vs. degradation in the nucleus? In collaboration with @heick.bsky.social’s lab we (@clemensplaschka.bsky.social and @juliusbrennecke.bsky.social labs) discovered a direct mechanistic link between the export and decay machineries: www.biorxiv.org/content/10.1... (1/x)

Still true

Our study on the biogenesis of neuronal circular RNAs is out in Genes&Development @genesdev.bsky.social ! genesdev.cshlp.org/content/earl... Our celebration picture features first authors @carlosalfonsog.bsky.social and @shimengjin.bsky.social holding the fabulous circular cake, and most co-authors.

We followed with a day packed with CryoEM! We heard about the cryoEM from Werner Kühlbrandt, STEM-EELs from Bonnie Murphy and CryoET from Martin Beck.

GBM Compact Focus on Condensate Biology is opened by Edward Lemke. Looking forward to a great meeting!

How do cells sort which RNAs to keep or destroy? New preprint from THJ, Brenneke and Plaschka labs shows that export and decay machineries (TREX2/PAXT) both recognise UAP56-bound RNAs. Whether they’re exported or degraded depends on where in the nucleus this happens. www.biorxiv.org/content/10.1...

Liquid-liquid phase separation of HP1? Not in our mouse fibroblasts… This paper by the Fabian Erdel group offers a fresh perspective on how this can be reconciled with seemingly conflicting reports: The phase separation propensity of HP1 decreases from yeast → fly → mouse. doi.org/10.1038/s414...

My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...

Join us for the Austrian Cryo-EM Symposium Nov 11–12 at @istaresearch.bsky.social! Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus. Register now 👉 cryoem-symposium.pages.ist.ac.at #cryoEM #teamtomo

We're very excited to welcome the new generation of #IMPRS students during our Symposium on Cellular Biophysics 🧪 This morning, we heard spokespersons Volker Dötsch and Martin Beck, and coordinator Pamela Ornelas, introduce the doctoral program to the new students! #imprs_cbp #biophysics #gradschool

We had a great start of the #IMPRS Symposium on Cellular Biophysics to welcome our new students. Thank you for your fascinating talks Michaela Müller-McNicoll, Bernhard Hampölz and Christian Münch 👏 #imprs_cbp #phd #biophysics

Excited to share our recent work about the role of the molecular chaperone TRAP1 as RNA-binding protein! #RBPs #HGSOC

Very cool story! congrats Markus and Niels!

Beautiful mechanistic story, how QKI by bridging intronic motifs with U6 snRNA ensures inclusion of weak 5’ splice sites that are essential for building sarcomeres. Congrats @kurianlab.bsky.social and @evannostrandlab.bsky.social labs & all involved.

New and simple chemical modifications to poly(A) tails extend protein expression -- a really easy one-pot method Great work by Linglan Fang and Wenrui Zhong in our lab! doi.org/10.1021/jacs.5c11900

Congratulations, Dr. Li! 👏 🎉 @yunqingli.bsky.social @crc1507.bsky.social @dfg.de @goetheuni.bsky.social

I am sooo excited. Starting tomorrow the next edition of the fabulous #emboiclip2 course begins. @koenig-lab.bsky.social, @zarnack-group.bsky.social, moi & Elias Bechara will present 3 improvements to the method, a semi-automated workflow for data analysis and an exciting line up of speakers. Ready?

Wer Barbaras Rhabarberbarbarbaren mochte, freut sich hierüber auf jeden Fall auch. Und damit Gute Nacht!

The original idea is from @lcochella.bsky.social, we just extended it a bit.

🎉 We’re excited to share our very first preprint!! 🎉 "Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells" 👉 doi.org/10.1101/2025... #FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience

My PhD paper is in press @cellpress.bsky.social and now online: www.sciencedirect.com/science/arti...! Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more! Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo

Extremely excited for the second version of this workshop at the MPI of Biophysics l, Frankfurt, that will happen 12-20. April 2026. Absolutely amazing lineup of speakers, I am very much looking forward to learning from everyone! Apply here: meetings.embo.org/event/26-in-...

Absolutely textbook material - how unprocessed/intron-retained RNAs get detained in the nucleus from Yongsheng Shi lab www.biorxiv.org/content/10.1...

This quote lives rent-free in my head. #SciComm #ScientificCommunications #MedicalCommunications (1/9) 🧪

The goal of a PhD is not to learn some facts or read a few papers or learn a bunch of techniques. The goal of a PhD is to learn independence, problem solving, how to finish things you start, resilience, & gain the ability to adapt & think creatively. Learning these things is hard.

This preprint from Helen Sakharova is one of the coolest things to come out of my lab: “Protein language models reveal evolutionary constraints on synonymous codon choice.” Codon choice is a big puzzle in how information is encoded in genomes, and we have a new angle. www.biorxiv.org/content/10.1...

On being a scientist www.science.org/content/blog...

Our paper on the spatial organization of nuclear paraspeckles is out in #PNAS! Excited to see what comes next from the teams of @shrinivaslab.bsky.social and @sneadlab.bsky.social at Northwestern! pnas.org/doi/10.1073/pnas.2504778122

Detecting Nuclear Pore Complex assembly in living cells www.biorxiv.org/content/bior...