How are RNAs sorted for export vs. degradation in the nucleus? In collaboration with @heick.bsky.social’s lab we (@clemensplaschka.bsky.social and @juliusbrennecke.bsky.social labs) discovered a direct mechanistic link between the export and decay machineries: www.biorxiv.org/content/10.1... (1/x)

Still true

Our study on the biogenesis of neuronal circular RNAs is out in Genes&Development @genesdev.bsky.social ! genesdev.cshlp.org/content/earl... Our celebration picture features first authors @carlosalfonsog.bsky.social and @shimengjin.bsky.social holding the fabulous circular cake, and most co-authors.

We followed with a day packed with CryoEM! We heard about the cryoEM from Werner Kühlbrandt, STEM-EELs from Bonnie Murphy and CryoET from Martin Beck.

GBM Compact Focus on Condensate Biology is opened by Edward Lemke. Looking forward to a great meeting!

How do cells sort which RNAs to keep or destroy? New preprint from THJ, Brenneke and Plaschka labs shows that export and decay machineries (TREX2/PAXT) both recognise UAP56-bound RNAs. Whether they’re exported or degraded depends on where in the nucleus this happens. www.biorxiv.org/content/10.1...

Liquid-liquid phase separation of HP1? Not in our mouse fibroblasts… This paper by the Fabian Erdel group offers a fresh perspective on how this can be reconciled with seemingly conflicting reports: The phase separation propensity of HP1 decreases from yeast → fly → mouse. doi.org/10.1038/s414...

My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...

Join us for the Austrian Cryo-EM Symposium Nov 11–12 at @istaresearch.bsky.social! Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus. Register now 👉 cryoem-symposium.pages.ist.ac.at #cryoEM #teamtomo

We're very excited to welcome the new generation of #IMPRS students during our Symposium on Cellular Biophysics 🧪 This morning, we heard spokespersons Volker Dötsch and Martin Beck, and coordinator Pamela Ornelas, introduce the doctoral program to the new students! #imprs_cbp #biophysics #gradschool

We had a great start of the #IMPRS Symposium on Cellular Biophysics to welcome our new students. Thank you for your fascinating talks Michaela Müller-McNicoll, Bernhard Hampölz and Christian Münch 👏 #imprs_cbp #phd #biophysics

Excited to share our recent work about the role of the molecular chaperone TRAP1 as RNA-binding protein! #RBPs #HGSOC

Very cool story! congrats Markus and Niels!

Beautiful mechanistic story, how QKI by bridging intronic motifs with U6 snRNA ensures inclusion of weak 5’ splice sites that are essential for building sarcomeres. Congrats @kurianlab.bsky.social and @evannostrandlab.bsky.social labs & all involved.

New and simple chemical modifications to poly(A) tails extend protein expression -- a really easy one-pot method Great work by Linglan Fang and Wenrui Zhong in our lab! doi.org/10.1021/jacs.5c11900

Congratulations, Dr. Li! 👏 🎉 @yunqingli.bsky.social @crc1507.bsky.social @dfg.de @goetheuni.bsky.social

I am sooo excited. Starting tomorrow the next edition of the fabulous #emboiclip2 course begins. @koenig-lab.bsky.social, @zarnack-group.bsky.social, moi & Elias Bechara will present 3 improvements to the method, a semi-automated workflow for data analysis and an exciting line up of speakers. Ready?

Wer Barbaras Rhabarberbarbarbaren mochte, freut sich hierüber auf jeden Fall auch. Und damit Gute Nacht!

The original idea is from @lcochella.bsky.social, we just extended it a bit.

🎉 We’re excited to share our very first preprint!! 🎉 "Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells" 👉 doi.org/10.1101/2025... #FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience

My PhD paper is in press @cellpress.bsky.social and now online: www.sciencedirect.com/science/arti...! Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more! Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo

Extremely excited for the second version of this workshop at the MPI of Biophysics l, Frankfurt, that will happen 12-20. April 2026. Absolutely amazing lineup of speakers, I am very much looking forward to learning from everyone! Apply here: meetings.embo.org/event/26-in-...

Absolutely textbook material - how unprocessed/intron-retained RNAs get detained in the nucleus from Yongsheng Shi lab www.biorxiv.org/content/10.1...

This quote lives rent-free in my head. #SciComm #ScientificCommunications #MedicalCommunications (1/9) 🧪

The goal of a PhD is not to learn some facts or read a few papers or learn a bunch of techniques. The goal of a PhD is to learn independence, problem solving, how to finish things you start, resilience, & gain the ability to adapt & think creatively. Learning these things is hard.

This preprint from Helen Sakharova is one of the coolest things to come out of my lab: “Protein language models reveal evolutionary constraints on synonymous codon choice.” Codon choice is a big puzzle in how information is encoded in genomes, and we have a new angle. www.biorxiv.org/content/10.1...

On being a scientist www.science.org/content/blog...

Our paper on the spatial organization of nuclear paraspeckles is out in #PNAS! Excited to see what comes next from the teams of @shrinivaslab.bsky.social and @sneadlab.bsky.social at Northwestern! pnas.org/doi/10.1073/pnas.2504778122

Detecting Nuclear Pore Complex assembly in living cells www.biorxiv.org/content/bior...

academic.oup.com/nar/article/... Check this our from @mixmue.bsky.social

same this was the biggest and fastest win against a pathogen in medical history also it was a brand new pandemic pathogen simply awe-inspiring, if you understand anything about the promise of clear thinking and hard work to do good and achieve great things

open.substack.com/pub/demwinsm... How can any one be so stupid as to “cancel” a Nobel prize winning technology with proven success? He must have fried his brain with drugs. At least it leaves the door open for European dominance in science.

Our RAPPL purification of ribosomes and associated material is out. I am really proud of this study in collaboration primary with Pavlovic-Djuranovic lab, as well as Jovanovic and Hashem Labs. This method aims to replace 60 years old purification of ribosomes by sucrose cushions rdcu.be/ezlhg

Important read!

Director at Max Planck - a unique position! The Open Call for Expressions of Interest in Max Planck Directorships is open now and can be submitted by the 31st of October 2025. ➡️ mpg.de/directors - Please share the Open Call among potential candidates.

I’m a bit late to the game here, but wanted to highlight this very clever technique from @paraspeckle.bsky.social’s group! Congrats to all authors!!

Very cool! How do cytosolic ribosomes discriminate between ER and mitochondria targeted proteins? NAC recognizes mitochondrial targeting sequences! Very important since over 95% of the mitochondrial proteome is translated in the cytosol and then imported to mitochondria. Congrats!

Festival season 🎉

Check out this exciting meeting and register! Fantastic line-up of speakers on cell biology of the nucleus and a great venue 🔥

AI for Cryo-ET 🌟 Our new paper presents a deep-learning framework that cleans up faulty tilt series in a more automated, precise and powerful way! 💪 Read more here: www.sciencedirect.com/science/arti...

The peer review process is a flawless system that has no issues whatsoever /s

👏Congratulations to @mixmue.bsky.social, @heilemannlab.bsky.social, and all co-authors on their recent publication in Nucleic Acids Research! Proud to see this work arise from the collaborative efforts of SCALE faculty, including Stefan Müller and Dorothee Dormann. academic.oup.com/nar/article/...

I am so incredibly excited to share our latest work, on the exploration of #RNA secondary structure ensembles and discovery of RNA regulatory structural switches in bacteria and human cells, just out in @natbiotech.nature.com: nature.com/articles/s41.... A short tread! (1/n)

RNA can control cell migration by acting at focal adhesions www.lifescienceeditors.com/2025/06/24/r...

Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @cp-cell.bsky.social, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. www.sciencedirect.com/science/arti...

SRSF12 is a primate-specific splicing factor that induces a tissue-specific gene expression program https://www.biorxiv.org/content/10.1101/2025.07.25.666902v1