Online Now: Toward community-driven visual proteomics with large-scale cryo-electron tomography of Chlamydomonas reinhardtii Online now:

super cool story! Congratulations @helena-stafflinger.bsky.social and the Wöhnert Lab.

Two of the three latest Breakthrough papers in #NAR are from our department. Congrats to @schneian.bsky.social and his amazing team!

Intrigued by a long-standing conundrum in small RNA biology—how nuclear Argonaute proteins silence transposons when they *need* target transcription for their own recruitment—we studied the piRNA pathway. And found a hidden RNA-decay axis from Piwi to the RNA exosome.

Happy to share our (@erin-schuman.bsky.social, @mpibrain.bsky.social) latest preprint „Brain-wide synaptosome profiling reveals localized mRNAs that diversify synapses“ (www.biorxiv.org/content/10.6...).

Great work led by Yunqing Li @yunqingli.bsky.social & another great collaboration with Hartmut Niemann (Bielefeld). Funded by CRC1507 'Membrane-associated protein assemblies' @crc1507.bsky.social at @goetheuni.bsky.social 🙏

⏰Call for Applications - Join Our Team and Help Shape Our Cluster @goetheuni.bsky.social and the Cluster of Excellence SCALE - Subcellular Architecture of Life are seeking 3 highly motivated scientists to join a vibrant and innovative research community on Campus Riedberg. Share with your network!

Application deadline: 18 January 2026 For details and application instructions, visit: berufungsportal.uni-frankfurt.de Further information about SCALE can be found at: scale-frankfurt.org @mpibp.bsky.social @mpibrain.bsky.social @proloewe.bsky.social @unimainz.bsky.social @FIAS

Take advantage of this fantastic opportunity to become part of the SCALE community! Several professorships and group leader positions are available at Goethe University and FIAS. We are looking for professors in the fields of molecular microbiology, cellular biochemistry, and molecular biochemistry.

Interested in the group leader positions in Computational Sciences, please visit the FIAS webpage for details: fias.institute/de/das-fias/...

This opening statement made me actually open and read the paper. You all should, too. It's a wonderful piece of work. Thought-provoking in the best sense. It may very well be that Yamuna & team have found a proxy measurement for local metabolic activity. Which would be a game changer.

How liquid-like is the nuclear pore barrier?🍝𖣐 Our new preprint shows that FG-NUPs exhibit nanosecond-scale, liquid-like mobility in living cells. 💧⚡O-GlcNAcylation and an importin-β gradient keep the FG network liquid-like, reconciling nuclear pore complex models.

Before you decorate the tree, come decorate your RNA next Thursday, 4 pm, 18.12.2025 Our last RNA event before the holidays. Also:Glühwein&snacks Registration: rmu-rna-salon.idloom.events/2-rmu-rna-sa... Please share @mixmue.bsky.social @cpi-exstra.bsky.social @scale-cluster-ffm.bsky.social

We analyzed changes in physiology relative to menopause using two large scale studies that include millions of lab tests. Rather than align by age, we used statistical inference to align tests to final menstrual period. (1/2) arunamed.com/the-menopaus...

Exceptional work by Enya (TU Delft) and Laurell (Frankfurt) 💪 and a great team 👍 & great support by our Exc Cluster @scale-cluster-ffm.bsky.social @goetheuni.bsky.social & we thank our Editor and the Reviewers for their valuable input @natcomms.nature.com #FluorescenceFriday #smartmicroscopy #RNA

It’s out 🥳🥳. Amazing new insights into Paraspeckles by SMART 3D STED imaging. Paraspeckles can be polar and fuse and have an interesting loop that contacts the nucleoplasm. Kudos to @heilemannlab.bsky.social, Sjoerd Stallinga and Bernd Rieger.

Made the mistake of opening Twitter: the amount of AI in Life Sciences grifters in there is just insane.

It has simply become unusable.

"In particular, we show that, if it is true that some degree of talent is necessary to be successful in life, almost never the most talented people reach the highest peaks of success, being overtaken by mediocre but sensibly luckier individuals" arxiv.org/abs/1802.07068

🤯This is wow! Molecular mechanism of mRNA export. by @juliusbrennecke.bsky.social @plaschkalab.bsky.social www.nature.com/articles/s41...

It was a true pleasure.

Great work of @deglushk.bsky.social from my PhD lab @mpibp.bsky.social on how to get more information out of all the membranes you see in cryoET data!

1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...

Im Exzellenzcluster @cpi-exstra.bsky.social untersuchen #Forschende interdisziplinär das Zusammenspiel von Herz und Lunge, Ziel ist u.a. die Entwicklung neuartiger Therapeutika. Zum Interview mit Prof. Dr. Dr. h.c. Stefanie Dimmeler von der @goetheuni.bsky.social geht es hier: youtu.be/aik52E5AlXg

Our photoswitchable HaloTag is out in Angewandte Chemie @angewandtechemie.bsky.social ! We now also show that this system can be used to control emitter density in SMLM. Congrats to Franzi, Bego, and our amazing collaborators. Check it out: onlinelibrary.wiley.com/doi/full/10....

Thrilled to share our work on transcription initiation and termination being spatially coordinated out today in Science! www.science.org/doi/10.1126/...

SCALE is a pioneering research center in partnership with Max Planck Institute of Biophysics, Max Planck Institute for Brain Research, FIAS - Frankfurt Institute for Advanced Studies, Universität des Saarlandes, Johannes Gutenberg University Mainz, and EMBL. 👉 Learn more: scale-frankfurt.org

Join the SCALE Community!

Wow! Max Planck is coming to Würzburg! 🥳

Congrats Mandy 🥳🤩

❓What if you could peek between your tilt series ❓ We are proud to introduce cryoTIGER -- deep-learning based tilt interpolation for enhanced reconstruction in cryo-ET. A great collaboration between Turoňová lab, @becklab.bsky.social, @hummerlab.bsky.social #teamtomo www.nature.com/articles/s42...

Heartfelt congratulations to @ralfsteinhilper.bsky.social @bjmurphylab.bsky.social on successfully defending his PhD thesis with summa cum laude! 👏💪🏆 For his doctoral research, Ralf used anaerobic sample preparation to study redox enzymes by single-particle cryo-EM.🔬 #phdlife #biophysics #excellence

Q.E.D works amazingly well! I was a skeptic at the beginning and then just really really impressed. For change 🥂

Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.

For the attention of all the Organelle researchers in Germany, the Annual meeting of the @gbmev.bsky.social study section Cellular Organelles will be held in Düsseldorf …. Seats fast filling up … please submit your abstract … information below: gbm-online.de/de/tagungska...

Stress granules have a limited impact on global translation regulation but serve to protect small ribosomal subunits and preinitiation complexes from degradation

How are RNAs sorted for export vs. degradation in the nucleus? In collaboration with @heick.bsky.social’s lab we (@clemensplaschka.bsky.social and @juliusbrennecke.bsky.social labs) discovered a direct mechanistic link between the export and decay machineries: www.biorxiv.org/content/10.1... (1/x)

Still true

Our study on the biogenesis of neuronal circular RNAs is out in Genes&Development @genesdev.bsky.social ! genesdev.cshlp.org/content/earl... Our celebration picture features first authors @carlosalfonsog.bsky.social and @shimengjin.bsky.social holding the fabulous circular cake, and most co-authors.

We followed with a day packed with CryoEM! We heard about the cryoEM from Werner Kühlbrandt, STEM-EELs from Bonnie Murphy and CryoET from Martin Beck.

GBM Compact Focus on Condensate Biology is opened by Edward Lemke. Looking forward to a great meeting!

How do cells sort which RNAs to keep or destroy? New preprint from THJ, Brenneke and Plaschka labs shows that export and decay machineries (TREX2/PAXT) both recognise UAP56-bound RNAs. Whether they’re exported or degraded depends on where in the nucleus this happens. www.biorxiv.org/content/10.1...

Liquid-liquid phase separation of HP1? Not in our mouse fibroblasts… This paper by the Fabian Erdel group offers a fresh perspective on how this can be reconciled with seemingly conflicting reports: The phase separation propensity of HP1 decreases from yeast → fly → mouse. doi.org/10.1038/s414...

My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...

Join us for the Austrian Cryo-EM Symposium Nov 11–12 at @istaresearch.bsky.social! Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus. Register now 👉 cryoem-symposium.pages.ist.ac.at #cryoEM #teamtomo

We're very excited to welcome the new generation of #IMPRS students during our Symposium on Cellular Biophysics 🧪 This morning, we heard spokespersons Volker Dötsch and Martin Beck, and coordinator Pamela Ornelas, introduce the doctoral program to the new students! #imprs_cbp #biophysics #gradschool

We had a great start of the #IMPRS Symposium on Cellular Biophysics to welcome our new students. Thank you for your fascinating talks Michaela Müller-McNicoll, Bernhard Hampölz and Christian Münch 👏 #imprs_cbp #phd #biophysics

Excited to share our recent work about the role of the molecular chaperone TRAP1 as RNA-binding protein! #RBPs #HGSOC

Very cool story! congrats Markus and Niels!

Beautiful mechanistic story, how QKI by bridging intronic motifs with U6 snRNA ensures inclusion of weak 5’ splice sites that are essential for building sarcomeres. Congrats @kurianlab.bsky.social and @evannostrandlab.bsky.social labs & all involved.