In another preprint from the @brianhie.bsky.social Lab and @synbiogaolab.bsky.social, they introduce Germinal, a generative AI system for de novo antibody design. Germinal produces functional nanobodies in just dozens of tests, making custom antibody design more accessible than ever before.

www.nature.com/articles/s41... Stunning work from the Chandran lab!

De politiek zegt de volkshuisvesting in Nederland weer te willen versterken. Maar met de huidige plannen zal het aandeel sociale huurwoningen de komende jaren blijven krimpen. Ik zette verschillende onderzoeksgegevens op een rijtje, Trouw schreef er een artikel over. Een draadje:

Exciting day. We’re rebooting our advanced proteomics course. Full house, Kelly about to kick things off!

Excited to share Modanovo, our transformer-based method for de novo peptide sequencing, which supports a broad range of post-translational modifications (PTMs)! www.biorxiv.org/content/10.1... #proteomics #massspectrometry #PTM

RFdiffusion3 is here: www.biorxiv.org/content/10.1...

Many of the most complex and useful functions in biology emerge at the scale of whole genomes. Today, we share our preprint “Generative design of novel bacteriophages with genome language models”, where we validate the first, functional AI-generated genomes 🧵

Naiavirus: an enveloped giant virus with a pleomorphic, flexible tail nature.com/articles/s41467-025-63463-6

One of our new manuscripts is now available on bioRxiv! Stay tuned!

Looks interesting (particularly for in silico affinity maturation) & code available on github: github.com/TencentAI4S/...

Our second paper explores the mechanism by which fusion-targeting antibodies neutralize the measles virus. It was exciting to integrate structural biology, virology, and biophysics to demonstrate that these F-targeting antibodies can provide complete protection against measles infection.

Veendam gooide de marktwerking overboord in de jeugdhulp en zie: de wachtlijsten verdwenen www.nrc.nl/nieuws/2025/...

This one is a bit of a departure from the usual and definitely a work in progress! We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below. Read on for details... 1/x

Zou er straks dan eindelijk een politieke meerderheid zijn om wonen weer betaalbaar te maken? Om maatregelen te nemen die echt helpen? Ik nam de verkiezingsprogramma’s door en werd zowaar een beetje hoopvol. Nieuwe column in @groene.nl, vandaag ook voor niet-abonnees www.groene.nl/artikel/een-...

David Baltimore, for much of the past three decades, has been one of my most helpful, thoughtful sources. I wrote an obit about his remarkable career, and I included a few of my interactions with him. www.science.org/content/arti...

Great annual tradition to start off the academic year: The Vaccine Symposium at UMCU. Very interesting talk by Galit Alter on systems serology.

La-Proteina from NVidia to do co-design of fully atomistic protein structures (sequence + side-chains + backbone) for up to 800 residues is now open source with permissive licensing 🖥️ github.com/NVIDIA-Digit... 🗎 arxiv.org/abs/2507.09466

Als het over de zorg gaat klinken al gauw de woorden ‘onhoudbaar’ en ‘onbetaalbaar’. Dat jaagt mensen de stuipen op het lijf, want dikke kans dat je die zorg in de toekomst wel nodig hebt. Maar wist je dat de kosten de afgelopen 15 jaar niet toenamen? Hier te lezen www.groene.nl/artikel/hoez...

#WestNileFever update - September. As of 3.09.2025, a total of 652 human cases of #WestNileVirus have been reported in 9 European countries: AL, BG, FR, EL, HU, IT, RO, RS, ES with 38 deaths. Italy is currently experiencing the largest outbreak (500 cases, 32 deaths). wnv-monthly.ecdc.europa.eu

In summary, we’ve found the rules to understand what a site needs to be glycosylated - an Asn in an NxS/T sequon without secondary structure and with a local sequence that tightly binds the OST groove to switch the enzyme ON.

Super excited by our new #glycotime preprint! A long-term project from my group with awesome collaborator @elisafadda.bsky.social Regulation of N-glycosylation efficiency by eukaryotic oligosaccharyltransferase www.biorxiv.org/content/10.1... thread below 👇

In new study led by @ckikawa.bsky.social, we provide near real-time data on human neutralizing antibody landscape to influenza by measuring ~26,000 titers to >100 recent viral strains Data can inform vaccine selection & evolutionary/epidemiological modeling www.biorxiv.org/content/10.1...

In NRC vandaag: We moeten de afbraak van de democratie niet te lijf gaan met een verdediging van de oude orde, maar met een hoopvol verhaal van democratisering www.nrc.nl/nieuws/2025/...

In under 24h following the newly identified outbreak of #Ebola in the DRC, the virus has been isolated, sequenced and the virus sequence data made publicly available. virological.org/t/the-16th-e...

So excited to see our newest study out in print! Led by the brilliant @jgezelle.bsky.social and @sophiekorn.bsky.social, we discovered how viruses from highly divergent families converge on a shared RNA structure mechanism to inhibit cellular nucleases. #RNAsky #LoveVirology

DRC just declared an Ebola outbreak with 13 deaths so far.

Prefusion gB of HSV bound with a neutralizing nanobody www.nature.com/articles/s41...

Before COVID we didn’t even know a virus causes multiple sclerosis. They just figured out how it does it. www.nature.com/articles/s41...

Happy to share a new preprint from the Clarke & Vallese (@fravallese.bsky.social) labs reporting #cryoem structures of two RBC stomatin complexes – with AQP1 & UT-B - continuing the SPFH theme from our recent vault preprint! This was a fun one and has been cooking for a while - read on for more! ⬇️

Ik zag Mona Keijzer onlangs bij Nieuwe van de Dag de hypotheekrenteaftrek (kosten: 11 mld p.j.) krampachtig verdedigen. Tegelijkertijd wijst ze investeringen in volkshuisvesting van de hand. Over deze ongelijke behandeling van koop en huur gaat mijn essay vandaag in NRC: www.nrc.nl/nieuws/2025/...

I am delighted to announce that the UW Department of Biochemistry has opened searches for TWO tenure-track positions. Descriptions and links in the following two posts.

#structuralphylogenetics #strphy #3di

Identification of broadly inhibitory anti-PfEMP1 antibodies by mass spectrometry sequencing of plasma IgG from a malaria-exposed child www.pnas.org/doi/abs/10.1...

Another day, another preprint on @biorxivpreprint.bsky.social! Here, we show how new machine learning tools can be leveraged to design new self-assembling protein nanoparticle immunogens in the absence of experimentally determined structures of the building blocks. www.biorxiv.org/cgi/content/...

Academia may not give you job security, flexibility, or wealth, but it will let you unexpectedly connect to eduroam in foreign cities

New online! Respiratory viral coinfections: interactions, mechanisms and clinical implications

Het tellen van onduidelijke dingen www.nrc.nl/nieuws/2025/...

De opstelling van de BBB maakt opnieuw duidelijk dat het woord migratie volkomen ongeschikt is om het debat te voeren. Wees preciezer! Column, vandaag ook te lezen voor wie (nog) geen abonnee is. www.groene.nl/artikel/arbe...

Our preprint, in collaboration with Rino Rappuoli & Emanuele Andreano, is out! Co-led by colleagues at TLS, my grad student Ling Zhou @lingzhou.bsky.social, and postdoc Emily Rundlet @cryoemily.bsky.social, we identified OPG153 as a poxvirus bnAb target via B cell isolation & AlphaFold3 prediction.

How did a brain gene end up behaving like a virus? Research has shown that there is an evolutionary connection between Arc, retroviruses, and virus-like genetic elements called retrotransposons. More at Molecule of the Month: pdb101.rcsb.org/motm...

Our #CryoET story on how a top antimalarial drug candidate perturbs the native malarial translation machinery is out @natsmb.nature.com🥳 rdcu.be/eBbrH A massive team effort led by @leonieanton.bsky.social Meseret Haile & Wenjing Cheng in collaboration with Jerzy Dziekan & the Alan Cowman! #TeamTomo

Wie ruzie krijgt met huisbaas Vesteda, moet stevig in zijn schoenen staan www.nrc.nl/nieuws/2025/...

Functional and epitope specific monoclonal antibody discovery directly from immune sera using cryo-EM pubmed.ncbi.nlm.nih.gov/40815640/ #cryoem

Niet alleen de farmaceutische industrie, ook universiteiten en ziekenhuizen dragen bij aan torenhoge medicijnprijzen. Hoogleraar Carla Hollak wil het tij keren: van nieuwe prijsmodellen tot een eerlijke verdeling van winsten bij publieke investeringen. www.ftm.nl/artikelen/ex...

(1/7) Training biomolecular foundation models shouldn't be so hard. And open-source structure prediction is important. So today we're releasing two software packages: AtomWorks and RosettaFold3 (RF3) [https://www.biorxiv.org/content/10.1101/2025.08.14.670328v2](www.biorxiv.org/content/10.1...)

Hopelijk inspireert dit boek #ZiekeZorg om duidelijk te maken dat pleistertjes plakken niet meer gaat helpen om de problemen in de zorg op te lossen. Er moet met de botte bijl worden ingegrepen. www.walburgpers.nl/nl/book/9789...

Very pleased to have our new work out where we perform a structure/function study on the bornavirus polymerase complex with fantastic coauthors. Have a read www.nature.com/articles/s41... @warwicklifesci.bsky.social @loiccarrique.bsky.social @franziskaguenl.bsky.social

Excited to share our new @natmicrobiol.nature.com paper revealing the most complete arenavirus glycoprotein complex (GPC) structures to date 🤩 www.nature.com/articles/s41...