Online Now! Signaling reprogramming via Stat3 activation unravels high-fidelity human post-implantation embryo modeling #stemcells

(1/8) Very Happy to share our lab’s 3D post-implantation human embryo model, made via signalling reprograming! 🙌 Huge thanks to the entire team and our collaborators, special shout-out to @cc0447.bsky.social (led the work) and @jinjin-0101.bsky.social (comp. analysis). www.cell.com/cell-stem-ce...

(1/3) A while back, my then-PhD student @htstuart.bsky.social stumbled on a finding that changed our lab’s direction 👀✨. Turns out, STAT3 mediated reprogramming generates intermediates (Gata6GFP+ cells) going through an earlier developmental stage with increased developmental potential 🚀

💓 Researchers in the @josesilvalab.bsky.social used #SmallMolecules to convert mouse ESCs into embryo founder cells, which generated a complete embryo model! Article: bit.ly/4orpbLb Episode with discussion: bit.ly/4oTURt2

🥂Congrats to Gao, Li & co for their new @natcellbio.nature.com study: they derive #trophectoderm stem cells from 32-cell mouse #embryos. These cells represent an early trophectoderm state, develop into #placenta cells and organoids and contribute to blastoid generation. rdcu.be/eAKzp bit.ly/4fyZ9Sg

Capturing early TE stem cells. From Zhang Jian’s lab, “Mouse trophectoderm stem cells generated with morula signalling inducers capture an early trophectoderm state”, with a small contribution from us. www.nature.com/articles/s41...

Very happy to share the work of Huanhuan Li et al. While not a natural embryo, you might not have known that if I hadn’t told you. (1/3)

Join the VGZT Eastern KEYNOTE lecture ☀️☕ TOMORROW 🗓️ Wednesday July 09 ⏰ 13:30 IST / 17:00 JST / 8:00 UTC / 10:00 CET Featuring: 1) Maithreyi Narasimha 👉Positioning tissues during Drosophila morphogenesis Jose Silva @josesilvalab.bsky.social 👉From founder cells to organogenesis-stage embryo model

Thank you VGZT community for your active participation 🌎 See below the session flyers for the rest of the season: 🌞 Eastern sessions: Happening on Wednesdays. Our keynote for this season: Maithreyi Narasimha and @josesilvalab.bsky.social [1/2]

Very grateful to the @lundstem.bsky.social and Filipe Pereira for hosting me. I truly enjoyed meeting and discussing with many colleagues at the Center. I also received very interesting feedback that will hopefully lead to collaborations and help further improve our embryo models.

An interesting study characterising human embryo gastrulation! rdcu.be/d5VmN