Francesca Cesari
@francesari.bsky.social
📤 2655
📥 56
📝 89
Chief Biological, Clinical and Social Sciences Editor of Nature Any views expressed here are my own
Two registered clinical trials in Nature report the successful use of the GLP-1 and glucagon receptor co-agonist Mazdutide for type 2 diabetes.🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
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Mazdutide versus placebo in Chinese adults with type 2 diabetes - Nature
Nature - Mazdutide versus placebo in Chinese adults with type 2 diabetes
https://www.nature.com/articles/s41586-025-10026-w
19 days ago
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A paper in Nature reports the prevalence of Alzheimer’s Disease Neuropathological Changes in a Norwegian population-based cohort, assessed using a blood-based biomarker🧪
www.nature.com/articles/s41...
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Prevalence of Alzheimer’s disease pathology in the community - Nature
The prevalence of Alzheimer’s disease neuropathological changes is reported based on blood-based biomarkers in a Norwegian population-based cohort.
https://www.nature.com/articles/s41586-025-09841-y
19 days ago
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An article in Nature assesses the effect of Australian protected areas on vegetation in adjacent areas, and finds evidence of a positive spillover effect, that is, increases in a given vegetation type relative to what would be expected from the broader landscape.🧪
www.nature.com/articles/s41...
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Protected area management has significant spillover effects on vegetation - Nature
Analysis of effect sizes of vegetation spillovers from protected areas in Australia shows that 71% of over 3,063 analysed protected areas had a positive spillover effect, and that these effects c...
https://www.nature.com/articles/s41586-025-09837-8
19 days ago
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A meta-analysis of 34,000 individuals identifies reproducible associations between gut microbial species and diet and health markers. The associations were used to generate a ranking of species that are either positively and negatively associated with health markers.🧪
www.nature.com/articles/s41...
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Gut micro-organisms associated with health, nutrition and dietary interventions - Nature
Comprehensive large-scale studies of multi-national populations identified microbiome species consistently associated with favourable and unfavourable health markers, informing future studies of the h...
https://www.nature.com/articles/s41586-025-09854-7
19 days ago
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Ancient DNA analysis at the important archaeological site of Shimao city in northern China provides insights into the social organization and burial practices in a Neolithic community🧪
www.nature.com/articles/s41...
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Ancient DNA from Shimao city records kinship practices in Neolithic China - Nature
Sequencing of 144 ancient genomes from Shimao city and its satellites presents pedigrees among tomb owners spanning up to four generations showing predominantly patrilineal descent structure across Sh...
https://www.nature.com/articles/s41586-025-09799-x
19 days ago
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A study in Nature finds that 0.37 million tonnes of wild meat are extracted annually in Amazonia.This amount of wild meat can meet nearly half of protein and iron dietary requirements for rural people and a substantial portion of their needs for B vitamins and zinc.🧪
www.nature.com/articles/s41...
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Healthy forests safeguard traditional wild meat food systems in Amazonia - Nature
Data provided by Amazonian peoples are used to estimate the value of wild animals as a source of food, including its spatial distribution and nutritional value, providing information that will be key ...
https://www.nature.com/articles/s41586-025-09743-z
19 days ago
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How related is economic inequality to mental health? This meta-analysis shows a complex picture in which this relationship is only evident among low-income populations and in contexts of high inflation. 🧪👇
www.nature.com/articles/s41...
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No meta-analytical effect of economic inequality on well-being or mental health - Nature
A meta-analysis of 168 studies reveals that economic inequality is not significantly associated with subjective well-being or mental health.
https://www.nature.com/articles/s41586-025-09797-z
29 days ago
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How do video glitches impact hiring decisions, trust in a medical provider, and parole decisions? A study published in Nature finds that these glitches negatively impact these decisions by breaking the illusion of face-to-face contact 🧪
www.nature.com/articles/s41...
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Video-call glitches trigger uncanniness and harm consequential life outcomes - Nature
Glitches in video calls can have a negative effect on the judgement of the people involved and correspond to worse outcomes in major areas of life such as job interviews and parole hearings.
https://www.nature.com/articles/s41586-025-09823-0
29 days ago
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Speech sounds like vowels and consonants in native and foreign languages elicit similar neural responses in the superior temporal, but only during native listening does this area encode word boundaries, frequency, and language-specific information. 🧪
www.nature.com/articles/s41...
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Shared and language-specific phonological processing in the human temporal lobe - Nature
The human superior temporal gyrus processes acoustic–phonetic properties of speech regardless of whether the language is familiar to the listener, but only encodes word boundaries and language-sp...
https://www.nature.com/articles/s41586-025-09748-8
about 2 months ago
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Marburg virus is a highly virulent/transmissible filovirus with no vaccine/treatments and recent outbreaks in Africa. Scientists have isolated/characterized a highly potent neutralizing monoclonal antibody effective against Marburg and related viruses Dehong and Ravn.🧪
www.nature.com/articles/s41...
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Potent neutralization of Marburg virus by a vaccine-elicited antibody - Nature
Nature - Potent neutralization of Marburg virus by a vaccine-elicited antibody
https://www.nature.com/articles/s41586-025-09868-1
about 2 months ago
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A Nature paper details a new AI model called EchoPrime, which can read and interpret echocardiograms 🧪👇
www.nature.com/articles/s41...
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Comprehensive echocardiogram evaluation with view primed vision language AI - Nature
Nature - Comprehensive echocardiogram evaluation with view primed vision language AI
https://www.nature.com/articles/s41586-025-09850-x
about 2 months ago
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A study looks at the mortality impacts of unmanaged rainfall and future sea level rise, with disproportionate risk for children, women, and residents of slums in a developing megacity🧪
www.nature.com/articles/s41...
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https://www.nature.com/articles/s41586-025-09730-4
about 2 months ago
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Computer vision, on which many AI applications rely on, is based on non-consensual datasets, compromising fairness and accuracy in AI. Now, an ethically curated, diverse human-image data set, sets a new standard for responsible data curation and trustworthy AI. 🧪
www.nature.com/articles/s41...
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Fair human-centric image dataset for ethical AI benchmarking - Nature
The Fair Human-Centric Image Benchmark (FHIBE, pronounced ‘Feebee’)—an image dataset that implements best practices for consent, privacy, compensation, safety, diversity and utility—can be used respon...
https://www.nature.com/articles/s41586-025-09716-2
about 2 months ago
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A paper in Nature reports high-resolution structures of aSyn fibrils 1B and their in vivo seeding product 1BP. They appear remarkably similar, suggesting a high-fidelity conformational replication process to perpetuate MSA-like pathology 🧪👇
www.nature.com/articles/s41...
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Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology - Nature
Synthetic fibril strain 1B is a pathogen that is capable of self-replication and inducing glial cytoplasmic inclusions in vivo in mice, and the structural features of 1B may underlie the pathology of ...
https://www.nature.com/articles/s41586-025-09698-1
about 2 months ago
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Snake bites kill/debilitate 1000s of people annually in Sub-Saharan African. A new nanobody cocktail is shown to be highly effective against 17 of the most dangerous African snake species. Unlike other anti-venoms it also protects against venom-induced dermal necrosis🧪
www.nature.com/articles/s41...
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Nanobody-based recombinant antivenom for cobra, mamba and rinkhals bites - Nature
A recombinant antivenom composed of eight nanobodies provides broad protection against venom-induced lethality and dermonecrosis in mice challenged with venoms from cobras, mambas and rinkha...
https://www.nature.com/articles/s41586-025-09661-0
2 months ago
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A new study in published in Nature presents a comprehensive resource of immunological changes occurring during normal aging 🧪
www.nature.com/articles/s41...
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Multi-omic profiling reveals age-related immune dynamics in healthy adults - Nature
This multi-omic longitudinal analysis of the healthy human peripheral immune system constructs the Human Immune Health Atlas and assembles data on immune cell composition and state changes w...
https://www.nature.com/articles/s41586-025-09686-5
2 months ago
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Where do invertebrates without calcium-rich bones or shells store their calcium? In the fruit-fly, at least, it’s the malpighian tubules, where calcium is mobilised by a neuropeptide hormone called Capability. 🧪
www.nature.com/articles/s41...
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Neuroendocrine control of calcium mobilization in the fruit fly - Nature
The peptide hormone Capa is responsible for regulating extracellular fluid Ca2+ levels in the fruit fly Drosophila melanogaster.
https://www.nature.com/articles/s41586-025-09670-z
2 months ago
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An article in Nature reports that ecosystem energy flow, through food consumption by wild birds and mammals, has decreased by over one third in sub-Saharan Africa since around 1700 🧪
www.nature.com/articles/s41...
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Energy flows reveal declining ecosystem functions by animals across Africa - Nature
An ecosystem energetics approach, quantifying trophic energy flows across species, offers a unified framework for linking animal biodiversity loss to changes in ecosystem function and Earth system pro...
https://www.nature.com/articles/s41586-025-09660-1
2 months ago
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A short-necked sauropodomorph from a new Triassic locality in Argentina shows sign of the neck extension that characterised its larger, later cousins.🧪👇
www.nature.com/articles/s41...
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A long-necked early dinosaur from a newly discovered Upper Triassic basin in the Andes - Nature
Discovery of a nearly complete skeleton of Huayracursor jaguensis, a Carnian dinosaur from the Northern Precordillera Basin in northwestern Argentina provides evidence of increased body size and early...
https://www.nature.com/articles/s41586-025-09634-3
3 months ago
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A vaccine central in A(H5) influenza virus antigenic space confers subtype-wide immunity 🧪👇
www.nature.com/articles/s41...
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A vaccine central in A(H5) influenza antigenic space confers broad immunity - Nature
A high-resolution antigenic map of influenza A(H5) haemagglutinin (HA) enables the design of immunogenic and antigenically central vaccine HA antigens that elicit antibody responses broadly covering t...
https://www.nature.com/articles/s41586-025-09626-3
3 months ago
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A paper in Nature presents MetaGraph, which indexes petabase-scale biological sequences for accurate and efficient searches across vast sequence space 🧪👇
www.nature.com/articles/s41...
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Efficient and accurate search in petabase-scale sequence repositories - Nature
MetaGraph enables scalable indexing of large sets of DNA, RNA or protein sequences using annotated de Bruijn graphs.
https://www.nature.com/articles/s41586-025-09603-w
3 months ago
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🧪 Women are represented as younger than men across occupations/social roles in data from Google,Wikipedia,IMDB, Flickr,YouTube and LLMs.The bias is strongest for occupations with high status/earnings.ChatGPT perpetuates this bias when generating and evaluating resumes.
www.nature.com/articles/s41...
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Age and gender distortion in online media and large language models - Nature
Stereotypes of age-related gender bias are socially distorted, as evidenced by the age gap in the representations of women and men across various media and algorithms, despite no systematic age differences in the workforce.
https://www.nature.com/articles/s41586-025-09581-z
3 months ago
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An article in Nature tracks trends in freshwater fish biodiversity in streams and rivers across the US over the last three decades and finds that fish biodiversity diverged across cold and warm streams, with a disproportionately large impact on cold streams.🧪
www.nature.com/articles/s41...
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Diverging fish biodiversity trends in cold and warm rivers and streams - Nature
In the past three decades, fish abundance, richness and uniqueness have diverged across cold and warm streams, and the effects on native fish communities of stream warming and increases in introduced fishes have magnified each other.
https://www.nature.com/articles/s41586-025-09556-0
3 months ago
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A study in Nature uncovers the mechanism behind a new metabolic class of drug for treatment of neuroblastoma 🧪👇
www.nature.com/articles/s41...
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Reprogramming neuroblastoma by diet-enhanced polyamine depletion - Nature
Enhanced polyamine depletion in neuroblastoma models decreases translation of mRNA codons with adenosine in the third position, reprogramming the tumour proteome away from cell cycle progression and towards differentiation.
https://www.nature.com/articles/s41586-025-09564-0
3 months ago
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In a Perspective article in Nature the Biodiversity Cell Atlas describes its plans and goals for mapping the tree of life with single-cell genomics technologies🧪👇
www.nature.com/articles/s41...
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The Biodiversity Cell Atlas: mapping the tree of life at cellular resolution - Nature
The Biodiversity Cell Atlas aims to create comprehensive single-cell molecular atlases across the eukaryotic tree of life, which will be phylogenetically informed, rely on high-quality genomes and use shared standards to facilitate comparisons across species.
https://www.nature.com/articles/s41586-025-09312-4
3 months ago
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A new study projects global burned areas and wildfire emissions using a machine learning–based approach, and estimates their impact on related mortality 🧪👇
www.nature.com/articles/s41...
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Global warming amplifies wildfire health burden and reshapes inequality - Nature
Nature - Global warming amplifies wildfire health burden and reshapes inequality
https://www.nature.com/articles/s41586-025-09612-9
4 months ago
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Repeated head trauma causes neuron loss and inflammation in young athletes 🧪👇
www.nature.com/articles/d41...
and the paper 👉
www.nature.com/articles/s41...
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Years of hits to the head prime the brain for decline
Repetitive head impacts trigger neuronal loss and disrupt blood vessels and immune cells long before the accumulation of neurotoxic tau protein.
https://www.nature.com/articles/d41586-025-02820-3
4 months ago
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A study in Nature presents Delphi-2M, a medical AI tool for predicting future health-related events using data from medical records. 🧪👇
www.nature.com/articles/s41...
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Learning the natural history of human disease with generative transformers - Nature
Delphi-2M forecasts a person’s future health, covering more than 1,000 diseases, provides insights into co-morbidity dynamics and generates synthetic data for the training of AI models that have never...
https://www.nature.com/articles/s41586-025-09529-3
4 months ago
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Do people cheat more when they delegate tasks to AI? A Nature paper shows that they do, and that LLMs are far more likely than humans to carry out unethical instructions (though it was possible to minimize this by including task-specific prohibitive guardrails).🧪👇
www.nature.com/articles/s41...
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Delegation to artificial intelligence can increase dishonest behaviour - Nature
People cheat more when they delegate tasks to artificial intelligence, and large language models are more likely than humans to comply with unethical instructions—a risk that can be minimized by ...
https://www.nature.com/articles/s41586-025-09505-x
4 months ago
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A new study in Nature reports the development of programmable antisense oligomers (ASOs) to silence genes of both DNA and RNA phages, and is applied to understand the functions and phenotypes associated with key genes in jumbo phage ΦKZ 🧪👇
www.nature.com/articles/s41...
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Programmable antisense oligomers for phage functional genomics - Nature
Establishing antisense oligomers as versatile, non-genetic tools to silence phage mRNAs opens applications in basic research and biotechnology, as shown by identifying essential factors for propagatio...
https://www.nature.com/articles/s41586-025-09499-6
4 months ago
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A study in Nature presents a new classification of human skeletal muscle subtypes in cancer cachexia, based on transcriptomics, including a comparison between human and rodent datasets. 🧪👇
www.nature.com/articles/s41...
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Molecular subtypes of human skeletal muscle in cancer cachexia - Nature
Unbiased clustering analysis of the skeletal muscle RNAome in patients with cancer identifies two molecular subtypes, one of which distinguishes individuals with cachexia and indicates ...
https://www.nature.com/articles/s41586-025-09502-0
4 months ago
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The ant Messor ibericus lays eggs that develop into males of two different species. Females of one of the species clone males of the other. This may be the first known case of a male-only clonal lineage that reproduces solely through other species’ ova.🧪
www.nature.com/articles/s41...
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One mother for two species via obligate cross-species cloning in ants - Nature
In a case of obligate cross-species cloning, female ants of Messor ibericus need to clone males of Messor structor to obtain sperm for producing the worker caste, resulting in males from the same moth...
https://www.nature.com/articles/s41586-025-09425-w
4 months ago
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Using epidemiological methods, a new study finds that the spread of the Great Fear during the French Revolution was not a result of emotional distress but rather the apparition of multiple independent locations. 🧪👇
www.nature.com/articles/s41...
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Epidemiology models explain rumour spreading during France’s Great Fear of 1789 - Nature
Epidemiological methods are used to show that the Great Fear of 1789, a series of peasant insurrections in rural revolutionary France, was driven by deliberate political action rather than spontaneous...
https://www.nature.com/articles/s41586-025-09392-2
4 months ago
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A study in Nature provides new global maps of land surface phenology that document the diversity, convergence and asynchrony of ecosystem function 👇🧪
www.nature.com/articles/s41...
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Global phenology maps reveal the drivers and effects of seasonal asynchrony - Nature
A global land surface phenology map predicts complex geographical discontinuities in flowering phenology, genetic divergence and harvest seasonality across a range of taxa.
https://www.nature.com/articles/s41586-025-09410-3
4 months ago
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A paper published in Nature presents genomic datasets for chaetognaths that illuminate the evolutionary history of these animals and their body plan. They also allow for their phylogenetic placement 👇🧪
www.nature.com/articles/s41...
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The genomic origin of the unique chaetognath body plan - Nature
Genomic, single-cell transcriptomic and epigenetic analyses show that chaetognaths, following extensive gene loss in the gnathiferan lineage, relied on newly evolved genes and lineage-specific tandem ...
https://www.nature.com/articles/s41586-025-09403-2
4 months ago
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A new chemical signalling system in species belonging to the Bacteroidota phylum regulates a range of distinct biosynthetic gene clusters and operates in an analogous manner to the quorum sensing systems of the well-studied Proteobacteria. 🧪👇
www.nature.com/articles/s41...
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Discovery of a widespread chemical signalling pathway in the Bacteroidota - Nature
The N-acyl-cyclolysine system regulates the expression of co-localized operons encoding diverse secreted molecules in Bacteroidota.
https://www.nature.com/articles/s41586-025-09418-9
4 months ago
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The >1000 lipid species found in eukaryotic cells have vital functions. Using a combination of microscopy, spectroscopy and modelling, scientists report the first quantitative map of retrograde flux of individual lipids in cells. 🧪👇
www.nature.com/articles/s41...
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Quantitative imaging of lipid transport in mammalian cells - Nature
Directional, non-vesicular lipid transport is responsible for fast, species-selective lipid sorting into organelle membranes.
https://www.nature.com/articles/s41586-025-09432-x
5 months ago
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New discoveries of an Australopithecus and Homo from Ethiopia dated to around 2.5 million years ago showed that the two genera were more or less contemporaneous.🧪👇
www.nature.com/articles/s41...
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New discoveries of Australopithecus and Homo from Ledi-Geraru, Ethiopia - Nature
Hominin fossils from the Ledi-Geraru Research Project area, Ethiopia, suggest that early Homo and Australopithecus species co-existed in the region more than 2.5 million years ago.
https://www.nature.com/articles/s41586-025-09390-4
5 months ago
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An unusual metabolite-based mechanism serves as protective layer against dysfunction of essential enzymes. A metabolite produced by the enzyme TGDS is crucial for rescuing the activity of UXS1 in low-NAD⁺ environments - its deficiency leads to Catel-Manzke syndrome.🧪👇
www.nature.com/articles/s41...
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A missing enzyme-rescue metabolite as cause of a rare skeletal dysplasia - Nature
In mammals, the enzyme TGDS produces UDP-4-keto-6-deoxyglucose, which binds to the catalytic pocket of UDP-xylose synthase, thereby regenerating the essential NAD+ cofactor of UDP-xylose synthase...
https://www.nature.com/articles/s41586-025-09397-x
5 months ago
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We are hiring! Please spread the word! 2 September application deadline
add a skeleton here at some point
5 months ago
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A new study sheds light on the microbiome in the wood of living trees. A single tree can host ~1 trillion microbes in its wood with heartwood and sapwood maintaining distinct profiles and with minimal similarity to other plant tissues or nearby ecosystem components. 🧪👇
www.nature.com/articles/s41...
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A diverse and distinct microbiome inside living trees - Nature
Microbiome analyses of living trees show that a single tree can host approximately one trillion bacteria, with microbial communities distinctly partitioned between heartwood and sapwood and with minim...
https://www.nature.com/articles/s41586-025-09316-0
5 months ago
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An article in Nature reports long-term declines in tropical forest arthropod diversity and function that may be linked to El Niño occurrence 🧪👇
www.nature.com/articles/s41...
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Stronger El Niños reduce tropical forest arthropod diversity and function - Nature
Time-series data from tropical forests tracking weather and declines in arthropod diversity and function show that fluctuations in species were largely dependent on their El Niño sensitivity and ecolo...
https://www.nature.com/articles/s41586-025-09351-x
5 months ago
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The Virtual Lab - an AI-human collaboration for sophisticated, interdisciplinary scientific research. Using a team of LLM scientist agents guided by an LLM principal investigator and human feedback, it designed new promising nanobody binders for SARS-CoV-2 v🧪👇
www.nature.com/articles/s41...
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The Virtual Lab of AI agents designs new SARS-CoV-2 nanobodies - Nature
Nature - The Virtual Lab of AI agents designs new SARS-CoV-2 nanobodies
https://www.nature.com/articles/s41586-025-09442-9
5 months ago
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A new FREP1 variant blocks malaria in mosquitoes without harming them. Linked to a gene drive, it could spread resistance and aid eradication—no drugs or insecticides needed. 🧪👇
www.nature.com/articles/s41...
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Driving a protective allele of the mosquito FREP1 gene to combat malaria - Nature
Coupling of a FREP1 variant to a gene-drive system allows the spread of a host malaria resistance allele through the mosquito population.
https://www.nature.com/articles/s41586-025-09283-6
6 months ago
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A paper in Nature presents CRAFT-seq, a plate-based assay for testing the functional effects of genetic variants on cell state and function by combining CRISPR editing, flow cytometry and single-cell RNA sequencing 🧪👇
www.nature.com/articles/s41...
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Precisely defining disease variant effects in CRISPR-edited single cells - Nature
A plate-based assay called CRAFTseq has been developed that uses ‘multi-omic’ single-cell RNA sequencing and direct genotyping of CRISPR edits to test the functional effects of genetic variants o...
https://www.nature.com/articles/s41586-025-09313-3
6 months ago
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An AI tool called Aeneas can predictively complete Latin inscriptions and relate them to others. In a way, it's like an algorithm that says that if you liked this inscription, you might want to look at these other ones. So interesting! 🧪👇
www.nature.com/articles/s41...
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Contextualizing ancient texts with generative neural networks - Nature
Aeneas, a generative neural network trained on ancient texts, helps historians contextualize inscriptions and perform epigraphic tasks, offering an improved starting point for historical research.
https://www.nature.com/articles/s41586-025-09292-5
6 months ago
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Great opportunity to join the Nature team! We are recruiting an Associate or Senior Editor who will be spearheading growth in Artificial Intelligence in Medicine and Biology content at Nature. Closing date 2 September 2025! 👇🧪
springernature.wd3.myworkdayjobs.com/SpringerNatu...
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Associate or Senior Editor, Nature (biological, clinical, and social science)
Title: Associate or Senior Editor, Nature (biological, clinical, and social science) Organization: Nature Portfolio Locations: New York or Jersey City – Hybrid Working Model Closing Date: September 2n...
https://springernature.wd3.myworkdayjobs.com/SpringerNatureCareers/job/New-York/Associate-or-Senior-Editor_JR103750
6 months ago
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Great opportunity to join the Nature team! We are recruiting an Associate or Senior Editor who will be spearheading growth in Artificial Intelligence in Medicine and Biology content at Nature. Closing date 2 September 2025! 👇
springernature.wd3.myworkdayjobs.com/SpringerNatu...
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Associate or Senior Editor, Nature (biological, clinical, and social science)
Title: Associate or Senior Editor, Nature (biological, clinical, and social science) Organization: Nature Portfolio Locations: New York or Jersey City – Hybrid Working Model Closing Date: September 2n...
https://springernature.wd3.myworkdayjobs.com/SpringerNatureCareers/job/New-York/Associate-or-Senior-Editor_JR103750
6 months ago
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Plant NLR receptors mediate pathogen resistance, and so their engineering could lead to crops with broader pathogen specificity and so broader disease resistance. A new study reports one such attempt achieving resistance to several potyviruses 🧪👇
www.nature.com/articles/s41...
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Remodelling autoactive NLRs for broad-spectrum immunity in plants - Nature
Cleavage by pathogen-derived proteases of an engineered chimeric protein activates its plant immune receptor component, enabling broad-spectrum resistance to pathogens in plants.
https://www.nature.com/articles/s41586-025-09252-z
6 months ago
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The preserved fin of an orca-sized ichthyosaur from the Jurassic Period shows that it was adapted for creeping up on its prey as silently as possible 🧪👇
www.nature.com/articles/s41...
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Adaptations for stealth in the wing-like flippers of a large ichthyosaur - Nature
Analysis of a fossilized front flipper of the Jurassic ichthyosaur Temnodontosaurus that preserves details of soft tissue indicates the presence of a serrated trailing edge that would have reduced noi...
https://www.nature.com/articles/s41586-025-09271-w
6 months ago
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