I am starting my lab at the University of Geneva next January! Incredibly excited to soon be joining the MOCEL department as an Asst. Professor. The lab will use evolutionary cell biology to study chromosomes, centromeres & speciation 🧬🔬🌱 Intrigued, want to join or collaborate? 🔗 helsenlab.org

In memory of Pierre Chambon (1931–2026): a visionary pioneer of modern molecular biology by Hinrich Gronemeyer in @embojournal.org link.springer.com/article/10.1...

Interesting. Full deletion of all introns in yeast was actually my project in the Staley lab, *20 years ago*. I actually found a bunch of phenotypes. We did this in collaboration with the Guthrie lab. www.cell.com/cell/abstrac...

1/ Very excited to share the first publication from my lab! In this work, we developed an efficient strategy to precisely mutate mammalian histone genes in their native genomic context using CRISPR prime editing: www.nature.com/articles/s41...

First preprint stemming from a fantastic collaboration with @hanhtkvu.bsky.social Shared PhD student and BIF fellow @gvaidya.bsky.social led this tour de force - check it out ! How does temperature affect whole-organism cellular trajectories?

Super excited that the first preprint from the lab is out! Led by an amazing student, Gaurav @gvaidya.bsky.social, jointly supervised with @mwdorr.bsky.social.

Frank Grosveld has been a giant in the field of long-range gene regulation. Inspirational to me and I am sure for many others. Rest in peace.

First pre-print from the lab, a collaborative effort led by Jess Bourn @bournsupremacy.bsky.social, a fantastic PhD in my group. We resolve a key problem in development + evolution: how do we quantify heterochrony and link temporal variation to phenotype? www.biorxiv.org/content/10.6...

Pressure works. Three days ago, I joined lawmakers pressuring the White House to stop its plan to dismantle a $368 million ocean monitoring system that is CRITICAL to understanding climate change and marine ecosystems, including right here off the coast of Oregon. Today, Trump backed down.

Excited to share our new preprint! 🧬❄️ by brilliant @mdreimann.bsky.social and great collaborators! Using cryo-ET&EM, we reveal archaeal chromatin in a near-native state: variable-beads-on-a-string fibers shaped by growth phase and histone composition #ArchaeaSky www.biorxiv.org/content/10.6...

"So ... so I said ... why not sign your treaty here, at Versailles?"

JIT 4 summer, the latest preprint from our lab, brilliantly led by @kaitezhang.bsky.social w/ support from Collepardo lab (@juliamaristany.bsky.social / @janhuemar.bsky.social). www.biorxiv.org/content/10.6... describes a new single-molecule epigenomic method, & discoveries it enables ... (1/n)

This will be cool! Featuring Valentina presenting her PhD work in my lab.

🚨Preprint Drop🚨 We are very pleased to release our study on DNA methylation dynamics at enhancers during ESC differentiation! This work was led by Marlet Morales-Franco and Priscillia Lhoumaud 🧵(1/13) www.biorxiv.org/content/10.6...

Thrilled to share the updated video of my paper in Nature with Maciej (under supervision of @simonemattei.bsky.social & @jomaalab.bsky.social) Proud to use Cryo-ET to uncover how hibernation factors are key to translation restart! To model PTMs in situ and render animations fulfilled my PhD dream!🥹🎉

Out today - structure of the human HIRA histone chaperone complex bound to nucleosomes. Ever wondered how nucleosomes are assembled in the wake of transcription? It takes a 'hulk of a protein complex'. Work by the amazing Wei Tian weetian558.bsky.social. www.biorxiv.org/content/10.6... 🧵

Sad news - he certainly was a towering figure with many influential discoveries - see below. Why he was never awarded the 'big' prize is truly baffling, but his many contributions to science will be remembered much longer than any prize. Thank you @alexis-verger.cpesr.fr for putting this together.

An historical figure of the transcription field has gone. Founder of @igbmc.bsky.social where I started my career. A great enabler as well.

Pierre Chambon was a great scientist. And a good man too. He alone opposed to leading British embryologists during the evaluation of a case of scientific misconduct more than 40 years ago, to defend young scientists against an establishment to which he belonged. An unforgettable lesson. RIP Pierre 💐

Excited to share our new study on CpG islands (CGIs) regulation by transcription factors (TFs)! CGIs drive most transcription initiation with unclear regulation. We find that chromatin-opening TFs are key players—following a surprisingly simple rule. 🧵 www.biorxiv.org/content/10.6... 1/9

Excited to share our first story led by @martinacapriati.bsky.social! How do cells control the expression of viability genes? We find that single transcription factors can drive both chromatin opening and gene activation from densely co-bound CpG island promoters, including at essential genes

Delighted to share our lab's latest (w/ inimitable @genophoria.bsky.social) in final form at @nature.com. Enormous lift by Sean Wang, @palindromephd.bsky.social & @martyyang.bsky.social to address extensive & constructive reviewer comments & see this through. (1/n) www.nature.com/articles/s41...

We are looking for an experienced light microscopy specialist, motivated to support our users in the Advanced Light Microscopy Facility at EMBL Heidelberg. embl.wd103.myworkdayjobs.com/en-US/EMBL/j... -closing date 11 May 2026 @eurobioimaging.bsky.social @globalbioimaging.bsky.social

Chers Collègues et Amis de Strasbourg, je serai à la Bibliothèque Nationale et Universitaire (BNU) le 21 avril à 18h30 pour partager mes souvenirs d’embryon. Apportez les vôtres! Consultation gratuite.

This is a FANTASTIC method to capture multilayer chromatin and gene regulation at allelic resolution(!!💥!!) on the same DNA molecule 🤩🥳🤩🥳 Well done @mpalamin.bsky.social and @arnaudkr.bsky.social 👏👏👏👏👏 - very beautiful work as always 💫💫💫!!

Want to know how histone marks regulate your favorite gene? Go single molecule with ChromSMF: integrated measure of chromatin accessibility and histone marks + DNA methylation, TF footprints and genotype for free! Very proud of @mpalamin.bsky.social ! @embl.org

There has never been a better time to study functional and mechanistic biology at the organismal (!) level than now in the age of AlphaFold and CRISPR.

Our study on shape diversity in cnidarians is now published. The final version includes extensive new data that substantially extend the original bioRxiv preprint. Congrats to everyone who contributed to this work! www.cell.com/cell/fulltex... @embl.org

Quantitative biology community: QBMM is back! Line up is just stellar and many abstract selected talks. Apply! 👇

New preprint from our lab... We applied our hopping technology to relocate CTCF binding sites to thousands of alternative positions in the Sox2 locus: www.biorxiv.org/content/10.6...

How do chromatin mark control TF activity and gene regulation? I will unfortunately not be at the @cshlmeetings.bsky.social Systems Biology this year, but very excited that @mpalamin.bsky.social will present her work @embl.org. Spoiler it involves a novel multiplexed single molecule genomics assays!

Very excited to announce the FIRST symposium on epigenome editing! These tools are becoming widely used in mol bio, ag & therapy. It's time to bring leaders together to discuss this rapidly growing and exciting field. And why not in Paris! Please register & share! (1/2) ctrlepiedit.sciencesconf.org

One frame. Many voices. ✨ This International Women’s Day, our Women in Science series features group leader Christa Bücker 🙌 Today, @chribue.bsky.social shares an important perspective on finding role models and becoming one for the next generation 👩‍🔬 @univie.ac.at @meduniwien.ac.at

📣 We are looking for new colleagues 🔬🧬🧪 The @lmcb-ucl.bsky.social at University College London @ucllifesciences.bsky.social are looking for outstanding candidates to sponsor for career development fellowships. Fellows would then be assessed for tenured positions at the end of the fellowship term.

Must read. Fascinating topic.

🧬 @danielibrahim.bsky.social, moderated by @stefanschoenfelder.bsky.social, on enhancer-promoter specificity & how promoter-proximal regions act as molecular filters. Register: us02web.zoom.us/webinar/regi... March 5, 4PM UK. #Genomics #GeneRegulation

Vendredi prochain 6 mars à 10h, début de mon cours 2026 @college-de-france.fr. Les relations conflictuelles entre les variations de l’ADN et l’évolution des structures🤓 L’ADN; cause proximale ou cause ultime? 🤔 Entrée libre, sortie libre! Amis Parisiens, 🙏RT 🤘

📢 Hiring! Our group @ncmbm.bsky.social seeks a Research Scientist contributing to: • Reproducible pipelines for large-scale genomics • cisreg signature analysis in breast cancer • Continued development of JASPAR • Cross-disciplinary collaboration Apply now 👉 www.jobbnorge.no/en/available...

1/3 New bioRxiv preprint from the lab: “Minute-scale coupling of chromatin marks and transcriptional bursts”. Led by Xiohui Gao & Chaebeen Ko. bioRxiv : www.biorxiv.org/cgi/content/...

🚨WE'RE RECRUITING AT @irbbarcelona.org !!!! --- ADVANCED GENOMICS FACILITY MANAGER --- An amazing opportunity to help us drive the fight against cancer and other aging-related diseases using Single-cell, Bulk and Spatial genomics!!!! APPLY NOW!!!! recruitment.irbbarcelona.org/jobs/7124180...

Come and join us at EMBL. Best way to get your scientific career started!

🤯🤯 #microsky #Phagesky #synbiosky

Very important work to reconcile canonical transcription initiation structures with the promoter diversity occurring in vivo. Some explanation on how the large majority of our promoters (TATA-less) ma initiate transcription through contacts downstream of the TSS.

Epigenetics that matters! Very cool work on hard to hard-to-access cell types . Finally some solid epigenetics examples that should be used in textbooks! Congrats to Mathieu and team @embl.org Rome!

This is nuts. Dead ringers fused. Cronenberg would have loved that.

Join @stirlingchurchman.bsky.social, @moffittlab.bsky.social, @saramostafavi.bsky.social, me and all speakers for the 2026 CSHL meeting Systems Biology: Global Regulation of Gene Expression, March 11-14. Abstract deadline January 9! More infos and registration at meetings.cshl.edu/meetings.asp...

Still time to apply until January, 19th!

The best chromatin kickstart pack you will find this year - please consider it if you want to get in the field or consolidate your skills. Hands on training and top notch speakers!

After a huge amount of work w/ @alex-stark.bsky.social's group, a new version of our Ledidi preprint is now out! In an era of AI-designed proteins, the next leap will be controlling when, where, and how much of these proteins are expressed in living cells. www.biorxiv.org/content/10.1...

An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost! www.biorxiv.org/content/10.6...