Congratulations to @karishmabisht.bsky.social with her paper on the effect of fever on influenza replication and innate immune activation! www.science.org/doi/10.1126/...

Now out in Science Advances: www.science.org/doi/10.1126/...

Molecular Explorations for 2026 Download our new calendar that highlights the work of Molecule of the Month creator Janet Iwasa

Bergen op Zoom belandde anderhalf jaar geleden in een acute zorgcrisis. Duizenden inwoners zaten zonder huisarts en konden nergens terecht. Om het tij te keren gingen artsen en zorgverzekeraars aan de slag met ongewone oplossingen. Maar wat leverde dat op? www.ftm.nl/artikelen/ho...

We are excited to share our new @CellCellPress paper revealing mechanisms of action of promising drugs against the helicase-primase of herpes simplex virus 1 (HSV-1) 🤩 harvardvirology.bsky.social www.cell.com/cell/fulltex...

Now online! Mechanisms of HSV-1 helicase-primase inhibition and replication fork complex assembly

We are happy to share that the preprint for Proteobench is available now on biorxiv! Check it out here: www.biorxiv.org/content/10.6... Congratulations and thanks to everyone involved for the great effort!

De hoi’s en hai’s van onze oud-premier klinken al ruim een jaar in de wandelgangen van de NAVO. Follow the Money vroeg zich daarom af: ‘Hoe is het nu met… Mark Rutte?’ Hij heeft in elk geval niet stilgezeten. De rapporten worden korter, de budgetten groter, en de corruptieschandalen talrijker.

Bon nadal a tothom!

Is het Netflix, Nike, Pfizer, of misschien toch een bedrijf waar je nog nooit van gehoord hebt? Nederland blijft een magneet voor multinationals die belasting ontwijken. Maar wie is de grootste buitenlandse belastingontwijker? In onze top 25 ontdek je welke bedrijven miljarden door Nederland pompen.

Visit PDB-101 to learn how structures of poxvirus proteins are helping researchers find new ways to combat mpox.

A broadly neutralizing antibody confers cross-genus protection against alphaherpesviruses by inhibiting gB-mediated membrane fusion pubmed.ncbi.nlm.nih.gov/41402251/ #cryoem

A broadly neutralizing antibody confers cross-genus protection against alphaherpesviruses by inhibiting gB-mediated membrane fusion www.nature.com/articles/s41...

Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

Congratulations @jcstark.bsky.social and the team, antibody-lectin chimeras (AbLecs), a new modality for cancer immune therapy, now published @natbiotech.nature.com. These bispecifics can block glyco-immune checkpoint receptor ligands directly at the immune synapse/activate immune effector functions

Rational design of next-generation filovirus vaccines combining glycoprotein stabilization and nanoparticle display with glycan modification pubmed.ncbi.nlm.nih.gov/41387700/ #cryoem

Human monoclonal antibodies that target clade 2.3.4.4b H5N1 hemagglutinin pubmed.ncbi.nlm.nih.gov/41390501/ #cryoem

I’m very happy (and grateful!) to share that I’m featured in a Nature Cancer Viewpoint about starting my lab at CNIO. In the Lab (www.rcglab.com) we’re combining AI, protein design and structural biology to study protein structures and design novel protein therapeutics for cancer. 🔬

Some of Nikita Levin and my thoughts on glycopeptide characterisation on the omnitrap. 🧪 #glycotime www.biorxiv.org/content/10.6...

Calicivirus assembly and stability are mediated by the N-terminal domain of the capsid protein with the involvement of the viral genome pubmed.ncbi.nlm.nih.gov/41379934/ #cryoem

PDB-101 hosts a gallery of the watercolor paintings of David S. Goodsell. These images integrate information from structural biology, microscopy and biophysics to simulate detailed views of the molecular structure of living cells

Over the past 5+ years I've had the honor of working with @wsdewitt.github.io @victora.bsky.social and many others on a project to "replay" affinity maturation evolution from a fixed starting point. matsen.group/general/2025...

IsoNet2 determines cellular structures at submolecular resolution without averaging https://www.biorxiv.org/content/10.64898/2025.12.09.693325v1

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An energy-based model of protein conformational space can be used to predict structure from sequence, sample from the conformational landscape, rank structures, and predict mutation effects. @sokrypton.org www.biorxiv.org/content/10.6...

New online: Atomic models of the Toxoplasma cell invasion machinery

I don’t like Liquid Glass

✨New preprint! 🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al! Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬 🔗👇

Insights into the AAV packaging mechanism: Cryo-EM Structure of the AAV2 Rep-Capsid Packaging Complex www.biorxiv.org/content/10.64898/2025.12.09.693273v1 #cryoem

I’m excited to announce that I will be starting my research group on computational enzyme design at the Generative Biology Institute, Oxford, UK (@eitoxford.bsky.social)! PhD applications are open, deadline is Jan 8th (www.chem.ox.ac.uk/genbio-dtp). Email [email protected] with any questions!

Thrilled to have defended my PhD last Friday on the structural characterization of two marine viruses! 🧪🔬👩🏽‍🔬 Deeply thankful to my two co-directors @carmensmp.bsky.social and Gabriela N. Condezo, and to everyone with whom I’ve shared this journey! ✨

Science for Life conference today at Beatrixtheater in Utrecht. Here’s @hansclevers.bsky.social kicking things off.

Congratulations former postdoc @jfhevler.bsky.social (in transit to Roche) and the team on their work using thermal proteome profiling along with glycosylation perturbagens to discover glycan-dependent protein functions at the proteome scale 👏 www.biorxiv.org/content/10.6...

How can AI and #cryoEM help save some of the biggest babies on the planet? 🐘🔬 Our new preprint identifies Elephant Herpesvirus gH/gL/gO as a receptor-binding complex and a promising vaccine candidate, now being tested in young elephants across European zoos! 💉 www.biorxiv.org/content/10.6...

HAP2 is an ancient fusogen and used by malaria parasites for gamete fusion during fertilisation 🦟 Please check out our preprint on Plasmodium falciparum HAP2 - crystal structure of domain 3 and nanobodies 🦙💎 still so much to discover about this fascinating protein 🥚 www.biorxiv.org/content/10.6...

Structural characterization of plum pox virus by cryo-electron microscopy pubmed.ncbi.nlm.nih.gov/41326719/ #cryoem

Honoured to be selected as one of this year’s EMBO Young Investigators! Grateful to my team and colleagues for all their support, and excited about the opportunities this will create for my group and for our work in structural virology. www.embo.org/press-releas...

Using PDB structures, researchers designed treatments for HIV infection, which are now part of effective drug regimens that halt the growth of the virus. Learn more at PDB-101 pdb101.rcsb.org/brow... #WorldAIDSDay

Explicit description of viral capsid subunit shapes by unfolding dihedrons by Ryuya Toyooka et al. www.nature.com/articles/s42...

Featured #paper shows mechanism of #malaria infection blocking. Read "Cryo-EM structure of endogenous Pfs230:Pfs48/45 complex with 6 antibodies reveals mechanisms of malaria transmission-blocking" by @utoronto.ca#paper#malariasing our CMCF beamline. https://bit.ly/47TWrVv 👈

How does fever work? Our new Science paper shows how elevated body temperature can protect against severe influenza and that avian-origin viruses escape this defence. This is likely one reason why bird flus and some pandemic influenzas can be so severe.🧵 www.science.org/doi/10.1126/...

Vogelgriep trof nog nooit zoveel wilde vogels in Europa als dit seizoen. Sinds het begin van dit vogelgriepseizoen meldde de Europese Autoriteit voor Voedselveiligheid ruim 1.400 besmettingen onder dood aangetroffen wilde vogels, twee keer zoveel als in rampjaar 2022. buff.ly/4YBiuhr

Human coronavirus HKU1 neutralization by glycan receptor mimicry pubmed.ncbi.nlm.nih.gov/41278654/ #cryoem

Ballistic Microscopy (BaM) pubmed.ncbi.nlm.nih.gov/41279100/ #cryoem

It’s been a while since I put together the Structural Virology starter pack, and I’m sure some new folks have joined Bluesky since then. There’s still plenty of space to fill, so if you’d like to be added to the list just let me know. #virology #cryoEM go.bsky.app/Qxv95BL

📢 Paper alert 📢 Chirality is known to be important for the movement of microorganisms and active matter. In our new paper out today in @natphys.nature.com, we show that chirality is used by malaria parasites to control their motion patterns: doi.org/10.1038/s415... Here comes a 🧵 ... (1/9)

Hello bsky 🦋 GlycoShape is now here to give you updates on our glycan 3D database, toolbox, glyco fun-facts and news! We just updated server, so clear your browser's cache, and build some glycoproteins with us 🍬 We'll have great new tools coming up soon, so follow us for some exciting #glycotime

Super happy to receive an M-2 weave grant from the NWO (Dutch Research Council). Together with Sayed Abd El-Whab we will study the molecular features of H5Nx HA and NA proteins. #glycotime www.nwo.nl/en/news/gran...

Wat betekent het voor ons als tech-miljardairs en cryptobedrijven de heerschappij van de banken zullen doorbreken? In zijn nieuwe boek ‘Geld genoeg, maar niet voor jou’ neemt Thomas Bollen je mee naar goudkluizen, banktorens en cryptofeestjes. www.ftm.nl/artikelen/ho...

Structures of the fusion glycoprotein from respiratory syncytial virus (RSV) were used to engineer effective vaccines to fight viral infection More at PDB-101: