Chuanxin Chen
@cc0447.bsky.social
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Associate investigator in GZlab. Fancy how stem cells can generate embryo models.
reposted by
Chuanxin Chen
Cell Stem Cell
4 months ago
Online Now! Signaling reprogramming via Stat3 activation unravels high-fidelity human post-implantation embryo modeling
#stemcells
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Signaling reprogramming via Stat3 activation unravels high-fidelity human post-implantation embryo modeling
Enhanced STAT3 activation combined with TGF-β inhibition reprograms human PSCs into cells specifying all early embryonic lineages. Upon 3D suspension culture, these cells self-organize within 6 days into post-implantation structures mimicking Carnegie stages 5–7 embryos, including gastrulation, with high morphological and molecular fidelity.
http://dlvr.it/TN6Tkq
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reposted by
Chuanxin Chen
José Silva & Lab
4 months ago
(1/8) Very Happy to share our lab’s 3D post-implantation human embryo model, made via signalling reprograming! 🙌 Huge thanks to the entire team and our collaborators, special shout-out to
@cc0447.bsky.social
(led the work) and
@jinjin-0101.bsky.social
(comp. analysis).
www.cell.com/cell-stem-ce...
loading . . .
Signaling reprogramming via Stat3 activation unravels high-fidelity human post-implantation embryo modeling
Enhanced STAT3 activation combined with TGF-β inhibition reprograms human PSCs into cells specifying all early embryonic lineages. Upon 3D suspension culture, these cells self-organize within 6 days i...
https://www.cell.com/cell-stem-cell/fulltext/S1934-5909%2825%2900303-0
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reposted by
Chuanxin Chen
José Silva & Lab
5 months ago
Very happy to share the work of Huanhuan Li et al. While not a natural embryo, you might not have known that if I hadn’t told you. (1/3)
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reposted by
Chuanxin Chen
Cell - a Cell Press journal
5 months ago
Now online! A complete model of mouse embryogenesis through organogenesis enabled by chemically induced embryo founder cells
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A complete model of mouse embryogenesis through organogenesis enabled by chemically induced embryo founder cells
A small-molecule-only strategy enables reprogramming ESCs into embryo founder cells that give rise to a high-fidelity embryo model directly and efficiently. This embryo model replicates embryogenesis from initial cell fate specification through E8.5–E8.75-like organogenesis, capturing all key developmental features within a single system.
http://dlvr.it/TMN9Nk
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