🚨Exciting news: A recent study from our #FOR5762 member @thevilchezlab.bsky.social has been selected for the cover of @febsletters.bsky.social! Huge congrats to @thevilchezlab.bsky.social, Saygın Bilican and all co-authors for this fantastic highlight on #ALS-linked #Nup107 mislocalization! 🎉

🚨 Thrilled to share this exciting new paper by our #FOR5762 member Prof. Thorsten Hoppe. This study reveals how leucine boosts mitochondrial function by protecting key proteins. Congratulations! 🎉 @cecad.bsky.social @unicologne.bsky.social @natcellbio.nature.com

🚨 Speaker Alert! 🚨 We’re thrilled to host @uweohler.bsky.social for the next #CRC1678 Seminar! 🧬 He’ll present: "Dissecting Regulatory Networks from Single-Cell Multi-Omics Data" 📅 November 6 📍 CECAD Lecture Hall ⏰ 3:00 PM Explore the frontier of computational biology and cellular complexity!

🧬🧬🧬Targeting Genome Stability to Mitigate Human Aging and Disease - read now our comprehensive review article written with Debbie Toiber how we can target the most fundamental mechanisms of aging and cancer. @annualreviews.bsky.social 🔗 go.shr.lc/3JohYMp

📢 We are thrilled that our Research Unit #FOR5762 is hosting this joint seminar with #CRC1678! Don't miss Prof. Bernd Bukau's talk about 'Mechanisms of Co-Translational Folding and Assembly of Proteins' !

🚨Check out this new study from our Research Unit member @bjornschumacher.bsky.social on gene expression patterns linked to age deceleration and rejuvenation during Dauer Diapause. Congratulations! 🎉

🎉What a wonderful way to wrap up the CGA Welcome Days! Today's party was a lot of fun! There was delicious "homemade" food, an exciting pub quiz, and just the nicest group of people. A big thank you to our PhD reps, Moritz and Anna, for putting everything together! We all really enjoyed ourselves.

🚨 Just 3 weeks left to apply for our 12 PhD positions in ageing research! 🚨 🏃‍♀️ Don't wait- hurry up and submit your application now! ✉️

It was great fun speaking with Debbie Toiber and @barakrotblat.bsky.social on my path to science and why studying aging is so important to me. open.spotify.com/episode/2brg...

🧓How aging drives neurodegenerative diseases🧠 @thevilchezlab.bsky.social @cecad.bsky.social has identified a direct molecular link between aging and neurodegeneration by investigating how age-related changes in cell signalling contribute to toxic protein aggregation.

⏰🔬⏳What if we could prevent age-related diseases before they even start? At #CECAD Cologne, that’s exactly our #mission! In this new video, Prof. Dr. Carien Niessen shares our vision uncovering the biology of #aging to improve #health. #HealthyAging @unicologne.bsky.social youtu.be/9ALNLpG3oYc

🔥🔥🔥Out now: our Perspectives article in @nataging.nature.com outlining how aging is driven by molecular damage leading to increasing molecular noise whose quantification could track aging with the precision of a clock @meyerdh.bsky.social @alexeimaklakov.bsky.social www.nature.com/articles/s43...

🌍👩‍🔬🤝 At #CECAD, excellence starts with #people! This new short film takes you inside our vibrant, international research #community, where #collaboration, #diversity, and #support drive discovery. ✨ Meet our researchers, hear their stories, and get a glimpse of life at CECAD! 🎥

A new study from our Research Unit identifies age-related hyperactivation of EPS8/RAC signaling as a driver of protein aggregation in neurodegenerative diseases, highlighting EPS8 and its regulators as potential therapeutic targets @cecad.bsky.social @unicologne.bsky.social @nataging.nature.com

Check out this new study from our Research Unit member @thevilchezlab.bsky.social on how C9orf72 ALS‐causing mutations lead to aggregation of nucleoporin Nup107 into stress granules

We have a 4-year postdoc position open in our Research Unit on proteostasis! The project explores inter-tissue regulation using advanced proteomics approaches. Collaborative & interdisciplinary environment. More details & application here: jobs-uk-koeln.onlyfy.jobs/job/pktg6ivj...

New Preprint out ! The proteasome maturation factor POMP moonlights as a stress-induced transcriptional regulator www.biorxiv.org/content/10.1... Lead by: @sgiando.bsky.social with: @muellermara.bsky.social , @erin-schuman.bsky.social , @marcvoo.bsky.social and many more Short thread below 🧵1/4

Happy to share our new preprint, where we find that anle138b reduces Huntingtin inclusions and improves disease phenotypes in #Huntington’sDisease models, showing its potential as an HD treatment. Great work by Miguel Padilha and several wonderful collaborators including thevilchezlab.bsky.social

C9orf72 ALS-causing mutations lead to nucleoporin Nup107 aggregation and subsequent pathological changes https://www.biorxiv.org/content/10.1101/2025.04.16.649118v1

Thrilled to announce that our DFG Research Unit on cell-autonomous regulation of proteostasis has been approved for funding!