Francesca Cesari
@francesari.bsky.social
📤 2614
📥 56
📝 67
Chief Biological, Clinical and Social Sciences Editor of Nature Any views expressed here are my own
An article in Nature tracks trends in freshwater fish biodiversity in streams and rivers across the US over the last three decades and finds that fish biodiversity diverged across cold and warm streams, with a disproportionately large impact on cold streams.🧪
www.nature.com/articles/s41...
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Diverging fish biodiversity trends in cold and warm rivers and streams - Nature
In the past three decades, fish abundance, richness and uniqueness have diverged across cold and warm streams, and the effects on native fish communities of stream warming and increases in introduced fishes have magnified each other.
https://www.nature.com/articles/s41586-025-09556-0
6 days ago
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A study in Nature uncovers the mechanism behind a new metabolic class of drug for treatment of neuroblastoma 🧪👇
www.nature.com/articles/s41...
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Reprogramming neuroblastoma by diet-enhanced polyamine depletion - Nature
Enhanced polyamine depletion in neuroblastoma models decreases translation of mRNA codons with adenosine in the third position, reprogramming the tumour proteome away from cell cycle progression and towards differentiation.
https://www.nature.com/articles/s41586-025-09564-0
6 days ago
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In a Perspective article in Nature the Biodiversity Cell Atlas describes its plans and goals for mapping the tree of life with single-cell genomics technologies🧪👇
www.nature.com/articles/s41...
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The Biodiversity Cell Atlas: mapping the tree of life at cellular resolution - Nature
The Biodiversity Cell Atlas aims to create comprehensive single-cell molecular atlases across the eukaryotic tree of life, which will be phylogenetically informed, rely on high-quality genomes and use shared standards to facilitate comparisons across species.
https://www.nature.com/articles/s41586-025-09312-4
6 days ago
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A new study projects global burned areas and wildfire emissions using a machine learning–based approach, and estimates their impact on related mortality 🧪👇
www.nature.com/articles/s41...
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Global warming amplifies wildfire health burden and reshapes inequality - Nature
Nature - Global warming amplifies wildfire health burden and reshapes inequality
https://www.nature.com/articles/s41586-025-09612-9
12 days ago
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Repeated head trauma causes neuron loss and inflammation in young athletes 🧪👇
www.nature.com/articles/d41...
and the paper 👉
www.nature.com/articles/s41...
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Years of hits to the head prime the brain for decline
Repetitive head impacts trigger neuronal loss and disrupt blood vessels and immune cells long before the accumulation of neurotoxic tau protein.
https://www.nature.com/articles/d41586-025-02820-3
12 days ago
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A study in Nature presents Delphi-2M, a medical AI tool for predicting future health-related events using data from medical records. 🧪👇
www.nature.com/articles/s41...
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Learning the natural history of human disease with generative transformers - Nature
Delphi-2M forecasts a person’s future health, covering more than 1,000 diseases, provides insights into co-morbidity dynamics and generates synthetic data for the training of AI models that have never...
https://www.nature.com/articles/s41586-025-09529-3
12 days ago
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Do people cheat more when they delegate tasks to AI? A Nature paper shows that they do, and that LLMs are far more likely than humans to carry out unethical instructions (though it was possible to minimize this by including task-specific prohibitive guardrails).🧪👇
www.nature.com/articles/s41...
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Delegation to artificial intelligence can increase dishonest behaviour - Nature
People cheat more when they delegate tasks to artificial intelligence, and large language models are more likely than humans to comply with unethical instructions—a risk that can be minimized by ...
https://www.nature.com/articles/s41586-025-09505-x
12 days ago
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A new study in Nature reports the development of programmable antisense oligomers (ASOs) to silence genes of both DNA and RNA phages, and is applied to understand the functions and phenotypes associated with key genes in jumbo phage ΦKZ 🧪👇
www.nature.com/articles/s41...
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Programmable antisense oligomers for phage functional genomics - Nature
Establishing antisense oligomers as versatile, non-genetic tools to silence phage mRNAs opens applications in basic research and biotechnology, as shown by identifying essential factors for propagatio...
https://www.nature.com/articles/s41586-025-09499-6
20 days ago
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A study in Nature presents a new classification of human skeletal muscle subtypes in cancer cachexia, based on transcriptomics, including a comparison between human and rodent datasets. 🧪👇
www.nature.com/articles/s41...
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Molecular subtypes of human skeletal muscle in cancer cachexia - Nature
Unbiased clustering analysis of the skeletal muscle RNAome in patients with cancer identifies two molecular subtypes, one of which distinguishes individuals with cachexia and indicates ...
https://www.nature.com/articles/s41586-025-09502-0
20 days ago
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The ant Messor ibericus lays eggs that develop into males of two different species. Females of one of the species clone males of the other. This may be the first known case of a male-only clonal lineage that reproduces solely through other species’ ova.🧪
www.nature.com/articles/s41...
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One mother for two species via obligate cross-species cloning in ants - Nature
In a case of obligate cross-species cloning, female ants of Messor ibericus need to clone males of Messor structor to obtain sperm for producing the worker caste, resulting in males from the same moth...
https://www.nature.com/articles/s41586-025-09425-w
28 days ago
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Using epidemiological methods, a new study finds that the spread of the Great Fear during the French Revolution was not a result of emotional distress but rather the apparition of multiple independent locations. 🧪👇
www.nature.com/articles/s41...
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Epidemiology models explain rumour spreading during France’s Great Fear of 1789 - Nature
Epidemiological methods are used to show that the Great Fear of 1789, a series of peasant insurrections in rural revolutionary France, was driven by deliberate political action rather than spontaneous...
https://www.nature.com/articles/s41586-025-09392-2
28 days ago
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A study in Nature provides new global maps of land surface phenology that document the diversity, convergence and asynchrony of ecosystem function 👇🧪
www.nature.com/articles/s41...
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Global phenology maps reveal the drivers and effects of seasonal asynchrony - Nature
A global land surface phenology map predicts complex geographical discontinuities in flowering phenology, genetic divergence and harvest seasonality across a range of taxa.
https://www.nature.com/articles/s41586-025-09410-3
28 days ago
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A paper published in Nature presents genomic datasets for chaetognaths that illuminate the evolutionary history of these animals and their body plan. They also allow for their phylogenetic placement 👇🧪
www.nature.com/articles/s41...
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The genomic origin of the unique chaetognath body plan - Nature
Genomic, single-cell transcriptomic and epigenetic analyses show that chaetognaths, following extensive gene loss in the gnathiferan lineage, relied on newly evolved genes and lineage-specific tandem ...
https://www.nature.com/articles/s41586-025-09403-2
about 1 month ago
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A new chemical signalling system in species belonging to the Bacteroidota phylum regulates a range of distinct biosynthetic gene clusters and operates in an analogous manner to the quorum sensing systems of the well-studied Proteobacteria. 🧪👇
www.nature.com/articles/s41...
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Discovery of a widespread chemical signalling pathway in the Bacteroidota - Nature
The N-acyl-cyclolysine system regulates the expression of co-localized operons encoding diverse secreted molecules in Bacteroidota.
https://www.nature.com/articles/s41586-025-09418-9
about 1 month ago
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The >1000 lipid species found in eukaryotic cells have vital functions. Using a combination of microscopy, spectroscopy and modelling, scientists report the first quantitative map of retrograde flux of individual lipids in cells. 🧪👇
www.nature.com/articles/s41...
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Quantitative imaging of lipid transport in mammalian cells - Nature
Directional, non-vesicular lipid transport is responsible for fast, species-selective lipid sorting into organelle membranes.
https://www.nature.com/articles/s41586-025-09432-x
about 1 month ago
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New discoveries of an Australopithecus and Homo from Ethiopia dated to around 2.5 million years ago showed that the two genera were more or less contemporaneous.🧪👇
www.nature.com/articles/s41...
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New discoveries of Australopithecus and Homo from Ledi-Geraru, Ethiopia - Nature
Hominin fossils from the Ledi-Geraru Research Project area, Ethiopia, suggest that early Homo and Australopithecus species co-existed in the region more than 2.5 million years ago.
https://www.nature.com/articles/s41586-025-09390-4
about 1 month ago
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An unusual metabolite-based mechanism serves as protective layer against dysfunction of essential enzymes. A metabolite produced by the enzyme TGDS is crucial for rescuing the activity of UXS1 in low-NAD⁺ environments - its deficiency leads to Catel-Manzke syndrome.🧪👇
www.nature.com/articles/s41...
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A missing enzyme-rescue metabolite as cause of a rare skeletal dysplasia - Nature
In mammals, the enzyme TGDS produces UDP-4-keto-6-deoxyglucose, which binds to the catalytic pocket of UDP-xylose synthase, thereby regenerating the essential NAD+ cofactor of UDP-xylose synthase...
https://www.nature.com/articles/s41586-025-09397-x
about 1 month ago
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We are hiring! Please spread the word! 2 September application deadline
add a skeleton here at some point
about 1 month ago
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A new study sheds light on the microbiome in the wood of living trees. A single tree can host ~1 trillion microbes in its wood with heartwood and sapwood maintaining distinct profiles and with minimal similarity to other plant tissues or nearby ecosystem components. 🧪👇
www.nature.com/articles/s41...
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A diverse and distinct microbiome inside living trees - Nature
Microbiome analyses of living trees show that a single tree can host approximately one trillion bacteria, with microbial communities distinctly partitioned between heartwood and sapwood and with minim...
https://www.nature.com/articles/s41586-025-09316-0
about 1 month ago
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An article in Nature reports long-term declines in tropical forest arthropod diversity and function that may be linked to El Niño occurrence 🧪👇
www.nature.com/articles/s41...
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Stronger El Niños reduce tropical forest arthropod diversity and function - Nature
Time-series data from tropical forests tracking weather and declines in arthropod diversity and function show that fluctuations in species were largely dependent on their El Niño sensitivity and ecolo...
https://www.nature.com/articles/s41586-025-09351-x
about 1 month ago
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The Virtual Lab - an AI-human collaboration for sophisticated, interdisciplinary scientific research. Using a team of LLM scientist agents guided by an LLM principal investigator and human feedback, it designed new promising nanobody binders for SARS-CoV-2 v🧪👇
www.nature.com/articles/s41...
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The Virtual Lab of AI agents designs new SARS-CoV-2 nanobodies - Nature
Nature - The Virtual Lab of AI agents designs new SARS-CoV-2 nanobodies
https://www.nature.com/articles/s41586-025-09442-9
about 2 months ago
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A new FREP1 variant blocks malaria in mosquitoes without harming them. Linked to a gene drive, it could spread resistance and aid eradication—no drugs or insecticides needed. 🧪👇
www.nature.com/articles/s41...
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Driving a protective allele of the mosquito FREP1 gene to combat malaria - Nature
Coupling of a FREP1 variant to a gene-drive system allows the spread of a host malaria resistance allele through the mosquito population.
https://www.nature.com/articles/s41586-025-09283-6
2 months ago
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A paper in Nature presents CRAFT-seq, a plate-based assay for testing the functional effects of genetic variants on cell state and function by combining CRISPR editing, flow cytometry and single-cell RNA sequencing 🧪👇
www.nature.com/articles/s41...
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Precisely defining disease variant effects in CRISPR-edited single cells - Nature
A plate-based assay called CRAFTseq has been developed that uses ‘multi-omic’ single-cell RNA sequencing and direct genotyping of CRISPR edits to test the functional effects of genetic variants o...
https://www.nature.com/articles/s41586-025-09313-3
2 months ago
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An AI tool called Aeneas can predictively complete Latin inscriptions and relate them to others. In a way, it's like an algorithm that says that if you liked this inscription, you might want to look at these other ones. So interesting! 🧪👇
www.nature.com/articles/s41...
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Contextualizing ancient texts with generative neural networks - Nature
Aeneas, a generative neural network trained on ancient texts, helps historians contextualize inscriptions and perform epigraphic tasks, offering an improved starting point for historical research.
https://www.nature.com/articles/s41586-025-09292-5
2 months ago
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Great opportunity to join the Nature team! We are recruiting an Associate or Senior Editor who will be spearheading growth in Artificial Intelligence in Medicine and Biology content at Nature. Closing date 2 September 2025! 👇🧪
springernature.wd3.myworkdayjobs.com/SpringerNatu...
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Associate or Senior Editor, Nature (biological, clinical, and social science)
Title: Associate or Senior Editor, Nature (biological, clinical, and social science) Organization: Nature Portfolio Locations: New York or Jersey City – Hybrid Working Model Closing Date: September 2n...
https://springernature.wd3.myworkdayjobs.com/SpringerNatureCareers/job/New-York/Associate-or-Senior-Editor_JR103750
2 months ago
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Great opportunity to join the Nature team! We are recruiting an Associate or Senior Editor who will be spearheading growth in Artificial Intelligence in Medicine and Biology content at Nature. Closing date 2 September 2025! 👇
springernature.wd3.myworkdayjobs.com/SpringerNatu...
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Associate or Senior Editor, Nature (biological, clinical, and social science)
Title: Associate or Senior Editor, Nature (biological, clinical, and social science) Organization: Nature Portfolio Locations: New York or Jersey City – Hybrid Working Model Closing Date: September 2n...
https://springernature.wd3.myworkdayjobs.com/SpringerNatureCareers/job/New-York/Associate-or-Senior-Editor_JR103750
2 months ago
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Plant NLR receptors mediate pathogen resistance, and so their engineering could lead to crops with broader pathogen specificity and so broader disease resistance. A new study reports one such attempt achieving resistance to several potyviruses 🧪👇
www.nature.com/articles/s41...
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Remodelling autoactive NLRs for broad-spectrum immunity in plants - Nature
Cleavage by pathogen-derived proteases of an engineered chimeric protein activates its plant immune receptor component, enabling broad-spectrum resistance to pathogens in plants.
https://www.nature.com/articles/s41586-025-09252-z
3 months ago
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The preserved fin of an orca-sized ichthyosaur from the Jurassic Period shows that it was adapted for creeping up on its prey as silently as possible 🧪👇
www.nature.com/articles/s41...
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Adaptations for stealth in the wing-like flippers of a large ichthyosaur - Nature
Analysis of a fossilized front flipper of the Jurassic ichthyosaur Temnodontosaurus that preserves details of soft tissue indicates the presence of a serrated trailing edge that would have reduced noi...
https://www.nature.com/articles/s41586-025-09271-w
3 months ago
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A study in Nature identifies a microbiome-produced metabolite that promotes atherosclerosis by activating myeloid cells in mice and humans 🧪👇
www.nature.com/articles/s41...
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Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature
Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...
https://www.nature.com/articles/s41586-025-09263-w
3 months ago
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👇Detailed quantification of the algal toxin presence in Arctic food webs by analysing bowel samples from bowhead whales collected over 19 years. Allows to evaluate potential increased risk of toxin prevalence in the Arctic due to changing climate 🧪https://www.nature.com/articles/s41586-025-09230-5
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Bowhead whale faeces link increasing algal toxins in the Arctic to ocean warming - Nature
An analysis of bowel samples from bowhead whales collected yearly from 2004–2022 indicates increasing algal toxin concentrations in Arctic food webs due to warming ocean conditions.
https://www.nature.com/articles/s41586-025-09230-5
3 months ago
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The nocturnal, migratory Bogong moth of south-east Australia may be the first invertebrate known to be able to use the stars to chart its course in a specific cardinal direction. Hitherto, only humans and some birds are known to have this ability.👇🧪
www.nature.com/articles/s41...
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Bogong moths use a stellar compass for long-distance navigation at night - Nature
Every spring, Bogong moths use the starry night sky as a compass to navigate up to 1,000 km towards their alpine migratory goal.
https://www.nature.com/articles/s41586-025-09135-3?utm_source=Live+Audience&utm_campaign=6fe00bd973-nature-briefing-daily-20250619&utm_medium=email&utm_term=0_-33f35e09ea-48941775
3 months ago
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Transparent peer review to be extended to all of Nature's research papers 🧪👇
www.nature.com/articles/d41...
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Transparent peer review to be extended to all of Nature’s research papers
From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science.
https://www.nature.com/articles/d41586-025-01880-9
4 months ago
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"Stop ignoring small-scale fisheries in economic models" Read the editorial 👉
www.nature.com/articles/d41...
and explore the research project called Illuminating Hidden Harvests
www.nature.com/immersive/d4...
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Small-scale fisheries
https://www.nature.com/immersive/d42859-025-00024-3/index.html
4 months ago
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The gender gap in math among first and second graders significantly increases after 4 months of schooling despite boys and girls having similar math scores upon entry. The gap increases regardless of sociodemographic differences with years of schooling, not age. 🧪👇
www.nature.com/articles/s41...
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Rapid emergence of a maths gender gap in first grade - Nature
Boys and girls exhibit very similar maths scores upon school entry, but a gender gap in favour of boys becomes highly significant after 4 months of schooling, which increases with years of schooling,&...
https://www.nature.com/articles/s41586-025-09126-4
4 months ago
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A promising way to control malaria is to incorporate antiparasitic compounds into bed nets to kill parasites in their hosts. Here 👇 a new anti-parasitic compound is shown to be taken up through mosquitoes's feet landing on nets and kill parasites within insect host. 🧪
www.nature.com/articles/s41...
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In vivo screen of Plasmodium targets for mosquito-based malaria control - Nature
An in vivo screen of small-molecule compounds to inhibit the mosquito-stage development of Plasmodium identified hits that can be incorporated into bed nets and led to effective parasite killing in th...
https://www.nature.com/articles/s41586-025-09039-2
4 months ago
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The 'Chicago' specimen of Archaeopteryx, the 'first bird', and only the 13th to be described, presents a wealth of new information about the skeleton, soft tissues and plumage of this iconic taxon. 🧪👇
www.nature.com/articles/s41...
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Chicago Archaeopteryx informs on the early evolution of the avian bauplan - Nature
Analysis of the 'Chicago' Archaeopteryx, a nearly complete and uncrushed specimen, reveals details of the skeleton, soft tissues and plumage of this taxon, providing information on the evolution to av...
https://www.nature.com/articles/s41586-025-08912-4
4 months ago
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A slab of rock from Australia dated to ~ 356 million years ago preserves the tracks of toes with claws, indicative of an animal more closely related to amniotes than amphibians - about 40 million years earlier than previously known amniote footprints and body fossils.🧪
www.nature.com/articles/s41...
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Earliest amniote tracks recalibrate the timeline of tetrapod evolution - Nature
Analysis of a fossil trackway from the earliest Carboniferous of Australia shows prints of toes with claws, suggesting that the origin of amniotes was at least 35–40 million years earlier than pr...
https://www.nature.com/articles/s41586-025-08884-5
4 months ago
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As discussed in the News and Views article 👇, a new analysis shows that large fractions of future generations will be exposed to extreme climate events that would occur only once every 10,000 years in the absence of global warming.
www.nature.com/articles/d41...
www.nature.com/articles/s41...
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Climate risk for younger generations is set to soar
An analysis shows that large fractions of future generations will be exposed to extreme climate events that would occur only once every 10,000 years in the absence of global warming.
https://www.nature.com/articles/d41586-025-01336-0
5 months ago
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Researchers have engineered bacteria to express enzymes that break down five organic pollutants in industrial waste water and saline soil 🧪👇
www.nature.com/articles/s41...
and
www.nature.com/articles/d41...
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Bioremediation of complex organic pollutants by engineered Vibrio natriegens - Nature
A synthetic biology approach was used to engineer Vibrio natriegens into a strain capable of bioremediating complex organic pollutants in saline wastewater and soils, thereby addressing notable threat...
https://www.nature.com/articles/s41586-025-08947-7
5 months ago
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A new study in Nature presents a nanofluid bioelectronic patch for intracellular drug delivery👇🧪
www.nature.com/articles/s41...
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A battery-free nanofluidic intracellular delivery patch for internal organs - Nature
A nanofluidic intracellular delivery (NanoFLUID) patch provides a versatile, biocompatible and efficient method for the targeted delivery of payloads to internal organs for therapeutic purposes and fo...
https://www.nature.com/articles/s41586-025-08943-x
5 months ago
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A new study reveals the diversity dynamics of plants across the Arctic. Quantification of temporal changes in species richness and composition showed that temperature and plant-plant interaction are the main drivers of directional change👇🧪
www.nature.com/articles/s41...
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Plant diversity dynamics over space and time in a warming Arctic - Nature
Warming temperatures and interactions between plants are the main drivers of changes in Arctic plant communities in response to climate change, and there is no evidence of overall biotic homogenizatio...
https://www.nature.com/articles/s41586-025-08946-8
5 months ago
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reposted by
Francesca Cesari
Magdalena Skipper
5 months ago
This Nature Award, in partnership with Sense about Science, is all about standing up for science This is timely opportunity to recognise those who promote science & evidence despite adversity Hurry, deadline April 30th 🧪
#AcademicSky
@natureportfolio.nature.com
www.nature.com/immersive/ma...
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Nature Awards The John Maddox Prize - Standing up for Science
Recognises researchers who stand up and speak out for science and evidence-based policy, advancing public discussion around difficult topics, despite challenges or hostility, and successfully making a...
https://www.nature.com/immersive/maddoxprize/index.html
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Reporting in Nature, Eitan Yaffe and colleagues demonstrate that resistance to an antibiotic can rapidly emerge in commensal gut bacteria in vivo, and that such resistant lineages can persist for a long period following cessation of the antibiotic. 👇 🧪
www.nature.com/articles/s41...
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Brief antibiotic use drives human gut bacteria towards low-cost resistance - Nature
Brief ciprofloxacin exposure in humans drives antibiotic resistance evolution in gut bacteria through selective sweeps, particularly involving DNA gyrase mutations, which persist long after exposure a...
https://www.nature.com/articles/s41586-025-08781-x
5 months ago
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The MICrONS Project is live! High resolution anatomical images of 200,000 cells and 523 million connections in the mouse primary visual cortex and nearby areas, with in vivo functional data from ~75,000 neurons! Have a look 👇 🧪https://www.nature.com/immersive/d42859-025-00001-w/index.html
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The MICrONS Project
An unprecedented dataset of high resolution anatomical images of individual cells in mouse visual cortex, mapped on to their responses. This integrated view of function and structure lays a foundation...
https://www.nature.com/immersive/d42859-025-00001-w/index.html
6 months ago
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Using a policy of eligibility for vaccine against shingles based on whether individuals were born before or after a fixed date, a study found that receiving the vaccine reduced the relative probability of new dementia diagnosis within 7 year by 20% 🧪https://www.nature.com/articles/s41586-025-08800-x
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A natural experiment on the effect of herpes zoster vaccination on dementia - Nature
Using a natural experiment that avoids common bias concerns, this study finds that the live-attenuated shingles vaccine reduced the probability of a new dementia diagnosis within a follow-up period of...
https://www.nature.com/articles/s41586-025-08800-x
6 months ago
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A new study describes the long-term effects of deep-sea mining on the diversity of biological communities on the seafloor. Even 40 years after a test mining experiment removing nodules of rare metals there are persistent negative effects on many types of organisms. 🧪👇
www.nature.com/articles/s41...
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Long-term impact and biological recovery in a deep-sea mining track - Nature
Nature - Long-term impact and biological recovery in a deep-sea mining track
https://www.nature.com/articles/s41586-025-08921-3
6 months ago
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Check out our
#Scientistsatwork
photo competition! 👇🧪
add a skeleton here at some point
7 months ago
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The proteosome doesn't only function in protein degradation, it is also involved in the defence against bacterial infection 👇🧪
www.nature.com/articles/s41...
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Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature
Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...
https://www.nature.com/articles/s41586-025-08615-w
7 months ago
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Researchers have developed an AI for a smartwatch that will call for help if its wearer is having a cardiac arrest 👇
www.nature.com/articles/s41...
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7 months ago
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www.nature.com/articles/d41...
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Trump 2.0: an assault on science anywhere is an assault on science everywhere
US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.
https://www.nature.com/articles/d41586-025-00562-w
7 months ago
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