Cryogenic electron tomography of condensed chromatin enables multiscale analysis of its structure. Learn more in a new #SciencePerspective: https://scim.ag/3Yfn1T3

Want to learn about how we use computational approaches at different scales to study biomolecular condensates? Check out our latest review, out in Advances in Physics X @juliamaristany.bsky.social @alinaemelianova.bsky.social @rcollepardo.bsky.social www.tandfonline.com/doi/epdf/10....

Our Science paper is out! Huge congratulations to @huabin-zhou.bsky.social, Mike Rosen, and the brilliant @janhuemar.bsky.social @juliamaristany.bsky.social and @kieran-russell.bsky.social from our group News: bit.ly/4avnkAr and bit.ly/3XBGVHS Great perspective by @vram142.bsky.social +K Zhang

Very excited to present OpenCGChromatin🔥🔥🔥 A new coarse-grained model that probes full chromatin condensates at near-atomistic resolution to reveal the molecular regulation of chromatin structure and phase separation Brilliantly led by @kieran-russell.bsky.social, with the Rosen and Orozco groups

Many thanks to @jojdavies.bsky.social for inviting us to take part in this exciting study, combining MCC ultra with simulations to explore how the biophysical properties of chromatin govern its structure in living cells. Simulations by @janhuemar.bsky.social and @juliamaristany.bsky.social

Check out our new work, led by talented @janhuemar.bsky.social, where we uncover that pioneer factor Oct4 remodels chromatin for DNA access not by opening it but by exploiting nucleosome breathing and forming clusters 🔥🔥🔥

We found that charge asymmetry along chromatin drives centromeres to the chromosome surface during cell division 🔥🔥🔥 If you want to know more, check our latest work in collaboration with the labs of Daniel Gerlich, Mike Rosen, and Sy Redding Simulations by superstar @juliamaristany.bsky.social

It was a huge treat for me personally, and the Chemistry Department more generally, to host you. Thank you for examining Pin Yu, and the inspiring talk and discussions ⭐️⭐️⭐️⭐️⭐️

So excited to finally see our CTPR-condensate work published! Well done Chris, Mateo, Julia et al. ❤️ @chemicalscience.rsc.org @phar.cam.ac.uk @rcollepardo.bsky.social @juliamaristany.bsky.social doi.org/10.1039/D5SC...

In this wonderful collaboration with K Maeshima and M Shimazoe we show that H1 in living cells acts as a liquid-like glue not a driver of stiff zigzag fibers 🔥🔥🔥 Each H1 bridges multiple nucleosomes and exchanges nucleosomes frequently: boosting both compaction and dynamical behaviour of chromatin

We are excited to announce a new faculty position here in Cambridge, for researchers in computational and/or theoretical biology, based jointly in Genetics and Mathematics. Come and join us! Happy to answer questions about research, teaching and working here. www.jobs.cam.ac.uk/job/50414/

To close, we have Jan Huertas from Cambridge University @janhuemar.bsky.social presenting our work in collaboration with the Rosen lab on the structure of chromatin inside condensates and the role of histone tails #BPS2025 @mgo-bps.bsky.social

María Aristizabal from Queen’s University in Canada tells us how combining experiments and simulations informs on why histone modifications are involved in cancer #BPS2025 @mgo-bps.bsky.social

Shoji Takada from Kyoto University in Japan describes his impressive multiscale simulations of transcription regulation #BPS2025 @mgo-bps.bsky.social

Serena Sanulli from Stanford University @serenasanulli.bsky.social discusses HP1 condensates and chromatin structure #BPS2025 @mgo-bps.bsky.social

Now is the turn of Paul Meneses from Taekjip Ha lab at Johns Hopkins and Harvard Medical School discussing single molecule measurements on native chromatin #BPS2025 @mgo-bps.bsky.social

Rob McGinty from University of North Carolina discusses structural mechanisms of nucleosome demethylation #BPS2025 @mgo-bps.bsky.social

Now we have Marcus Woodworth from University if Pennsylvania telling us about chromatin states in native chromatin visualised with expansion microscopy #BPS2025 @mgo-bps.bsky.social

First is Michael Poirier from Ohio State, discussing the pathways by which H1 loads into nucleosomes #BPS2025 @mgo-bps.bsky.social

Starting now #BPS2025 @mgo-bps.bsky.social

Do you like chromatin, condensates, single-molecule imaging? Then you’ll love our #BPS2025 MGO symposium. TODAY at 1:30 pm

Proud to have the final version of our paper on mutations + condensates + scaling laws published in @elife.bsky.social! Work led by @juliamaristany.bsky.social w/ @rcollepardo.bsky.social ! Read the digest here: elifesciences.org/digests/9906...

Are you in #BPS2025? Come to join us at the MGO Symposium this afternoon!

Introducing Mpipi-Recharged🔥🔥🔥 Our Mpipi coarse-grained model for biomolecular condensates now includes a pair-specific electrostatic potential that improves its predictions, including for challenging charged systems—all while still treating solvent and ions implicitly pubs.acs.org/doi/10.1021/...

Who's going to #BPS2025? Please join us at the MGO Symposium @mgo-bps.bsky.social on Saturday 1:30 pm Room 511ABC Featuring experiments, simulations, and all the scales by @serenasanulli.bsky.social @melikel.bsky.social @maristizabal.bsky.social @janhuemar.bsky.social and more Please repost! 🚀✨

Don't miss these two super exciting talks on chromatin tomorrow at 5pm UK time! Zoom link below This is part of the Multiscale Genome Organisation subgroup of the 2025 Biophysical Society Meeting (BPS)

📢 Join us! We are recruiting an Associate Professor/Professor of Molecular and Cellular Biology to join our innovative research community! Find out more about the position and apply: https://buff.ly/4iYDBjv

we are recruiting a postdoc to work on a collaborative project with the lab of Nynke Dekker in Oxford @nynkedekkerlab.bsky.social. Please RT www.hubrecht.eu/job/postdoc-...

We’re hiring! 🚨 We’re looking for motivated postdocs to join our team and help us advance the frontiers of chromatin simulations Learn more and apply here: www.jobs.cam.ac.uk/job/50052/ Women and underrepresented profiles in STEM are encouraged to apply Please repost to help us spread the word!

What is the multiscale structure of chromatin condensates? How does it shape thermodynamic and material properties? We address this at near-atomistic resolution🔥🔥🔥 using cryoET (Rosen & Villa labs, led by H Zhou), a new multiscale model (K Russell) and cryoET-guided sims (J Huertas & J Maristany)

The Institut Pasteur has decided to leave X (formerly Twitter) to join BlueSky! 🦋 The Institut Pasteur made this decision due to several serious issues observed on the X platform since its acquisition. Join us here to continue advocating for science. www.pasteur.fr/en/home/pres...

We’re excited to share our work describing the role of mechano-dependent sorbitol in biomolecular condensate formation, published @cellcellpress.bsky.social cell.com/cell/abstrac...

1/ 🚨We’re thrilled to share our latest study: "Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟 www.biorxiv.org/content/10.1... How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️

Happy holidays from the Collepardo group ♥️

“Biomolecular condensates control and are defined by RNA–RNA interactions that arise in viral replication”. New results from a wonderful collaboration with @gladfelterlab.bsky.social and Christine Roden (who just started her lab at University of Montreal!!) www.biorxiv.org/content/10.1...

Is chromatin ordered or disordered? It all depends on the linker DNA length. Check our latest work with Mike Rosen and Sy Redding. We explore how changes in linker DNA length (as small as 1 bp) fine-tune chromatin structure, between order and disorder, and the properties of chromatin droplets

Hope to see you on Monday 2nd of December for our Cambridge Epigenetics Club (in person) plus Networking with wine and cheese.

Reposting here before deleting X: Don’t get mad, get equal: putting an end to misogyny in science nature.com/articles/d41... By me & my dear friend Alison Bentley @natureportfolio.bsky.social RT widely & connect me to Academia speaking up accounts, esp for women, minorities & ECRs

Hi Bluesky! I made a 3D chromatin starter pack. Let me know if you would like to be added. go.bsky.app/6tTQdqQ