I hope people listening to this talk appreciate -#2D2 #TCR is not a representative #TCR as one thought and appreciate the beauty of reactivity of almost #1000 #MOG #specific #TCRs < #real #world #data helping #modeling that all wants to do!!

I am #ecstatic hear that #Chandrani Thakur, #postdoc in the lab -her abstract has been selected for a #talk at #Gordon #Research #conference "2026 Immune Circuitry and Molecular Pathways in Tissue Homeostasis, Infection, and Disease"

#Absolute #disaster #save #scientists #curiosity 10,000 scientists gone: Trump’s cuts create an unprecedented brain drain geneticliteracyproject.org/2026/04/21/1... via @GeneticLiteracy

Well Avi is #inducted to our #team with this good #pMHC #monomer prep with a little help from Julia

Programmable cellular protein factories | Science www.science.org/doi/10.1126/...

B lymphocyte protein factories produced by hematopoietic stem cell gene editing | Science www.science.org/doi/10.1126/...

How did COVID mRNA vaccines improve favorable responses and patient outcomes for cancer immunotherapy? www.nature.com/articles/s41... A new report today on the priming of CD8+ T cells by these vaccines, a likely explanation www.nature.com/articles/s41...

Here is that #paper @Nature #mRNA #vaccines engage unconventional pathways in #CD8+ #Tcell #priming #KenMurphy #SuinJo #ChandraniThakur @WashUNeurology @washumedicine www.nature.com/articles/s41...

It's #Wednesday -I am so excited to see a collaborative paper coming out as print 11AM. Its a privilege to have contributed a tiny part along with senior author who has written #immunology #textbook!

What a #fantastic day for #science and #young #minds -this is such a #great #news www.nsf.gov/news/nsf-ann...

As the deadline approaching for our #offered #prospective #graduate #students to #accept our #offer -I cant explain how thrilled I am to welcome them! I know many of them accepted and they are exceptional

Thank you to @HCneuro for awarding our lab a #2025 #pilot #award to examine the role of #adaptive #immune #system in #Parkinson #Disease @WashUNeurology hopecenter.wustl.edu/funding-awar...

Proud to be attending #Neuroinflammation in Health & Disease, this June in Whistler with @keystoneSymposia.bsky.social Looking forward to big ideas, bold science, and great conversations. keysym.us/KSNeuroInflam26 #KSNeuroInflam26

Hoping all are #happy and #well #fed #our #team

See you at the #AAIC2026 as it will be my first AD #conference presenting our work on #Adaptive #immunity #Tcells in #Alzheimer #disease @alzheimerssoc.bsky.social

Made it to THE #BRIDGE

Driving towards Edmund Pettus Bridge, #SELMA…the #heart is #heavy #martinlutherking #freedom #johnlewis

It’s hard to leave this place…..but

what the #sun #sand #water does to #mind is simply amazing

Here is the preprint Combined talimogene laherparepvec and binimetinib in patients with NRAS-mutated melanoma induces anti-tumor immunity www.medrxiv.org/content/10.6...

This will soon be online as #preprint. Collaboratively, our first attempt to understand #tumor #response upon #oncolytic #virus #TVEC #therapy in #melanoma by a brilliant student in our lab

We are hiring! The Brown Lab is looking for a computational biologist to join our team. If you enjoy working with single-cell and spatial genomics data and want to study how immune cells develop and function, we’d love to hear from you! Apply here: hhmi.wd1.myworkdayjobs.com/External/job...

" #Immunological #knowledge" In parallel to overweight articles, Twitter and Bluesky-type publishing has appeared: short announcements that highlight a finding or advertise an article. Does this add to information overload? www.nature.com/articles/s41...

Imagine how much #revenue could have been #generated if there were no #funding #delays at #NIH www.fiercebiotech.com/research/des...

#Preprint #alert " we define developmentally programmed differences in #Tfh #differentiation and function with implications for #pediatric #vaccine #design" www.biorxiv.org/content/10.6...

I will be in #London from July 12-18 if anyone wants to talk about #TCRs I am all yours! @ox.ac.uk @dunnschool.bsky.social #UCL @britsocimm.bsky.social

If anyone interested in #postdoc #opportunities in our lab, please let us know. marie-sklodowska-curie-actions.ec.europa.eu/node/1495

If one #develops a #new #science #technology -perhaps it was developed to address a specific question. Doesn't mean that that technology needs to be applied to every scientific problem...just because one has that technology/method!

#Congratulations to all @cancergrand.bsky.social winners www.cancergrandchallenges.org/new-teams-an...

When days are filled with #failures -it’s #fantastic to get an email for a collaborative publication “#Final #decision -#accepted at nature!

It’s #always a #great #feeling when #submitting a #manuscript

We are still accepting applications for postdoc positions in our lab! Please repost!

#Excited about this

I am super excited that Avi Lukacher MSTP student has joined our lab. Welcome aboard!

#Loving these words as drive home #accepted #in #principle

When it #comes to #TCR #sequencing -the word I #detest is #oligoclonality -what does that even mean? It means something if one #sequenced #enough otherwise it means #nothing

#sky #always #seems #falling….But it #NEVER #does

Happy #Lunar #New #Year -Year of the #Horse

Thanks to #Hopecenter #pilot #grant @washuneurology.bsky.social for #funding our proposal to explore adaptive immunity in #neurodegeneration < lead by #Juliabals in our lab

Back in #2019 I was cleaning my bench at #stanford and heading over to #saintlouis time flies -I was #young

interesting article, what #BS -As #scientists we should be like #performers -what the world has come to!! Public-speaking tips from the experts: what scientists can learn from comics, musicians and actors www.nature.com/articles/d41...

After accounting for healthy vaccinee bias, #RZV #vaccination remains associated with a statistically #significant #lower #risk of #dementia www.nature.com/articles/s41...

Projection was, 70 million people tuning into last night's event...what happened?? Oh well, lol!

Any #suggestion on #companies selling #leukopaks -we are #specifically looking for #HLA typed #Leukopaks?

"There are several possible reasons for this unsettling state of affairs" www.nature.com/articles/s41...

I think about this a lot -especially during #grant and #paper #review -the given #proposal #paper is not #novel because someone else proposed that idea (in the grant/paper) before and executed poorly?

#NOA is in #today from #NIH. We are very much looking for #postdocs with expertise in #TCR #molecular #biology and #protein #engineering #autoimmunity

I know all of us are busy with our lives. I am sure all of us will reflect after 5 minutes listening #streets #of #mineapolis @brucespringsteen.net youtu.be/wWKSoxG1K7w?...

I must have #missed #something #new from this paper "Overall, given the numerous immunological parallels between pet shop mice and humans observed by us .. these findings may provide at least a partial explanation for the rise of allergic disease over the last century" www.nature.com/articles/s41...