The first cut is the deepest: Cleavable signal peptides direct thousands of different nascent proteins to the endoplasmic reticulum. Oddly, SPs are all different and nevertheless cleaved with exquisite specificity. Our new cryo-EM structures + MD solve this paradox: www.nature.com/articles/s41...

Very happy that NWO supports this major upgrade of our national EM infrastructure. It is great that this initiative got broad support all over NL, and it will EMPower fantastic science - looking forward to that! www.uu.nl/en/news/33-m...

Congratulations Marten! We hope this new version of pytom will be useful to many cryo-ET enthusiasts.

Exciting Bijvoet Seminar by Marie-Eve Aubin-Tam from @tudelft.bsky.social on the engineering of bioinspired and living materials!

Online today at @naturecomms.bsky.social and a great opportunity for our first post @bsky.app: in a major team effort, we reveal the structural mechanisms for centrosomal recruitment and organization of the human microtubule nucleator γ-TuRC: www.nature.com/articles/s41...

And now to something completely different: the response of an anaerobic archaeon to oxidative stress. Tubular nanocompartments encapsulate virus-like particles! Great work by Wenfei Song and many colleagues from @bijvoet-centre.bsky.social and @mib-wur.bsky.social. www.biorxiv.org/content/10.1...

Center for Molecular Medicine at UMC Utrecht is looking for a Principal Investigator in the field of fundamental Cancer Biology! The vacancy states tenure track level, but also candidates with a more advanced career are very welcome to apply. www.werkenbijumcutrecht.nl/vacatures/we...

I guess I should have posted a bit earlier, but I'm very excited that my #MSCA application got accepted! I'll be working at @fridof.bsky.social lab @utrechtuniversity.bsky.social to develop my #teamtomo skills on my project: Protein ER-ways! Here's to gaining new insights on ER protein biogenesis!

In one of our first publications in 2025, with colleagues from St. Louis, Leiden and Boston, we shed light on the molecular mechanisms of motile cilia, structures used by cells to propel themselves through fluid or to move fluid across their surfaces. www.nature.com/articles/s41...

Starkes Signal!! Über 60 dt. Hochschulen & Forschungsinstitutionen haben heute ihren Ausstieg bei X bekanntgegeben, s.u. #eXit X sei nicht mehr vereinbar mit ihren Grundwerten: „Weltoffenheit, wissenschaftliche Integrität, Transparenz und demokratischer Diskurs.“ Liste der Beteiligten hier:

My new life in blue starts with sharing a preprint of amazing Max Gemmer’s ex vivo analysis that sheds light on the machinery responsible for inserting many multispanning transmembrane proteins into the ER membrane #teamtomo: www.biorxiv.org/content/10.1...