This week, we published in @science.org an article outlining the current ethical and societal implications of research involving human neural #organoids and #assembloids, their transplantation, and highlighted potential next steps.

(1/2) Considering a career in neuroscience? In this bonus clip from NeuroSociety Stories, @sergiuppasca.bsky.social, a neuroscientist pioneering technology to recreate human brain tissue and neural circuits in the lab, shares why this is a pivotal moment for neuroscience. #neurosociety #neuroscience

Applications are now open for the Stanford course on neural #assembloids! Deadline: December 12

By popular demand — the next edition of our hands-on @Stanford @BrOrganogenesis course is coming in 2026! This year, the focus turns to neural #assembloids, reflecting the growing movement toward modeling circuit-level and complex cell-cell interactions in brain disease. 🧠 Deadline: mid-December

The 2nd Int'l Personalised Medicine Conference is coming up, including keynote talks from @natrajanlabicr.bsky.social, @goldlabcharite.bsky.social , @sergiuppasca.bsky.social , Naomi Wray, Ewan Pearson and Richard Dobson @kingscollegelondon.bsky.social ✍️ conferences.au.dk/internationa...

We are getting closer to this special event at Asilomar

Less than two weeks left to register for the inaugural conference on Assembloids & Complex Cell-Cell Interactions at @cshlnews.bsky.social Check out the topics and amazing lineup of speakers!

A bittersweet day as another postdoc leaves to start an independent lab at St Jude’s Children Hospital. Xiaoyu Chen led fearless work on developing a therapeutic approach for Timothy syndrome—now advancing toward clinical trial.

Recent conversation at the @danafoundation.bsky.social about neural assembloids and organoids, their applications and ethical challenges (including more on the upcoming Asilomar conference)

One week left to register for the 1st conference on assembloids at @cshlnews.bsky.social this December. Spectacular list of speakers (see below) tackling cell-cell interactions across tissues and organs Two amazing keynotes: Ruslan M. Medzhitov & Joanna Wysocka #assembloids #organoids

I wanted to share a quick update on this call, which has received an overwhelmingly positive response. While I will carefully review the hundreds of applications received, I sincerely apologize that I won’t be able to respond to everyone. Those selected for an interview will be notified soon.

Yesterday we had a brilliant start to #ARNASydney2025. We kicked off with the #RNA in neuroscience & RNA tech, AI & Bioinformatics sessions. Speakers included @sergiuppasca.bsky.social, Mike Clark, @sabaaltaf.bsky.social, Nicole Green and several others #RNASky @unswrna.bsky.social

Last day to sign up for the Asilomar meeting 👇

Great news about our upcoming meeting at Asilomar on the Ethics of Neural #Organoids and #Assembloids Research! We secured additional support to waive the registration fee for at least 30 participants, which is especially beneficial for trainees If interested, complete the form at the link below

Consider joining us at Stanford as a postdoctoral fellow! If you have a published paper or a preprint, will graduate in the next period, and are excited to work in California, email me your CV and a brief statement of your research interests and trajectory by the end of August.

Short article on neuronal maturation in the primate cortex with Kent Imaizumi in the lab www.cell.com/neuron/fullt...

@sergiuppasca.bsky.social / @stanford.edu

Brief summary of our lab work and mission! So much more to do!

This looks like an impressive symposium on #organoids (h/t @sergiuppasca.bsky.social) Stellar speaker line-up; Osaka, January 2026 🧪🧫 www.takeda-pharma.jp/program.html

A clever forebrain assembloid model! Congratulations!

Our recent overview of human stem cell models for studying neuropsychiatric disorders (including their limitations and future directions) is now openly available @annualreviews.bsky.social of Neuroscience With the great @rebeccalevymdphd.bsky.social

Our latest work is out today in @science.org: a self-organizing system that models organizer-driven patterning and commissural axon guidance in human neural development. Work led by Massimo Onesto with Neal Amin in the lab

🧠 Join us in Rotterdam for a one-day meeting focused on iPSC-Driven Therapeutic Innovation for Brain Disorders! We’re thrilled to announce our keynote speaker @sergiuppasca.bsky.social 📅 Event date: September 19, 2025 📍 Location: Erasmus MC Rotterdam 🔗 Register now: www.neurodevdisorders.org

Model organism communities are fantastic. Good work, "Drosophilists"! www.nature.com/articles/d41...

Sharing today the latest from our lab, just published in Nature Biomedical Engineering. As stem cell models gain traction for disease modeling and drug testing, one of the bottlenecks has been scaling up production. In work led by Yuki and Genta, we present a simple and cost-effective solution.

Strong interest already in the upcoming Asilomar meeting on the ethical and societal implications of human neural #organoids, #assembloids, and their transplantation. Just 10 days left to apply—details at the link below.

This should be an excellent, and (we hope) important meeting. Join us!

Excited to announce that applications are open for the Asilomar meeting on The Ethical and Societal Implications of Neural Organoids, Assembloids, and Their Transplantation! As the technologies & applications of 3D neural models evolve, a number of ethical and societal issues are emerging.

Thrilled to introduce the newest PhD from the lab—Dr. Massimo Onesto—who successfully defended his thesis @stanfordmedicine.bsky.social. An exciting day for an exceptional scientist! Behind is the now-traditional “assembloids cake” we put together for the occasion. Congratulations, Massimo!

Looking forward to a thought-provoking session today at @isscr.org in Hong Kong—discussing emerging ethical questions around neural #organoids, #assembloids, and their transplantation. Join us at 2 PM in Hall 3G.

A few weeks ago, I talked to @neildegrassetyson.com on his StarTalk Radio about our efforts to understand human brain disorders with stem cell models including #assembloids. We touched on the promise of these technologies, the challenges & the mission behind the work www.youtube.com/watch?v=HEBj...

Over the past couple of weeks, several asked if I could share the individual slides summarizing our recently published framework in @nature.com on designing experiments with #organoids, #assembloids, and transplantation. Here they are—6 slides capturing the key takeaways👇

Congratulations on this important advance!

Attending a great lecture by @sergiuppasca.bsky.social last week led me to re-read a recent overview he wrote with @rebeccalevymdphd.bsky.social on #assembloids & scalable approaches to study human neuropsychiatric disorders ICYMI — very clear, very balanced, very good 🧪 @annualreviews.bsky.social

Cortical Development Conference 2025 - Giardini Naxos, Sicily, Italy 25 May to 28 May 2025 Organizers: G Fishell, AR Kriegstein, Z Molnár and F Vaccarino @corticaldev2025 e-mail regarding registration: [email protected] For other inquiries: [email protected]

Outstanding conference at the @humantechnopole.bsky.social Many thanks to the host-organizers!

Thank you!

Fabulous #neurogen25 keynote lecture by @sergiuppasca.bsky.social in Milan this evening. Sergiu weaved a truly inspiring narrative of progress in the field of brain organoids, crediting many brilliant students & postdocs in his lab, and highlighted key questions on the horizon for psychiatry 👏👏 🧪🧫🧠

Time to celebrate two more postdocs from the Pasca lab who are departing this month to start their own groups– at Johns Hopkins and in Shanghai. Warmest congratulations Xiao & Jin, and all the best! Traditional selfie at our lab party with a now classical #assembloid cake (not shown).

A superb discovery! Congratulations!

This is a bittersweet week as we say goodbye to a phenomenal postdoc in the lab— Xiangling Meng—who is leaving to start her own independent lab at Baylor College of Medicine.

Great overview of recent work from the lab on assembloids and applications to studying sensory dysfunction in neurodevelopmental disorders. Thank you BBRF for your support over the years!

Always a pleasure to meet and learn along with all the outstanding workshop participants and fantastic Pasca lab workshop leaders and speakers

This week we welcome on campus 2025 class of students for our hands-on Stanford Brain Organogenesis course. With students joining from across the globe, this is our most international class yet—diving into cutting-edge neural #organoid and #assembloid methods, ready to bring them back to their labs.

Honored to work with @sergiuppasca.bsky.social on this review of methods to model neuropsychiatric disorders

What human experimental models do we currently have to study brain disorders—and where do they fall short? In our recent @annualreviews.bsky.social, @rebeccalevymdphd.bsky.social and I examine the landscape of human stem cell models—2D systems, 3D #organoids, #assembloids, and transplantation.

The de-extinction of the dire wolves? "Colossal Baloney"— @stemcells.bsky.social www.latimes.com/business/sto... @latimes.com by @hiltzikm.bsky.social

New from Dr. @sergiuppasca.bsky.social's lab: four-part #assembloids that model the neural sensory pathway! Read the @nature.com paper from Drs. Ji-il Kim, Kent Imaizumi, and the team: go.nature.com/3RLmd56 Listen to the episode: bit.ly/42QHFvW

Thank you for the great summary and outlooking perspective on our recent work!

The deadline for the @cshlmeetings course on #autism spectrum disorder is approaching. This was my entry into the field more than 15 years ago. While this will be my final year co-organizing it, I am looking forward to the stimulating discussions in the beautiful Banbury Center. More details 👇