New preprint from our lab! What can we learn about the properties of gene regulatory elements by CRISPR’ing a random set of accessible sites in human cells? Find out here: www.biorxiv.org/content/10.1... 👇 1/

Thrilled to share that our Group Leader Prof. Azim Surani, together with Prof. Davor Solter, has been awarded the 2026 Paul Ehrlich & Ludwig Darmstaedter Prize 🎉 for discovering genomic imprinting—a breakthrough that reshaped genetics and launched modern epigenetics.

Most read, I hear! Here is your chance to read what @mariekeoudelaar.bsky.social and I had in mind when writing this together.

The community of Drosophila researchers is amazing, mutually supportive and collaborative. Right now a key resource for our community, @flybase.bsky.social , is threatened by the cancellation of its NIH grant and is seeking community help in raising short term funds 1/n 🧪 please share

So, we (Dylan Liabeuf and Anastasiia Maksiuk) are organising the first Berlin symposium on organoids. The objective is to bring together the Berlin organoid community and to develop further interactions. Info: www.bihealth.org/en/notices/b... Free registration: www.bihealth.org/en/news/even...

New paper on the role of H3K4me3 at enhancers! We (led by Haoming Yu) used dCas9 epigenome editing to add H3K4me3 to intergenic enhancers. This was (1) sufficient to turn up transcription at open, active regions and (2) has no effect on target gene transcription. genesdev.cshlp.org/content/earl...

Excited to share our new study in @cp-devcell.bsky.social dissecting how the brain-associated transcription factor OTX2 drives anteriorization of the mammalian gut by enhancer remodeling using stem cell-based models. #development #enhancers #patterning #stemcells www.cell.com/developmenta...

Great honor to be nominated as one of the top 10 Falling Walls Foundation Science Breakthroughs of the Year 2025 in the Life Sciences. A big thank you to @ovarylab.bsky.social & @tabeamarx.bsky.social for their outstanding contributions, & to everyone else who helped move this project forward.

Excited to share the latest work from the lab led by @eharo84.bsky.social, in which we have used synthetic biology to explore the mechanisms by which different types of long-range enhancers ensure robust and precise developmental gene expression www.biorxiv.org/content/10.1...

🤩 Very excited to share our new work! We have derived euploid and aneuploid trophoblast organoids and extra-embryonic mesoderm cell lines from early human embryos. In doing so, we have characterised the tissue requirements for their specification. If you want to know more, continue reading….

Check out this exciting meeting and register! Fantastic line-up of speakers on cell biology of the nucleus and a great venue 🔥

To all post-docs: The Genome Biology dept ‪@embl.org has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Delighted to see this work published! Congrats to Chris Todd and everyone involved - happy to have been part of the team.

Save the Date! Development has teamed up with the Wellcome-funded consortium the Human Developmental Biology Initiative to co-organise a meeting on #HumanDevelopment. 📅7 - 9 Sep 2026 📍University of Warwick, UK Register your interest for #HumanDev26: www.biologists.com/meetings/dev...

Please pread the word. We have just launched the Hubrecht International PhD Program (HIPP). Are you looking for a PhD position in molecular and developmental biology or related subject in an international, very supportive and collaborative environment? Then apply to the HIPP!! 👇

Join the VGZT Eastern KEYNOTE lecture ☀️☕ TOMORROW 🗓️ Wednesday July 09 ⏰ 13:30 IST / 17:00 JST / 8:00 UTC / 10:00 CET Featuring: 1) Maithreyi Narasimha 👉Positioning tissues during Drosophila morphogenesis Jose Silva @josesilvalab.bsky.social 👉From founder cells to organogenesis-stage embryo model

GSCN Conference (15. - 17. Oct 2025 in Munich)! Extended Deadline: 21 July 2025. Submit your abstract for an oral presentation & get an early bird ticket by 21.7.! Save on registration and secure your spot in the scientific program. Register and submit your abstract here: ➙ gscn-conferences.org

Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/

⚠️ I am really excited to share the work of Anastasios Balaskas, an excellent PhD candidate in the lab, with the wider world. Tasos made a significant advance: generating a stem cell-based embryo model that contains both posterior and anterior neural tissues of the late-stage gastrulating embryo.

🌟Congratulations to Azim Surani @gurdoninstitute.bsky.social @cam.ac.uk for receiving the 2025 Kyoto Prize - Basic Sciences. Azim's research fundamentally advanced our understanding of developmental biology🔬🧬 www.gurdon.cam.ac.uk/kyoto-prize-... #KyotoPrize #AzimSurani #DevelopmentalBiology

Our review on ➡️"Histone modifications in development" is out 🍾 in 🔖 Development @dev-journal.bsky.social urnal.bsky.social‬ Read more about histone tail and globular domain modifications during development: journals.biologists.com/dev/article/...

This is a piece that I and @karsten-rippe.bsky.social discussing a lot, and a topic that is very close to my heart. The editors @naturerevgenet.bsky.social gave us the stage to do so, and the final version of our review is now available under this link: rdcu.be/erP1u A short thread follows 1/n

Textbooks: “Enhancers are just a bunch of TFBSs” But how do they REALLY work? New paper with many contributors here @berkeleylab.lbl.gov, @anshulkundaje.bsky.social, @anusri.bsky.social A 🧵 (1/n) Free access link: rdcu.be/erD22

Join us next Wed, for three amazing ECR researchers_ @fueyoraquel.bsky.social, @kaiamattioli.bsky.social and Laura talk about their work in #FragileNucleosome seminar series! In case you haven't joined any of the previous 2025 sessions, here is registration link: us06web.zoom.us/webinar/regi...

Calling all European #Drosophila labs. Time for all of us, that are able, to step up to support FlyBase during this funding crisis.

Really looking forward to @radaiglesiaslab.bsky.social's talk on "Gaining mechanistic insights into long-range gene regulation through synthetic biology approaches" in @enhancedgenomics.bsky.social's seminar series. 📅 June 5th 2025 tomorrow ⏰ 4pm GMT Please join us: us02web.zoom.us/webinar/regi...

www.nature.com/articles/s41... Dev bio is amazing !!

🔬✨ Excited to share a major milestone from my PhD research at Institut Curie, where I am a first author in a recently published paper in Nature Communications! www.nature.com/articles/s41...

🚨Preprint alert!🚨 Great collaboration with the lab of Stefan Schoenfelder @stefanschoenfelder.bsky.social - we dissect the role of non-canonical enhancers in human pluripotent stem cells. 👇

How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭 Check out our paper - fresh off the press!!! We find widespread functional conservation of enhancers in absence of sequence homology Including: a bioinformatic tool to map sequence-diverged enhancers! rdcu.be/enVDN github.com/tobiaszehnde...

Join our team as a postdoc and explore the exciting world of transposable elements and developmental biology with us! @imbavienna.bsky.social @vbcscitraining.bsky.social

Come and join us if you are in Münster on Thursday!

Tomorrow — for anyone in the Frankfurt area that might be interested in 3D genome folding, cell aging and splicing.

📢 Have you registered for 'Gene regulation: one molecule at a time' yet? Submit your abstract by 8 April! 👉🏼 s.embl.org/grg25-01-bl #EMBLSingleMolecule will bring together single molecule genomics and imaging to study mechanisms across the central dogma at molecular resolution 🧬🔍

Check out this preprint on MLL2 by Srinjan Basu's lab @srinjan.bsky.social; I am happy to contribute a bit to this tour de force work www.biorxiv.org/content/10.1...

🚨Exciting lecture alert!🚨 If you're in Göttingen on Feb 19 at 1:15 PM, don’t miss this year’s Ernst Caspari Lecture by Meritxell Huch @merihuchlab.bsky.social from MPI Dresden @mpicbg.bsky.social - join us for an inspiring talk!

2025 EMBO workshop on "Enhancer Mechanics and Enhanceropathies" now open for registration I was at the 2023 workshop in Marseille and it was a great event - recommend!

Does your research focus on chromatin and epigenetics? Then join #EMBLChromatin 🙌 Don't miss the opportunity to connect with experts and be part of the conversation! 🗓️ 13 – 16 May 2025 📍 EMBL Heidelberg and Virtual 📩 Submit your abstract by 18 February 2025 ➡️ s.embl.org/chr25-01-bl

Hear, hear! The Universtiy Medical Center Goettingen is inviting applications to its new Medical Scientist Program “Genomic responses to disease plasticity” funded by the EKF Stiftung. The program will support early-career bioscientists with a PhD eager to do clinically-oriented research... 1/n

Super excited to share our new study from the @jbuenrostro.bsky.social Lab in @nature.com! We developed a computational method for tracking transcription factor and nucleosome binding using single-cell ATAC-seq and deep learning. Paper: www.nature.com/articles/s41...

I am thrilled to share our latest work, released today 🤩 www-nature-com.insb.bib.cnrs.fr/articles/s41... It results from years of hard work by the team and long-time collaborators, with special thanks to PhD student Clara Roidor and collaborator Laurène Syx.

With pleasure we share our preprint reporting robust and cost-effective expansion of naive human Pluripotent Stem Cells without feeder cells. A fantastic collaborative effort with @leeboratory.bsky.social @jzylicz.bsky.social @pasquelab.bsky.social and Nicolas Rivron. tinyurl.com/5n6z9rt9