🚀 Our new paper is out in Nature Communications! We uncovered a mechanistic switch to boost myelination: deleting Gtf2i in myelinating glia enhances Sox10/Mbp activity → thicker myelin, faster conduction, improved motor coordination. Open access link: www.nature.com/articles/s41...

Thrilled to share our new paper @cp-cell.bsky.social: “Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.” This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling. 🔗 www.cell.com/cell/fulltex... Faust et al., Cell 2025

If you're interested in trafficking of #myelin constituents in #oligodendrocytes, and of course you are, you may want to check out our new preprint. It's very nice PhD work by @sophiesiems.bsky.social, and we're grateful to all who contributed! www.biorxiv.org/content/10.1...

Our new paper on metformin, myelin, mitochondria and metabolism is now out at rdcu.be/eDbFD Thanks to Nina and all of the team!

Please RT: My lab in the Neuroscience Dept at MUSC is hiring a technician. We study oligodendrocytes — unique non-neuronal brain cells — using cutting-edge imaging. Recent grads especially encouraged to apply. Feel free to reach out! #neurojobs musc.wd1.myworkdayjobs.com/MUSC/job/Cha...

Discovery of oligodendrocyte enhancers that regulate Sox10 expression journals.plos.org/plosgenetics... #oligodendrocyte #myelin

Fantastic new study on the role of TMEM63a in oligodendrocyte-dependent myelination in the CNS from the Swetha Murthy lab: pubmed.ncbi.nlm.nih.gov/40694323/

We had fun assembling images and describing approaches for imaging oligodendrocytes and myelin in vivo, in organotypic slices, and in fixed tissues. This work started in the lab of @jgrutzendler.bsky.social over 10 years ago and continues to keep us busy. www.nature.com/articles/s44...

A nice Review on 3P neuroimaging in NR Neuro. The images never fail to amaze me. www.nature.com/articles/s41...

Excited to share this new paper from the lab, now out in @cp-immunity.bsky.social! Led by the talented @bendevlin.bsky.social and in collab with @anneschaefer.bsky.social. a brief 🧵

Excited to share that two studies from my postdoc research were published back to back! In the first, we uncovered the molecular basis of axon spheroids—a key hallmark of Alzheimer's disease—and demonstrated their potential reversibility. www.nature.com/articles/s43...

Happy to share our latest publication on subcellular myelin proteomics and structural changes in Alzheimer disease www.nature.com/articles/s41...

It is out! Read how you achieve 1.7 mm deep 3-photon imaging in prefrontal cortex with dendritic spine resolution over a week. www.nature.com/articles/s42...

For those who want a distraction and/ or are interested, here's the latest from the group, led by Phil Braaker www.nature.com/articles/s41...

Our lab's 1st paper, led by @fchrisbennett.bsky.social & @waisenberg.bsky.social. A decade thinking how to directly assess the impact of microglia replacement. Yrs of hard work. This kind of work is needed to expand brain disease care for kids & the vision for safer, more effective cell therapy.

Excited to share this new work led by the talented Mike Dolan @dolan in collaboration with Evan macosko See below for details and preprint

Fun to have contributed a little to this, led by the team of the incomparable Guoqiang Yu. Suspect that this will prove to be an immensely popular image analysis platform for interrogation of dynamic signallingl! www.sciencedirect.com/science/arti...

Happy to see my work published in Journal of Neuroinflammation! Thanks to my amazing mentor @jkhuang.bsky.social and all the co-authors George Melchor, Meghan Bullard, @philgrossphd.bsky.social for their continued help and support. jneuroinflammation.biomedcentral.com/articles/10....

Excited to share our latest paper! We argue that in MS, the primary immune attack isn’t on myelin or myelinated axons — but on the ion & water homeostasis machinery in astrocyte endfeet. A short thread on this new perspective 1/11

Interested in #oligodendrocyte metabolism and/or #multiplesclerosis? Our paper is now at Biorxiv! We show that oligos express MCT2, the high affinity monocarboxylate transporter, well known for supplying neurons with astrocyte-derived lactate (astro-neuron lactate shuttle)👇

🥼 Janelia researchers led by @boazmohar.bsky.social @nspruston.bsky.social @rhodamine110.bsky.social & @svoboda314.bsky.social @alleninstitute.bsky.social have developed a new imaging tool that maps brain-wide changes in neuronal connections. 🧠 🔗 www.janelia.org/news/new-ima...

journals.biologists.com/dev/article/... New work from the lab characterizing sensory-dependent transcriptomes in mouse V1 across neuronal and glial cell types. Some fun nuggets in here, and all data publicly available for download and re-analysis. Happy gene hunting!

So happy we finally published this great piece from Antje Keller @antjekeppler.bsky.social and colleagues on the path forward for FAIR bioimage sharing. www.nature.com/articles/s41...

Cool paper about a couple of things I love www.nature.com/articles/s42...

Peer review completed within 7 days! Paying peer reviewers! Yes, it's possible. Fast & Fair peer review by @biologyopen.bsky.social More innovation from @biologists.bsky.social Details here: www.biorxiv.org/content/10.1...

🚨iGluSnFR4 is finally out!🚨🧪 We present iGluSnFR4f and 4s, a novel pair of genetically-encoded glutamate indicators designed for high-fidelity imaging of synaptic activity in the living brain. ⬇️ www.biorxiv.org/content/10.1... 🎥 Below: iGluSnFR4s detecting minis in cultures w/ TTX #Neuroscience

I'm pleased to share our most recent study led by Matija Zelic. We profiled human ALS spinal cords to uncover neuroinflammatory microglia and astrocyte states and show a key role for Ripk1 as a contributor to the pathological tissue environment in ALS. www.cell.com/immunity/ful...

This is awesome! Need immunostaining with two rabbit primary antibodies? No problem, with this approach. We will be looking into this more closely. Great to have such careful validation and optimization work with these tools, thank you Horrocks’ lab!

An interesting preprint from the Horrocks' lab detailing the behavior of secondary nanobodies (such a @nanotag.bsky.social ones) at the single molecule level and optimizing protocols for multiplexed labeling: doi.org/10.1101/2025...

🚨The first #preprint of the #FalconeLab is OUT!🥹🚨 We found that varicose-projection astrocytes are not a physiological type of #astrocytes but they are rather associated with neuropathology. Read more here, feedback is welcome!! More details👇👇 1/ www.biorxiv.org/content/10.1...

Highly recommend!!! Just fantastic to see all the awesome science from my BlueSky community scientists 👩🏼‍🔬 🧪🔬🧠

Introducing @ethanhugheslab.bsky.social from Colorado Undoubtedly the best hair at the conference but also co-chair of the 2027 GRC Glial meeting alongside Nicola Allen. Ethan is a neuro-oligo-dendroglia guy. If you are looking to work or study abroad check out his lab: www.ethanhugheslab.com

⭐️ Starterpack for networks and organisations fostering collaborations of glia enthustiasts ⭐️ go.bsky.app/JaGgbrT

Excited to finally have this published! Out today in @naturecomms.bsky.social, we show that following demyelination in a mouse model of Multiple Sclerosis, treatment of senescent microglia with senolytics leads to improved remyelination. www.nature.com/articles/s41... 1/3

TODAY IS THE DAY! 🧪☀️⬇️ Join us at the Lincoln Memorial or your local site to Stand Up for Science!

I started my lab more then 4 years ago, and we have endured some very challenging times ever since.…I am very excited to share the first paper from my lab, published now in @naturemethods.bsky.social www.nature.com/articles/s41...

Delighted to share the published version of this work from brilliant #CancerNeuroscience post-doc Tara Barron detailing GABAergic neuron-to-glioma synapses in #DIPG/#DMG. 🧵 Open access link: www.nature.com/articles/s41...

🔅📍The Concept of Neuroglia - the State of the Art Circa 1900📍🔅 onlinelibrary.wiley.com/doi/full/10....

PAMs, DAMs, and WAMs: tracking microglia across the development and disease landscape www.biorxiv.org/content/10.1...

🧠📈 Now available on the Allen Brain Cell Atlas - aging mouse brain data! Explore the most comprehensive and detailed single-cell dataset of the aged and young adult mouse brain. Contains 1.2 million high-quality, single-cell transcriptomes. 🔭 Explore: knowledge.brain-map.org/abcatlas?def...

We lack tools to rapidly track >1-2 changing signals in brain fluids. Peter Kalugin and an amazing team begin to address this challenge with simultaneous, real-time tracking of many (10+) neuromodulatory signals using Multiplexed Optical Recording of Sensors on a micro-Endoscope. Feedback welcome!

Brilliant work by Takeharu Nagai and team: Creating coveted bioluminescence colors for simultaneous multi-color bioimaging www.science.org/doi/10.1126/...

Extremely happy to share our manuscript jointly authored by me and the amazing Lyndsay Osso! An awesome collaboration between the @ethanhugheslab.bsky.social , Dan Denman and Autobahn Therapeutics. www.nature.com/articles/s41... 🧵

New paper out from the lab! Led by @gdfnunes.bsky.social and Lindsay Osso in collaboration with the lab of Dan Denman. Check it out! 🔬 🐭 🧠 www.nature.com/articles/s41...

Hi #neuroscience community! This is one of my favorite posts ever. In close collaboration with @liddelowsa.bsky.social and Ye Zhang, we've built a new tool that we are eager to share! www.webseq.net

Cool new manuscript from the Huang lab!!

I also added and updated some KTZ LUTs! Can't wait to see how it looks on your cool data!

Excited to share our new work identifying PKC as a druggable target for modulating microglia in order to enhance myelin repair. 🧵 #remyelination #multiplesclerosis www.science.org/doi/10.1126/...

Did you ever wonder about the role of oligodendrocytes in Parkinson's disease? Check out our new unsolved mysteries article in collaboration with the Burbulla lab! It is quite certain that a lot of work moves in this direction. journals.plos.org/plosbiology/...