This was a fun new collaboration using selective ribosome profiling to understand how the subunit composition of the ER translocon is tailored by the nascent chain. Congratulations to everyone involved! www.nature.com/articles/s41...

Beautiful reconstitution of amino acid stress-dependent ISR activation by my @harvardcellbio.bsky.social colleagues presenting a unifying mechanism for GCN2 activation, which requires ribosome collisions and is enhanced by cognate uncharged tRNA in the A site! www.science.org/doi/10.1126/...

Thoughts from our own Tom Rapoport on the role of basic science in curing disease. magazine.hms.harvard.edu/articles/rev...

NIH funding supporting the HMMER and Infernal software projects has been terminated. NIH states that our work, as well as all other federally funded research at Harvard, is of no benefit to the US.

New work @harvard by Miguel Gonzalez-Lozano @harperlabhms.bsky.social & @ernstschmid.bsky.social in Johannes Walter lab charts structural interactome of endosomes. #XL-MS #Alphafold Funded by @asapresearch.parkinsonsroadmap.org & NIH. Science continues-despite attacks www.nature.com/articles/s41...

I appreciate the offers from other scientists to help Harvard (students, labs, etc) through this attack, but what would be most helpful is for you to use your position to contact your elected representatives and make it clear this fight isn't just Harvard, it will affect you, and their districts too

Trump administration is terminating $2.7 billion in research funding to Harvard: Work on breast cancer, impact of nutrition on fertility, antibiotic resistance and hundreds of other topics all dead “It feels like the academic equivalent of nuclear war" www.wbur.org/news/2025/05...

Exactly - @embo.org RNA Meets Protein Decay was a much-needed scientific hurrah! Thanks to all the participants for the exceptional quality of presentations and active engagement! And to @pauligroup.bsky.social, Manuela, and the @impvienna.bsky.social for being amazing hosts!!

Cup? Platter? Stained glass? Our imaginations were inspired (even during uncertain times!) by these beautiful molecular complexes: the Erlin and prohibitin complexes implicated in quality control at the ER and mitochondria, respectively. Check them out here: www.biorxiv.org/content/10.1...

My father-in-law, Jack Strominger, and I wrote a letter to the @wsj.com editor about the current threats to science due to Trump's funding freeze. Please repost! www.wsj.com/opinion/scie...

How do cells achieve an optimal mitochondrial distribution? Excited to share a piece of this puzzle: www.science.org/doi/10.1126/...

~1 week left to register for the EMBO workshop on RNA meets protein decay! #EMBOrnaDecay Come join us for a fun time and invigorating scientific discussions in Vienna! meetings.embo.org/event/25-rna...

Amazing meeting last week in Germany: 130th International Titisee Conferences on Stress Signalling in Development and Disease organized by Brenda Schulman & @micharapelab.bsky.social !

My thesis work on codanin-1/CDAN1 and the histone chaperone ASF1 is officially out! Take a look here:

@samanthasedor.bsky.social's pet project taking us into completely new directions is out in print form! rdcu.be/edKuA

Check out these insights into (and the importance of) delivering ubiquitin-independent proteasomal substrates for degradation in the nucleus!

Congratulations to our own Spyros Artavanis-Tsakonas for recieving the Wiley Prize for his work on the Notch Signaling pathway! We deserved recognition for a pioneer in developmental biology. newsroom.wiley.com/press-releas...

Join me, @talleylambert.bsky.social, @bethcimini.bsky.social, @florianjug.bsky.social & Hunter Elliott for our two week CSHL course on microscopy & image analysis starting March 24, 2025! Applications are due 1/31/25. meetings.cshl.edu/courses.aspx...

A reminder that the Brown lab has an opening for a postdoc fellow: brown.hms.harvard.edu/jobs/242. This might suit someone from the #cilia community interested in learning structural biology. Deadline extended to the 10th Jan.

Introducing Dr. Samantha Sedor! #PhDone

So many things happen on proteasomes! It was fun to dig into how a the active thioreductase TXNL1 engages the regulatory particle! www.biorxiv.org/content/10.1...

Happy to be making our first post on bluesky - a photo from our recent departmental retreat. Looking forward to sharing new discoveries and news from our trainees and faculty, as we continue to build a cell biology community here - check us out at cellbio.hms.harvard.edu

A small molecule degrader of the translation termination factor eRF1 = a metal-dependent molecular glue on ribosomes Learn more here! rdcu.be/du2ZX

Check out the protein compartmentalization and sorting minisymposium at #cellbio2023 today starting at 3:30 pm in Room 254A!