The authors of a new Perspective argue that clinicians are rightly expected to disclose their gaps in knowledge or their inability to forecast an outcome. Yet emerging AI tools often cannot, or will not, do the same. Read the Perspective: https://nej.md/4fgdg0D

Science nerds of BSKY: Next week I’m interviewing Prof. Sir John Bell about recent medical breakthroughs, touching on - Gene therapies & cancer vaccines - Tech in healthcare more broadly - Ethics & regulation This includes a Q&A where I can field your questions. If you have any please post below 🙏

You can follow the latest updates on the recent Ebola outbreak in the Congo and Uganda through the @topics.medsky.network feed. It’s made up of trusted sources including health organizations like @who.int, healthcare workers, and reporters.

WHO has declared the #Ebola outbreak in DRC and Uganda a Public Health Emergency of International Concern (PHEIC). First time this has been done without consulting an emergency committee. Extraordinary move that speaks to how concerning the facts on the ground look right now

Clinical and #Care Coordination Predictors of Adverse Outcomes in a Geriatric #Emergency Department "...The existence of an established #PrimaryCare relationship significantly predicted lower in-hospital mortality..." #Frailty #Geriatrics www.jamda.com/article/S152...

ESCMID 2026 highlights Dalbavancin PK (DOTS‑PK) – Two doses may not be enough High protein binding and wide inter‑patient variability: 1/3 patients may be sub‑therapeutic by day 22 Bottom line: Consider monitoring levels or adding a third dose in complex infections clarityinitiative.org/home

📣 New publication: Andes hantavirus outbreak on a cruise ship - an ESCMID Emerging Infections Subcommittee (EIS) rapid assessment www.clinicalmicrobiologyandinfection.org/article/S119...

The Ebola outbreak in the DRC has now been confirmed as the Bundibugyo strain. This is not good news, there are no licensed or candidate vaccines for this strain. No monoclonal antibodies. I am sure experimental antivirals will be tried. www.afro.who.int/countries/de...

So good. Have spent years fighting this fight, with hand tied behind my back by lack of great evidence. This study is going to get quoted and cited in microbiology MDTs the world over +++ #IDSky #ClinMicro #AMR

📣 New #Communicable drops Mon, 18 May! Our editors - Erin McCreary, PharmD, Josh Davis, Marc Bonten, Anne-Grete Märtson, Angela Huttner #Communicable- discuss some of the Late Breaker trials that caught their attention at #ESCMIDGlobal2026, and whether results will change their practice🎙️ #IDSky #clinmicro

Version 3. I've extended the orange-shaded area to cover the full 45 days (WHO number) and indicated each week since the date post-onset of Case 1's symptoms (dpo). May 10th was a day when 2 people became symptomatic and also tested positive. I've used green

Finally I migrated here after a hiatus of a few years! Hoping to interact with many friends new and old interested in microbial pathogenesis, AMR and of course #Klebsiella pneumoniae!!! Still learning to navigate around...

We are hiring @umichmicroimmuno.bsky.social ! Tenure-track assistant professor position in our Microbiology and Immunology department. We are especially looking for someone working in bacterial pathogenesis

Our paper is finally out! 🥳 If you want to know how a single Salmonella effector rewires the whole macrophage transcriptional landscape by hijacking one host transcription factor, check our latest research! Thanks to the @thurstonlab.bsky.social and @peterwshill.bsky.social labs for an amazing work!

Nice demonstration by @maxgg.bsky.social et al that some, but not all, non tuberculous mycobacteria (NTM) intracellular growth in macrophages is pH sensitive #TBSky #immunosky onlinelibrary.wiley.com/doi/10.1111/...

Two weeks on ID consults → some highlights: • Staph aureus from the urinary tract (yes, really) • “Explosive pleuritis” (still a great name) • Sinus fungal balls that aren’t so scary • Poor CD4 recovery in HIV • And why strep taxonomy = chaos And an A+ team! @nejm.org voices.nejm.org/doi/full/10....

🆕💥🟢Systematic Review and Meta-Analysis 20 studies (one RCT, 19 observational studies) N: 3,816 patients Adjunctive corticosteroids were not associated with reduced mortality in non-HIV PJP. However, the overall certainty of evidence was very low #idsky www.ijidonline.com/article/S120...

The @ukhsa.bsky.social DoxyPEP monitoring framework is now out. Grateful to have had the opportunity to contribute to this as part of my @nihr.bsky.social Professorship & looking forward to working with colleagues on these studies over the coming years.

Why does antibiotic resistance evolution vary between patients? Come to @officialuom.bsky.social @mermanchester.bsky.social to help us find out! 2.5 year @wellcometrust.bsky.social postdoc position in experimental evolution Closing 15 May. Apply here: www.jobs.manchester.ac.uk/Job/JobDetai...

Agree re potentially practice changing. Will be interesting to see if/when its performance gets tested in identifying asymptomatic (but probably infectious) TB cases. Could have even bigger impact on transmission and lowering case numbers. #IDSky #TBSky

An interesting new study, by Clare Smith’s lab and me, here at Duke. We found that during Mtb infection, CCR6 knockout mice (on a B6 background) form necrotic pulmonary granulomas, have increased IL17 production and have sex specific differences in susceptibility. journals.asm.org/doi/10.1128/...

Interesting description of heteroresistance to piptaz, but from a highly monitored patient in a clinical trial. And was not associated with treatment failure Most patients don't have post-antibiotic microbiology samples, so maybe this happens commonly (& inconsequentially) #IDSky #ClinMicro #UTISky

This is really rather cool - macrophages nibbling live cells to maintain immune tolerance. A must for journal club soon... #immunosky

Rapid, affordable, and easy-to-use diagnostic testing for tuberculosis is needed. In a multinational study, the accuracy of a tuberculosis diagnostic deployable to peripheral health care centers was assessed. Full study results: https://nej.md/48RWCjW #InfectiousDisease

A major serogroup C meningitis outbreak is unfolding in Chad, amid mass displacement driven by war in Sudan. It deserves far more attention than it is getting. Since Jan more than 1,500 patients have been admitted to isolation units amid meningitis C & measles. www.msf.fr/communiques-...

I'm pretty convinced by the recent Bayesian meta-analysis of selective decontamination of the digestive tract for ventilated patients. evidence.nejm.org/doi/10.1056/... I have to admit that I instinctively *really* don't like this as an idea (but hey - I guess that's what RCT evidence is for) #IDSky

Australia 🇦🇺 eliminated trachoma making it the third country this year. This is the first NTD eliminated from Australia with Buruli ulcer, leprosy and scabies remaining. www.who.int/news/item/29... #IDSky

Rejection is part of science. So is resilience. 🔬 Tim Blower and @stewartlab.bsky.social share how setbacks helped shape their careers. We don't talk about this enough. 🔁Please repost and share your own stories of defeat or bouceback. Break the stigma! lister-institute.org.uk/news/resilie...

Impressive - @bsacandjac.bsky.social now has 10,000 members worldwide! #ClinMicro #AMR #IDSky @raseaton66.bsky.social

At #ESCMID2026 Trial Run session, Dr. David. Paterson made a call to the ID community to join platform trials. So I want to tell you how we did that. I am a clinician, and also medical lead for IPC and stewardship. Our small but mighty ASP was already reviewing all pts with bacteremia 1/ #IDSky

🧐”Tongue swab-based Targeted Universal #Tuberculosis Testing in people living with HIV in KwaZulu-Natal, South Africa”

📣Never underestimate #TB. Your patient in a high-income country that you diagnosed with ulcerative colitis may have it instead. These authors describe a case of #GI #tuberculosis in our #Debunkingdogma series led by @dremilymcd.bsky.social #IDSky #GISky #clinmicro www.cmi-comms.org/article/S295...

Out now! Our preprint reviewing effects of extreme weather events on TB. papers.ssrn.com/sol3/papers.... @mjsaunder.bsky.social with Lauren Linde & Leo Martinez @bostonu.bsky.social & many others @tb-lshtm.bsky.social @lshtm-tbmod.bsky.social @lshtm-planet.bsky.social

Honestly I thought tailgating was just trying to sneak into the stadium behind someone who had a ticket! 😅 Instead... "Tailgating is a pre-game social event hosted in stadium parking lots before games,..., with fans typically congregating many hours before the match begins to consume food & drink"

NEW: 40 years ago today, disaster struck at Chernobyl. For decades, scientists have tried to understand how nearby wildlife has responded to nuclear catastrophe. Is it adapting to cope with radiation, for example? Many such questions still litter the landscape. www.bbc.co.uk/future/artic...

www.nejm.org/doi/full/10..... #idsky #medsky. NEJM presented the case as part of a series looking at health impacts of climate change

It's a critical moment for focus, as viral #hepatitis #elimination goals should be within reach but require advocacy, investment, evidence-based implementation... & absolute steely determination. #IDSky #LiverSky #MedSky 🧪 @ukhsa.bsky.social @whoeurope.bsky.social www.thelancet.com/journals/lan...

At least close the lid!!!! 😰

Great review from @gpollara.bsky.social et al of role of IL-17 in #MTb – for anyone interested in double-edged sword of cytokine response to mucosal pathogens. Come for the obscure Latin anecdote, stay for the deep dive into contextual consequences of IL-17 activation! bit.ly/4n8oiHv #IDSky #TBSky

Does anyone know why @orcid.org & @europepmc.org no longer have a functioning interface. Its gone from working fine, to broken, to removed entirely as an option and I can't see that @orcid.org have put anything out about this on their news page about this....

Nope, sorry, still too soon.... 🫣

Numerically more needed renal replacement therapy. In my view, mortality likely lower with cefazolin. AKI definitely lower. No good reason to stick with flucloxac. My practice has certainly changed. Fluclox may surprisingly cause considerable microbiome pertubation: www.nature.com/articles/s41...

📰 The UK's largest ever real-world study into RSV vaccination has confirmed that babies born to vaccinated mothers are up to 85% less likely to end up in hospital with an RSV chest infection. Thanks to all the NHS health professionals who deliver this vital programme 👏

I think i'd missed this. Generates many hypotheses (in my head anyway) on the biological pathways that may be underlying this increased risk of death for many years after TB diagnosis & treatmnent. #IDSky #TBSky www.nature.com/articles/s41...

The Dolomites are pretty today.

Important piece of work that guides much of our OPAT practice in UK. It's also impressive in its acceptance of the evidence. Literally the guideline for use of IV antibiotics is advocating for use of oral antibiotics instead! 👏 #IDSky #ClinMicro #AMR #OPAT

🔥Just published 2026 Updated good practice recommendations for OPAT in adults & children in the UK Oral antimicrobial therapy should always be used in preference to IV where these have equivalent efficacy unless there are other relevant factors* #idsky academic.oup.com/jacamr/artic...

This is both hilarious in its hypothetical accuracy on what makes a cool Nature paper nowadays, but also utterly frightening. Imagine overlaying this prompt with some more details and maybe data for half the desired story.... 😨 #AcademicSky

Given some on here have shown an interest in reading about bacterial staining today, this is something to get your teeth into www.thelancet.com/journals/lan...

Super exciting news 🚨 I am hiring a technician to join my brand new lab at the University of Birmingham! @imibirmingham.bsky.social Come and support my BBSRC-funded research on understanding how staphylococci survive antibiotics. Please share! 🧫🧪 www.jobs.ac.uk/job/DRH271/a...