Dans cette revue écrite avec Pierre et @paolodelosrios.bsky.social nous partons du postulat que les interactions entre Hsp70 et Hsp110 existant dans les eukaryotes peuvent potentiellement déjà exister dans les prokaryotes. Si on regarde plus précisément certains dérivés des Hsp70, il est probable

Excited to share our new paper out today in @science.org 🎉 We show that HGT via natural competence drives diversification of chromosomal integrons in V. cholerae 🤩 Below a 🧵 on key findings incl. background on natural competence in V. cholerae 1/ #microsky #phagesky www.science.org/doi/10.1126/...

Cairo airport Sempre Forza Toro

Looking forward to it!

Finally some good news for our honey bees. Source: ScienceDaily share.google/5TYWHPuogMrT...

Postdoc opening with us at EPFL! Experimental project on how ATP driven chaperone cycles keep proteins out of equilibrium. We will quantify energy use, kinetics, and functional outcomes, including clients whose native-like functional state is stable only by sustained chaperone action.

Interested in uncovering how the #Golgi reacts to stress? Apply NOW to the @hellerschmiedlab.bsky.social @imprs-lm.bsky.social #chembio #cellbio #biochemistry

I subscribe each and every statement here. What I am just afraid of is that it might not work. Say that we were able to replace all present oil consumption by other (preferably renewable) sources. Oil would still be there to be used, ON TOP OF the renewables, ... 1/2

We are hiring a postdoc in computational biophysics and machine learning studies of intrinsically disordered proteins We aim to study the function of IDPs by combining CG MD, ML and bioinformatics in collaboration with @tanjamittag.bsky.social & @rhp-lab.bsky.social tinyurl.com/REWIRE-PD

You can't miss it. It is one in a lifetime meeting! (technically, it is one every third year, but each of them is one in a lifetime). See you there!

🗃️ EPFL adheres to the F.A.I.R. data principles, advocating for the proper management of data and code. In this course, you will gain a foundational understanding of Research Data Management, and explore the EPFL services that can better meet your needs. Register here: bookwhen.com/fr/epfl_libr...

Here it is! Thanks to @fcaredda.bsky.social (who did the heavy lifting) , @lgennai.bsky.social and Andrea Pagnani. It has been a really fun collaboration. journals.plos.org/ploscompbiol...

Thanks for highlighting our work on combining AI-based organelle dynamics detection in phase contrast with fluorescence! www.nature.com/ncomms/edito... @natcomms.nature.com and Nelio Rodriguez. Spearheaded by @wl-stepp.bsky.social with collaborators @jclandoni.bsky.social @maweigert.bsky.social

... and here it is. If you must produce TDP-43 in a P2 lab (as it is increasingly the case as it is recognised as dangerous), take a look at what Subhasis and Satyam have come up with. Any further feedback is most welcome. www.sciencedirect.com/science/arti...

Great work (as usual) from Claudio Grimaldi. From a broader angle, it is (astro)biophysics. actu.epfl.ch/news/if-alie...

Join us at the @crick.ac.uk for the 2026 meeting of the UK proteostasis community! We especially encourage students and postdocs to attend and share their work. All talks (except the keynotes) will be selected from abstracts.

📣 Our department @compbiophys.bsky.social is hiring a PhD Student or Postdoc in the field of theory and methods for non-equilibrium theory and atomistic simulations of complex biomolecules. Check out our website for the possible projects & further information: ⬇️ www.mpinat.mpg.de/5199181/01-26

💯 open.substack.com/pub/paulwell...

Distribution and evolutionary significance of the DnaK–DnaJ–GrpE (KJE) chaperone system in Archaea The paper is already here in its pre-proof form! I'll do a small thread on it a bit later. Really happy to share it. www.sciencedirect.com/science/arti...

This is the way.

Meloni : "riprendere il dialogo ed evitare una escalation" Se parla di escalation militare e/o economica con gli USA, forse Meloni dovrebbe porsi delle domande

Best thing I’ve read this morning, from a human rights lawyer in Mexico. Translation is in the ALT-text.

With this regime anything is possible…

The sun behind the mountains, their shadows on the clouds, their reflections on the lake

Cool work by Satyam and Subhasis! They show how to purify native-like TDP-43 while respecting all the safety rules that could limit the kind of instruments and procedures that can be used. A lot of small gems hidden in it, by the way. www.biorxiv.org/content/10.6...

I’m excited to announce that I will be starting my research group on computational enzyme design at the Generative Biology Institute, Oxford, UK (@eitoxford.bsky.social)! PhD applications are open, deadline is Jan 8th (www.chem.ox.ac.uk/genbio-dtp). Email [email protected] with any questions!

Same angle, yesterday night and this morning

Like 30 seconds earlier

Good morning

Three German universities offering post-docs for researchers "who cannot conduct or continue their work in the USA appropriately because of actual political pressure. " www.uni-konstanz.de/zukunftskoll...

Good news! Now invest more instead of cutting, on both sides! (Of course I have a conflict of interest being a scientist 😉)

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Fantastic opportunity! Great project with a great PI. A no-miss opportunity

Early afternoon

Morning

this morning

After the rain

Immortal

Je lance donc la suite de #lesmétazoairesdupèreconnard après la grande musaraigne. Cela sera des formats courts juste pour présenter un métazoaire un peu rigolo / étrange / spécial. Aujourd'hui Heterocephalus glaber, dit le Rat-taupe nu. De l'Ordre des Rodentia et du sous-ordre des Hystricomorpha.

I am super excited to announce that we have a tenure-track faculty position in biophysics open in the Department of Physics at Carnegie Mellon! 🧪 Interfolio link: apply.interfolio.com/174360 PLEASE, share widely across the blue skies! Let me briefly explain what we're looking for: 1/10

‘Nuf said

They claim that 1) tariffs will pay for the tax cut and 2) tariffs will move production to the US. Once production is back to the US, how will the lower income from tariffs pay for the tax cut? edition.cnn.com/2025/09/15/p...

Here we are, trying to teach an old, but always fantastic dog (Direct Coupling Analysis) some new tricks! It learns them pretty well. Together with @fcaredda.bsky.social @lgennai.bsky.social and bluesky-absent Andrea Pagnani. www.biorxiv.org/content/10.1...

A no-miss opportunity to join EPFL. We are a vibrant (had to use it 😉) community working in all branches of basic sciences and engineering, and interdisciplinary studies are strongly encouraged. If you want more information, contact the committee heads, or feel free to DM me. tinyurl.com/bd27ky7p

Walking up beautiful Swiss mountains and talking protein homeostasis (among other things) with good friend and colleague Pierre Goloubinoff

Who said “friends” and entered? Should I follow?

what a marvel

This programme is ideal for professional development (incl a budget for that) and comes with a competitive package - make sure to check it out