Lisa Gennai
@lgennai.bsky.social
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PhD at EPFL | Biophysics and Machine Learning
reposted by
Lisa Gennai
Paolo De Los Rios
3 months ago
Here we are, trying to teach an old, but always fantastic dog (Direct Coupling Analysis) some new tricks! It learns them pretty well. Together with
@fcaredda.bsky.social
@lgennai.bsky.social
and bluesky-absent Andrea Pagnani.
www.biorxiv.org/content/10.1...
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Controllable Protein Design via Autoregressive Direct Coupling Analysis Conditioned on Principal Components
We present FeatureDCA, a statistical framework for protein sequence modeling and generation that extends Direct Coupling Analysis (DCA) with biologically meaningful conditioning. The method can levera...
https://www.biorxiv.org/content/10.1101/2025.08.18.669886v1
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