We'll soon be covering the promise of CAR T-cells in autoimmune neurological disorders in our dedicated Special Collection, Guest Edited by Professor Marinos Dalakas. In the meantime, you can learn about this emerging treatment modality for autoimmune disease here: www.nature.com/articles/d41...

New real-life cohort study from Argentina compares the aspects of subcutaneous vs intravenous #natalizumab in #MultipleSclerosis: journals.sagepub.com/doi/full/10....

Ofatumumab is approved for adults with #MultipleSclerosis - but what is its utility in pediatric patients? Wenlin Wu and colleagues present Case Series data from four pediatric patients: journals.sagepub.com/doi/full/10....

Can a mobile app facilitate digital documentation and communication in acute #stroke, and improve documentation rates and treatment times? Stevens and colleagues designed a pilot study to find out: journals.sagepub.com/doi/full/10....

Could brain natriuretic peptide and echocardiographic parameters serve as biomarkers for predicting new atrial fibrillation after acute ischemic stroke? Stefano Forlivesi and colleagues investigate: journals.sagepub.com/doi/full/10.... #Stroke #AFib

New from our Special Collection on Innovative treatments for migraine: a new era Here, Katsuki and colleagues present trends in real-world use of #lasmiditan for migraine in Japan, using nationwide health insurance claims data. journals.sagepub.com/doi/full/10....

New #SystematicReview from our Special Collection on Neuromyelitis Optica Spectrum Disorders: Which environmental risk factors influence the onset of the disease? Find out more here: journals.sagepub.com/doi/full/10....

Posterior circulation stroke: What predicts recovery after thrombectomy? Post hoc analysis of 353 patients shows 24-h NIHSS ≤9 is the strongest predictor of favorable 90-day mRS. ΔNIHSS and % change less reliable. #Stroke journals.sagepub.com/doi/full/10....

New Case Series online: #Migraine with brainstem aura with abnormal EEG discharges easily misdiagnosed as epilepsy journals.sagepub.com/doi/full/10....

New article in our Special Collection: New Frontiers in Acute Reperfusion Therapies for Acute Ischemic Stroke This Review synthesizes evidence for the effectiveness of "Drip & Ship" model in acute #stroke care: 🚑 journals.sagepub.com/doi/full/10....

Could #MultipleSclerosis phenotypic profiles be distinguishable at diagnosis? Aurora Zanghi and colleagues use a multimodal #biomarker approach to investigate: journals.sagepub.com/doi/full/10....

Is increased middle cerebral artery peak systolic velocity associated with the development of malignant media infarction after endovascular thrombectomy? Find out more in this study, recently published in Therapeutic Advances in Neurological Disorders: #stroke journals.sagepub.com/doi/full/10....

A new RCT online! Lisa Schäfer and colleagues show how multidisciplinary online care can improve mental health, vitality, and quality of life in women with X-linked adrenoleukodystrophy - a model that could be scaled for other rare disorders. #RareDisease journals.sagepub.com/doi/pdf/10.1...

New study by Matteo Foschi et al reveals sex-specific patterns in #MultipleSclerosis progression: Women—especially postmenopausal—face higher risk of disability worsening independent of relapses, while men experience greater impact per event: journals.sagepub.com/doi/full/10....

New Review online! Here, Joost Smolders and colleagues argue that aggressive treatment of early acute focal inflammatory activity in #MultipleSclerosis can extend the window for BTK inhibition and slow down progression journals.sagepub.com/doi/full/10....

New Review online! Here, Wolfgang Jost and Jiri Koschel discuss approaches for diagnosing and treating cardiovascular symptoms in #Parkinson’s disease: journals.sagepub.com/doi/full/10....

🧠 20 years of #natalizumab in #MultipleSclerosis care: A new Review reflects on two decades of clinical experience with natalizumab—its efficacy, safety, and evolving role in treatment strategies. 📖 Read this Open Access article here: doi.org/10.1177/1756...

Elevated liver enzymes (AST, ALT, GGT) may correlate with lower #migraine prevalence—especially migraines without aura. Could glutamate regulation be a metabolic clue in migraine pathology? New study by Angela Ruban and colleagues: journals.sagepub.com/doi/full/10....

Could GLP-1 receptor agonists affect Parkinson’s disease progression? Check out this recent meta-analysis by Tsai et al: journals.sagepub.com/doi/full/10....

Which imaging and soluble #biomarkers best predict progression from relapsing-remitting #MultipleSclerosis to secondary progressive MS? Sini Laaksonen & colleagues investigate: journals.sagepub.com/doi/full/10....

In #ALS, analysis of 636 patients (2013–2023) found racial and ethnic disparities in care: Non-Hispanic Black patients had higher tracheostomy rates, and Hispanic patients were less likely to receive riluzole. Survival was similar across groups. 🔗 journals.sagepub.com/doi/epdf/10....

In rescue stenting after failed thrombectomy, dual antiplatelet therapy post-procedure improved outcomes and reduced mortality and stent occlusion vs single therapy. Most occlusions occurred within 24 h, underscoring early management importance. 🔗 journals.sagepub.com/doi/epdf/10....

In #ParkinsonsDisease, orthostatic hypotension (OH) is a disabling feature linked to poor quality of life and fall risk. This review summarizes pharmacologic and nonpharmacologic strategies for managing OH in PD. 🔗 journals.sagepub.com/doi/epdf/10....

Case series: #Levodopa–carbidopa intestinal gel (LCIG) reduced “off” time & dyskinesia in young-onset #MSA-P patients with preserved levodopa response. While ADLs declined with progression, LCIG may offer benefit for selected cases. journals.sagepub.com/doi/epdf/10....

🧪 Long-term study of #Cladribine in #MultipleSclerosis shows no loss of humoral immunity after up to 7 years. Patients maintained protective IgG to common pathogens & mounted new responses (e.g. SARS-CoV-2). Supports strong long-term safety profile. journals.sagepub.com/doi/epdf/10....

New national guidelines for #MyastheniaGravis in Israel standardize diagnosis & treatment. They integrate antibody testing, imaging, thymectomy recommendations, & tailored immunotherapy to improve outcomes & reduce care disparities. journals.sagepub.com/doi/epdf/10....

Review: immune tolerance in #NMOSD/#MOGAD as an alternative to long-term immunosuppression. Strategies include antigen-specific vaccines/nanoparticles, Treg/Breg cell therapy, and gene editing. Aim: durable remission with fewer systemic effects. journals.sagepub.com/doi/epdf/10....

Phase IV MAGNIFY-MS (n=270) in relapsing #MS: cladribine tablets achieved 64% NEDA-3 and 60% NEPAD at 2 years; ARR 0.09 (0.04 Tx-naïve). Biomarkers improved with OCB reduction in 76%, lower KFLC and IgG indices, sustained NfL decline, and no OCT thinning. journals.sagepub.com/doi/epdf/10....

Cross-sectional study in #MultipleSclerosis (n=80): serum GFAP was higher in progressive MS & correlated with TSPO-PET activity, lesion load, and reduced brain volumes. Findings support sGFAP as a biomarker of astrocyte-driven pathology and MS progression journals.sagepub.com/doi/epdf/10....

Narrative review on neuropsychiatric disorders in #Parkinsons highlights depression, anxiety, apathy, hallucinations & impulse control disorders as common features. Early detection & tailored multidisciplinary care are essential to improve QoL. Read here: journals.sagepub.com/doi/epdf/10....

Prospective study in branch atheromatous disease (#stroke subtype): early intensive therapy with dual antiplatelets + high-intensity statins reduced early neuro deterioration (34.1% vs 48.1%) & improved 90-day outcomes, with no ↑ in major bleeding. Read: journals.sagepub.com/doi/epdf/10....

Study in #NMOSD (AQP4-IgG+) & #MOGAD: higher serum GFAP, but not NfL, was linked to lower hippocampal & thalamic volumes and ↑ CSF volume on MRI. Findings support sGFAP as a biomarker of disease activity in AQP4-IgG+NMOSD. Read here: journals.sagepub.com/doi/epdf/10....

New online: READAPT multicenter: #DAPT in mild–moderate ischemic #stroke; anterior vs posterior infarcts (n=932; propensity matched). 90-day recurrent events similar (3.1% vs 2.9%); safety comparable. Posterior infarcts had worse 90-day mRS. Read here: journals.sagepub.com/doi/epdf/10....

📊 In a 13-year real-world study of 3850 MS/NMOSD DMT courses, 24.2% were stopped due to AEs. Just 1.7% were atypical, 3.1% unusually severe—spotlighting rare but impactful safety signals. 🔗 journals.sagepub.com/doi/epdf/10.... #NeuroTwitter #MS #NMOSD

Yesterday was #MyalgicEncephalomyelitis & #ChronicIllness Awareness Day In honour of those living with chronic immunological + neurological conditions, we’re spotlighting new research on generalized myasthenia gravis from Therapeutic Advances in Neurological Disorders 🧵👇

📡 In a patient with refractory epilepsy, personalized ANT-DBS settings (125 Hz, 50 μs) suppressed theta/alpha activity more than standard clinical settings (145 Hz, 90 μs). Gamma suppression in-clinic also linked to >50% seizure reduction over 1 year. doi.org/10.1177/1756...

📉 In 14 MuSK-MG patients, efgartigimod reduced MG-ADL scores from 10.1 to 2.2 by week 4 (p=0.001); 93% maintained benefit >8wks, and 71% reached minimal symptom expression by week 12. Lower steroid needs with CD20/tacrolimus combo. doi.org/10.1177/1756...

📊 In this US claims study (n=1,568), natalizumab as first-line MS therapy cut relapse rates more than later-line use (ARR: 1.48→0.28 vs 0.92→0.41) and showed greater reductions in hospital stays, ER visits, and outpatient use. doi.org/10.1177/1756...

🚨 Call for Papers — New Frontiers in Acute Reperfusion Therapies for AIS 🧠 TAN invites submissions on large core infarcts, tandem occlusions, AI in neuroimaging & more. Help shape the future of stroke care. 🗓️ Deadline: Sept 19, 2025 🔗 journals.sagepub.com/topic/collec...

🚨 A meta-analysis of 26 trials (160k+ participants) suggests GLP-1 drugs (like semaglutide in Ozempic/Wegovy) may significantly reduce dementia risk—potentially via anti-inflammatory effects, not just glucose control. 🧠 More via @newscientist: www.newscientist.com/article/2475...

🧪 In early Parkinson’s disease, higher baseline plasma NfL levels were linked to both persistent and new-onset fatigue at 2-year follow-up. NfL may serve as a predictive biomarker for fatigue subtype conversion in PD. Read here: journals.sagepub.com/doi/epdf/10....

In RRMS, 6 months of dimethyl fumarate therapy significantly altered gut microbiota composition, increasing Firmicutes families and reducing Bacteroidetes and Proteobacteria. Pre-treatment profiles predicted both 1-year disease activity and adverse events journals.sagepub.com/doi/epdf/10....

Fatigue (HR 1.98, p=0.024) and poor sleep (HR 2.19, p=0.004) at epilepsy diagnosis predict ASM resistance. Depression severity mediated 18.5% (fatigue) and 23.7% (sleep) of the effect. 🔗 journals.sagepub.com/doi/epdf/10....

🚨 Call for Papers! 🚨 New Frontiers in Acute Reperfusion Therapies for Acute Ischemic Stroke is now open for submissions From large core infarction to AI-driven imaging—help shape the next chapter of stroke care. Deadline: Sept 19, 2025 🔗 journals.sagepub.com/topic/collec...

🧠 In GBS and MFS-GBS overlap, sequential efgartigimod after IVIg may reduce anti-ganglioside antibody titers and shorten disease course, especially in IVIg non-responders. All 3 patients improved—2 with restored ambulation or eye movement Read here: journals.sagepub.com/doi/epdf/10....

🧠 A novel CACNA1S triadopathy causes exertional myalgia, weakness, and hyperCKemia. Muscle MRI showed early edema and late fatty degeneration; p.Arg1242Gly may link periodic paralysis with congenital myopathies. journals.sagepub.com/doi/epdf/10....

🧠 A multicenter MRI-based radiomics model accurately distinguished Parkinson’s disease from MSA-P, with a combined radiomic-clinical nomogram reaching AUCs of 0.973 (train) & 0.963 (test). A step toward precision diagnostics in neurodegeneration. 🔗 journals.sagepub.com/doi/epdf/10....

📉 In a nationwide study of 899 NMOSD patients, rituximab halved relapse risk vs oral agents (HR: 0.479, p<0.001). While RTX had higher upfront costs, it proved more cost-effective long-term due to fewer relapses and less disability progression. 🔗 journals.sagepub.com/doi/epdf/10....

🧠 Poststroke aphasia (PSA) patients showed altered gut microbiota, higher inflammation, and disrupted brain network topology vs controls. fMRI revealed compensatory right-hemisphere activation and decreased nodal strength near left-hemisphere lesions. 🔗 doi.org/10.1177/1756...

🧠 A 45-year-old woman with drug-resistant bilateral temporal lobe epilepsy achieved 3-year seizure freedom after SEEG-guided asymmetric radiofrequency thermocoagulation—despite bilateral injury. Neuropsych function also improved. 🔗 doi.org/10.1177/1756...