👋On my way to the @isscr.org meeting in Montreal. Looking forward to meeting as many of you as possible! Feel free to message me ;) In the meantime, who hasn't read our Editorial on the #StemCell #embryo model collection we just announced at @natcellbio.nature.com ? #ISSCR2026 👉Here: rdcu.be/fsIeP

Our #stemcell editor Daniel Klimmeck is now en route to Montreal, and curious to discuss your work with you at #ISSCR2026!

👋Attending the @isscr.org meeting in Montreal this week? Our #StemCell & development editor @slefkopoulos.bsky.social will be there and happy to chat - message him! #ISSCR2026 🍰In the meantime, take a look at our new Collection of stem cell-based #embryo model papers: www.nature.com/collections/...

👋In this month's editorial, we introduce a Collection of articles in the area of #StemCell - based #embryo models. The collection will be updated as we publish new content. 👉Read here: rdcu.be/frN7h www.nature.com/articles/s41...

☕Cao, Lin, Feng, Chen, Wu et al. develop a mouse developmental single-cell atlas covering 2-cell stage through to birth. www.nature.com/articles/s41...

Ok, who will be attending the @isscr.org meeting next week in Montreal? I ‘ll be around, so don’t hesitate to reach out to discuss your work for @natcellbio.nature.com or just meet in person and have a chat! :) #ISSCR2026 www.isscr2026.org

☕He, Wang, Ding et al. report a transcriptomic atlas of human female reproductive tract segments from fetuses at gestational weeks 10 to 25. 👉https://rdcu.be/fq3ms www.nature.com/articles/s41...

🥂Single-cell transplantations of long-term #hematopoietic stem cells(HSCs), in-depth phenotyping and mathematical modeling identify reconstitution kinetics as a unifying metric of HSC potency and extrinsic regulation as a driver of lineage bias. @natcellbio.nature.com www.nature.com/articles/s41...

A study published in Nature identifies an electrocardiogram marker by using an AI model trained on electrocardiograms of individuals that experienced sudden cardiac death. www.nature.com/articles/s41...

☕Single-cell transplantations of long-term HSCs, in-depth phenotyping and mathematical modeling identify reconstitution kinetics as a unifying metric of HSC potency and extrinsic regulation as a driver of lineage bias. @simonhaas.bsky.social @milsommick.bsky.social www.nature.com/articles/s41...

☕Wei et al. show that Meg3+ #hematopoietic stem cells (HSCs) expand upon #aging and present with an increase in H3K23ac levels observed already at middle age. Inhibiting H3K23ac ameliorates megakaryocyte/platelet and myeloid skewing in aged HSCs. www.nature.com/articles/s41...

I will never get over how good this is! Already on day 3 of @bacell3d.bsky.social organoid conference - great science and discussions, as always!

There’s actual proof that I used to be a researcher myself!

☀️Our June issue is out! Cover: mechanical polarization 👉Perspective: #RNA in #aging 👉Review: #ExtracellularVesicles 🔬 #hematopoiesis #epigenetics #mechanobiology #morphogens #ferroptosis #LipidDroplets #CellMigration #melanocytes #embryos #CancerStemCells & more! www.nature.com/ncb/volumes/...

☕This Review discusses the roles of #ferroptosis in shaping the immune landscape in glial #tumors and highlights potential strategies that combine ferroptosis induction with #immunotherapy for a durable control of gliomas. #CellDeath 👉https://rdcu.be/foVLA www.nature.com/articles/s41...

Felix Gunawan, assistant professor at the University of Toronto and co-affiliate group leader at the University of Münster, was born and raised in Indonesia but moved to Canada during high school. @natcellbio.nature.com spoke to him about his journey as an LGBTQIA+ immigrant: #PrideInSTEM 🌈

🏳️‍🌈This June, we celebrate Pride by discussing with @gunawanlab.bsky.social about his personal and academic journey as an LGBTQIA+ immigrant. Happy Pride month! #PrideinSTEM #LGBT 👉https://rdcu.be/forCt www.nature.com/articles/s41...

🌈 At a time when progress can't be taken for granted, I 'm especially proud to share this @natcellbio.nature.com Q&A piece. I had the pleasure to discuss with @gunawanlab.bsky.social about his inspiring journey as an LGBTQIA+ immigrant. #PrideInSTEM 👉 rdcu.be/fnXQ6 www.nature.com/articles/s41...

A lovely time chatting about interesting work @events.embl.org #EESMechanobiology! as senior editor @natcellbio.nature.com & as advisory editor npj Biological Physics & Mechanics. Got a quick selfie w/ @embojournal.org senior scientific editor Ieva Gailite at #MeetTheEditor session on Wednesday 😁🤳🏽

📻A two-part podcast series on reproducible research with Emma Ganley, Director of Strategic Initiatives at @protocolsio.bsky.social, and Robin Padilla, Director of Product Management at Springer Nature’s Digital Life Science Solutions! shows.acast.com/reproducibil...

Attending #EESMechanobiology ? If so, be sure to find and chat with @djdavid.bsky.social (Daryl), one of our senior scientific editors. He'll be on site on Tuesday and Wednesday.

Who ‘ll be attending the @bacell3d.bsky.social conference this year? I ‘ll be there! Feel free to drop me a note if you wanna discuss a manuscript for @natcellbio.nature.com or just to have a chat! #BaCell3D2026 www.bacell3d.com

☕Yu, Li et al. explore the #metabolome of neurons, microglia and astrocytes under normal, ageing and #Alzheimers disease conditions. They find enrichment of glutathione and polyamine metabolism in microglia, which decreased with #aging and in Alzheimer’s disease. bit.ly/4tV7XaQ

☕ @nicolettapetridou.bsky.social & co report a feedback loop between Nodal signaling and tissue phase transitions in zebrafish #embryos. Nodal alters adhesion, triggering tissue rigidification and reduced porosity, which limits its diffusion and speeds up Lefty expression. go.nature.com/4vgBYmo

Landmark cancer trial shows success against pancreatic cancer, often described as undruggable. The experimental drug, daraxonrasib, disarms all three members of the RAS family of proteins, which are notoriously difficult to target #MedSky 🧪 www.nature.com/articles/d41...

☕Ge, Wang, Zhao, Guo et al. report a role for stress granules in suppressing #ferroptosis by sequestering ferritin upon irradiation and temozolomide treatment in #glioblastoma stem cells, which may potentially be targeted for improved efficacy. 👉https://rdcu.be/flToi bit.ly/49z9Dzv

☕The authors provide a spatial transcriptomic atlas of cynomolgus monkey #embryos at Carnegie stages 9 and 10 and further do comparative analyses using public human and mouse data to dissect conserved and species-specific transcriptional programs. 👉https://rdcu.be/flpt3 bit.ly/4efr21J

👋Our May issue is out! Cover: #Trogocytosis - inspired delivery 👉Perspective: #lipids #endocytosis 👉Review: #organelles in #aging #longevity 🔬 #gastruloids #LeukemiaStemCells #ferroptosis #ribosome #chromatin #cGAS #immunotherapy #glioblastoma #alzheimers & more! www.nature.com/ncb/volumes/...

☕ @shainlab.bsky.social , @bishaltandukar.bsky.social & co dissect the mutational, gene expression and morphological features of adult human skin melanocytes at single-cell resolution. bit.ly/4wzMyX0

☕ @riddhiman.bsky.social et al. use experimentally matched mass-spec and RNA-seq to quantify proteins, phosphosites & transcripts across 4 stages of human & mouse gastruloid development. @jshendure.bsky.social @leastarita.bsky.social @nobuhamazaki.bsky.social @dschweppe.bsky.social bit.ly/4dAYyA1

☕Paquola et al. present a technique named lipid-trap mass spectrometry (LTMS) to study lipid–protein interactions directly captured from mammalian cells. bit.ly/4tEPW10

☕ @joshifrenster.bsky.social @amartinezarias.bsky.social & co utilize mosaic mouse #gastruloids as a model of cell fitness & competition, identifying a temporal window between primed pluripotency and early gastrulation during which #CellCompetition occurs in mammalian #embryogenesis. bit.ly/4cBmfGK

A feature in Nature outlines how a burgeoning field examining a method to reverse cellular aging is launching its first clinical trial to find out if dialling back cell development can safely refresh aged tissues and organs. 🧪

👋Our April issue is out! Cover: Visualizing #lipids 👉2 Perspectives: #embryo models 👉Comment on #mitochondria DNA 🔬 #telomeres #leukemia #ferroptosis #pyroptosis #PhaseSeparation #CellAdhesion #BreastCancer #lncRNA #metabolism #autophagy #microscopy & more! www.nature.com/ncb/volumes/...

☕ @mathilda95.bsky.social @nadlerlab.bsky.social & co introduce a correlative light and electron #microscopy workflow, Lipid-CLEM, combining near-native #lipid probes and on-section labelling via click chemistry. Lipid-CLEM quantitatively analyses lipids in membrane nanodomains. bit.ly/4moYLJH

📰Our editor Zhe Wang will be attending the AACR Annual Meeting in San Diego. Please feel free to reach out to him ([email protected]) if you would like to meet in person to discuss your work and ask questions about Nature Cell Biology.

📣 New Perspective out in @natcellbio.nature.com! With an interdisciplinary team of scientists, ethicists & lawyer we propose embedded ethics as a framework for navigating the complex ethics of human stem cell–based embryo models. www.nature.com/articles/s41... Free full text link: rdcu.be/fckmY 🧵

A study published in Nature presents CHARM, a single-cell 'four-omics' sequencing method that profiles genome conformation, histone modifications, chromatin accessibility, and gene expression within the same cell.🧪👇 www.nature.com/articles/s41...

Cooking lunch today, I was shocked: there exist purple potatoes! I ‘d no idea (and didn’t buy them myself; they were sent to me from a company supporting organic local produce & sustainability (by including products super markets would not buy as they ‘re crooked or whatever; highly recommend it!))

☕After performing a focused CRISPR–Cas9 screen, Skafar et al. identify riboflavin (vitamin B2) as a regulator of FSP1 stability that modulates phospholipid peroxidation and #ferroptosis sensitivity in #cancer cells. bit.ly/4t91gm1

🥳 I am happy to share our latest manuscript published in @natcellbio.nature.com We use #Gastruloids to study #CellCompetition during early mammalian development and find not only that this is highly pronounced in our system but also tightly restricted in time. (1/12) www.nature.com/articles/s41...

☕Zhang, Han, Tan, Lu, Ma et al. report that kynurenine derived from peritumoral #adipose tissue is hijacked by #cancer cells to mediate #ferroptosis resistance, a process that could potentially be targeted with immunotherapy to inhibit tumor growth. bit.ly/4uWc73X

☕New Review article discussing the mechanisms underlying both cavitation and folding #amniogenesis, as well as various recent stem cell-based human #embryo models developed to elucidate amniotic formation and function. 👉https://rdcu.be/e9wos bit.ly/4uGeh7v

Thrilled to share that our latest review—led by @aysegulerdemm.bsky.social—synthesizing insights into complex intrinsic and extrinsic metabolic regulation of HSC fate and its implications for leukemogenesis, is published in March 2026 issue of @natcellbio.nature.com. @nickvangastel.bsky.social

👋Our March issue is out! Cover: #Adipose – #tumor in #immune escape 👉Reviews on: #metabolism #hematopoiesis ; #amnion ; #brain #lipids 🔬 #mitochondria #LipidDroplets #aging #autophagy #mechanobiology #neurodegeneration #ferroptosis #chromatin #metastasis & more! www.nature.com/ncb/volumes/...

☕Wang et al. show that promyelocytic leukemia protein (PML) reduces polyG inclusions via chaperone-mediated disaggregation and proteasome-dependent degradation. This suggests a possible role for PML in various neurodegenerative diseases. 👉https://rdcu.be/e7dOe bit.ly/4ucFCy1

Mitochondria contact lipid droplets through the mitochondrial import complex binding to lipid metabolism enzyme Ayr1 👉https://rdcu.be/e7dRa bit.ly/4baJZAO

☕Xia, Zhang, Peng, Chen et al. find that #Leydig cells and macrophages show bidirectional mitochondrial transfer through #ExtracellularVesicles, ensuring Leydig cells have functional #mitochondria. The exchange is needed for testosterone production. bit.ly/40US4Vy

☕New Review discusses #brain #lipid #metabolism from a cellular perspective, focusing on lipid uptake, de novo synthesis, storage, breakdown and intercellular transfer, and highlights its emerging implications for brain health and disease. 👉Read here: rdcu.be/e8rlJ bit.ly/4rxWpJm

☕Wan, Li, Cao et al report a feedback crosstalk between THY1+ #cancer #StemCells and neutrophils via #migrasome - mediated release of #mitochondria, which induces a pseudohypoxic state and promotes metastasis. 👉https://rdcu.be/e51HE bit.ly/3ZZRw0q