We're no longer asking whether mRNA works. We're refining it. New in Nature: ac4C, an mRNA modification that boosts protein yield AND accuracy, reducing translational errors. This is what a maturing platform looks like—precision, molecule by molecule. 🔗 www.nature.com/articles/s41...

Ten months ago I had never written an op-ed. I believed the work spoke for itself. It doesn't. When the government calls a lifesaving technology unsafe and scientists stay silent, the silence becomes the story. A new @jhu.edu profile on why I stopped staying quiet: hub.jhu.edu/2026/06/24/j...

In Opinion The system that turned Gila monster venom into GLP-1 drugs is being dismantled through research budget cuts, Jeff Coller writes in a guest essay. “Less support for scientists means strange questions no one will get to chase. Exploring those questions is how medicine advances.”

A Federally funded doctor was curious about a lizard's biology. That work became Ozempic. The administration just proposed a rule requiring grants to "advance the president's policy priorities." The lizard would never have been studied. My piece in today's NYT: www.nytimes.com/2026/06/20/o...

Mindscape 357 | Jeff Coller @jmcoller.bsky.social on mRNA, Vaccines, and Bespoke Therapeutics. You won't want to miss this one - beyond the political/cultural noise, the science of mRNA therapies is amazing. #MindscapePodcast www.preposterousuniverse.com/podcast/2026...

Misinformation about mRNA vaccines is shaping legislation & policy. We wrote this for anyone who needs a rigorous, citable resource to push back against false narratives. #mRNA #GetTheMessage #Vaccines #HHS #FDA #CDC rnajournal.cshlp.org/content/earl...

#GetTheMessage - Did you know? After 300+ days in the hospital, Baby KJ went home—sitting up, waving, and growing. His parents were once told to consider end-of-life care. Now they're watching him thrive, thanks to mRNA technology. www.chop.edu/news/worlds-...

This @science.org article discusses evidence that suggests mRNA vaccines such as the COVID-19 vaccine may also help fight tumors in cancer patients. BDP @jmcoller.bsky.social comments on this possible effect of mRNA vaccines. www.science.org/content/arti...

A surprise bonus from COVID-19 vaccines: bolstering cancer treatment | Science | AAAS www.science.org/content/arti...

RFK Jr. is jeopardizing American's lives. Please see this interview published online today in the WSJ. www.wsj.com/video/series...

Halting mRNA vaccine development in the US has broader implications beyond infectious diseases, impeding innovative cancer and rare disease treatments. Science is interconnected; each step forward contributes to collective knowledge and new breakthroughs. www.sciencenews.org/article/mrna...

In the @wsj.com, BDP @jmcoller.bsky.social writes about how mRNA vaccines are among the most promising tools in modern medicine and how the United States' leadership in biomedical innovation is now at risk. www.wsj.com/opinion/rfk-...

Recent policy changes are putting American biotechnology leadership at risk while potentially restricting access to new treatments. It's time to refocus this debate & prioritize innovation over political rhetoric. Please read my discussion in today's Wall Street Journal. apple.news/AEckHTX4qTKW...

Thank you to Science Friday for hosting me and for this important conversation about mRNA technology and current policy directions. www.sciencefriday.com/segments/mrn...

Thank you Aaron for having the courage to speak out. We need all scientist to follow in Aaron's footsteps, call your local news and give an interview.

What we heard this week 🧵 #MedSky "This is a really reckless decision." -- @jmcoller.bsky.social, of @jhu.edu, discussing HHS Secretary Robert F. Kennedy Jr.'s decision to cancel $500 million in funding and wind down development of #mRNA vaccines. www.medpagetoday.com/washington-w...

mRNA medicines are the best medicine, but thanks to RFK Jr., laughter will have to be our booster shot! #mRNA, #NewYorker

apnews.com/video/medica... experts react to RFK Jr. canceling $500M in vaccines development projects

Robert F. Kennedy Jr.'s decision to cancel $500 million in funding and wind down development of mRNA vaccines is a disastrous one -- especially with the looming threat of an H5N1 avian influenza pandemic, sources told MedPage Today. @jmcoller.bsky.social www.medpagetoday.com/washington-w...

This decision risks ceding America's competitive advantage in biotechnology to other nations expanding their investments in mRNA research. American patients may increasingly depend on foreign innovation for breakthrough treatments. www.statnews.com/2025/08/05/m... via @statnews.com

I nice little story from the lab: dx.plos.org/10.1371/jour...

New gene therapy approach targets rare genetic diseases by boosting expression of autism-linked genes. "We stand on the brink of medical breakthroughs—we are so close." @jmcoller.bsky.social www.oneneurojhu.org/2025/06/26/a...

In a new @nature.com e article, BDP @jmcoller.bsky.social talks about mRNA’s potential not just in thwarting infectious threats but also in treating many of the same chronic conditions targeted by RFK Jr’s ‘Make America Healthy Again’ initiative. www.nature.com/articles/d41...

Nature reports how the Trump administration’s anti-mRNA sentiment has sparked fears that this once-celebrated technology, widely seen as a major engine of next-generation vaccines and therapeutics, could soon find itself on the chopping block. #medsky 🧪

Nature reports how the Trump administration’s anti-mRNA sentiment has sparked fears that this once-celebrated technology, widely seen as a major engine of next-generation vaccines and therapeutics, could soon find itself on the chopping block. #medsky 🧪

‘Despite the promise of this technology … we are risking squandering our leadership in the mRNA space in the 21st century,’ @jmcoller.bsky.social, an expert on RNA biology from Johns Hopkins University.

Research Saves Lives www.youtube.com/watch?v=ySP9...

Top F.D.A. Vaccine Official Resigns, Citing Kennedy’s ‘Misinformation and Lies’ www.nytimes.com/2025/03/28/h...

"Federal support underpins the entire spectrum of scientific research, from basic discoveries to medications for our families," BDP @jmcoller.bsky.social speaks on the impact of cuts to NIH support. hub.jhu.edu/2025/03/19/n...

Biochemical analysis of human eIF4E-DCP2 interaction: Implications for the relationship between translation initiation and decapping https://www.biorxiv.org/content/10.1101/2025.03.21.644491v1

There are days in life that shake you. I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University & academic career... 1/🧵

A nonsensical threat to: One of the most important advances in biotechnology of our time, already being used to successfully treat refractory cancers, enable genome editing, develop vaccines for infectious diseases for which there are none, treat autoimmune diseases, and more.

Our dean is taking the message to where it needs to hit. www.foxnews.com/opinion/cutt...

Research not only saves lives, it stimulates economic growth - this is a fact. #NIH, #ResearchSavesLives www.forbes.com/sites/michae...

China is poised to dominate biotechnology in the 21st century - The Hill

PSA - Please to all RNA researchers out there, please refrain from using the "V" word. Use mRNA Neoantigen Therapies for Cancer, mRNA Medicines, mRNA Therapeutics. Messaging of the message is critical in this moment. #mRNA

Five Things I Did Last Week 1. Guided a team of young scientists. 2. Made discoveries that may benefit children with rare diseases. 3. Listened to patients and families. 4. Felt humbled by their trust in scientists and medical professionals. 5. Served the American people.​​​​​​​​​​​​​​​​

I talked to NIH officials, current and former, about what's been happening inside the agency since the Trump administration shut down their grantmaking pipeline in January. Their stories showed just how willing our new leaders are to break the law: www.theatlantic.com/health/archi...

Friends, I am at a loss of words for how devastating it would be to lose the entire intramural #NIH program. Some of the biggest medical and scientific breakthroughs have come from scientists in the NIH Intramural program. #SaveTheNIH 🧬🧪 🖥️ 🧠 www.science.org/content/arti...

Wondering if your study section cancelled? I update this sheet daily. As of today, 56/124 study sections that should have met since Jan 2, 2025 have "not met as scheduled." docs.google.com/spreadsheets...