Stress controls epigenetic inheritance! A histone ubiquitylation-based regulatory hub links stress/environmental signaling to heterochromatin self-propagation and epigenetic inheritance-reshaping how we think about development, drug resistance, and cancer 👉 nature.com/articles/s41586-025-09899-8

Excited to share our new publication introducing NoLMseq, a method based on laser microdissection of individual nucleoli that enables single-cell mapping of genome-nucleolus interactions across development and under cellular stress. www.nature.com/articles/s41...

Finally out! We introduce NoLMseq, a #nucleolus laser microdissection method to capture single-cell genome-nucleolus interactions in normal and stressed nucleoli, revealing novel insights into genome organization & function. www.nature.com/articles/s41...

Explore RNA's role in epigenetics, DNA repair, transcription & genome organisation - directly with leaders from academia & industry at #GenReg26! Remaining talks to be filled from submissions - register & submit by 04 Sep 2025 to join us in Mexico. Speakers, details & registration➡️ bit.ly/46JQbze

Very excited to share our latest work in #MolCell showing NPM1 stabilizing the association of nucleolus associated domains (NADs) and recruiting G9a to establish their repressive chromatin states. www.sciencedirect.com/science/arti...

Online Now: The nucleolar granular component mediates genome-nucleolus interactions and establishes their repressive chromatin states Online now:

Delighted to share that the results of my main postdoc project are now published in @nature.com 🔗 doi.org/10.1038/s415...

Our new study of chromatin ubiquitylation by variant PRC1 on the single-molecule scale: We visualize directly how vPRC1 ubiquitylates neighboring nucleosomes during a single binding event, showing a potential mechanism how H2Aub domains are established. www.science.org/doi/10.1126/...

Together with the De Ridder lab www.deridderlab.nl we just published a review on deep learning as a tool for gene expression analysis/ prediction: rdcu.be/elQCc.

Very happy to share the peer-reviewed version of our paper in which we study the formation and function of pair-wise and multi-way enhancer-promoter interactions in gene regulation (see thread below): www.nature.com/articles/s41...

The EMBL conference '#Chromatin & #Epigenetics' opens today! Organized by 🌟Asifa Akhtar @mpi-ie.bsky.social 🌟Amanda Fisher @ox.ac.uk 🌟Bing Ren @ucsandiego.bsky.social 🌟Dirk Schübeler @fmiscience.bsky.social Looking forward to an exciting meeting! @events.embl.org #EMBLChromatin

Very excited to share our latest work revealing a prominent role for LADs in commisioning cell fates in mouse organ & tissue development, particularly of the limb. Amazing work by Isabel and Samy together with @stemundi.bsky.social & @drmrobson.bsky.social www.biorxiv.org/content/10.1...

Online Now: ZNF574 is a quality control factor for defective ribosome biogenesis intermediates Online now:

Exciting PhD project available in our lab (time sensitive)! 👇