❓ How can proteins lead to personalised Alzheimer’s treatment? Discover how Prof @sj-marzi.bsky.social team have been observing changes in the brains microglia and their responses to Alzheimer’s. Read more about Prof Marzi’s work 👉 lnkd.in/e4iaqqq9

UK DRI @ukdri.ac.uk at King’s, London. Seeks Research Assistant in Dr Sarah Marzi’s @sj-marzi.bsky.social group to support stem cell culture, assays, and genomic work on neurodegenerative disease. Closing date: 6th October www.dementiaresearcher.nihr.ac.uk/job/research...

From fellowship heartbreak to rewriting success — stories of resilience in research funding on this week’s podcast. Available to Watch on YouTube now, or wait until Monday to find it in your podcast app. youtu.be/ZbaRKM18hP0?...

Join us at the FENS Single-Cell & Spatial Omics Winter School with: @sarabiz86.bsky.social @rongfan8.bsky.social @gokcegroup.bsky.social @gioelelamanno.bsky.social @sj-marzi.bsky.social @jplopez-atalaya.bsky.social Ana Falcão Florian Rosenberger Gabriel Baró Bosiljka Tasic Barbara Treutlein

☣️🐀 Pesticide exposure in rats changes epigenetic signatures in different brain regions! Latest paper from our fruitful collaboration with Emily Rocha and Tim Greenamyre, linking epigenetic signatures of exposure to toxicants to Parkinson's disease: www.nature.com/articles/s41...

Cells in key brain regions involved in Parkinson’s retain a ‘memory’ of pesticide exposure that disrupts gene expression🧬 Research by @sj-marzi.bsky.social & colleagues unlocks understanding of the mechanisms behind the role of pesticide exposure in Parkinson’s👉 buff.ly/1F16eUB

Good times discussing all things #epigenetics and #microglia at our symposium with this awesome group: @jonasneher.bsky.social, @kooistrasm.bsky.social, @mancusorenzo.bsky.social. And enjoying the sun and science at #glia2025 in Marseille, while hoping that fires can be contained.

Really excited to speak at the Canadian Conference on Epigenetics. Join us in beautiful Banff in November 👇🏻

Excited to share that a chapter of my PhD has just been published in Nature Communications! We profiled the transcriptomic and chromatin landscapes of microglia expressing the different APOE variants, which were xenografted into the brains of an Alzheimer's disease (AD) mouse model 🧠🧬 1/n

The APOE gene is a major genetic risk factor for Alzheimer's, but different versions of the protein confer strikingly different risk profiles. New research led by ‪@sj-marzi.bsky.social‬ offers insight into how the different versions of APOE affect microglia👉https://buff.ly/pyFh7jy

How does APOE change your risk of developing Alzheimer's disease? At least partially by changing the function of immune cells in your brain 🧠🧬 New paper out in @natcomms.nature.com today: www.nature.com/articles/s41... @ukdri.ac.uk @kingsioppn.bsky.social @imperialbrains.bsky.social

So lucky to have the best lab. Will miss @kittybmurphy.bsky.social so much 😢❤️ but excited to see her future successes in ancient genome research!

Trying to get cell type specific insights from bulk brain epigenetic studies? Check out our new method CHAS for cell type deconvolution in brain studies of histone acetylation. Reanalysis of bulk data from >300 samples revealed novel cell type specific epigenetic associations across brain diseases👇🏻

Really nice work from the @nottalexi.bsky.social lab using functional genomics to show that genetic risk for multiple neurodegenerative diseases is linked to disease-specific microglial pathways. Congrats Aydan, @mangiruben.bsky.social and Alexi 👏🏻✨

We are so happy to share our latest paper "CHAS infers cell type-specific signatures in bulk brain acetylation studies of neurological and psychiatric disorders". www.cell.com/cell-reports... @ukdri.ac.uk @kingsioppn.bsky.social @imperialbrains.bsky.social

Wonderful evening with @liddelowsa.bsky.social following his visit to @imperialbrains.bsky.social @ukdri.ac.uk 🧠

I am so excited to share our review on microglial heterogeneity @natureneuro.bsky.social! It was a fantastic effort by the lab, led by @c9laura72.bsky.social and Alma Mohebiany. We provide a critical view on the plethora of microglial cell states in health and disease. www.nature.com/articles/s41...

My FOMO of missing #ADPD2025 is at least partially alleviated by knowing that our team is super well represented by our brilliant PhD student Paulina. Check out her awesome poster on cell type specific histone acetylation in #Alzheimer's disease brain and say hi (poster 160) 🧠🧬

New study by IoPPN researcher Dr Sarah Marzi in @naturecomms.bsky.social offers a new set of guidelines for designing epigenetic studies, based on a new technique, CUT&Tag, which analyse a type of gene regulation mechanism #neuroskyence #AcademicSky www.kcl.ac.uk/news/guideli...

Want to know how CUT&Tag works compared to ChIP-seq for studying epigenetic changes in cells and tissues?🧬 @sj-marzi.bsky.social systematically compares the new method to the existing standard, providing useful guidelines for others planning epigenetic studies 👉https://buff.ly/KFSGkzr

We're so thrilled to finally share with you the published version of our CUT&Tag optimization and benchmarking paper "CUT&Tag recovers up to half of ENCODE ChIP-seq histone acetylation peaks" - out in @naturecomms.bsky.social today: www.nature.com/articles/s41...

OK, I'm not going to say a word about this. Go ahead and list what's wrong with this study. We need a generation of reviewers to be confident expressing their concerns, just as we need researchers not to perform these wasteful and damaging studies in the first place. www.nature.com/articles/s41...

When you get your resident gamer to build the workstation for your @nanoporetech.com sequencer 😎 Yes, we definitely need all those colourful lights ⚡⚡⚡

The highlight of #AAIC APOE and lipid biology? @liddelowsa.bsky.social and @oihaneuh.bsky.social seem to think so! 🥰🦭

I am very excited to host Dr Sarah Marzi @sj-marzi.bsky.social in our virtual seminar series 'The 3D Regulatory Genome' for her talk on "Epigenetic regulation of environmental and genetic risk in neurodegenerative diseases" 📅 March 13th 2025 ⏰ 4 pm GMT Join us at: us02web.zoom.us/webinar/regi...

Just one day left to apply as computational genomics postdoc in our lab. Apply by tomorrow, 8 of March: my.corehr.com/pls/coreport...

A real pleasure to examine this excellent thesis! Huge congrats to the freshly baked doctor Eleonore, and to her awesome supervisors Jo and Nurun 👏🏻🎉🧠

📢 Next up in "The 3D Regulatory Genome" Series: @sj-marzi.bsky.social on "Epigenetic Regulation in Neurodegenerative Diseases" - exploring how epigenetics link genetic variants & environment to Alzheimer's/Parkinson's. Join us! Register: us02web.zoom.us/webinar/regi... #Neuroscience #Epigenetics

Exciting new role for a Computational Genomics Research Associate in the lab of @sj-marzi.bsky.social at the UK DRI at King's! Lead projects exploring the epigenome and transcriptome of brain cells in neurodegenerative diseases 🧠 🗓️ Deadline: 08 March 2025 Full info & to apply 👉 shorturl.at/fk7jS

The advert is officially live and you can apply online here: tinyurl.com/yd5bsvfb

📢 Our lab is looking for a bioinformatics postdoc. We have lots of exciting projects to work on, including single cell (epi-)genomics, microglia xenotransplantations and nanopore long reads splicing analysis. Look out for the official advert next week and get in touch in the meantime 🧬🧠

Excellent explainer by @philipcball.bsky.social on why now more than ever scientists need to resist the logic of "anticipatory obedience" www.chemistryworld.com/opinion/scie...

Thank you to @ukdri.ac.uk Group Leader @sj-marzi.bsky.social for joining us today & for her great talk on ‘Gene regulatory signatures of pesticide exposure in in vitro and in vivo models of #Parkinson’s disease @kavlioxford.bsky.social @oxforddpag.bsky.social @sophielfarrow.bsky.social

📢 CUT&Tag version 3 Sometimes the preprint to paper route can be quite the odyssey. And so in that vein, we are delighted to give you version 3 of our CUT&Tag optimization and benchmarking manuscript: www.biorxiv.org/content/10.1...

If you know anyone who's looking for a PhD in neurodegenerative diseases with a focus on data science and epidemiology, this scheme looks great. I would be happy to supervise projects in the Global Health Innovation stream. liss-dtp.ac.uk/applying-to-...

If you know anyone who's looking for a PhD in neurodegenerative diseases with a focus on data science and epidemiology, this scheme looks great. I would be happy to supervise projects in the Global Health Innovation stream. liss-dtp.ac.uk/applying-to-...

Newest lab member 🤩

Just in time for the holidays, we are thrilled to give you the latest preprint from our lab: Unique nigral and cortical pathways implicated by epigenomic and transcriptional analyses in a rotenone rat model of Parkinson's disease doi.org/10.1101/2024...

Couldn't agree more with Paul Nurse that “Research institutes and units play a unique, beneficial role in the UK’s RDI landscape and this sector should be expanded....” So the MRC should rethink their regressive decision to close MRC Units. www.science.org/content/arti...

Just in time for the holidays, we are thrilled to give you the latest preprint from our lab: Unique nigral and cortical pathways implicated by epigenomic and transcriptional analyses in a rotenone rat model of Parkinson's disease doi.org/10.1101/2024...

Huge congrats to the neurogenomics labs' brilliant most recent doctor @al-murphy.bsky.social 🥳

Fantastic bioinformatics PhD opportunities in the DRIVE Health CDT at KCL. Including two exciting projects on (epi-)genomics in ALS supervised by Ahmad Al Khleifat and me. Apply by 30 January 👇 drive-health.org.uk/projectpages... www.drive-health.org.uk/projectpages...

Best of times at the neurogenomics Christmas celebration last night 🥰🎄⭐️

Note that both @selinawray.bsky.social and I managed to match the lecture theatre furniture with our outfits today 😅😎

So excited that our work on predicting gene expression from histone modifications using deep learning is out in NAR today. Brilliant to work with lead author @al-murphy.bsky.social and collaborators Aydan Askarova, @borislenhard.bsky.social and Nathan Skene 🧬⭐️🙏 academic.oup.com/nar/advance-...

A full lecture theatre to hear @sj-marzi.bsky.social talk this lunchtime! 🤩

Two fantastic days of collaboration meetings in Exeter. Lots of exciting progress on our cell type specific epigenetic maps for #Alzheimer’s disease in the Brains for Dementia Research cohort🧬🧠

Excited to see that the science community is being brought back to life here ✨ I'm Kitty, a postdoc in the lab of @sj-marzi.bsky.social, UK DRI @ King's College London, focused on cell type-specific epigenetic variation in neurodegenerative disorders 🧠 P.S. I will be on the 2025 job market. 1/2

PhD opportunity: If you're interested in how astrocytes and the meninges talk to each other and how this is affected in dementia come do your PhD with us in Edinburgh (cc: Karen Horsburgh and Ingo Schiessl)! www.findaphd.com/phds/project...

Every 10 minutes, a woman is killed. #NoExcuse UNiTE to End Violence against Women www.un.org/en/observanc...