🌞 open.spotify.com/album/3SUEJU...

New work from Tahirov x Lim collaboration! @qixianghe.bsky.social from my lab contributed the cryo-EM structures for this work. We are excited to help explain how anti-HSV drugs work and to guide their future development. www.science.org/doi/10.1126/... @unmc.bsky.social @uwbiochem.bsky.social

Researchers immunized an alpaca and a llama with snake venoms, and combined some of the antibodies produced into a potent cocktail go.nature.com/47QZkGc

🧪 🦠 Prefusion structure, evasion and neutralization of HSV-1 glycoprotein B www.nature.com/articles/s41...

🧬 Thrilled to share our latest paper in @natmicrobiol.nature.com 📄 A collaboration to give the Flaviviridae (home to Zika, Dengue & HCV) a much-needed taxonomic re-think. Our at-scale AI structure prediction gave a complementary perspective on viral evolution. www.nature.com/articles/s41...

Glad to see our antibody design paper finally out in @nature.com (and congrats to lead authors and everyone involved )! At Xaira we are excited about pushing antibody design further to bind harder targets and make drugs for unmet medical needs. Paper: www.nature.com/articles/s41...

Now online! Generation of antigen-specific paired-chain antibodies using large language models

The Dutch Research Council (NWO) announced large investments in 11 (inter)national research infrastructures this week, and we are very happy that includes investments in our electron microscopy and mass spectrometry facilities, through projects EMPower and BioBeyond-NL: www.nwo.nl/en/news/nati...

“resolving power in a range of 600,000–800,000 for peptide ions across the whole m/z range, with a high repetition rate of 300 Hz (averaged to 0.5–4 Hz for enhanced dynamic range)” Let’s see if Waters can make a big dent in the proteomics field with this

Neutralizing antibodies against Chikungunya virus and structural elucidation of their mechanism of action pubmed.ncbi.nlm.nih.gov/41184282/ #cryoem

Very happy that NWO supports this major upgrade of our national EM infrastructure. It is great that this initiative got broad support all over NL, and it will EMPower fantastic science - looking forward to that! www.uu.nl/en/news/33-m...

Thrilled, and admittedly relieved, to see this major investment in Dutch #cryoEM become reality! 🇳🇱🔬 Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠 www.uu.nl/en/news/33-m...

Our new preprint is out 🥳🥳🥳 Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence? 👇

Since early 2024 we have been working with @brukercorporation.bsky.social on the first prototype timsOmni instrument, integrating an Omnitrap into a timsTOF. Here we report for the first time on the use of this instrument for protein-centric antibody sequencing. See www.biorxiv.org/content/10.1...

We are excited to share the final program for the NVMS Fall Meeting on November 19, 2025, at the House of Connections in Groningen. Download the program here: www.nvms.nl/index.php/nv... See you all there! 😀🧪✨ #NVMS #MassSpec #RUG #Science

Excited to share a new paper led by @andreaslaustsen.bsky.social, Anne Ljungars, @tpjenkins.bsky.social, Shirin Ahmadi and Nick Burlet. It was a privelege to be a part of this amazing team! www.nature.com/articles/s41...

We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated. mrc.tal.net/vx/appcentre...

Mijn stem ging naar Sarah Dobbe @sp.nl.

STEMMEN!!!

Happy to announce the publication of our work exploring under-appreciated genetic diversity in the human IGHC region. Awesome work by @uddalok.bsky.social. So grateful for our amazing co-authors. @williamlees.bsky.social @guryaari.bsky.social @ayeletperes.bsky.social www.cell.com/cell-genomic...

New Title Alert: HADDOCK3- is the next generation integrative modeling software in the long-lasting HADDOCK project. Learn more here: buff.ly/gInH6VV #SBGrid #SBGridSoftware #StructuralBiology

Mysteries of trafficking of the vRNP segmented genome and assembly of influenza A virus revealed by in situ cryo-ET! 🔗 rdcu.be/eMmct We are very excited that our paper is finally out! 🎉 Big congratulations to Moritz Wachsmuth-Melm and to everyone involved.

Visualizing influenza A virus assembly by in situ cryo-electron tomography www.nature.com/articles/s41...

Finally, just about 2 years after finishing the postdoc the last part of my work is finally online! We determined the structure of HSV-1 Origin Binding Protein, the viral initiator of DNA replication, by cryo-EM 🧪🧬🧶🧵 #cryoEM #structuralbiology

📢 We are announcing the Adaptive Immune Profiling Challenge 2025! Can you predict immune state labels from adaptive immune receptor repertoires? 💰 $10,000 prize pool! 🗓️ Launches Nov 5 on @kaggle.com More Info: uio-bmi.github.io/adaptive_imm...

www.biorxiv.org/content/10.1... Really excited to have our work out in the world. CCHFV has a 450kDa L-Protein, about twice the size of L-Proteins from other segmented RNA viruses. We have used cryoEM and functional assays to begin to understand it this massive multifunctional protein works.

Politici, bestuurders en media slaan alarm over ‘onhoudbare’ zorgkosten, terwijl burgers juist vinden dat er meer geld naar de zorg moet. Maar wat als die paniek helemaal niet terecht is? @mirjamderijk.bsky.social rekent genadeloos af met de grootste mythes over onze zorguitgaven.

Our latest work on #COVID immunity and imprinting in humans. Led by Ale Tortorici and Kaiti Sprouse with @aminaddetia.bsky.social and several others! www.biorxiv.org/content/10.1...

Learn how our hunt for the native structure of top antimalarial target PfATP4🧂led to the discovery of PfABP, an unknown essential binding partner, out now! @natcomms.nature.com 👉 rdcu.be/eLRlH 🦠🔬❄️ A team effort led by @mehsehret.bsky.social & Anurag Shukla @akhilvaidya.bsky.social! #cryoEM #malaria

The countdown to the end of DRC's most recent #Ebola outbreak has begun with the release from hospital of the last known patient. Of 64 cases (53 confirmed, 11 probables), there have been 45 deaths & 19 survivors. +35,000 people were vaccinated in this response. www.afro.who.int/news/last-eb...

Our paper on the phenomenon of persistence and latency in Ebola virus in an unobserved reservoir is finally out in preprint: www.biorxiv.org/content/10.1...

Check out our paper on intricate nested interactions between viruses and virus satellites of haloarchaea and their nanosized DPANN symbionts. Excellent collaboration with @deemteam.bsky.social, @anagtz.bsky.social and Michail Yakimov Free access link: rdcu.be/eLtCH 🧵 by @yifanzhou.bsky.social 👇

Our manuscript describing @riley-research.bsky.social's GlyCounter informatics tool is now in press at Molecular and Cellular Proteomics. Congrats to first-author Katie Kothlow, her first first-author paper! The manuscript is available here: www.mcponline.org/article/S153...

Now out in Science! Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. In @vcushing.bsky.social's magnum opus, we use #cryoEM to figure out how the CDK-activating kinase recognises CDKs to fully activate them - a key step in cell cycle control. www.science.org/doi/10.1126/...

🚨 new paper alert 🚨 Here, we describe and evaluate a "best-of-both-worlds" vaccine technology platform that combines the benefits of mRNA vaccines and computationally designed protein nanoparticle immunogens: bit.ly/47s7btG.

mRNA vaccines 🤝 designed nanoparticle immunogens

Very cool study by Adinda Kok from her time in Rotterdam. Lucky to have her with our team in Utrecht now. www.nature.com/articles/s41...

Heel goed. www.nrc.nl/nieuws/2025/...

Our universal peptide spectrum Annotator (and codebase rustyms) is now published in Analytical Chemistry, check it out! pubs.acs.org/doi/10.1021/... github.com/snijderlab/a... github.com/jspaezp/rust...

Just out📢 Our new paper published in @natmicrobiol.nature.com describes highly potent cross-neutralizing human monoclonal antibodies against H5Nx influenza viruses. Close collaboration with Sara Andrews lab and Tongqing Zhou lab at the VRC. Link to the article: rdcu.be/eKV9T 1/2

Our Pyrodictium cannulae paper is out in its final form! Cannulae assemble into calcium-stabilized tubular filaments stable at 100 °C—a unique archaeal cell–cell connection. Led brilliantly by @mikesleutel.bsky.social & @vinceconticello.bsky.social. www.nature.com/articles/s41467-025-64120-8

Our universal peptide spectrum Annotator (and codebase rustyms) is now published in Analytical Chemistry, check it out! pubs.acs.org/doi/10.1021/... github.com/snijderlab/a... github.com/jspaezp/rust...

October is #BreastCancerAwarenessMonth Read how Trastuzumab monoclonal antibodies targeting HER2 receptors are at the forefront of breast cancer treatment

Not sure if this is THE first charge detection commercial MS release from a major vendor, but it’s certainly one of the first. Analyses macromolecules from 100 MDa and beyond. No charge state deconvolution necessary. www.waters.com/nextgen/au/e...

Very excited that my final postdoctoral work is now online in Cell @cellpress.bsky.social. www.sciencedirect.com/science/arti... Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.

Stabilized Full-Length Measles Fusion Protein Elicits Potent Immunity and Protection In Vivo https://www.biorxiv.org/content/10.1101/2025.10.07.681039v1

After all, spotted a paper that comes without “AI“ as method! The authors present a graph-theory-based framework for 2D MS/MS, enabling <1s/sample de novo sequencing via PageRank-based ion grouping & fragmentation tree reconstruction: pubs.rsc.org/en/content/a... #MassSpec #GraphTheory

The 2025 #NobelPrize in Chemistry has been awarded to Susumu Kitagawa, Richard Robson and Omar M. Yaghi “for the development of metal–organic frameworks.” Stay tuned for the full story to come! cen.acs.org/people/nobel... #ChemNobel #Chem #Chemistry #chemsky 🧪