🚀 Now out in print: AGE DECELERATION AND REVERSAL GENE PATTERNS IN DAUER DIAPAUSE. How we can learn from nature of to slow aging and rejuvenate. Big congrats to Khrystyna Totska, João Barata, Walter Sandt, and @meyerdavid.bsky.social! @cecad.bsky.social onlinelibrary.wiley.com/doi/10.1111/...

🚨Check out this new preprint from our Research Unit member @irinadudanova.bsky.social uncovering vulnerability profiles of cortical cell types in #HuntingtonsDisease. @biorxivpreprint.bsky.social

🚨TOMORROW🚨 📢 We are excited to welcome Prof. Malene Hansen (Buck Institute for Research on Aging) for a seminar hosted by #FOR5762 and #RTG2550. “Cellular recycling in aging and disease - the importance of taking out the trash” 📅 Dec 3, 2025 🕓 3:00 PM 📍 MPI for Biology of Aging – Auditorium

🔥🔥🔥Now out in print: how do germ cells instruct the soma and how does the soma impact inheritance? Together with Shoma Ishikawa we provide a comprehensive overview of The Somatic Impact on Inheritance and the Germline Control of the Soma - www.annualreviews.org/content/jour...

🚨Exciting news: A recent study from our #FOR5762 member @thevilchezlab.bsky.social has been selected for the cover of @febsletters.bsky.social! Huge congrats to @thevilchezlab.bsky.social, Saygın Bilican and all co-authors for this fantastic highlight on #ALS-linked #Nup107 mislocalization! 🎉

🚨 Thrilled to share this exciting new paper by our #FOR5762 member Prof. Thorsten Hoppe. This study reveals how leucine boosts mitochondrial function by protecting key proteins. Congratulations! 🎉 @cecad.bsky.social @unicologne.bsky.social @natcellbio.nature.com

🚨 Speaker Alert! 🚨 We’re thrilled to host @uweohler.bsky.social for the next #CRC1678 Seminar! 🧬 He’ll present: "Dissecting Regulatory Networks from Single-Cell Multi-Omics Data" 📅 November 6 📍 CECAD Lecture Hall ⏰ 3:00 PM Explore the frontier of computational biology and cellular complexity!

🧬🧬🧬Targeting Genome Stability to Mitigate Human Aging and Disease - read now our comprehensive review article written with Debbie Toiber how we can target the most fundamental mechanisms of aging and cancer. @annualreviews.bsky.social 🔗 go.shr.lc/3JohYMp

📢 We are thrilled that our Research Unit #FOR5762 is hosting this joint seminar with #CRC1678! Don't miss Prof. Bernd Bukau's talk about 'Mechanisms of Co-Translational Folding and Assembly of Proteins' !

🚨Check out this new study from our Research Unit member @bjornschumacher.bsky.social on gene expression patterns linked to age deceleration and rejuvenation during Dauer Diapause. Congratulations! 🎉

🎉What a wonderful way to wrap up the CGA Welcome Days! Today's party was a lot of fun! There was delicious "homemade" food, an exciting pub quiz, and just the nicest group of people. A big thank you to our PhD reps, Moritz and Anna, for putting everything together! We all really enjoyed ourselves.

🚨 Just 3 weeks left to apply for our 12 PhD positions in ageing research! 🚨 🏃‍♀️ Don't wait- hurry up and submit your application now! ✉️

It was great fun speaking with Debbie Toiber and @barakrotblat.bsky.social on my path to science and why studying aging is so important to me. open.spotify.com/episode/2brg...

🧓How aging drives neurodegenerative diseases🧠 @thevilchezlab.bsky.social @cecad.bsky.social has identified a direct molecular link between aging and neurodegeneration by investigating how age-related changes in cell signalling contribute to toxic protein aggregation.

⏰🔬⏳What if we could prevent age-related diseases before they even start? At #CECAD Cologne, that’s exactly our #mission! In this new video, Prof. Dr. Carien Niessen shares our vision uncovering the biology of #aging to improve #health. #HealthyAging @unicologne.bsky.social youtu.be/9ALNLpG3oYc

🔥🔥🔥Out now: our Perspectives article in @nataging.nature.com outlining how aging is driven by molecular damage leading to increasing molecular noise whose quantification could track aging with the precision of a clock @meyerdh.bsky.social @alexeimaklakov.bsky.social www.nature.com/articles/s43...

🌍👩‍🔬🤝 At #CECAD, excellence starts with #people! This new short film takes you inside our vibrant, international research #community, where #collaboration, #diversity, and #support drive discovery. ✨ Meet our researchers, hear their stories, and get a glimpse of life at CECAD! 🎥

A new study from our Research Unit identifies age-related hyperactivation of EPS8/RAC signaling as a driver of protein aggregation in neurodegenerative diseases, highlighting EPS8 and its regulators as potential therapeutic targets @cecad.bsky.social @unicologne.bsky.social @nataging.nature.com

Check out this new study from our Research Unit member @thevilchezlab.bsky.social on how C9orf72 ALS‐causing mutations lead to aggregation of nucleoporin Nup107 into stress granules

We have a 4-year postdoc position open in our Research Unit on proteostasis! The project explores inter-tissue regulation using advanced proteomics approaches. Collaborative & interdisciplinary environment. More details & application here: jobs-uk-koeln.onlyfy.jobs/job/pktg6ivj...

New Preprint out ! The proteasome maturation factor POMP moonlights as a stress-induced transcriptional regulator www.biorxiv.org/content/10.1... Lead by: @sgiando.bsky.social with: @muellermara.bsky.social , @erin-schuman.bsky.social , @marcvoo.bsky.social and many more Short thread below 🧵1/4

Happy to share our new preprint, where we find that anle138b reduces Huntingtin inclusions and improves disease phenotypes in #Huntington’sDisease models, showing its potential as an HD treatment. Great work by Miguel Padilha and several wonderful collaborators including thevilchezlab.bsky.social

C9orf72 ALS-causing mutations lead to nucleoporin Nup107 aggregation and subsequent pathological changes https://www.biorxiv.org/content/10.1101/2025.04.16.649118v1

Thrilled to announce that our DFG Research Unit on cell-autonomous regulation of proteostasis has been approved for funding!