Arnaud Krebs
@arnaudkr.bsky.social
📤 1556
📥 439
📝 83
Group leader at EMBL Heideberg
https://www.embl.org/groups/krebs/
The best chromatin kickstart pack you will find this year - please consider it if you want to get in the field or consolidate your skills. Hands on training and top notch speakers!
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19 days ago
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Jacob Schreiber
23 days ago
After a huge amount of work w/
@alex-stark.bsky.social
's group, a new version of our Ledidi preprint is now out! In an era of AI-designed proteins, the next leap will be controlling when, where, and how much of these proteins are expressed in living cells.
www.biorxiv.org/content/10.1...
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Programmatic design and editing of cis-regulatory elements
The development of modern genome editing and DNA synthesis has enabled researchers to edit DNA sequences with high precision but has left unsolved the problem of designing these edits. We introduce Le...
https://www.biorxiv.org/content/10.1101/2025.04.22.650035v2
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Rob Klose
23 days ago
An early Christmas present for those interested in chromatin and transcription! Fantastic work from
@au-ho-yu.bsky.social
and
@aleksszczurek.bsky.social
. Thanks to Inge and Michiel for their help. Please repost!
www.biorxiv.org/content/10.6...
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SET1/MLL complexes control transcription independently of H3K4me3
Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...
https://www.biorxiv.org/content/10.64898/2025.12.08.692985v1
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EMBL Events
24 days ago
Are you ready for the 17th edition of 'Transcription and chromatin'? Our conference remains a must-attend event for anyone engaged in the forefront of transcription research and we hope you can join us! 🧬 25 – 28 August 2026 Submit your abstract by 25 May:
s.embl.org/trm26-01-bl
#EMBLTranscript
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Epigenetics at Helmholtz Munich
24 days ago
👉 Chromatin Summer School 2026 – Apply Now! Join us in Munich 17–29 August 2026 for an immersive program on chromatin biology: 🔬 Expert lectures 🧪 Hands-on training 🤝 Global networking Open to 14 PhD students worldwide (sponsorship available) 👉 Apply here:
bit.ly/4oGDR8f
#ChromatinBiology
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Summary - Summer School on Chromatin Biology: A Hands-On Expedition
https://bit.ly/4oGDR8f
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Karolin Luger
24 days ago
Its out!!!
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Rob Schneider
24 days ago
Please RT 📧 Registration open for ➡️"Summer School on Chromatin Biology" Our 2 weeks hands on expedition 🧪👩💻August 2026. 3. edition. Learn CUT@Tag, CUT@Run, ChIPseq, ATACseq AND to analyse your own data at
@helmholtzmunich.bsky.social
Daily letures by experts in the field ! ▶️
shorturl.at/jrA8i
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Wyeth Wasserman
about 1 month ago
It's always exciting when the latest edition of JASPAR comes out. Great leadership by
@amathelier.bsky.social
and pleased to welcome
@anshulkundaje.bsky.social
to the journey.
#Jaspar2026
academic.oup.com/nar/advance-...
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Zeitlinger Lab
about 1 month ago
We are pleased to announce a new preprint by
@mlweilert.bsky.social
: “Widespread low-affinity motifs enhance chromatin accessibility and regulatory potential in mESCs” (
www.biorxiv.org/content/10.1...
). See summary and longer recap below: (TLDR; low-affinity motifs matter as pioneers!)
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Widespread low-affinity motifs enhance chromatin accessibility and regulatory potential in mESCs
Low-affinity transcription factor (TF) motifs are an important element of the cis-regulatory code, yet they are notoriously difficult to map and mechanistically incompletely understood, limiting our a...
https://www.biorxiv.org/content/10.1101/2025.11.18.685822v1
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Uwe Ohler
about 1 month ago
Deadline is coming up soon!!
www.mdc-berlin.de/career/jobs/...
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Six AI Fellowships in Human Health
Six Independent Fellow Positions in Artificial Intelligence for Human Health in Berlin
https://www.mdc-berlin.de/career/jobs/six-ai-fellowships-human-health
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Arnaud Krebs
about 2 months ago
The 21st Course on Epigenetics which will take place from March 25th to April 1st, 2026 at the Institut Curie (Paris). The Course is open to M2 and PhD students. Application via the Advanced Training Office website before December 15th, 2025 at:
minilien.curie.fr/3avv47
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Epigenetics - 21st Course on Epigenetics 2026: Towards a quantitative understanding of nuclear dynamics during development and diseases | Institut Curie Advanced Training
The aim of this course is to provide an overview of epigenetic mechanisms and their links to gene expression and chromatin dynamics, in different systems. The diverse functions of the nucleus involvin...
http://minilien.curie.fr/3avv47
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And the science is amazing! Apply!
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about 1 month ago
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Max Planck Institute of Immunobiology and Epigenetics
about 2 months ago
This Thursday, we’re pleased to welcome Philipp Korber. Prof Korber leads a research group on “Nucleosome Positioning & Remodeling in Yeasts” at the
@bmc-lmu.bsky.social
in Munich. His work has identified ATP-dependent chromatin remodelers as major determinants of nucleosome positioning. Join us!
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Tanmay Bharat
about 2 months ago
An Asgard archaeon with internal membrane compartments Brilliant study led by
@fmacleod.bsky.social
and Andriko von Kügelgen. Tight collaboration with
@buzzbaum.bsky.social
and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
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Ewan Birney
2 months ago
Vous êtes étudiant(e) en informatique, ingénierie ou mathématiques dans une université ou une grande école ? La biologie et le fonctionnement du vivant vous intéressent ? Envie d'élargir vos horizons ? Ce stage pourrait vous convenir.
www.ebi.ac.uk/about/jobs/i...
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EMBL-EBI / Embassy of France in London Internships
In collaboration with the Embassy of France in London, we are offering a number of paid internships to computer-science, statistics and bioinformatics students.
https://www.ebi.ac.uk/about/jobs/internships/embl-ebi-french-embassy-london-internships/
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Chris Estell
3 months ago
Ding ding! New Restrictor paper out showing that ZC3H4 affects transcription universally at a checkpoint downstream and distinct to Integrator! Sequential verification of transcription by Integrator and Restrictor: Molecular Cell
www.cell.com/molecular-ce...
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Sequential verification of transcription by Integrator and Restrictor
Estell and Łazowski et al. show that Integrator and Restrictor form distinct pathways for early attenuation of RNA polymerase II: Integrator acts at the promoter-proximal pause site, whereas Restricto...
https://www.cell.com/molecular-cell/fulltext/S1097-2765%2825%2900785-3
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Yad Ghavi-Helm
3 months ago
Ever wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one? Check our latest preprint, led by
@mmasoura.bsky.social
, to find out!
www.biorxiv.org/content/10.1...
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Promoter-proximal gatekeepers restrict pleiotropic enhancer inputs to achieve tissue specificity
Developmental enhancers are central regulatory elements that can activate multiple genes, yet how they selectively regulate one gene over its neighbours remains unclear. Using the Drosophila twist E3 ...
https://www.biorxiv.org/content/10.1101/2025.09.23.678065v2
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Blanka Majchrzycka
3 months ago
Out now! 🎉 Check the thread & preprint to see why we think E–P specificity is real in mammals — and, well, a few other interesting things popped up too 👀 Huge thanks to
@danielibrahim.bsky.social
,
@arnaudkr.bsky.social
&
@stemundi.bsky.social
and fantastic people in their labs — what a journey! 🧪🔬
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A genetic engineering tour de force by
@blanka-majchrzycka.bsky.social
. Systematic dissection of promoter function in relevant genomic context! Spoiler, promoter matters! Happy we could help on this!
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3 months ago
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Teresa Rayon
3 months ago
Model organisms as platforms for training scientific minds
www.nature.com/articles/s41...
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James Briscoe
3 months ago
The
@crick.ac.uk
is recruiting Early Career Group Leaders - Lab set-up, research costs, salaries for up to 5 researchers - Support for up to 12 years - Access to our core facilities - Competitive salary - Fantastic colleagues - All areas of biology Deadline 27 Nov
www.crick.ac.uk/careers-stud...
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Early career group leaders
We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.
https://www.crick.ac.uk/careers-study/faculty/early-career-group-leaders
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Unique opportunity to get hands on experience at post-doc+ level in cutting edge environment!
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3 months ago
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Janelia Research Campus
4 months ago
📢We're
#hiring
Group Leaders! Apply to lead a lab at Janelia & advance biology using theory, computational modeling & machine learning. 🔹5-year renewable appointment 🔹Pioneer new tools & approaches 🔹Collaborate across disciplines Apply by Nov. 4👉
https://janelia.link/groupleader
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Christa Buecker
3 months ago
Two more days to apply for the VBC PhD program! Join us in beautiful Vienna to explore exciting scientific questions under fantastic mentorship and in an outstanding training environment!
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Bart Deplancke
3 months ago
🧵1/ Excited to share our new paper introducing a new
#singlecell
assay: scTF-seq, a high-throughput single-cell approach to explore how transcription factor (TF) dose shapes cell identity and reprogramming outcomes. 🔗
www.nature.com/articles/s41...
Big congrats to the entire team @EPFL & @SIAT_China
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Dissecting the impact of transcription factor dose on cell reprogramming heterogeneity using scTF-seq - Nature Genetics
This study introduces single-cell transcription factor (TF) sequencing, a single-cell barcoded and doxycycline-inducible TF overexpression approach that reveals dose-sensitive functional classes of TFs and cellular heterogeneity by mapping TF dose-dependent transcriptomic changes during the reprogramming of mouse embryonic multipotent stromal cells.
https://www.nature.com/articles/s41588-025-02343-7
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Christa Buecker
3 months ago
Congratulations! nice to see this out!
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VIB.AI
3 months ago
We're growing the
VIB.AI
Machine Learning Unit, and we're hiring! 📌 Head of the Machine Learning Unit 📌 LLM Engineer Both roles are based in Leuven, Belgium, at the heart of a thriving research ecosystem.
https://vib.ai/en/opportunities#/job-list
Apply by October 31st.
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Rob Schneider
3 months ago
#Jobalert
🚨: Please RT ! Looking for a
#PhD
student for exciting project on the interphase between epigenetics and cellular metabolism: How do (nuclear) metabolic enzymes reguate chromatin function ?
#epigenomics
,
#epigenetics
,
#metabolism
www.helmholtz-munich.de/en/ife/job-o...
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Arnaud Krebs
4 months ago
✨Exciting news: the main story of my PhD is out in Science! Together with Christine Moene
@cmoene.bsky.social
, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation. 📖 Read the full story here:
www.science.org/doi/10.1126/...
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Functional maps of a genomic locus reveal confinement of an enhancer by its target gene
Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...
https://www.science.org/doi/10.1126/science.ads6552
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Christine Moene
4 months ago
Have you ever wondered how the exact location of a gene affects it's activity? The main story of my PhD deals with exactly that question, and is now published in Science! ✨
www.science.org/doi/10.1126/...
My amazing co-author and friend
@mathiaseder.bsky.social
summarized the highlights for you
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EMBL
4 months ago
Join EMBL AI! We have ambitious plans to transform life sciences research through AI. Interested in using ML/AI to solve complex interdisciplinary challenges? We’re looking for two senior leaders based at EMBL Heidelberg👇
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FragileNucleosome
4 months ago
We're getting started in ~90 minutes! In addition to watching the seminars, remember you can join us on Discord to chat about transcription and chromatin whenever you want!
discord.com/invite/dXqT89r
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László Tora
4 months ago
Do not forget to apply to the FEBS Advanced Lecture Course: 6th Danube Conference on Epigenetics (19–22 October 2026, Budapest, Hungary. Will be a great meeting as always. Check out the site:
network.febs.org/posts/febs-a...
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FEBS Advanced Lecture Course: 6th Danube Conference on Epigenetics
The FEBS Advanced Lecture Course: 6th Danube Conference on Epigenetics will take place 19–22 October 2026 in Budapest, Hungary. Here we give a taste of the scientific content, flag some of the speaker...
https://network.febs.org/posts/febs-advanced-lecture-course-6th-danube-conference-on-epigenetics
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Surfin' NuRD
4 months ago
Check it out, Chromatin Kids! Chromatin remodeller does stuff to Transcription Factors! Functions where it is seldom seen! Both decreases and increases chromatin accessibility! How cool is that?
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Arnaud Krebs
4 months ago
Excited to share another new preprint from our lab in which we developed a cluster-based phasing strategy using long read nano-NOMe-seq data to link distinct CTCF binding states—captured at the single molecule level—to the transcriptional status of genes:
biorxiv.org/content/10.1...
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Luca Giorgetti lab @FMI
4 months ago
Become our colleague at
@fmiscience.bsky.social
! The FMI is a very special place to start your lab: a vibrant international institute with world-class research groups and facilities, core funding, fantastic trainees, great colleagues😅, and a collegial culture. Get in touch if you're interested!
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Norwegian Centre for Molecular Biosciences and Medicine (NCMBM)
4 months ago
📢Last chance today! We are looking forward to receiving your applications👇!
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Ewan Birney
5 months ago
Just brilliat work by Kasit and colleagues in
@arnaudkr.bsky.social
's group
@embl.org
. This is leveraging the "everyday" length of ONT (20KB) plus exogenous modification to sort out co-occupancy between enhancers and promoters (and inter-enhancer).
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Mathias Boulanger
5 months ago
Huge thanks to the co-first author
@kasitc.bsky.social
Also thanks to Rene, Marc Jan, Karine, Kim, and especially
@arnaudkr.bsky.social
@embl.org
@dfg.de
. Finally, Kasit will be presenting the story at the
@cshlnews.bsky.social
#cshlmoet
next week! Please stop by if you are around!
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This is not a HiC map! Ever wondered if multiple enhancers get activated simultaneously? We measured chromatin accessibility on thousands of molecules by nanopore to create genome-wide co-accessibility maps. Proud of
@mathias-boulanger.bsky.social
@kasitc.bsky.social
Biology in the thread👇
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5 months ago
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Nature Reviews Genetics
5 months ago
Our featured article: Epigenome dynamics in early mammalian embryogenesis by Adam Burton & Maria-Elena Torres-Padilla
go.nature.com/45UA8Ob
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Epigenome dynamics in early mammalian embryogenesis - Nature Reviews Genetics
Upon fertilization and during early mammalian development, major changes in cellular plasticity occur. This is accompanied by large-scale epigenome remodelling, as has been recently highlighted by the...
https://go.nature.com/45TsxPQ
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EMBL Events
5 months ago
🎉 Congrats to the poster prize winners at #EMBLSingleMolecule! 🏅 Adam Cawte, University of Oxford, UK 🏅 Masa Shimazoe, National Institute of Genetics, Japan 🧬 Explore their winning abstracts & posters in our latest blog post: 🔗
https://s.embl.org/grg25-01-posters
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Alex Radzisheuskaya
5 months ago
Registration is still open for Transcription and Chromatin UK 2025. Join our growing research community in Manchester this September!
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Stephen Curry
5 months ago
Funny how many institutions that self-refer as “leading” have a wait-and-see approach to decision making…
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Ragnhild Eskeland
5 months ago
We are hiring! A 3-year postdoc in
#Chromatin
#Cancer
#Epigenetics
at University of Oslo, Norway and co-supervised by
@amathelier.bsky.social
You will be part of @cancelluio.bosky.social. We focus on
#Sarcoma
#Epigenome
#CRISPR
and Drug screen studies. Find out more and apply here:
shorturl.at/DtLHM
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Postdoctoral Research Fellowship in Chromatin Biology and Cancer Epigenetics (283381) | University of Oslo
Job title: Postdoctoral Research Fellowship in Chromatin Biology and Cancer Epigenetics (283381), Employer: University of Oslo, Deadline: Wednesday, August 20, 2025
https://shorturl.at/DtLHM
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Rada-Iglesias Lab
5 months ago
Excited to share the latest work from the lab led by
@eharo84.bsky.social
, in which we have used synthetic biology to explore the mechanisms by which different types of long-range enhancers ensure robust and precise developmental gene expression
www.biorxiv.org/content/10.1...
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Synthetic engineering demonstrates that synergy among enhancers involves an increase in transcriptionally productive enhancer-gene contacts
Enhancers are non-coding cis-regulatory elements that control the expression of distally located genes in a tissue- and time-specific manner. Recent studies indicate that enhancers can differ in their...
https://www.biorxiv.org/content/10.1101/2025.08.08.669284v1
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Typas Lab
5 months ago
EMBL is back on hiring faculty! Check out the multiple open positions: 3 PIs- 2 in Heidelberg incl. our Molecular Systems Biology Unit, 1 in Grenoble 1 Head of Unit (Cell Biology & Biophysics, Heidelberg). Closing deadlines in Sep! +3 more positions to come out then, stay tuned...
@embl.org
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Eileen Furlong
5 months ago
Open Team Leader position
@embl.org
to head & reshape our Genomics Core facility. Interested in providing & developing state-of-the art omics tech to a wide community? A very vibrant, dynamic place to work with fantastic colleagues. Closing Sept 30th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
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Team Leader – Genomics Core Facility and Method Development
Are you ready to lead a cutting-edge Genomics Core facility while developing state of the art genomics methods? Join us at EMBL! We are seeking talented scientists to develop and lead a cutting-edge G...
https://embl.wd103.myworkdayjobs.com/en-US/EMBL/job/Team-Leader---Genomics-Core-Facility-and-Method-Development_JR2103
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Schubeler Lab
5 months ago
Excited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity.
www.sciencedirect.com/science/arti...
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Norwegian Centre for Molecular Biosciences and Medicine (NCMBM)
5 months ago
📢One month left to apply to our Group Leader position! 🌟A chance to be part of
@nordicembl.bsky.social
: “The Partnership connects us with an exceptional network of researchers, facilities, and complementary expertise. It opens doors to meaningful scientific exchange”, says
@amathelier.bsky.social
.
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