Our article on human multidomain protein biogenesis is now published in @natsmb.nature.com www.nature.com/articles/s41...

Time to close the EMBO-FEBS Susan Lindquist School on Proteostasis 2025 in Espoo, Finland. Four intensive days of fabulous presentations, discussions, and mentoring, fostering scientific exchange between senior and junior members of the proteostasis field. Thank you to all participants!

Why are α-synuclein aggregates in Parkinson’s disease (PD) toxic at the cell biological level? Our new study shows that α-syn fibrils hijack the ESCRT membrane repair system, triggering a feedback loop that worsens aggregation. You can find it at: authors.elsevier.com/sd/article/S...

Curious about the structure and functional analysis of one of the most abundant and enigmatic extracellular #chaperones and one of the highest genetic risk factor for developing late onset #Alzheimer’s disease? Check out our paper on Clusterin/ApoJ! #proteostasis #apolipoprotein rdcu.be/ezRLv

schaechter.asmblog.org/schaechter/2... #MicroSky

This preprint from Helen Sakharova is one of the coolest things to come out of my lab: “Protein language models reveal evolutionary constraints on synonymous codon choice.” Codon choice is a big puzzle in how information is encoded in genomes, and we have a new angle. www.biorxiv.org/content/10.1...

🚨 Happy to share our first pre-print 🎉 on the causes of ribosome-associated degradation of CFTR and other transmembrane proteins. We explore how protein folding, ER insertion, and elongation dynamics influence translation arrests in this new class of RQC targets.👇 www.biorxiv.org/content/10.1...

Last call to apply for the Susan Lindquist School on Proteostasis EMBO-FEBS Lecture Course, 16-19 Sept 2025 in Espoo, Finland! Open for postdocs and PhD students. DL June 15! meetings.embo.org/event/25-pro...

Join the Hallegger Lab in Oxford! A post-doc position available to develop neuronal cell models to characterise how TDP-43 aggregation leads to its dysfunction in MND. Highly collaborative project funded by My Name'5 Doddie Foundation @MNDoddie5 Please repost and share widely!

New from our lab @crick.ac.uk, in collaboration with the Enchev and Bukau labs. By studying a protein that is difficult to fold, we discover fascinating new mechanisms by which the ribosome supports protein biogenesis. www.biorxiv.org/content/10.1...

Thrilled to share our new method in-cyclo NMR that lets us watch molecular machines in action — decoding molecular machine kinetics with atomic precision and exceptional time resolution in one go! 🚀 Check it out: doi.org/10.1038/s414... #NMR #StructuralBiology

Our research group studies #ribosomes. Our favorite region of interest is the ribosomal tunnel. We realized that it has been missing a Wikipedia page until now, so we decided to create one. Read, edit, enjoy👇 en.wikipedia.org/wiki/Ribosom...

🚨 Deadline extended! 🚨 Registration for the 2nd UK Proteostasis Network meeting in Dundee is open until 30 April! 🧬 Plenty of chances for selected talks from abstracts 📅 3–5 June 2025 📍 Dundee 🗓️ Program now live! Sign up and view the programme here: dundee.ac.uk/events/joint...

📢 New PhD Opportunity 🧬🧪 Excited to share a fully funded PhD studentship is available in my lab @gdsc-sussex.bsky.social 📅 Deadline: 2nd May 2025 👉 www.sussex.ac.uk/study/fees-f... Please share with anyone who might be interested.

🚨 Fully-funded 4-yr MRes+PhD studentship @Imperial 🚨 Join our team (w/ Prof Hugh Brady @Imperial + Dr Jacob Bush @GSK) on an exciting PhD project developing a covalent cyclic peptide discovery platform with a focus on immuno-oncology targets 🔬🔥 📅 Deadline: 27 April 2025

doi.org/10.1515/hsz-... I am super happy to share this review as my first post on Bluesky. After submitting my PhD thesis at the start of the year, my PI Elke Deuerling suggested to write this review with her, covering many of the findings of my thesis. I am excited to see it published today!

We're hiring again! Now looking for a postdoctoral fellow to join us on our mission to improve methods for testing human variants at scale. 🔎🧬🧪 Many potential projects to tackle, all in the top-tier research environment of the @crick.ac.uk. crick.wd3.myworkdayjobs.com/External/job...

Run BioEmu in Colab - just click "Runtime → Run all"! Our notebook uses ColabFold to generate MSAs, BioEmu to predict trajectories, and Foldseek to cluster conformations. Thanks @jjimenezluna.bsky.social for the help! 🌐 colab.research.google.com/github/sokry... 📄 www.biorxiv.org/content/10.1...

Delighted our work on the development of a prime editing screening platform in HAP1 is now published in Cell Genomics. This was led by Christina Kajba and Michael Herger, who did very well to optimise all aspects. (Preprint thread: x.com/TheGenomeLab...) www.cell.com/cell-genomic...

New cryo-EM/ET story - a brilliant collaboration with Sergey Melnikov's lab in Newcastle @sergeymelnikov.bsky.social and Stefan Pfeffer's lab in Heidelberg @pfeffercryolab.bsky.social. Great work in particular by Karla Helena-Bueno and @sophiekopetschke.bsky.social www.nature.com/articles/s41...

Sign up now for EMBO | FEBS Lecture Course "Susan Lindquist School on Proteostasis" in Espoo, Finland, 16 – 19 September 2025 Abstract submission & registration deadline: 15 June meetings.embo.org/event/25-pro... #EMBOFEBSproteostasis #EMBOevents🧪

We're recruiting a senior scientist. Great opportunity for somebody interested in building a career in the wonderfully supportive research environment that is the Crick. 🧪 crick.wd3.myworkdayjobs.com/External/job...

Applications for our Future Leaders in Biomedical Sciences scholarships are now open. These scholarships are aimed at students of Black or mixed Black heritage who wish to undertake a PhD in biological or biomedical sciences. Learn more and apply. ⬇️ www.crick.ac.uk/careers-and-...

Applicants of Black or mixed Black heritage can apply to my lab through the new Future Leaders in Biomedical Sciences programme. www.crick.ac.uk/careers-and-...

Just one week left to apply!

Our spring round of PhD recruitment is now open! We’re looking for researchers of any nationality with backgrounds in biological or biomedical sciences, physics, chemistry, maths or computer science. Find out more and apply by midday, 19 March: www.crick.ac.uk/careers-stud...

Autophagy UK & Proteostasis UK joint meeting -June 3-5. Exploring the lifecycle of cellular components from synthesis to degradation. Going to be a great meeting and we look forward to welcoming you to Dundee! Exciting lineup of speakers and opportunities for ECRs Register here: tinyurl.com/mr3p49f9

Today @gogs-k.bsky.social, @tlhr.bsky.social, and I are launching @bindresearch.org, a UK-based not-for-profit research startup to deliver publicly–available tools and datasets to make intrinsically disordered proteins druggable. 🍝 💊🧲 💻 🦠

👀📅👇One week left to apply for this fully-funded UK PhD - closing date 3rd February. Come and join my lab in beautiful York to work on protein-RNA interactions in FMDV, then follow up with virology experiments at the world-leading Pirbright Institute🧬 Please share widely!

Join us in beautiful Prague to study molecular physics. My group is offering a PhD position at UCT Prague, Czechia related to #protein - #RNA interactions. For more details, visit mhko.science/p/positions/ or contact us directly at [email protected].

We're hiring a postdoc! Applications from any nationality welcome. Projects around protein folding in cells, ribosomes, chaperones etc. 4 yr contract, fantastic research environment @crick.ac.uk crick.wd3.myworkdayjobs.com/External/job...

Protein quality control is a tug-of-war between degradation machinery and chaperones that promote folding. Thrilled to see our latest manuscript is now published! 👇 Follow 🧵 for quick summary journals.biologists.com/jcs/article-...

I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication, with 8 years of funding at the Francis Crick Institute. Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now! 3 postdoc positions advertised soon.

Lots to agree with in that article - in particular, concern that lack of the prospect of a peer review barrier could gradually erode standards. And as always I emphasize pro-preprint =/ anti-peer-review; the goal should be to improve critical assessment not abandon it. But a few quick thoughts. 1/n

To quote @denisduboule.bsky.social , IMHO one of the best definition of curiosity-driven basic research & serendipity "going off to look for mushrooms and coming back with blueberries. If you are payed to find the mushrooms, you won't come back with the blueberries. You will come back with nothing.

Very excited to present the structural and mechanistic basis for stress response silencing by the monster E3 ligase SIFI. www.biorxiv.org/content/10.1...

Exciting findings demonstrating a new mycobacterial hibernation factor that blocks the ribosomal exit tunnel on the 50S subunit. 🧪 #MicroSky #RNASky www.biorxiv.org/content/10.1...

I love CAT tails (how cool is to have an RNA-independent pathway to synthesize polypeptides at the ribosome). Check out our preview article on a recent study from the Young-Jun Choe's lab written by @shriyakamat.bsky.social www.cell.com/molecular-ce...

As a biochemist, I am continually surprised that people keep rediscovering that tags affect protein properties

Theodor W. Hänsch, from his Nobel lecture in 2005 (www.nobelprize.org/prizes/physi... Curiosity-driven research vs goal-oriented research

The dark side of fluorescent protein tagging: the impact of protein tags on biomolecular condensation www.biorxiv.org/content/10.1...

Cryptosporidium is an important public health threat, and it deserves better genetic tools to study it! Here we’ve developed a targeted in vivo CRISPR genetic screen to identify parasite genes required for survival and virulence… www.biorxiv.org/content/10.1...

Multi-protein assemblies orchestrate co-translational enzymatic processing on the human ribosome. Understanding how methionine cleavage can be rapidly followed by N-terminal acetylation. Two independent research papers: www.nature.com/articles/s41... and www.nature.com/articles/s41...

I can't find African Scientists and researchers easily on here. As the second largest continent with 1.3 billion inhabitants our perspectives matter. I'm creating a starterpack to find folks, follow them and amplify them. If you are an African Scientist let me know below so I can add you. Thanks.

Here’s my spreadsheet of starter packs (>80!) related to broadly ‘mechanistic biology’ plus some intriguing extras Complete with collective nouns I’ve been tracking these but now can’t keep up Hope it’s helpful 2/2 docs.google.com/spreadsheets...

So I did a bit of a search around and these are the past and present Francis Crick Institute folks that I could find. I can't guarantee they're talking about science, but if they are, you know it's going to be cool science 😉 FYI - @thecrick.bsky.social go.bsky.app/2tMmrSY

Ribosome - Gustav Klimt Style

For people interested in chaperones, protein quality control, proteostasis and cellular homeostasis, here is the link of the webinars we (P. Goloubinoff, A. Barducci, N. Nillegoda and I) hosted during the COVID pandemics. A lot of material! tinyurl.com/27y5wpzy

We have a fully-funded 4 year PhD position in the lab, for October 2025 entry. Both UK and international students are eligible to apply. Please share and get in touch if you're interested 🧬🧪🦠 www.findaphd.com/phds/project...