Michael Feldbrügge (@mfeldbruegge.bsky.social)

Why do RBPs need multiple RNA-binding domains? We show transcriptome-wide that the endosomal mRNA transporter Rrm4 uses its three RRMs to differentiate functional binding sites from accessory ones. Great collaboration with @koenig-lab.bsky.social and Zarnack lab www.biorxiv.org/content/10.1...

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Dissecting the RNA binding capacity of the multi-RRM protein Rrm4 essential for endosomal mRNA transport RNA-binding proteins (RBPs) utilize multiple RNA-binding domains (RBDs) to engage with extensive mRNA networks. Understanding the intricate interplay of modular RBDs is essential for uncovering RBP fu... https://www.biorxiv.org/content/10.1101/2025.02.12.636894v1