Mapping single-cell diploid chromatin fiber architectures using DAF-seq - @uwgenome.bsky.social @uwdeptmedicine.bsky.social go.nature.com/4rFTAHy

Our study on the molecular function of translational activators for mitochondrial protein synthesis is published: rdcu.be/eSWxT A great collaboration with @stirlingchurchman.bsky.social and @sshaolab.bsky.social with structural work from our @pelleeas.bsky.social Funded by @kawresearch.bsky.social

Oxidative phosphorylation complexes contain subunits encoded by both the nuclear and mitochondrial genomes. How do cells coordinate the synthesis and assembly of these complexes at the inner membrane? We teamed up with Martin Ott (@mitolab.bsky.social) to address this in two recent papers.

Our new pre-print from the Greenberg and Churchman labs shows that activity-dependent modulation of RNA stability is a major, and underappreciated, mechanism of gene regulation in neurons. Tutorial below! www.biorxiv.org/content/10.1... (1/11)

First time posting here — and first-ever Single Molecule Conference 🧬 Held right at @embl.org Heidelberg, where I work! 4 days full of great science and great people. Fantastic meeting! 🔬 Curious to see where the single molecule field is going next! 👀 #EMBLSingleMolecule @events.embl.org

Honored to receive 1st Place Poster Award 🏆 at the EMBL meeting "Gene Regulation: One Molecule at a Time"! Thank you to all who visited and engaged in exciting discussions. Grateful to the organizers for an excellent event! #EMBLSingleMolecule

#EMBLsinglemolecule was a blast! Happy to host the birth of single molecule genomics as a field and to think about the future with the microscopy crowd. Thanks to participants and organizers!

The molecular feedback mechanisms that maintain yeast mito-nuclear balance represent elegant solutions to a major vulnerability in eukaryotic cells. I was privileged to be involved in this fascinating study!

In a new study by our @pelleeas.bsky.social, we reveal how Mrx4 organizes translational regulation of cytochrome b synthesis at the mitoribosomal tunnel exit. Thanks @kawresearch.bsky.social for funding and @stirlingchurchman.bsky.social for the fun collaboration! academic.oup.com/nar/article/...

🗨️💡Great conversations during well-attended lunch time panel discussions at #EMBLSingleMolecule Panel 1️⃣: Single molecule genomics data analysis Chair: @stirlingchurchman.bsky.social Panel 2️⃣: Single molecule microscopy data analysis Chairs: @laghalab.bsky.social, Dan Larson @arnaudkr.bsky.social

Absolutely thrilled of hosting the #EMBLSingleMolecule community together @embl.org for the first time under one roof! Exciting data and prospects!

🍪 Taking a breather at 'Gene regulation: one molecule at a time' — where the science is complex, but the coffee is simple (and much needed!). From single-molecule insights to lively hallway conversations, it's clear: breakthroughs happen both in the lab and over lattes. ☕🧬 #EMBLSingleMolecule

A big day for preventing mitochondrial diseases from transmitting to the next generation www.nature.com/articles/d41... www.nejm.org/doi/full/10.... www.nejm.org/doi/full/10.... www.nejm.org/doi/full/10....

Welcome to the inaugural edition of 'Gene regulation: one molecule at a time' 🤩🧬 #EMBLSingleMolecule Most of the participants are already on site – now time for some science! Our Scientific Organisers: 🔹 @stirlingchurchman.bsky.social 🔹@arnaudkr.bsky.social 🔹 @laghalab.bsky.social 🔹 Daniel Larson

🧬 🧪The world’s on 🔥 BUT in the interest of sharing small wins, I am helping build something cool at EpiCypher that I'm proud of: Fiber-seq is an LRS assay that maps chromatin accessibility, DNAme, and DNA sequence on single molecules. If your jam is functional genomics/epigenetics, check this out.

Mitochondrial RNAs can be found in mitochondrial RNA granules (MRGs) where they are processed. However, here the authors show that during transcription arrest, mt-mRNAs form granules distinct from MRGs. @stirlingchurchman.bsky.social‬ www.life-science-alliance.org/content/8/9/...

Want to write to your community about the importance of science funding? Join me on zoom this Friday at 12pm ET / 9am PT to learn to write an op-ed as part of the #McClintockLetters initiative! Sign up to write a letter and register for the workshop here: blogs.cornell.edu/asap/events-...

Make America Love Harvard Again

I appreciate the offers from other scientists to help Harvard (students, labs, etc) through this attack, but what would be most helpful is for you to use your position to contact your elected representatives and make it clear this fight isn't just Harvard, it will affect you, and their districts too

REMINDER.....REMINDER......REMINDER 3 DAYS LEFT TO COMMENT ON SCHEDULE F 1/n

Our papers, device designs, and protocols are used by biotech companies every day. Basic science is not a luxury - federal funding drives the very earliest R&D that powers biotech and trains the next generation of scientists (3/3). #WithoutNSF

In 100 days in office, US President Donald Trump has destabilized eight decades of government support for science. This has included terminating more than 1,000 grants in areas such as climate change, cancer, and HIV prevention. Will US science survive Trump 2.0? www.nature.com/articles/d41...

📅 Genomic Technologies Open Science Day - June 9 FREE event featuring expert developers and users! Register: www.jax.org/scienceday25/ Happening in person at @washu.bsky.social and online in partnership with NHGRI and @jacksonlab.bsky.social 🧪🧬🖥️👩‍🔬 #STS Learn more at genometdcc.org#outreachevents

Don’t forget to register for this special conference. If you like gene regulation from single molecule approaches, please join us #EMBLSingleMolecule. Imaging and Omics and a bit of theory for lots of fun!

This is a pitch-perfect version of the argument we all need to be making. Thank you so much, Stirling and Jack.

This is a much more important letter in WSJ than their recent Op-Ed from Hillsdale College. This is very important about what public funding of science means

My father-in-law, Jack Strominger, and I wrote a letter to the @wsj.com editor about the current threats to science due to Trump's funding freeze. Please repost! www.wsj.com/opinion/scie...

🚨 Join us for the @faseborg.bsky.social Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!

And on other news. My first contribution to science as a postdoc with @stirlingchurchman.bsky.social is out! We discuss the knowns and unknowns of post-transcriptional splicing. It was really fun to write with the great @karinechoquet

Do your experiments involve direct RNA sequencing? Single molecule FISH or MS2/PP7 RNA labeling? SunTag imaging to study translation? Come to #EMBLSingleMolecule this summer to learn how single molecule data inform models of gene regulation! Modeling and data analysis will be discussed in depth!

Send us your abstract before easter! Extended deadline! we got lots of cool stories already! We would also welcome submissions with a focus on Translation and life of RNA!

Super excited our paper on circRNA stability in the brain and their use as life experience markers is out! @inespatop.bsky.social www.cell.com/cell-reports...

Also interesting: Ask ChatGPT to draw what it imagines you look like. I'm wondering what other people get. Please share!

🚨 Last chance to submit abstract for 'Gene regulation: one molecule at a time' 🧬✍🏼 👉🏼 s.embl.org/grg25-01-bl ℹ️ #EMBLSingleMolecule will catalyse the emergence of a new generation of mechanistic models of the regulation of genes across each steps of the central dogma. 📅 Deadline: 8 April!

Modern science wouldn’t exist without the online research repository known as arXiv. Three decades in, its creator still can’t let it go.

Researchers at MIT turned a skin cell into a neuron without having to go through that pesky intermediate stem cell step. Truly incredible. news.mit.edu/2025/mit-eng...

REGISTRATION OPEN for @faseborg.bsky.social Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair | June 1 - 5, 2025 | Nashville, Tennessee. Apply before it is too late: events.faseb.org/event/mitoch... Please re-post!

In 1948, Jack Strominger wrote a report advocating for the formation of a National Science Foundation as a 23 year-old medical school student. He proposed we emerge from a world where our laboratories "depended on a flow of basic scientific facts from abroad". pmc.ncbi.nlm.nih.gov/articles/PMC...

If you are interested in mitochondria, Nashville is the place to be June 1-5. Check out this FASEB meeting. Please RT. events.faseb.org/event/mitoch...

Don't miss this exciting conference dedicated to the study of gene expression regulation, one molecule at a time! Technologies ranging from (epi)genomics, (epi)transcriptomics, to functional (epi)genetics and imaging! @stirlingchurchman.bsky.social @laghalab.bsky.social @arnaudkr.bsky.social

I highly recommend working with Martin! Exciting science and supportive mentor!

I'm really excited for this conference! I'd love to see you there. There will be many invited talks and special workshops on data analysis and theoretical modeling!

One of the coolest and most novel findings I’ve seen in years. This is why I work in worms. To find things no one even really knew to look for. Like a conserved system that splices transposons out of mRNAs to prevent otherwise lethal insertions in essential genes! - www.biorxiv.org/content/10.1...

Excited to announce here my postdoc work in Danica Fujimori's lab is published open-access. With @stirlingchurchman.bsky.social, @fraserlab.bsky.social, & Takeuchi-Tomita lab, we use biochemical & structural approaches to investigate mitoribosomal inhibition by antibiotics doi.org/10.1093/nar/...

I am excited for this opportunity to chair the Department of Biochemistry and Biophysics at Weill Cornell Medicine! news.weill.cornell.edu/news/2025/01...

🅲🅾🅾🅻 🆃🅴🅲🅷🅽🅾🅻🅾🅶🆈 “Bacterial-MERFISH” provides ~1000-fold volumetric expansion of individual cells, charts gene expression in hundreds of thousands of cells, deciphering bacterial single-cell heterogeneity, intracellular transcriptome organization, and bacterial adaptation to µm-scale niches in vivo

transcription people: are there examples where a transcriptional program gets re-set by cell division?