Francesca Cesari
@francesari.bsky.social
📤 2713
📥 57
📝 119
Chief Biological, Clinical and Social Sciences Editor of Nature Any views expressed here are my own
The first multinational representative dataset from LMICs on child sexual exploitation and abuse shows the role of technology, individual, familial and sociocultural factors in facilitating it.🧪
www.nature.com/articles/d41...
Read the full paper here
www.nature.com/articles/s41...
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Child sexual abuse enabled by digital technologies is widespread and under-reported
One in six Internet-using adolescents in parts of Africa and Asia faced technology-facilitated sexual abuse in 2020–21. As digital access expands globally, better protection is crucial.
https://www.nature.com/articles/d41586-026-01325-x
about 21 hours ago
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Plants need nitrogen but use it inefficiently. A new study shows that, in maize, the plastoglobule droplets within chloroplast organise key nitrogen-fixation enzymes, supercharging nitrogen use. The findings could be relevant to growing crops using less fertiliser. 🧪👇
www.nature.com/articles/s41...
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Plastoglobules compartmentalize nitrogen assimilation in maize - Nature
Chloroplast plastoglobules act as nitrogen-assimilation hubs in maize, with key enzymes enhancing nitrogen-use efficiency and offering new strategies for developing high-yield, sustainable crops.
https://www.nature.com/articles/s41586-026-10610-8
8 days ago
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A new study in Nature quantifies mining-induced deforestation of dense forest across sub-Saharan Africa. For each hectare of deforestation attributed to the mine an additional 34 hectares of forest were lost to offsite drivers such as agricultural expansion. 🧪
www.nature.com/articles/s41...
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Mining triggers extensive additional deforestation in sub-Saharan Africa - Nature
Extensive mining activity leads to large-scale deforestation of dense tropical forests across sub-Saharan Africa, driven particularly by key energy transition minerals such as cobalt.
https://www.nature.com/articles/s41586-026-10551-2
8 days ago
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A study in Nature details a machine learning model that can use front facing smartphone cameras to approximate heart rate 🧪👇
www.nature.com/articles/s41...
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Passive heart-rate monitoring during smartphone use in everyday life - Nature
A machine-learning model that uses smartphone cameras to measure heart rate in the background during normal daily phone use and subsequently estimate resting heart rate could make it easier for p...
https://www.nature.com/articles/s41586-026-10507-6
8 days ago
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The oldest known eukaryotes, living around 1.75 billion years ago, were largely restricted to oxygenated bottom waters, only expanding into planktonic habitats during the Neoproterozoic Era (from a billion to 540 million years ago)🧪 See new study published in Nature👇
www.nature.com/articles/s41...
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Early fossil eukaryotes were benthic aerobes - Nature
Integrated palaeontological, sedimentological and geochemical analyses of ancient rocks from Australia show that early eukaryotes were largely restricted to oxygenated benthic habitats, probably posse...
https://www.nature.com/articles/s41586-026-10533-4
20 days ago
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A study in Nature quantifies the contribution that insect pollinators make to nutrient intake and income in smallholder farming communities in Nepal > they are responsible for 44% of people’s farming income and over 20% of their intake of key micronutrients.🧪
www.nature.com/articles/s41...
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Pollinators support the nutrition and income of vulnerable communities - Nature
Quantification of links among insect pollinators, crop plants, nutrient intake and income of smallholder communities in Nepal show that pollinators substantially contribute to their income and micronu...
https://www.nature.com/articles/s41586-026-10421-x
22 days ago
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A new study shows that individuals listening both to language and auditory stimuli while anesthetized still showed neural responses in the hippocampus indicating that the information was still being processed, despite the fact that patients were seemingly unconscious.🧪
www.nature.com/articles/s41...
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Plasticity and language in the anaesthetized human hippocampus - Nature
In the hippocampus, complex processing of sensory stimuli occurs even in the unconscious state.
https://www.nature.com/articles/s41586-026-10448-0
29 days ago
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A study in Nature suggests that in the absence of deforestation the Amazon forest could transition to a non-forest state with 3.7-4.0oC of global warming. With 22 to 28% deforestation a more widespread transition could occur with 1.5-1.9oC of warming🧪
www.nature.com/articles/s41...
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Deforestation-induced drying lowers Amazon climate threshold - Nature
The Amazon forest faces a near system-wide transition of 62−77% of the area under a combination of 1.5–1.9 °C global warming and 22−28% deforestation.
https://www.nature.com/articles/s41586-026-10456-0
29 days ago
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Androgens generally dampen anti-cancer immunity. A new study finds that in brain tumours they counteract a neural pathway that would otherwise suppress anti-tumour responses, making androgen signalling protective within the brain. 🧪
www.nature.com/articles/s41...
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www.nature.com/articles/d41...
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Androgen loss accelerates brain tumour growth via HPA axis activation - Nature
Androgens have distinct roles in the brain, acting as immune-based tumour suppressors through neuroinflammation and neuroendocrine mechanisms.
https://www.nature.com/articles/s41586-026-10451-5
29 days ago
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Published in Nature, the results of the PEACE project, a clinical autopsy program to study the evolution of lung cancer.
www.nature.com/articles/s41...
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Evolutionary characterization of lung cancer metastasis - Nature
DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-smal...
https://www.nature.com/articles/s41586-026-10428-4
about 1 month ago
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A study in Nature compiles data on wild meat consumption in Central Africa from over 12,000 households spanning 252 locations. Wild meat consumption increased from 0.73 to 1.10 million tonnes between 2000 and 2022, with an increasing demand from towns and cities.🧪👇
www.nature.com/articles/s41...
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Increase in wild animal consumption across Central Africa - Nature
Wild meat is a fundamental component of the diets of rural Central African populations, accounting for 20% of the recommended daily protein intake, compared with 13% and 6% for those living in towns a...
https://www.nature.com/articles/s41586-026-10422-w
about 1 month ago
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This longitudinal study shows that racial diversity in higher education is associated with higher student salaries in top earning professions like law and business.👇🧪
www.nature.com/articles/s41...
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Racial diversity in higher education is associated with higher student salaries - Nature
A longitudinal study shows that racial diversity in higher education is associated with higher student salaries at graduation, indicating that policies to increase or leverage racial diversity enhance...
https://www.nature.com/articles/s41586-026-10425-7
about 1 month ago
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Through a decade-long warming experiment, a study in Nature demonstrates that warming significantly increases antibiotic resistances in grassland soils🧪👇
www.nature.com/articles/s41...
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Decade-long warming accelerates antibiotic resistance in grassland soils - Nature
Decade-long warming increased soil antibiotic-resistance genes by about 24%, enriching resistant microbes and gene transfer, driven by selection for thermal tolerance and linked traits, with implicati...
https://www.nature.com/articles/s41586-026-10413-x
about 2 months ago
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Hundreds of loci under selection are discovered in ancient genomic data of West Eurasians in a new Nature paper 🧪👇
www.nature.com/articles/s41...
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Ancient DNA reveals pervasive directional selection across West Eurasia - Nature
Analysis of 15,836 ancient West Eurasian genomes reveals hundreds of instances of directional selection, showing that sustained changes in allele frequency were widespread, rather than being...
https://www.nature.com/articles/s41586-026-10358-1
about 2 months ago
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A study in Nature describes a modular tool for targeted transfer of mitochondria to different cell types 🧪
www.nature.com/articles/s41...
and News & Views piece 👇https://www.nature.com/articles/d41586-026-00910-4
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Cell-type-targeted mitochondrial transplantation rescues cell degeneration - Nature
MitoCatch is a cell-type-specific mitochondrion-targeting system that links mitochondria and the cell surface by protein binders and delivers mitochondria into the target cell.
https://www.nature.com/articles/s41586-026-10391-0
about 2 months ago
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A Nature paper reports the identification of a genetic locus that is associated with the efficacy of GLP-1 medication for weight loss 👇🧪
www.nature.com/articles/s41...
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Genetic predictors of GLP1 receptor agonist weight loss and side effects - Nature
Identification of genetic variants associated with the efficacy and side effects of GLP1 medications could underpin development of precision medicine approaches in the treatment of obesity.
https://www.nature.com/articles/s41586-026-10330-z
2 months ago
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A study published in Nature presents CHARM, a single-cell 'four-omics' sequencing method that profiles genome conformation, histone modifications, chromatin accessibility, and gene expression within the same cell.🧪👇
www.nature.com/articles/s41...
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Gene regulatory landscape dissected by single-cell four-omics sequencing - Nature
Combining single-cell parallel profiling of genome conformation, histone modifications, chromatin accessibility and gene expression reveals dynamics and intranuclear spatial clustering of epigenome pr...
https://www.nature.com/articles/s41586-026-10322-z
2 months ago
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A unique strategy to target glioma stem cells uses a synthetic superenhancer selectively expressed in these cells. The combination of cytotoxic and immune-modulatory payloads elicits significant anti-tumour effects and prevents recurrence in mouse models. 🧪👇
www.nature.com/articles/s41...
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Synthetic super-enhancers enable precision viral immunotherapy - Nature
Synthetic super-enhancers enable specific delivery of anticancer payloads, achieving tumour elimination after a single dose in a mouse model of aggressive glioblastoma.
https://www.nature.com/articles/s41586-026-10329-6
2 months ago
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In this week’s special issue of Nature, four papers present multi-team collaborations testing reproducibility, replication and analytical robustness in the social and behavioural sciences. 🧪👇
www.nature.com/immersive/d4...
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Building trust in scientific evidence
Big reproducibility efforts describe how methods and analysts shape results in behavioural and social sciences.
https://www.nature.com/immersive/d42859-026-00015-y/index.html
2 months ago
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A study in Nature integrates wearable watch data with blood biomarkers to predict insulin resistance🧪👇
www.nature.com/articles/s41...
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Insulin resistance prediction from wearables and routine blood biomarkers - Nature
A machine-learning model that integrates data from wearable devices (such as smartwatches) with blood biomarkers and demographic data can predict whether someone has insulin resistance, enabling timel...
https://www.nature.com/articles/s41586-026-10179-2
2 months ago
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A policy evaluation in northern Nigeria shows the importance of education and community support in delaying child marriage among girls. 👇🧪
www.nature.com/articles/d41...
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www.nature.com/articles/s41...
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Marriage of adolescent girls in Nigeria reduced by 80% by ‘big push’ intervention
A locally tailored, big-push intervention to educate unmarried adolescent girls in 18 communities in northern Nigeria reduced rates of marriage from 86% to just 21%. Interventions that address complex...
https://www.nature.com/articles/d41586-026-00720-8
3 months ago
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A tiny fossil fish (less than 3cm long) from the 436-million-year-old Chongqing Fish Bed represents the earliest articulated remains of any bony fish in the fossil record, and informs our understanding on the origins of all bony fishes today.🧪👇
www.nature.com/articles/s41...
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The oldest articulated bony fish from the early Silurian period - Nature
A tiny, articulated, near-complete osteichthyan from the early Silurian Chongqing Lagerstätte, represents the oldest osteichthyan occurrence including microfossils, and the earliest articulated remain...
https://www.nature.com/articles/s41586-026-10125-2
3 months ago
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A new study describes a skin-intrinsic pathway whereby infection triggers the release of metabolites from keratinocytes. The metabolites in turn act as an "endogenous adjuvant" to drive antibody responses both locally and distally.🧪👇
www.nature.com/articles/d41...
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www.nature.com/articles/s41...
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Skin cells boost distant antibody responses
How the skin enables immune defences is not fully clear. Now a pathway has been found in skin cells that boosts the production of antibodies to protect the whole body.
https://www.nature.com/articles/d41586-026-00379-1
3 months ago
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An article in Nature finds that tropical insects have a limited ability to cope with future warming, based on an analysis of around 2,300 insect species along Afrotropical and Neotropical elevational gradients.🧪👇
www.nature.com/articles/d41...
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Rising temperatures pose a threat to tropical insects
An assessment of sensitivity to increasing temperature for thousands of insect species in mountainous terrain reveals a risk of insect biodiversity loss in tropical lowlands.
https://www.nature.com/articles/d41586-026-00377-3
3 months ago
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Hunter-gather ancestry persisted widely well until after the arrival of farming in the Rhine-Meuse region and may have contributed to the Bell Beaker expansion in the area, a Nature paper reports 👇🧪
www.nature.com/articles/s41...
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Lasting Lower Rhine–Meuse forager ancestry shaped Bell Beaker expansion - Nature
A distinctive population with high hunter-gatherer ancestry persisted 3,000 years later than in most European regions, contributing to later Lower Rhine–Meuse Bell Beaker users.
https://www.nature.com/articles/s41586-026-10111-8
4 months ago
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A genetic variant in Cyclin D3 that was historically under positive selection in Sardinians impairs parasite growth in erythroblasts, suggesting that malaria – now eradicated in Sardinia – was the selective pressure. See paper published in Nature 👇🧪
www.nature.com/articles/s41...
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Reduced cyclin D3 expression in erythroid cells protects against malaria - Nature
Population-level analyses and in vitro experiments show that a specific genetic variant of cyclin D3 inhibits the growth of the malaria-causing parasite Plasmodium falciparum in erythrocytes, and sugg...
https://www.nature.com/articles/s41586-026-10110-9
4 months ago
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reposted by
Francesca Cesari
Nature Portfolio
4 months ago
A feature in Nature examines the research about aphantasia, which is the experience of people with no mental imagery, and how it could offer a window into consciousness.
#Neuroskyence
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Many people have no mental imagery. What’s going on in their brains?
People with aphantasia are offering a window into consciousness.
https://go.nature.com/3NX9aPz
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Targeting the somato-cognitive action network (SCAN) rather than motor regions doubles efficacy of TMS treatments for Parkinson’s disease. Seems that various DBS targets for Parkinson’s are selectively connected to the SCAN rather than effector-specific motor regions.🧪
www.nature.com/articles/s41...
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Parkinson’s disease as a somato-cognitive action network disorder - Nature
The substantia nigra and all Parkinson’s disease deep-brain stimulation targets are selectively connected to the somato-cognitive action network rather than to effector-specific motor regions.
https://www.nature.com/articles/s41586-025-10059-1
4 months ago
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A unified 1 Mb DNA model with genome‑wide, single‑base outputs: AlphaGenome advances variant effect prediction across expression, chromatin, TF binding, and splicing modalities. 🧪👇
www.nature.com/articles/s41...
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Advancing regulatory variant effect prediction with AlphaGenome - Nature
AlphaGenome, a deep learning model that inputs 1-Mb DNA sequence to predict functional genomic tracks at single-base resolution across diverse modalities, outperforms existing models in variant effect...
https://www.nature.com/articles/s41586-025-10014-0
4 months ago
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A new study projects future impacts of climate change on malaria burden in Africa through 2050, using 25 years of data on climate, extreme weather, malaria burden and control interventions, and socioeconomic environment. 🧪👇
www.nature.com/articles/s41...
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Projected impacts of climate change on malaria in Africa - Nature
Projected impacts of climate change on malaria burden in Africa by 2050 highlight the urgent need for climate-resilient malaria control strategies and robust emergency response systems to safeguard pr...
https://www.nature.com/articles/s41586-025-10015-z
4 months ago
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Muscularis macrophages help maintain gut homeostasis but also spread α-synuclein along the gut-brain axis, promote T cell expansion, and drive Parkinson’s disease progression in mice, a Nature paper reports. 🧪👇
www.nature.com/articles/s41...
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Intestinal macrophages modulate synucleinopathy along the gut–brain axis - Nature
Muscularis macrophages, housekeepers of enteric nervous system integrity and intestinal homeostasis, modulate α-synuclein pathology and neurodegeneration in models of Parkinson’s disease, and understa...
https://www.nature.com/articles/s41586-025-09984-y
4 months ago
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Two registered clinical trials in Nature report the successful use of the GLP-1 and glucagon receptor co-agonist Mazdutide for type 2 diabetes.🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
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Mazdutide versus placebo in Chinese adults with type 2 diabetes - Nature
Nature - Mazdutide versus placebo in Chinese adults with type 2 diabetes
https://www.nature.com/articles/s41586-025-10026-w
6 months ago
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A paper in Nature reports the prevalence of Alzheimer’s Disease Neuropathological Changes in a Norwegian population-based cohort, assessed using a blood-based biomarker🧪
www.nature.com/articles/s41...
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Prevalence of Alzheimer’s disease pathology in the community - Nature
The prevalence of Alzheimer’s disease neuropathological changes is reported based on blood-based biomarkers in a Norwegian population-based cohort.
https://www.nature.com/articles/s41586-025-09841-y
6 months ago
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An article in Nature assesses the effect of Australian protected areas on vegetation in adjacent areas, and finds evidence of a positive spillover effect, that is, increases in a given vegetation type relative to what would be expected from the broader landscape.🧪
www.nature.com/articles/s41...
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Protected area management has significant spillover effects on vegetation - Nature
Analysis of effect sizes of vegetation spillovers from protected areas in Australia shows that 71% of over 3,063 analysed protected areas had a positive spillover effect, and that these effects c...
https://www.nature.com/articles/s41586-025-09837-8
6 months ago
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A meta-analysis of 34,000 individuals identifies reproducible associations between gut microbial species and diet and health markers. The associations were used to generate a ranking of species that are either positively and negatively associated with health markers.🧪
www.nature.com/articles/s41...
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Gut micro-organisms associated with health, nutrition and dietary interventions - Nature
Comprehensive large-scale studies of multi-national populations identified microbiome species consistently associated with favourable and unfavourable health markers, informing future studies of the h...
https://www.nature.com/articles/s41586-025-09854-7
6 months ago
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Ancient DNA analysis at the important archaeological site of Shimao city in northern China provides insights into the social organization and burial practices in a Neolithic community🧪
www.nature.com/articles/s41...
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Ancient DNA from Shimao city records kinship practices in Neolithic China - Nature
Sequencing of 144 ancient genomes from Shimao city and its satellites presents pedigrees among tomb owners spanning up to four generations showing predominantly patrilineal descent structure across Sh...
https://www.nature.com/articles/s41586-025-09799-x
6 months ago
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A study in Nature finds that 0.37 million tonnes of wild meat are extracted annually in Amazonia.This amount of wild meat can meet nearly half of protein and iron dietary requirements for rural people and a substantial portion of their needs for B vitamins and zinc.🧪
www.nature.com/articles/s41...
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Healthy forests safeguard traditional wild meat food systems in Amazonia - Nature
Data provided by Amazonian peoples are used to estimate the value of wild animals as a source of food, including its spatial distribution and nutritional value, providing information that will be key ...
https://www.nature.com/articles/s41586-025-09743-z
6 months ago
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How related is economic inequality to mental health? This meta-analysis shows a complex picture in which this relationship is only evident among low-income populations and in contexts of high inflation. 🧪👇
www.nature.com/articles/s41...
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No meta-analytical effect of economic inequality on well-being or mental health - Nature
A meta-analysis of 168 studies reveals that economic inequality is not significantly associated with subjective well-being or mental health.
https://www.nature.com/articles/s41586-025-09797-z
6 months ago
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How do video glitches impact hiring decisions, trust in a medical provider, and parole decisions? A study published in Nature finds that these glitches negatively impact these decisions by breaking the illusion of face-to-face contact 🧪
www.nature.com/articles/s41...
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Video-call glitches trigger uncanniness and harm consequential life outcomes - Nature
Glitches in video calls can have a negative effect on the judgement of the people involved and correspond to worse outcomes in major areas of life such as job interviews and parole hearings.
https://www.nature.com/articles/s41586-025-09823-0
6 months ago
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Speech sounds like vowels and consonants in native and foreign languages elicit similar neural responses in the superior temporal, but only during native listening does this area encode word boundaries, frequency, and language-specific information. 🧪
www.nature.com/articles/s41...
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Shared and language-specific phonological processing in the human temporal lobe - Nature
The human superior temporal gyrus processes acoustic–phonetic properties of speech regardless of whether the language is familiar to the listener, but only encodes word boundaries and language-sp...
https://www.nature.com/articles/s41586-025-09748-8
7 months ago
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Marburg virus is a highly virulent/transmissible filovirus with no vaccine/treatments and recent outbreaks in Africa. Scientists have isolated/characterized a highly potent neutralizing monoclonal antibody effective against Marburg and related viruses Dehong and Ravn.🧪
www.nature.com/articles/s41...
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Potent neutralization of Marburg virus by a vaccine-elicited antibody - Nature
Nature - Potent neutralization of Marburg virus by a vaccine-elicited antibody
https://www.nature.com/articles/s41586-025-09868-1
7 months ago
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A Nature paper details a new AI model called EchoPrime, which can read and interpret echocardiograms 🧪👇
www.nature.com/articles/s41...
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Comprehensive echocardiogram evaluation with view primed vision language AI - Nature
Nature - Comprehensive echocardiogram evaluation with view primed vision language AI
https://www.nature.com/articles/s41586-025-09850-x
7 months ago
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A study looks at the mortality impacts of unmanaged rainfall and future sea level rise, with disproportionate risk for children, women, and residents of slums in a developing megacity🧪
www.nature.com/articles/s41...
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https://www.nature.com/articles/s41586-025-09730-4
7 months ago
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Computer vision, on which many AI applications rely on, is based on non-consensual datasets, compromising fairness and accuracy in AI. Now, an ethically curated, diverse human-image data set, sets a new standard for responsible data curation and trustworthy AI. 🧪
www.nature.com/articles/s41...
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Fair human-centric image dataset for ethical AI benchmarking - Nature
The Fair Human-Centric Image Benchmark (FHIBE, pronounced ‘Feebee’)—an image dataset that implements best practices for consent, privacy, compensation, safety, diversity and utility—can be used respon...
https://www.nature.com/articles/s41586-025-09716-2
7 months ago
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A paper in Nature reports high-resolution structures of aSyn fibrils 1B and their in vivo seeding product 1BP. They appear remarkably similar, suggesting a high-fidelity conformational replication process to perpetuate MSA-like pathology 🧪👇
www.nature.com/articles/s41...
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Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology - Nature
Synthetic fibril strain 1B is a pathogen that is capable of self-replication and inducing glial cytoplasmic inclusions in vivo in mice, and the structural features of 1B may underlie the pathology of ...
https://www.nature.com/articles/s41586-025-09698-1
7 months ago
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Snake bites kill/debilitate 1000s of people annually in Sub-Saharan African. A new nanobody cocktail is shown to be highly effective against 17 of the most dangerous African snake species. Unlike other anti-venoms it also protects against venom-induced dermal necrosis🧪
www.nature.com/articles/s41...
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Nanobody-based recombinant antivenom for cobra, mamba and rinkhals bites - Nature
A recombinant antivenom composed of eight nanobodies provides broad protection against venom-induced lethality and dermonecrosis in mice challenged with venoms from cobras, mambas and rinkha...
https://www.nature.com/articles/s41586-025-09661-0
7 months ago
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A new study in published in Nature presents a comprehensive resource of immunological changes occurring during normal aging 🧪
www.nature.com/articles/s41...
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Multi-omic profiling reveals age-related immune dynamics in healthy adults - Nature
This multi-omic longitudinal analysis of the healthy human peripheral immune system constructs the Human Immune Health Atlas and assembles data on immune cell composition and state changes w...
https://www.nature.com/articles/s41586-025-09686-5
7 months ago
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Where do invertebrates without calcium-rich bones or shells store their calcium? In the fruit-fly, at least, it’s the malpighian tubules, where calcium is mobilised by a neuropeptide hormone called Capability. 🧪
www.nature.com/articles/s41...
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Neuroendocrine control of calcium mobilization in the fruit fly - Nature
The peptide hormone Capa is responsible for regulating extracellular fluid Ca2+ levels in the fruit fly Drosophila melanogaster.
https://www.nature.com/articles/s41586-025-09670-z
7 months ago
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An article in Nature reports that ecosystem energy flow, through food consumption by wild birds and mammals, has decreased by over one third in sub-Saharan Africa since around 1700 🧪
www.nature.com/articles/s41...
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Energy flows reveal declining ecosystem functions by animals across Africa - Nature
An ecosystem energetics approach, quantifying trophic energy flows across species, offers a unified framework for linking animal biodiversity loss to changes in ecosystem function and Earth system pro...
https://www.nature.com/articles/s41586-025-09660-1
7 months ago
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A short-necked sauropodomorph from a new Triassic locality in Argentina shows sign of the neck extension that characterised its larger, later cousins.🧪👇
www.nature.com/articles/s41...
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A long-necked early dinosaur from a newly discovered Upper Triassic basin in the Andes - Nature
Discovery of a nearly complete skeleton of Huayracursor jaguensis, a Carnian dinosaur from the Northern Precordillera Basin in northwestern Argentina provides evidence of increased body size and early...
https://www.nature.com/articles/s41586-025-09634-3
8 months ago
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