New paper from the @rcollepardo.bsky.social lab!!!!! This time, we turn our attention to Oct4, a key pioneer transcription factor 👇👇👇👇 With simulations by @janhuemar.bsky.social, we propose a mechanism through which the clustering of Oct4 upon chromatin binding enhances chromatin plasticity 🧬⚛️👩‍

🚨 🚨 🚨 New preprint alert!!! 🚨 🚨 🚨 In the past, we have learnt that Oct4 can induce nucleosome breathing on the mono-nucleosome level. But what happens when you have a fibre of multiple nucleosomes? www.biorxiv.org/content/10.1... @rcollepardo.bsky.social @juliamaristany.bsky.social

🚨 New paper out in Nature Comms! From the Rosen, Redding and Collepardo Labs, we uncover how #nucleosome spacing fine-tunes the architecture of #chromatin condensates. 👇 A short thread on how physical #genome organization emerges from molecular interactions: www.nature.com/articles/s41...

🌱Join us for the first #FragileNucleosome seminar of this spring! We are excited to host @juliamaristany.bsky.social & @chribue.bsky.social this week! If you have registered before you can join from the same link, if not, don't forget to register! us06web.zoom.us/webinar/regi...

We are happy to share our work on local #nucleosome dynamics integrating #temperature inputs into an #epigenetic switching mechanism. ⚠️ Preprint alert!! www.biorxiv.org/content/10.1...

What is the multiscale structure of chromatin condensates? How does it shape thermodynamic and material properties? We address this at near-atomistic resolution🔥🔥🔥 using cryoET (Rosen & Villa labs, led by H Zhou), a new multiscale model (K Russell) and cryoET-guided sims (J Huertas & J Maristany)

So excited to see our most recent paper in collaboration with the Rosen Lab out in Bioarxiv today!! 🔥🔥 We look into chromatin condensates in high resolution! 🧪🔬👩‍🔬 Using cryo-ET and MD sims, we studied chromatin condensates across scales, from individual amino acids to their network architecture!

Exciting new preprint alert! 🚨 The Collepardo lab, teaming up with Huabin Zhou and the Rosen lab we took a deep, high-resolution look into chromatin condensates! [1/6] #Chromatin #MD @rcollepardo.bsky.social @juliamaristany.bsky.social www.biorxiv.org/content/10.1...

The Multiscale Genome Organisation is now on Bluesky! Our first post is to announce our next webinar. Join us next week on Tuesday, Jan. 28th at 12:00 E.T. for two exciting talks by Pablo Dans and @gfudenberg.bsky.social See you all there! Link: mit.zoom.us/j/91715298970

How does chromatin linker length affect its emergent phase behavior? 🧬👩‍🔬 We explore this question via microscopy and MD simulations: Our new paper, in collaboration with the Rosen and Redding Labs, is out today!! 🔥