Interested in the heterogeneity of blood vessels in the CNS? Here we review the unique features of the spinal cord vasculature, its barrier properties and neurovascular interactions, highlighting unknown aspects and future research directions. @CRC1366 @erc.europa.eu @immunosens.bsky.social

“Using Human Brain Tissue in Research” NC3Rs supported @nc3rs.bsky.social Date & time: Friday, 7 November 2025 13:00–16:00 Prof Maria Thom Mr Martin Gillies Mr Ciaran S. Hill Location: UCL Institute of Advanced Studies Registration (event is free): www.eventbrite.co.uk/e/networking...

Another evidence for lactate influx, not efflux, in neurons. However, it suggests that in neonates, where levels of circulating lactate are high, lactate used by neurons is blood-derived, and that neonatal astrocytes might also use lactate. www.nature.com/articles/s41...

Prenatal Acetaminophen Exposure Does Not Disrupt Human Fetal Brain Development in Cortical Organoid Models https://www.biorxiv.org/content/10.1101/2025.10.07.681041v1

Alkalinization of glial cells increases lifespan and healthspan in C. Elegans www.science.org/doi/10.1126/...

Immune signatures link myelin oligodendrocyte glycoprotein antibody–associated disease to other autoantibody-mediated conditions www.science.org/doi/10.1126/...

Interested in #epigenetics #DNAmethylation #omics #Dementia #oligodendrocytes? Join us tomorrow👇

Myelin pathology is a key feature of X-linked Dystonia Parkinsonism https://www.biorxiv.org/content/10.1101/2025.10.07.680990v1

GlialCAM Cytoplasmic Signaling in Oligodendrocytes and Astrocytes is Essential for White Matter Homeostasis in the Brain https://www.biorxiv.org/content/10.1101/2025.10.03.680331v1

SV2A-PET imaging uncovers cortical synapse loss in multiple sclerosis | Science Translational Medicine www.science.org/doi/10.1126/...

What role does #myelination play in #PrefrontalCortex development? This study shows that juvenile #demyelination disrupts PV #interneuron firing & self-inhibition, revealing a developmental window where myelination is essential for long-term cortical function @plosbiology.org 🧪 plos.io/4mI4lVO

Remyelinated fibers have a distinct lipid profile compared to intact myelin www.sciencedirect.com/science/arti...

How are #circadian rhythms established during development? This study shows that maternal metabolic signals oscillate in the fetal #SCN before the endogenous #clock becomes functional, offering a plausible mechanism for maternal entrainment of the developing clock @plosbiology.org 🧪 plos.io/3VD45fZ

NeuroMAP @neuromarseille.bsky.social @univ-amu.fr organise une visite de laboratoire sur le campus de la Timone le 14 Novembre ! Venez rencontrer nos chercheurs 👩🏻‍🔬🧑🏽‍🔬 neuro-marseille.org/events/journ...

"Post-Synaptic Density Proteins in Oligodendrocytes are Required for Activity-Dependent Myelin Sheath Growth" www.sciencedirect.com/science/arti...

Progenitor Timing Shapes NG2-Glia Fate and Oligodendrocyte Differentiation https://www.biorxiv.org/content/10.1101/2025.09.24.678191v1

How do different tissues respond to mitochondrial dysfunction? @candrewfrank.bsky.social &co show that Complex I depletion triggers ROS-driven compensatory signaling in #MotorNeurons, but degeneration in muscles, with implications for #MitochondrialDisease @plosbiology.org 🧪 plos.io/4nLUIGJ

Despite recent advances in green genetically encoded #potassium indicators (GEPOs), red-shifted GEPOs have been slower to come. @piatkevich.bsky.social &co present 2 new red #fluorescent #indicators for visualizing neuronal K+ dynamics in culture & in mice @plosbiology.org 🧪 plos.io/42niaSz

Peroxisomal metabolism of branched fatty acids regulates energy homeostasis www.nature.com/articles/s41...

Hexokinase 2 (HK2) is known for its metabolic role in #glycolysis. This study shows that it also functions as an #RNAbindingProtein that regulates mRNA translation, particularly of SOX10, promoting #melanoma cell proliferation independently of glycolysis @plosbiology.org 🧪 plos.io/3ViI1qL

We have a new Postdoc position advertised as part of our recent long-term Wellcome funding to join an established Postdoc and technician. I’m so excited to explore the role of the glycocalyx in CNS-inflammation. So many tools and expertise to work with! www.jobs.manchester.ac.uk/Job/JobDetai...

📢 2 PhD positions on the role of GLIA in brain function 📢 Neuronal Clues to Astrocytes in the Developing Brain https:// tinyurl.com/4m3uuf2a Neuroimmune strategy to treat Alzheimer’s disease https:// tinyurl.com/c7stnur5 #opportunities #neuroscience #neuroskyence #graduates

Exciting meeting in beautiful Ascona, Switzerland!!

Spatial transcriptomics of compartmentalised inflammation in a natural disease multiple sclerosis cohort. https://www.biorxiv.org/content/10.1101/2025.09.10.675210v1

Very pleased to publish this new review with Farah Wahbeh on the role of #EBV in #Multiplesclerosis. I learned a lot writing this, I hope others find it useful too www.neurology.org/doi/10.1212/...

I am advertising for a #postdoc for a 3 year BBSRC-funded project exploring the role of macrophages in salivary gland development. The successful candidate will be based at @edinuni-irr.bsky.social at @uni-of-edinburgh.bsky.social. Closing date: 9th Oct. elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

AAV-BI30, an endotheliotropic #AdenoAssociatedVirus for transducing vascular tree in #CentralNervousSystem Brain/Retina/Spinal Cord 👉>AAV-BR1 esp. in artery/vein 👉Also transduce #EndothelialCell in #Aorta/Liver/Lung/Kidney @natcardiovascres.nature.com 2022 pmc.ncbi.nlm.nih.gov/articles/PMC...

Whoa - neuronal ciliary proteome! Tons to dig into here - different from kidney cilia proteome (perhaps unsurprising) and enriched for many postsynaptic proteins, strengthening previous suggestions of cilia as postsynaptic signaling structures. @nachury.bsky.social www.biorxiv.org/content/10.1...

Researchers have created a miniaturized microscope for real-time, high-resolution, non-invasive imaging of brain activity in mice. www.science.org/doi/10.1126/...

Neurons sequester the cholesterol-inhibiting TFEB in oligodendrocyte cytoplasm to safeguard myelination and neural function www.sciencedirect.com/science/arti...

If you're interested in trafficking of #myelin constituents in #oligodendrocytes, and of course you are, you may want to check out our new preprint. It's very nice PhD work by @sophiesiems.bsky.social, and we're grateful to all who contributed! www.biorxiv.org/content/10.1...

The cellular associates of late life changes in white matter microstructure https://www.biorxiv.org/content/10.1101/2025.09.02.673734v1

Species-specific Rates of Fatty Acid MetabolismSet the Scale of Temporal Patterning of Corticogenesisthrough Protein Acetylation Dynamics https://www.biorxiv.org/content/10.1101/2025.08.27.672586v1

Our new paper on metformin, myelin, mitochondria and metabolism is now out at rdcu.be/eDbFD Thanks to Nina and all of the team!

The lab is having a good few months for publications with this one as well in case you missed it: doi.org/10.1016/j.ym... www.sciencedirect.com/science/arti... (Thank you Themis and Francesca, and all!)

A focus on the normal-appearing white and gray matter within the multiple sclerosis brain: a link to smoldering progression link.springer.com/article/10.1...

AAV-Based Intracerebral Administration of BDNF Promotes Myelin Repair and Cognitive Improvement After Cuprizone-Induced Demyelination. onlinelibrary.wiley.com/doi/10.1002/...

Scn2a-linked myelination deficits and synaptic plasticity alterations drive auditory processing disorders in an ASD mouse model www.nature.com/articles/s41...

Reduced Accumulation Rate and Morphological Changes of Newly Generated Myelinating Oligodendrocytes in the Corpus Callosum of Aged Mice onlinelibrary.wiley.com/doi/10.1002/...

Mark Pownall and Liyun Miao's (co-first) original paper from the Giraldez lab is here: www.science.org/doi/10.1126/...

"Fasting, ketogenic, and anti-inflammatory diets in multiple sclerosis: a randomized controlled trial with 18-month follow-up" bmcnutr.biomedcentral.com/articles/10....

Repeated exposure to heatwaves is accelerating ageing in people, according to a study. The impact is broadly comparable with the damage smoking, alcohol use, poor diet or limited exercise can have on health. 🧪🌡️☀️ www.theguardian.com/environment/...

📢Last week to REGISTER: Registration closes on the 1st Sep for a 2-day international conference "Interventions & Recovery" on 10-11th Sep🧠 Don't miss out - check out our fantastic Programme and register now!👇 neuroscience.cam.ac.uk/camneuro-eve...

Have you already had a look at the novel study led by @valentinacerr.bsky.social (👇👇)?👩🏼‍🔬📊🔬 This is the most extensive single cell #transcriptomic atlas of cerebellar astrocyte heterogeneity you can find around. An unvaluable resource for those interested in #astrocyte biology and #cerebellum!

Therapeutic genetic restoration through allogeneic brain microglia replacement www.nature.com/articles/s41...

TET enzymes remove #DNAmethylation markers; @ismaelhdeznunez.bsky.social @clark-lab-retina.bsky.social &co show that these enzymes are required for #photoreceptor cells to initiate the genetic program to become rods instead of cones, & for maturation of the #retina @plosbiology.org 🧪 plos.io/3UaVBfl

Exercise-induced plasma-derived extracellular vesicles increase adult hippocampal neurogenesis https://www.biorxiv.org/content/10.1101/2025.08.02.668291v1

📢JOB ALERT📢 @rikeshrajani.bsky.social is looking for a postdoctoral Research Fellow to join the Rajani Lab as part of the new national BHF-UK DRI Centre for Vascular Dementia Research. edin.ac/3GGUwZn

Thank you @CUAnschutz for highlighting our work on the role of brain metabolism in Alzheimer's Disease 🧠👩🏼‍🔬 news.cuanschutz.edu/department-o...

🚨New publication alert from the #BettencourtLab! Naiomi Rambarack's first first-author paper 👏 : #DNAmethylation #dysregulation of #STX6 and other #FTLD #genetic risk-associated loci". #Dementia Big thanks to all contributors and funders! @alzheimersresearchuk.org rdcu.be/euZmw