Extremely proud of Dr Janis Transfeld, who defended her PhD. Janis' project was a heroic undertaking to profile the epigenome of in vivo human dopaminergic neurons, which she then leveraged to interpret Parkinson's risk variants. @jaenice.bsky.social @ukdri.ac.uk @imperialbrains.bsky.social 🎉🎓🍾

Really nice work from the @nottalexi.bsky.social lab using functional genomics to show that genetic risk for multiple neurodegenerative diseases is linked to disease-specific microglial pathways. Congrats Aydan, @mangiruben.bsky.social and Alexi 👏🏻✨

A first first-author paper by Aydan Askarova with @mangiruben.bsky.social & @sj-marzi.bsky.social showing that genetic risk for neurodegenerative conditions is linked to disease-specific microglial pathways. @ukdri.ac.uk 🎉 🍾 journals.plos.org/plosgenetics... More to come from Aydan soon!

Many thanks to the excellent team on this, including @kittybmurphy.bsky.social , Yuqian Ye, Maria Tsalenchuk and @nottalexi.bsky.social 🙏🏻🙏🏻

Nice to see this finally published! Congratulations @jack-humphrey.bsky.social www.nature.com/articles/s41... (Collaborative work with Panos Roussos and his team! ) Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing

Wonderful evening with @liddelowsa.bsky.social following his visit to @imperialbrains.bsky.social @ukdri.ac.uk 🧠

@nottalexi.bsky.social we are looking forward to your presentation at #Neuroepi25 in Malta.🌞 Please share with your followers to let them know early bird registration & talk submission closes on 24 April 2025! Find out more: bit.ly/42ls1an #FusionNeuro

Massive congrats and gratitude to lead authors Leyla Abbasova, Paulina Urbanaviciute, Di Hu and Joy Ismail, as well as collaborators Brian Schilder, @nottalexi.bsky.social and Nathan Skene 🙏🏻🥰 It's been a long journey, but I'm so glad I got to share it with these excellent colleagues!

Postdoc position #1 is live! Please apply / spread the word! lms.mrc.ac.uk/work/vacanci...

Thank you for the invite, it was great to hear about the amazing science being done in the centre during my visit!

Last day @ukdri.ac.uk @imperialbrains.bsky.social before starting my maternity leave 🍼 I will only briefly come back before heading to Turin for a new adventure 🇮🇹 Millions thanks to this bunch of people who supported me through these last 4 intense years! 💙🙏

Very excited to share our latest publication in @NatureGenet! Our manuscript shows how Mendelian Randomization (MR) isolates putatively causal links between cell-type specific gene expression & brain phenotypes. www.nature.com/articles/s41... Tweetorial below 👇

Happy holidays from the Neurogenomics groups at Imperial with the @sj-marzi.bsky.social and Skene labs ☃️. We had a wonderful evening of Nepalese food, quizzes and an epigenetics-inspired sip and paint 🎨🍷🧬

So excited that our work on predicting gene expression from histone modifications using deep learning is out in NAR today. Brilliant to work with lead author @al-murphy.bsky.social and collaborators Aydan Askarova, @borislenhard.bsky.social and Nathan Skene 🧬⭐️🙏 academic.oup.com/nar/advance-...

Looking forward to another amazing Neuroepigenomics meeting, held in Malta this coming year!

OK, I've made a Starter Pack on Neuroepigenetics, Chromatin, and Gene Regulation! Please share and let me know who else should be added to this list. go.bsky.app/6LWE4dr

News & Views with @irholtman.bsky.social on spatial and single-cell gene expression analyses of Alzheimer's and Down's Sydrome www.nature.com/articles/s41.... This is a commentary on the work by the Swarup lab: www.nature.com/articles/s41....

Professor Valentina Escott-Price in the UK Dementia Research Institute at Cardiff University is looking for a Research Associate in Bioinformatics and Machine Learning. Closing date: 1st December. www.dementiaresearcher.nihr.ac.uk/job/research...

Excited that my work bestie @nottalexi.bsky.social has joined the blue site. Anyone interested in epigenomics, brains and neurodegeneration, give him a follow 🧠🧬👇

Making the transition over to bluesky 👋 I'm a group leader with the UK Dementia Research Institute at Imperial working on epigenetics and dementia 🧬🧠