Today, the Dutch nodes of the European Life and Medical Science Research Infrastructures discuss their strategy and sustainability for the future at @naturalis.bsky.social in Leiden. We are representing @instruct-eric.bsky.social and structural biology.

Only a few days left to apply for our EMBO course with a great lineup of speakers and tutors! Please feel free to RT! Course website: meetings.embo.org/event/25-bio... Organizers: myself, @amjjbonvin.bsky.social @bioinfo.se @lindorfflarsen.bsky.social Location: www.ibg.edu.tr

Automated detection of macromolecules in cryo-ET data of cellular samples is challenging. Here, we introduce "pytom-match-pick", a GPU-accelerated, open-source interface that improves the efficiency and accuracy of macromolecule detection in cellular contexts: www.sciencedirect.com/science/arti...

The artists from Sensu have worked with @thermofishersci.bsky.social and made this beautiful video on the applications of structural biology: www.youtube.com/watch?v=m3QA... Check out our YouTube channel for videos we made with Sensu about our work: www.youtube.com/@BijvoetCenter

Indeed I'm happy to be here! Looking forward to great science 💪🏼

We are happy to host, on behalf of the Netherlands, the Council meeting of Instruct-ERIC (@instruct-eric.bsky.social), the European Research Infrastructure Consortium for structural biology. If you are interested in accessing state of the art structural biology technology, see instruct-eric.org.

We are very happy to have Christoph Müller from the EMBL (@embl.org) as the final speaker of the joint session of Instruct-ERIC (@instruct-eric.bsky.social) and the Bijvoet Centre at the 2025 Bijvoet Symposium!

Delighted to be in Utrecht to learn from our users in the Netherlands, we can always do better!! @utrechtuniversity.bsky.social @nkinl.bsky.social @necen.bsky.social

The next speaker this afternoon is Michael Leung of @hubrechtinstitute.bsky.social, who conducted Cryo-EM studies at NeCEN in @unileiden.bsky.social through Instruct! instruct-eric.org/centre/necen...

Since this month, Eva Bertosin (@thedneva.bsky.social) has joined the Bijvoet Centre, bringing her expertise on biophysics and DNA origami. Welcome Eva!

Beautiful and inspiring talk by Sheena Radford of the @radford-lab.bsky.social at the Astbury Centre for Structural Molecular Biology (@astbury-bsl.bsky.social) from the University of Leeds (@universityofleeds.bsky.social) at our annual Bijvoet Symposium!

Great to have almost the entire Bijvoet Centre together for our 2025 Bijvoet Symposium! Looking forward to a lot of exciting science!

The manuscript describing the new modular version of HADDOCK is finally available as a preprint! The result of a team work over several years, supported by @bioexcelcoe.bsky.social @bijvoet-centre.bsky.social @esciencecenter.bsky.social - www.biorxiv.org/content/10.1...

Simultaneous polyclonal antibody sequencing and epitope mapping by cryoEM and mass spec: how far can we go? Check out the final version of our paper in eLife: elifesciences.org/articles/101...

We are very happy to host Max Bonomi (@bonomimax.bsky.social) from the Institute Pasteur (@pasteur.fr) for a Bijvoet Seminar about structural and dynamic biology with integrative approaches.

#GBMLunch on April 23! Speaker: Tzviya Zeev Ben Mordeha @tzviyazbm.bsky.social from @bijvoet-centre.bsky.social Title: Cryo-EM single particle analysis meets cryo-ET at the sperm tail Chair: Cristina Paulino from @uniheidelberg.bsky.social Organized by the GBM Study Group "Structural Biology"

In this recent publication, we used an Orbitrap Astral mass spectrometer to rapidly analyze plasma glycoproteins, identifying over 3000 glycoPSMs in 40 minutes, with potential for high-throughput clinical applications: www.nature.com/articles/s41...

The first project I worked on, right after joining @bijvoet-centre.bsky.social!

Interested in advanced therapeutics such as mRNA? See the latest work of Evolène Deslignière, doi.org/10.1016/j.om..., in collaboration with Pfizer, using innovative mass spectrometry & photometry @bijvoet-centre.bsky.social to obtain precision measurements on mRNA purity & structural integrity

And now to something completely different: the response of an anaerobic archaeon to oxidative stress. Tubular nanocompartments encapsulate virus-like particles! Great work by Wenfei Song and many colleagues from @bijvoet-centre.bsky.social and @mib-wur.bsky.social. www.biorxiv.org/content/10.1...

Exciting Bijvoet Seminar by Marie-Eve Aubin-Tam from @tudelft.bsky.social on the engineering of bioinspired and living materials!

We congratulate Markus Weingarth of our #NMR spectroscopy group here at @utrechtuniversity.bsky.social with the recent award of a new #NWO funded project to tackle antibiotic toxicity. www.uu.nl/en/news/cons...

Just out by Shelley Jager: rdcu.be/edEnO. One of the fastest & deepest plasma glycoproteomics studies. Take home message; we even detect glycosylated cytokines and chemokines, but also still need better software. #glycotime @utrechtuniversity.bsky.social @bijvoet-centre.bsky.social

In this recent study, we used liposomes with E. coli lysates to mimic cellular crowding. We were able to achieve physiological macromolecular crowding levels, creating a platform that enables the controlled study of physiological crowding effects. pubs.acs.org/doi/10.1021/...

I am honoured to receive a Vici grant from the Dutch Research Council to study sperm functional maturition at the female reproductive tract and to study how sperm establish interaction with an egg www.uu.nl/en/news/nine...

We are proud to announce that Tzviya Zeev (@tzviyazbm.bsky.social) and Markus Weingarth each have been awarded a prestigious NWO Vici award! Read more here about the research they plan to do with their grants: www.uu.nl/en/news/nine.... Congratulations to both on their achievement!

De #uniutrecht werkt aan beleid om werken met AI in goede banen te leiden.

In this collaboration, it is revealed how structural diversity in computationally designed protein assemblies leads to subunit flexibility. Cryo-EM, native mass spectrometry and simulations reveal features of protein assemblies that enable flexibility in design. www.nature.com/articles/s41...

I guess I should have posted a bit earlier, but I'm very excited that my #MSCA application got accepted! I'll be working at @fridof.bsky.social lab @utrechtuniversity.bsky.social to develop my #teamtomo skills on my project: Protein ER-ways! Here's to gaining new insights on ER protein biogenesis!

Another successful PhD defense @bijvoet-centre.bsky.social @utrechtuniversity.bsky.social revealing the new world of immunoglobulomics. Congratulation Danique and your paranimfs Tatiana Shamorkina, Sofia Kalaidopoulou Nteak and co-promotor Albert Bondt👌

Today we celebrated the start of the spinoff company Abvion (www.abvion.bio) from our Biomolecular Mass Spectrometry and Proteomics research group! @hecklab.bsky.social

In this recent paper, we describe a new site-specific method for kinase inhibitor profiling maps drug binding with amino acid precision. This approach enhances target identification, uncovers off-target effects, and expands kinase coverage. www.sciencedirect.com/science/arti...

We have an exciting opportunity for a new independent group leader with an interest in structural/molecular biology and machine learning to join our Division of Structural Studies at the @mrclmb.bsky.social! 🥳 Re-posts appreciated. www.nature.com/naturecareer...

My first post on this forum! 😄 I am happy to share that our #openaccess review on the #molecular mechanisms of #actin filament polymerization and dissasembly is now online @cp-trendscellbio.bsky.social www.cell.com/trends/cell-... Big thanks to my amazing colleagues in Dortmund

Registration is now open for the 3rd MS+M conference. Very happy to host this edition in Utrecht. We have an exciting program at the intersection of single molecule imaging and mass spec. Registration and details in the link below: msandm2025.org

We are excited to announce that registration for the 3rd MS+M meeting is open. The meeting is in Utrecht (NL) October 1-3, 2025 and co-chaired by @hecklab.bsky.social, Kyle Fort (ThermoFisher), Kelvin Anggara (MPI Stuttgart) and @joostsnijder.bsky.social. See msandm2025.org

Microtubules are regulated by lattice geometry. Here, using cryo-electron tomography, we reveal that about a quarter have expanded lattices and changed stability. This lattice spacing might guide protein interactions and control microtubule function in cells. rupress.org/jcb/article/...

In a recent publication, we describe our discovery that in rheumatoid arthritis, synovial fluid proteome mirrors plasma, including IgG1 antibodies, suggesting proteins pass directly into joints, aiding pathology insights and therapeutic monitoring. www.sciencedirect.com/science/arti...

Just wrapped up a hearing after objecting to a failed grant application. That’s a first. Was very insightful, will find out soon just how big a snowball’s chance in hell really is 😉 Fingers crossed!

Still one month to register for the 2025 @bioexcelcoe.bsky.social summerschool in Sardinia! Check bioexcel.eu/events/summe...

In one of our first publications in 2025, with colleagues from St. Louis, Leiden and Boston, we shed light on the molecular mechanisms of motile cilia, structures used by cells to propel themselves through fluid or to move fluid across their surfaces. www.nature.com/articles/s41...

Happy New Year from the Bijvoet Centre! 🎉 Wishing everyone in the structural biology community a successful and inspiring 2025. We're excited to start the year by joining BlueSky – looking forward to connecting and sharing science on this new platform. #StructuralBiology #Biochemistry