The protein complex NAC slows down the rate of protein synthesis right at the start. An international research team with significant involvement of #UniKonstanz biologists has now discovered what underlies this previously unknown function of NAC. Details: t1p.de/x7rm4

Extremely proud to see this published in Nature today. Spear-headed by Jae Ho Lee from Judith Frydmans group and with help from Marina Rodninas group we studied the determinants of NAC ribosome association using selective ribosome profiling. www.nature.com/articles/s41...

Last X-Mas, the ribosome gave you methionine, but the very next day, MetAP took it away. This year, to save histones from tears, NatD gives you an acetyl group. ⭐️ Explore our latest paper with the Deuerling lab @uni-konstanz.de and Shu-ou Chan lab @caltech.edu! www.science.org/doi/10.1126/...

Great paper explaining the fine details of NatA ribosome binding and how HYPK helps to optimize binding kinetics. Also explains why KO worms have a phenotype, something that I never fully understood. Still, I would be very interested to know why Nt-acetyation is restricted to cotranslational action?

How does the kinase ZAK sense ribosome collisions? Find out in our latest collaboration with the @greenlab.bsky.social @doubleshuang.bsky.social @Vienna Huso: 1/4 rdcu.be/eRmJl #ribosome #cryoEM #LMU #JHMI

Nature research paper: Structural basis of regulated N-glycosylation at the secretory translocon go.nature.com/49vhkr5

Want to know how lipidation of some nascent chains takes place by NMT2-- Check our latest work on how NAC couples Protein Synthesis with Nascent Polypeptide Myristoylation on the Ribosome out today @embojournal.org‬: www.embopress.org/doi/full/10....

Very cool study! also nicely complementing the recent selective ribosome profiling study from the Shu-ou Shan lab. I am intriguied what might be the proposed inhibitory mechanism shielding proteins from cotranslational insertion.

Emmanuel Levy @elevylab.bsky.social has joined BlueSky 🌟 with a fantastic Cell paper with Shu-ou Shan, showing the interactome of the TOM complex and how cotranslational mito import prioritizes large globular domains. Beautiful science! Give him a warm welcome 🎉 link: www.cell.com/cell/fulltex...

Check out our new preprint on the discovery of a molecular switch in NAC that mediates nascent chain sorting on the ribosome and prevents mitochondrial protein mistargeting by SRP. A great collaboration with the Shan Lab @Caltech and the Qi Lab @UVA: www.biorxiv.org/content/10.1...

www.biorxiv.org/content/10.1... I am excited to share a big part of my thesis in preprint form, where we analysed the determinants of NAC-binding to translating ribosomes using selective ribosome profiling in C. elegans.

Last Friday I defended my PhD thesis. It was great day and I am so excited for what’s to come next!

NAC continues to deliver. What a fascinating protein!

News from the Lab! Congrats to everybody involved!

doi.org/10.1515/hsz-... I am super happy to share this review as my first post on Bluesky. After submitting my PhD thesis at the start of the year, my PI Elke Deuerling suggested to write this review with her, covering many of the findings of my thesis. I am excited to see it published today!