Remarkable!! Would you peer review in 4 days if you got paid ~$300? “Paying reviewers … led to faster first editorial decisions — an average of 5.5 working days, down from nearly 38 for unpaid reviews”

It was an absolute pleasure to write a News&Views for @andersshansen.bsky.social lab's newest paper in NSMB. Here, the authors provide absolute quantification of chromatin loops genome-wide: www.nature.com/articles/s41...

Does every enhancer work with every promoter? With @jengreitz.bsky.social and Will Greenleaf, we revisit this long-debated question and resolve an outstanding contradiction in the field. A tour 🧵👇 www.biorxiv.org/content/10.6...

Excited to see James' Genome-wide Absolute Quantification of Looping paper out in @natsmb.nature.com : www.nature.com/articles/s41... This has been in collaboration with @lucagiorgetti.bsky.social @leonidmirny.bsky.social @zechnerlab.bsky.social labs. Brief thread below on some key updates

An extraordinary cancer stat recently just dropped: zero. That’s how many UK women in their early 20s died from cervical cancer between 2020-24. My latest @opinion.bloomberg.com is on 20 years of HPV vaccines--& how the US could better maximize the potential of this critical public health tool (🎁):

Our evil ORFeome paper is out! In collaboration with @alex-stark.bsky.social, we screened ~4,000 viral proteins and secreted effectors from bacteria and parasites, covering hundreds of diverse pathogens, for phenotypes in human cells.

I am thrilled to share our paper out in @cp-cell.bsky.social : "Systematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways." (1/4) www.cell.com/cell/fulltex...

I am on paternity leave but I need to talk about this work by the @andersshansen.bsky.social lab that was published @natsmb.nature.com. The authors provide absolute quantification of chromatin loops across the genome. www.nature.com/articles/s41... Putting actual numbers in E-P, P-P and all loops!

Frank Grosveld, born in 1948, passed away last Friday. He was a colossal scientist in the transcriptional control of gene expression during development and helped us understand the complex regulation of beta-globin genes. His work will remain as a reference. May he rest in peace.

It is out 😍 check it out!! Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning. @cschwayer.bsky.social @silviabarbiero.bsky.social @davidbrueckner.bsky.social @ehannezo.bsky.social www.cell.com/cell/fulltex...

Very interesting new preprint from @jengreitz.bsky.social lab arguing that rather than there being significant enhancer-promoter compatibility, promoters simply differ in their enhancer responsiveness. If promoters are responsive, they respond to all enhancers. www.biorxiv.org/content/10.6...

☕Valdivieso, Rozmaric et al. show that wounding rapidly induces a #senescent state in skin cells involving p21 protein induction, without the need for new #transcription. These senescent cells are beneficial to early stages of healing. @lbitrauma.bsky.social www.nature.com/articles/s41...

Truly bizarre story of how two papers from the 1940s by physics pioneer Max Planck have been "retracted" from Naturwissenschaften, potentially by an algorithm, for anachronistic "plagiarism" issues, leaving the current editor baffled (but it is Springer Nature so.... www.science.org/content/arti...

Congratulations to Prof Richard Durbin, winner of the 2026 Genetics Society Medal! His pioneering work in computational genomics has transformed how we analyse and understand genome sequences.

Congrats to Oliver Bower, @inaharasimov.bsky.social and everyone involved on the publication of our latest findings! www.nature.com/articles/s41...

Our latest is out in Nature Genetics with @soumyakundu.bsky.social @anshulkundaje.bsky.social and @sbmontgom.bsky.social ! We built a resource of predicted variant effects on chromatin accessibility, and FLARE to identify disease variants with extreme effects. www.nature.com/articles/s41...

For the first time, we can see individual mRNAs in 3D inside cells at nm precision. Their shapes vary by gene and subcellular location. Congrats @fbzt.bsky.social & team @impvienna.bsky.social Top 1% @qedscience.bsky.social Edited by @lifescienceeditors.bsky.social www.biorxiv.org/content/10.6...

New preprint: Cells surviving #osimertinib frequently enter a defective S phase with DNA replication and segregation errors Preventing S phase avoids emergence of #drug resistance Great work from Kieron May Collaboration with Matt Martin @astra-zeneca.bsky.social www.biorxiv.org/content/10.6...

bioRxiv alert! CoPhasing resolves haplotype-specific 3D chromatin structures from GAM data, revealing extensive structural heterogeneity between human homologous chromosomes and its interplay with histone modifications and gene expression! Thanks to all coauthors! www.biorxiv.org/content/10.6...

Our last contribution is out. A short review asking a simple question : do the multiple Mediator complex functions reflect an expansion of its activity as a complex, or the emergence of specialized functions at the level of individual subunits? portlandpress.com/biochemsoctr...

(1/n) Very excited to share tri-lab collab (Mirny & Zechner) led by Harvey, Henrik & Jack: Q: How do enhancers & promoters interact in space (contact vs. action-at-a-distance) and time (stable vs. transient)? A: Transient E-P contact (~25-42 nm lasting ~10-20 sec): www.biorxiv.org/content/10.6...

After some good funding news, we are hiring! Looking for a postdoc to join our team and lead our explorations into transposon repression by the nuclear lamina. Check out the full ad on our lab website at buchwalter-lab.github.io/postdoc-ad.pdf + contact me to learn more!

a small attempt to capture this enormous loss and what Greg meant and means to so many. www.cell.com/cell/fulltex...

‪doi: doi.org/10.1038/s414... 📣 Our study is now out in Nature Communications detailing that the type I interferon pathway is suppressed by HUSH in early human development: Its complete epigenetic lockdown!! Incredible work from James Holt 📣 😎

Interested in hearing about mechanisms of cohesin-dependent vs. -independent enhancer regulation? @karissalhansen.bsky.social will be presenting her work **Tues June 23rd 8am CET** www.biorxiv.org/content/10.6... www.science.org/doi/10.1126/... Thank you @genome-org-aus.bsky.social ! 👇

🚨 Excited to share the latest work from my lab “Explainable AI identifies H3K18ac as a new marker of active enhancers” www.biorxiv.org/content/10.6.... Spearheaded by the amazing Khizra Maqsood and Duarte Pólvora-Brandão with contributions from Jareth, Bhavana, Catalin, Roxana, Olivia and Fanny. 1/n

Finally out in @Cellcellpress! Proteins with long IDRs are prone to misfolding during protein synthesis. This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones. www.cell.com/cell/fulltex...

🚨Preprint Drop🚨 We are very pleased to release our study on DNA methylation dynamics at enhancers during ESC differentiation! This work was led by Marlet Morales-Franco and Priscillia Lhoumaud 🧵(1/13) www.biorxiv.org/content/10.6...

If you have experience in biochemistry/cryo-EM, are interested in DNA replication, and would like to do a postdoc in New York - our lab has positions available! Just DM or email me with your CV.

📢 We are looking for a Junior Group Leader to join us at @institutcurie.bsky.social! Having joined the department just over a year ago, I can honestly say that it is an exceptionally stimulating and supportive scientific environment, filled with outstanding colleagues — all in the heart of Paris.

Postdoc position available now in the Smith Group lsi.exeter.ac.uk/groups/smith... to test the hypothesis that differentiation biases between human pluripotent stem cell lines may be eliminated by reversion to the naïve state. careers.exeter.ac.uk/vacancies/79...

Thermo Fisher now has a page up in response to our observations. They flatly deny that images were manipulated or fabricated while repeating that images were "optimized for presentation and clarity on the website", no lie, six times. www.thermofisher.com/us/en/home/l...

Whichever of the purple dots you look at turns more purple.

We’ve recently been awarded a MIRA R35 and an R01 to study non-canonical roles and missense mutations of the Polycomb system in health, cancer, and neurodevelopmental disorders. We are seeking an animal tech with lab manager duties. Please share!

Nature research paper: Cell-type-resolved genetic variation shapes inflammatory bowel disease risk go.nature.com/4o3hSJS

I am sending an open letter to Thermo Fisher. Their response to my response to their manipulated western blot is bullying and petty. Yes, this western blot really is manipulated, it is unfair on me to say otherwise. I don't make those accusations lightly, and I have a (minor) reputation to defend.

Planning a Perturb-seq experiment? Building virtual cells? First step to good models is good data. How many cells to profile? How deeply to sequence? What statistical power? Check out PerturbPlan — new tool from Ziang Niu in Katsevich Lab www.perturbplan.com www.biorxiv.org/content/10.6...

The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)

Exciting breakthrough technology from the lab, now live in @cellcellpress.bsky.social ! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!

Epigenetics Update - Universal transcriptomic hallmarks of mammalian ageing and mortality www.nature.com/articles/s41... Alexander Tyshkovskiy and Vadim N. Gladyshev (Harvard Medical School) in nature.com #Epigenetics #Aging #Mortality #DNAm --- epigenometech.com

My Fragile Nucleosome seminar is now on YouTube www.youtube.com/watch?v=ksXp... I discuss our recent work showing that linker histone H1 behaves as a liquid-like glue for chromatin organization in living human cells 🧬 Paper: www.science.org/doi/full/10.... Huge thanks to @fnucleosome.bsky.social!

Excited to share that I will start my lab at the Center for Integrative Genomics in Lausanne @unil.bsky.social in Jan 2027! I’m looking for PhD students fascinated by how cells build tissues and excited about developing new technologies to study development across scales. www.wanlab.bio/pages/9397

📢 Structural variants disrupting PITX2 from its enhancers linked to Axenfeld-Rieger Syndrome highlight the importance of non-coding structural variants in genetic diagnoses. 🧬 🔗 Read more: www.nature.com/articles/s41...

⚡New preprint from the lab⚡: A key early checkpoint in gene expression is promoter proximal pausing of RNA polymerase II. For over 20 years, we as field have not been able to recreate pausing under realistic cellular conditions. @robertovn.bsky.social shows that ELOF1 is the missing piece.

@theguardian.com @jennykleeman Such a shame to see a respected outlet fall for this. Human germline editing deserves rigorous scrutiny, not celebrity profiles that amplify attention-seeking behaviour and techno-utopian fantasies. www.theguardian.com/science/2026...

📣 POSTDOC position available in the Feschotte Lab at Cornell to work on #TRANSPOSONS! More details below. Pls send informal application or inquiry ASAP by DM or email to cf458_at_cornell.edu. Pls spread the word 🙏 #TEsky www.thefeschottelabatcornell.com

Our study comparing promoter existence and emergence in random vs genomic DNA is finally published!!! TLDR: the E. coli genome has more promoters than random DNA (even in intergenic regions), and promoters emerge ~3x more readily from random DNA than genomic DNA. (1/2)

Every scientist should know: • antibodies (Abs) can bind the wrong target • non-validated Abs can lead to false conclusions • Abs should be validated before use YCharOS tests commercial Abs in KO cell lines ycharos.com Only Good Antibodies makes the data easy to browse onlygoodantibodies.co.uk

Mechanisms of magnetosensing in pigeons - a surprise appearance of macrophages! Getting home in the dark | Science www.science.org/doi/10.1126/...

Wrote a short piece on Transposable Elements as catalysts of evolutionary innovation for a forthcoming special issue of @naturerevgenet.bsky.social on, duh, Evolutionary Innovation! www.nature.com/articles/s41...