The first cut is the deepest: Cleavable signal peptides direct thousands of different nascent proteins to the endoplasmic reticulum. Oddly, SPs are all different and nevertheless cleaved with exquisite specificity. Our new cryo-EM structures + MD solve this paradox: www.nature.com/articles/s41...

Sub-cellular chemical mapping using correlated cryogenic electron and mass spectrometry imaging online @natmethods.nature.com, led by Hannah Ochner, collaboration with @catfranco.bsky.social and @kiranrpatil.bsky.social labs doi.org/10.1038/s415...

1/WHO's IHR Emergency Committee has issued formal recommendations for the Bundibugyo virus PHEIC. Yesterday's press briefing gave the most complete picture yet of what's happening on the ground. Full update thread 🧵 #EbolaOutbreak

How do sperm and egg fuse? Surprisingly, we still don’t fully know… Our field has uncovered many pieces of the fertilization puzzle, but not how they fit together. We identify ✨ SPARK ✨ - a conserved sperm complex that couples sperm-egg binding to fusion. tinyurl.com/34cm4xat Read on! 🧵👇

Wrapped up a great symposium today, thanks to all our guests and speakers!

In NL kan je je kind op grond van geloofs- of levensovertuiging uit het onderwijssysteem trekken. Maar die vrijstelling 'is bedoeld voor ouders met extreem gedachtegoed. De overheid faciliteert dit.' aldus een kinderrechtenonderzoeker. Ondertussen maken influencers er een verdienmodel van.

The outbreak of #Ebola #Bundibugyo is now the 3rd largest on record. The #WHO country rep in DRC, Anne Ancia, told the World Health Assembly today that the suspected case count is now over 500, with 130 suspected deaths. This will be hugely difficult to contain. www.unognewsroom.org/story/en/312...

Excited to share our new preprint! Using deep mutational scanning and multivalent engineering, we developed our SARS-CoV-2 spike-targeting macrocyclic peptide into a potent inhibitor that blocks infection in HAE cultures and protects hamsters after intranasal dosing. chemrxiv.org/doi/full/10....

Under the IHR (2005), @drtedros.who.int, the Director General of WHO, having consulted the States Parties where the event is occurring, has determined that the Ebola disease caused by Bundibugyo virus in DRC & Uganda constitutes a public health emergency of international concern bit.ly/3P4ZDac

I’ve been trying to understand what we know and don’t know so far about the concerning Ebola outbreak in DRC. Still lots of uncertainty at the moment but here‘s what I have been able to find out so far. Story is here (thread coming later): www.science.org/content/arti...

Finally got my copy of @mollycrabapple.bsky.social’s new book, can’t wait to dig in.

De Belastingdienst houdt al jarenlang belangrijke documenten achter in rechtszaken met burgers en bedrijven. In meerdere zaken werden rechters verkeerd geïnformeerd en kwamen cruciale stukken pas na lange juridische procedures boven water, soms zelfs nadat ondernemers al waren veroordeeld.

LJI Professor, President & CEO Erica Ollmann Saphire, Ph.D., talks #measles AND big steps her lab has taken in developing a measles treatment: youtu.be/oy8xnsSb4U0?... #ImmuneSystem #Immunology #Virology #Viruses #Health #Medicine #SanDiego

The abstract deadline for the FASEB Virus Structure and Assembly Conference is approaching - May 25! Join us for an exciting meeting on structural virology, virus assembly, RNA biology, and antiviral therapeutics. We look forward to seeing you there! #FASEB #Virology #StructuralBiology #CryoEM

#Ebola: New outbreak in NE DRC, in Ituri province, where the large 2018-2020 outbreak took place. Security issues there make responses challenging. DRC has announced this one is caused by the Bundibugyo species of Ebola. Only 2 previous Bundibugyo outbreaks (2007, 2012). No licensed vaccine for it.

New Ebola outbreak in Ituri, DRC, with 65 reported deaths, so far. My heart goes out to people there, already suffering from deadly attacks on civilians. www.aljazeera.com/news/2026/5/... Ebola could spread because of people displaced from conflict, says #AfricaCDC. africacdc.org/news-item/af...

Open q to the #cryoem crowd - what’s your fav NN/ML picker for hard SPA targets? We use topaz with good results, but there have been a bazillion new pickers over the last years… It is often hard to tell from the paper on each picker, as the training data matters a lot for topaz at least..

Benchmarking Boltz-2 for Screening of Therapeutic Antibody-Antigen Interactions www.biorxiv.org/content/10.64898/2026.05.13.724924v1 #cryoem

Open and closed forms of assembled henipavirus nucleoprotein suggest structural basis of genome access www.science.org/doi/10.1126/...

New online! Concepts of RNA virus evolution for the design of better antiviral countermeasures

HELP! These are some very funky viral O-linked glycans. This is the low mass range of an HCD scan on the glycopeptide. Challenge: What the hell am I looking at? Asking for a friend 😉. #glycotime

Happy to announce our mini symposium: INVECTA – from structural virology to oncolytic vectors The symposium will take place on the occasion of our ongoing Marie Curie Staff Exchange program INVECTA. Hope to see you there!

For 40 years the 8-nt ‘Kozak Sequence’ was thought to mark sites of translation initiation. In a new study, we revise this model by identifying an ~80-nt sequence—the extended Translation Initiation Sequence (eTIS)— that guides ribosomes to correct start sites. 🧵 www.biorxiv.org/content/10.6...

With Eugene Koonin, we wrote a rather comprehensive review on the origin, evolution and organization of the #virosphere. We describe all 10 viral realms and the logic behind them, and so much more. Check it out! comptes-rendus.academie-sciences.fr/biologies/ar...

Amazing work from Charlotte Lewis - our latest preprint describes structure guided development of an antiviral peptide, targeting VP2 portal assembly - a strategy that may have broad application to treat or prevent calicivirus disease. www.biorxiv.org/content/10.6...

We are excited to be at our annual Bijvoet Symposium today, for a day filled with exciting structural biology presented by our PhD students and postdocs!

Bijvoet Symposium today, here’s Gunnar Schroeder kicking things off. @bijvoet-centre.bsky.social

Human neutralizing antibodies targeting the measles virus hemagglutinin and fusion surface proteins pubmed.ncbi.nlm.nih.gov/42102820/ #cryoem

Honoured to receive the 2026 ACS Infectious Diseases Early Career Award alongside Laura Dassama and Patrick Dolan! Grateful for this recognition, and especially grateful to my wonderful colleagues, collaborators, and lab members who made the work possible. axial.acs.org/biological-c...

Read about our story in the Washington Post!

Link to our story: www.sciencedirect.com/science/arti...

Measles is coming back. Until now, we didn't know how human antibodies actually recognize and neutralize the virus. No structure of either measles surface protein bound to a human antibody had ever been reported. We set out to change that.

The next episode in our quest at @utrechtuniversity.bsky.social to answer "what do we know about your antibodies?" Structural promiscuity in the human circulatory IgA1 clonal repertoire | PNAS www.pnas.org/doi/10.1073/.... Funded by @erc.europa.eu. Congrats to Amber Rolland

Really happy to see this paper out now in PLOS Pathogens - a really nice collaboration with @alanlparker.bsky.social - led by Kasim Waraich and Rosie Mundy. journals.plos.org/plospathogen...

De uitkomst van een algoritme kan genoeg zijn om jou als verdachte burger te behandelen, ook als je niks verkeerd hebt gedaan. Overheidsinstanties gebruiken risicoprofielen om criminaliteit op te sporen. Nu roept de Staatscommissie tegen Discriminatie en Racisme op om met die praktijken te stoppen.

Happy to announce our mini symposium: INVECTA – from structural virology to oncolytic vectors The symposium will take place on the occasion of our ongoing Marie Curie Staff Exchange program INVECTA. Hope to see you there!

Congratulations to Albert J.R. Heck, recipient of the 2026 #ASMS John B. Fenn Award for Distinguished Contribution! A leader in the field, his work continues to shape the future of #massspectrometry. We’re excited to celebrate his achievements at #ASMS2026 in San Diego.

Meet my new neighbour. Moved into a sycamore in the backyard last winter, now raising a family of three in an abandonded magpie’s nest.

📢 We are now recruiting a PhD student in Structural and Molecular Virology in Sweden 🇸🇪 Work on RNA viruses using cryo-EM and in situ cryo-ET, with access to world-class microscopy infrastructure Perfect for candidates with backgrounds in biochem, structural bio, and virology More info ⬇️

We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:

'In een arena waarin de meningsvorming van bovenaf wordt gestuurd gaat het politieke debat niet over het oprukken van de oligarchie en de technocratie, maar nog steeds over immigratie.' www.nrc.nl/nieuws/2026/...

Broad neutralization of influenza B hemagglutinin antibodies via receptor mimicry and glycan engagement pubmed.ncbi.nlm.nih.gov/42060718/ #cryoem

De Limburgse ondernemer Martijn W. lijkt met voorkennis te hebben gehandeld bij defensie-inkopen. Zijn bedrijven werden eerder onderzocht door FTM vanwege schulden, meerdere faillissementen en strafrechtelijk onderzoek. Nu start Defensie een intern onderzoek naar een mogelijk ambtelijk lek.

Vaccination generates broadly cross-neutralizing antibodies to the HIV Env apex pubmed.ncbi.nlm.nih.gov/42056526/ #cryoem

The past, present and future of de novo protein design www.nature.com/articles/s41...

Co-release of tick-borne encephalitis virus RNA and structural proteins via virus-like particles and extracellular vesicles www.microbiologyresearch.org/content/jour...

Open #postdoc fellowship in my group. Virus replication and cryo-ET. Projects can be tailored to ambitious candidates with diverse backgrounds, so don't hold back from applying! DM for more info. Deadline 22May. Apply here: umustipendie.varbi.com/en/what:job/... #virus #virology #teamtomo #cryoEM

We are looking for a PhD student to study chromatin changes related to heart regeneration, in collaboration with @bakkerslab.bsky.social . Please share and apply! www.hubrecht.eu/nl/vacature/...

Moderne oorlogsvoering gebeurt op afstand, aangestuurd door algoritmen. De drones en satellieten die in Oekraïne en Gaza zijn getest, bepalen nu de conflicten in Iran en Libanon. Met haar onderzoek wil Lauren Gould laten zien hoe groot de impact hiervan is, ook lang nadat de bom gevallen is.