Also another good synopsis here elizabethginexi.substack.com/p/summary-of...

Online Now: Design principles of a membrane-spanning ubiquitin ligase Online now:

MIT president: Why so many optimistic scientists are losing heart www.statnews.com/2026/05/27/s... via @statnews.com

The first cut is the deepest: Cleavable signal peptides direct thousands of different nascent proteins to the endoplasmic reticulum. Oddly, SPs are all different and nevertheless cleaved with exquisite specificity. Our new cryo-EM structures + MD solve this paradox: www.nature.com/articles/s41...

🚨🧠🔬 Dopamine was discovered over a century ago, and has long been thought to only signal through metabotropic means. In our new preprint, we provide evidence that dopamine can directly signal through the "orphan" GluD ionotropic receptors. More to come! #iGluRs #neuroscience #dopamine #cryoEM

Excited to share our work uncovering SNOR, a ribosome-associated factor that promotes translation restart after dormancy published in Nature!! This was, as usual, a wonderful collaborative effort between our group and the Mattei Lab @simonemattei.bsky.social @embl.org www.nature.com/articles/s41...

I'm incredibly honored at election into the American Academy for Arts and Sciences. And Jodi Foster and Rita Moreno too! Credit goes to the amazing people I've been lucky to work with over many years. www.amacad.org/news/new-mem...

Congratulations to Manu Hegde, Group Leader & Joint Head of @cellbiol-mrclmb.bsky.social, who has been elected a member of the American Academy of Arts & Sciences. Congratulations also to the #LMBalumni joining him, Julie Ahringer & Edward Egelman. Read more: mrclmb.ac.uk/news-events/... #LMBNews

Very proud of Kevin Choi, who was a postbac in my lab starting in the midst of the most difficult circumstances possible - during the pandemic and was a spectacular scientist. Congratulations to Kevin and all co-authors on this paper.

Very sad to hear of the passing today of our UCSF colleague Mike Bishop at the age of 90. A legendary and inspiring figure. He also led UCSF as Chancellor. Have a listen to his Nobel lecture. youtube.com/watch?v=CDv7...

I've been leading a big project at Methods in Enzymology over the past year or so: editing three back-to-back-to-back volumes of articles describing the latest advances in methods for studying lipids and membranes — thank you to the 50 #lipidtime luminaries who contributed the 51 chapters! Details 👇

China pledges billion-dollar spending boost for science www.nature.com/articles/d41...

Exciting new discovery from @jimwellsucsf.bsky.social and coworkers, a new class of potential cancer antigens flipped onto the cell surface via autophagy-associated exocytosis, featuring first author and former PhD student Corleone Delaveris! #proudofalumni

China increases science funding again (by at least 7-% over the next 5 years) as it pledges billion-dollar spending boost for science 🧪 www.nature.com/articles/d41...

Nature research paper: Convergent MurJ flippase inhibition by phage lysis proteins go.nature.com/4aAWHKb

🧵Antibiotic resistance is a public health crisis. But viruses called phages have been solving this problem for millennia. New research in @nature.com reveals how 3 different phages attack the same weak spot—a protein called MurJt—potentially leading to a new class of antibiotics.

Happy to finally share the amazing results of our long-term collaboration with Karin Reinisch’s lab on how bridge lipid-transfer proteins (BLTPs) cooperate with partner proteins to orchestrate lipid delivery. A quick thread (1/7) www.biorxiv.org/content/10.6...

BREAKING: Hundreds gathered at San Francisco’s Ocean Beach to form a human banner reading “It Was Murder 🇺🇸 ICE Out,

“Uruguay did what most nations still call impossible: it built a power grid that runs almost entirely on renewables—at half the cost of fossil fuels. The physicist who led that transformation says the same playbook could work anywhere—if governments have the courage to change the rules.”

Final version is out! Our large-scale cryo-ET dataset 🔬 of Chlamydomonas reinhardtii 🦠 is now published in @cp-molcell.bsky.social Huge collaborative effort! So glad to see the community already using it to develop new resources & tools. Check it out here: shorturl.at/z4i4c #CryoEM #CryoET

Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

It’s out! Using cryo-ET in Dicty cells, we take a fresh in situ look at vaults. Surprisingly, we uncover vaults associated with ER and NE membranes, and find that many vaults enclose ribosomes in defined orientations, opening new avenues to their cellular function! www.biorxiv.org/lookup/conte...

Our study on the molecular function of translational activators for mitochondrial protein synthesis is published: rdcu.be/eSWxT A great collaboration with @stirlingchurchman.bsky.social and @sshaolab.bsky.social with structural work from our @pelleeas.bsky.social Funded by @kawresearch.bsky.social

Fresh from the deep—a rarely seen giant in Monterey Bay. 🤩 Last month, MBARI Senior Scientist Steven Haddock and the Biodiversity & Biooptics Team spotted a seven-arm octopus (Haliphron atlanticus) holding a crimson helmet jelly (Periphylla periphylla). Learn more: www.mbari.org/animal/seven...

New preprint out! We show that PROTAC-induced ubiquitination can bypass canonical ERAD to degrade ER membrane proteins. Wonderful collaboration w/ @dannomura.bsky.social and huge credit to grad student superstar Sydney Tomlinson! www.biorxiv.org/content/10.1...

🍰Up for reading more about both studies? Here is the News & Views article written by Deborah Fass & Carolyn S. Sevier: 👉https://rdcu.be/eR1Vg bit.ly/48BWLbv

Nature research paper: ZAK activation at the collided ribosome go.nature.com/4a9cika

How is N-glycosylation regulated? Check out our story, part of a terrific collaboration with our colleagues at Stanford and Northwestern. Congratulations to everyone! rdcu.be/eQNsJ

Our story on GroEL/ES action during cotranslational folding is now published @natcomms.nature.com. Led by former-student Alzbeta Roeselova, and in collaboration with Rado Enchev's lab @crick.ac.uk. www.nature.com/articles/s41...

Never seen our campus like this before. Like every single tree decided to turn red at the same moment

Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more ⬇️ and ➡️ rdcu.be/eNgIO

🎉 Huge congrats to Maya Schuldiner from the Weizmann Institute (Israel) for the 🏅 Otto Warburg Medal 2026! Her work on how proteins find their way to organelles and how these organelles talk to each other has reshaped how we think about cells 🧬✨ #OWM #WeizmannInstitute @elsevierconnect.bsky.social

In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below:

Proud to share our first lab pre-print: “SND3 is the membrane insertase within a fungal multipass translocon” where @tzujingyang.bsky.social solved the structure of a ribosome-associated SND3-translocon complex involved in ER membrane protein insertion ➡️ doi.org/10.1101/2025...

This was a fun new collaboration using selective ribosome profiling to understand how the subunit composition of the ER translocon is tailored by the nascent chain. Congratulations to everyone involved! www.nature.com/articles/s41...

New online: Global analysis of translocon remodeling during protein synthesis at the ER

A university that signs the “compact” is one that acknowledges its own inability to compete and succeed based talent and merit. It would signal insecurity and mediocrity to current and future students and faculty. Say no. Recruit the best people, protect their freedom and support their hard work.

Proximity-specific ribosome profiling reveals the logic of localized mitochondrial translation: Cell www.cell.com/cell/fulltex...

Principles of cotranslational mitochondrial protein import: Cell www.cell.com/cell/fulltex...

GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling | Science www-science-org.proxy.uchicago.edu/doi/10.1126/...

Thoughts from our own Tom Rapoport on the role of basic science in curing disease. magazine.hms.harvard.edu/articles/rev...