Delighted to share our latest research from the 23andMe Research Team, just published in @nature.com ! We looked at data from >27,000 participants to uncover how human genetics influences weight loss efficacy and side effects of GLP-1 medications like semaglutide. A short thread 🧵👇

This is a really important paper in an area that is hard to study. I would recommend any student read this preprint to see how confounding issues arise even in clever assays. Internal Ribosome Entry Sites (IRES) are very interesting because they bypass normal translation initiation mechanisms. 1/

This is quite something from Singapore's Minister of Foreign Affairs, Vivian Balakrishnan, in an interview with Reuters. The end of the post-war order, diagnosed in technocratic language. www.mfa.gov.sg/newsroom/pre...

Writing out a conversation I’ve been having a lot at this conference: Things in US science are far, far worse than people know. Far worse than even other scientists know. 1/

Genuinely just bonkers to watch the USA do this to one of the most successful and innovative hubs of scientific research the world has ever seen. All those years of Free Speech On Campus debates and it turns out they actually wanted less cancer research. Absurd.

I’ve spent all my free time this month thinking about training and data leakage in protein/RNA models. What models learn vs what you think they learn. You can find interesting and powerful things if you do it carefully. Looking forward to reading this.

Mom, come pick me up, the best lack all conviction and the worst are full of passionate intensity.

We have an open position for a #PhD student (last week to apply!) & a lab technician/TA. For more information see: www.beuschlab.org/join-us Interested in understanding post-transcriptional regulation and how #RNA #splicing decisions are made? Then take a look or share with people who might be! 🧪🧫

Congress rejected massive cuts to US science budgets for 2026, but much of the money still isn’t flowing to researchers. The culprit? The White House Office of Management and Budget (OMB) is quietly slow-walking the release of funds. 🧵👇

This is my love letter to mRNA: an Ignite talk I gave as a fundraiser for the Lawrence Hall of Science. Custom mRNA cancer vaccines could be a game changer, but anti-science policies make their future so uncertain. www.youtube.com/watch?v=WUlu...

A lot of people, including me, were wondering how an IRB could ever approve this study. The answer is that no IRB did. The person who “signed off” on approval from the only ethics board that reviewed it had resigned three years earlier. His signature was used without his knowledge.

Of so many things to be infuriated about, this is perhaps my biggest gripe. Pancreatic cancer patients, who face a future without hope, are being denied a potential game-changing therapy www.mskcc.org/news/can-mrn...

In terms of what cures are being lost: - Epstein-Barr virus is perhaps the major trigger for multiple sclerosis - herpes simplex virus causes cold sores, genital herpes, infections in babies, deadly meningitis - shingles virus causes an intensely painful disease

Happy birthday to one of my favourite haters, Charles Darwin

Let's celebrate #DarwinDay by reminding ourselves that everyone has moments when they feel worse for wear. Darwin wrote to Charles Lyell in 1861: "But I am very poorly today & very stupid & hate everybody & everything." www.darwinproject.ac.uk/letter/DCP-L... So, hang in there, #academicsky! 🧪🌏🐵

“Success in US science has come from sustained funding and welcoming the best talent from around the world, yet both of these advantages are in decline” www.science.org/doi/10.1126/...

The flu and pneumonia kill over 45,000 people a year. Moderna developed a new mRNA flu vaccine for people 50 and older--who are most at risk. Prasad, unilaterally, against the recommendation of experts within the agency, denied Moderna's appplication. www.statnews.com/2026/02/11/m...

Do you want to understand how RNA #splicing decisions are made? We‘ve got a PhD position open for you (see 👇👇)!! Please share #RNAsky and RT! tinyurl.com/4ztu9cb9

You know what they’re going to store in those warehouses? People

I love absolutely everything about this piece about life after college in Davis Square, Somerville. It's 15 years before my time but every single thing rings true. "I wanted to be edgy but I had no edges at all. I was a blur." www.newyorker.com/magazine/202...

Judge Biery signed the order with a photo of Liam and two bible verses: The first is "But Jesus said, Suffer little children, and forbid them not, to come unto me: for of such is the kingdom of heaven." The second is simply "Jesus wept." Astonishing thing for a judge to do.

A Minnesota woman observing ICE agents in her car was cornered on one-way streets. An agent approached, called her by name—citing facial recognition. Days later, her Global Entry and TSA privileges were revoked, with no explanation.

We could have 4 JWST’s or a science mission at every planet. The NIH could be funded for two years. Or 1.5 years or so of USAID funding, if it still existed. This is how they’re spending our tax dollars. This is our money.

"I didn’t realize, in the hours before his name was released to the public, that the man millions of people had seen lying facedown on the pavement from multiple angles of eyewitness video was my childhood best friend." Read more from @kristenradtke.bsky.social: www.theverge.com/policy/86856...

Thank you Minnesota

As a someone with a 33 year NIH-funded lab whose grant is supposed to be reviewed this week, shut NIH down if that is what's needed to end ICE terrorism. Innocent lives are more important 🧪

in case you're curious about how angry Minnesota is about ICE, it was -20 today

This is the first example I’ve seen of an American government using AI to meaningfully misrepresent actual events with the intent to deceive the public. We are at Stalinesque levels of propaganda. donmoynihan.substack.com/p/past-the-b...

He goes on to describe one of his officers being stopped when she was off-duty solely because she's non-white, harassed by ICE goons who slapped her phone out of her hand as she tried to record, only to be let go when she finally revealed she was a cop.

The conference (agreement between House and Senate) appropriations bill that includes HHS and NIH was released this morning. www.appropriations.senate.gov/news/majorit... 1/5

These are concentration camps. And these are the numbers they're comfortable sharing.

The Murphy Lab did our annual retreat this week. This year's theme was using AI (what it's good and bad for). I wanted to be open-minded to make sure we are not missing something we should be using it for, so we did a few exercises to test, and had presentations.

someone's gotta go in and tighten the gyre. we can't be having all this widening, it's not sustainable

Like the best satire, this takes a turn from the ridiculous to the sublime.

Super proud of Joe - he's done fantastic work in the Ingolia lab. His paper last summer was a tour de force dissecting real functional constraints on disordered protein regions. A yeast paper, with just two authors, in Nature!

I don't think you non-science people realize what it takes to get a grant funded by NIH. Started experiments in Sept 2021 to generate 3 new mouse mutants to model human disease. Prelim dara shows they have relevant disease phenotypes worthy of study. Need a small grant first to characterize /1

Breaking some news for @coyotemedia.org here. Incredibly sad about this — some of the best nights of my life have involved this club — but I’m also so honored and grateful to Ramona, Kathleen and Lynn for trusting me with this story. www.coyotemedia.org/san-francisc...

Up until this year, the US invested $10bn in mRNA technology. HHS canceled $500m (22 projects) on mRNA research. The advent of the Covid vaccine was just the beginning of next gen vaccines. It will be expanded to HIV & cancer. Life goes on while leaving us behind. www.theguardian.com/commentisfre...

"the researchers found that withdrawing support for rapidly advancing mRNA vaccine technology could result in over 49,000 preventable deaths annually among patients diagnosed with four major cancers"

2025 was a banner year for the lab: much science was done. And for me: I got tenure! But it was a hard year for science, for being a scientist, for a future that depends on science. In 2026, I want to share a clearer picture of the enterprise of science and the amazing things it is accomplishing.

The devastation I feel about this attack on science in particular is hard to cope with. It’s like watching my dad die all over again. I would do anything to spare someone a death via pancreatic cancer.

FDA intends to put its most serious warning on Covid vaccines. The agency's “black box” warning is the latest move by RFK & the Trump regime to undermine a vaccine that saved millions of lives. The plan shocked outside experts, who say there's no basis for the warning www.cnn.com/2025/12/12/h...

The past is so recent www.nytimes.com/2025/11/24/u...

In a special edition of her “How to teach this paper” column, Ashley Juavinett @analog-ashley.bsky.social explains how to best educate students about how the business of scientific research actually works. www.thetransmitter.org/how-to-teach... #neuroskyence

Just an absolutely gutting essay by Tatiana Schlossberg, a writer, mother of two young children, and cousin of RFK Jr who is dying of leukemia. www.newyorker.com/culture/the-...

In the century leading up to 1975, nearly 6000 freighters went down in the Great Lakes. The Edmund Fitzgerald was the last. The last. In 50 years, not a single commercial freighter has been lost in the Great Lakes. Why? It's NOAA. Of course it's NOAA.

Giant copy of the Constitution being carried down Pennsylvania Avenue.

after millions of views and shares of my Portland Frog art. (thank you all🙏🏾) I got requests to highlight priests, and chickens, and Chicagoans, and T-Rexes, and more… all of us who refuse to bend the knee. so this is for US. 𝚂𝚝𝚊𝚗𝚍 𝚃𝚊𝚕𝚕. 𝚆𝚎 𝚆𝚒𝚕𝚕 𝚆𝚒𝚗.

Some problems have simple solutions. This new “Compact for Academic Excellence in Higher Education” is one. The answer is simply saying no. Simple does not mean easy. But Brown, Dartmouth, MIT, Vanderbilt, Univ of AZ, UPenn, USC, UT Austin & UVA must understand what they’ll lose if they sign on.