My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...

Huge thanks to all of our peer reviewers! Thanks to your efforts, we’ve helped to restore and preserve over 10,000 trees in ancient woodland! 🌳 #PeerReviewWeek #PRW2025 #notforprofit #ForestofBiologists

We’re organizing a conference at @ijmonod.bsky.social in Paris, January 2026, in memory of M.P. Sheetz — pioneer in cell mechanics and mechanobiology, co-discoverer of kinesin, and founder of @mbisg.bsky.social. Join us to explore his legacy. mikeinmemoriam.sciencesconf.org

Out today. 🙏 again to everyone for this wonderful piece of work, in particular to Aurelie @aurhin.bsky.social Chase @chasebolt.bsky.social and Brent @homeobox.bsky.social. 🙏 also to the Harris lab @fish4walking.bsky.social and @neilshubin.bsky.social @biology-unige.bsky.social @college-de-france.fr

Our new preprint is up! This is the main postdoc work of @wiesner-t.bsky.social focusing on exocytosis along the axon shaft and its regulation by the sub membrane actin-spectrin scaffold: www.biorxiv.org/content/10.1... Read the thread below for a summary of our findings 🧵1/11

Side hustle level-up! My book, IN THE BEGINNING, will be published by @harperonebooks.bsky.social in 2027! It's about the human embryo, how it gets built, and what it means for where we come from and where we're going. @harpercollins.bsky.social (1/2) @socdevbio.bsky.social #devbiol #scicomm

Early-career researchers: want to run your own lab? 🌟Max Planck Research Groups offer 6+ years, up to €2.7M in funding, open-topic freedom, team support & tenure-track opportunities. Intrigued? 😃Apply by Oct 14, 2025! www.mpg.de/max-planck-r...

Happy to share our latest publication on the role of Citrullination in the hair follicle stem cell lineage! Congratulations Kim Vikhe Patil and our fantastic collaborators from the Maria Kasper, Ryan Driskell and Priyanka Sharma labs! www.science.org/doi/10.1126/...

My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...

Very happy to share our new study from CAM team @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social (MPZPM) on the unanticipated “hidden fluidity” in jammed epithelia. Congrats to Yuan Shen and great collaboration with Walter Kob. www.biorxiv.org/content/10.1...

From the lab of @sarawickstrom.bsky.social Piezo1 balances membrane and cortex tension to stabilize intercellular junctions and maintain the epithelial barrier journals.biologists.com/jcs/article/...

We are all super happy and proud to see our work on the function and evolution of the #cephalic #furrow published in @nature.com. Let me say a few things about the background and history of this work on the #Evolution_of_Morphogenesis (1/12)

[email protected], @sarawickstrom.bsky.social & team discover that Piezo1 balances membrane & cortex tension to stabilize intercellular junctions & maintain the epithelial barrier. journals.biologists.com/jcs/article/... Article: journals.biologists.com/jcs/article/... #OpenAccess

Read more about this research in our ‘First person’ interview with Ahsan Javed @ahxanjaved.bsky.social: journals.biologists.com/jcs/article/...

The #25EngLife conference is over and it was great, including the talks by @sarawickstrom.bsky.social, @bladoux.bsky.social and @routierlab.bsky.social. Many thanks to @stefandiezlab.bsky.social and the other organizers🙏🏻

New preprint! 🚨 We uncover a slow adaptation to stretch that links star-bundling of keratin filaments with nuclear escape from its keratin cage. Led by @tomgolde.bsky.social‬ 🙌 @IBECBarcelona www.biorxiv.org/content/10.1...

Just started our @bcube-tud.bsky.social - organized Engineering Life 2025 #25EngLife conference in #Dresden! Excited to have everybody around!

Great session with flash talks at #25EngLife. Here @lettermann.bsky.social presenting his work on malaria parasite motility.

Is euchromatin really “open”? Our new study @bioRxiv suggests otherwise. Using super-resolution imaging @shiori-iida.bsky.social‬ @masaashimazoe.bsky.social reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing. www.biorxiv.org/cgi/content/...

Final call to register and submit abstracts for the @faseborg.bsky.social conference on the Mechanobiology of the Cell Nucleus (#MBNSRC) to be considered for platform presentations. The conference takes place in Melbourne, FL, Oct. 26-30, 2025. See more info at: events.faseb.org/event/Mechan...

Excited to share our new publication in Nature Physics about the mechanical memory of morphology in confined migrating cells by @kyohalie.bsky.social 🥳 Super fun collab with @davidbrueckner.bsky.social and @gcharras.bsky.social 👏🏻 Enjoy the reading www.nature.com/articles/s41...

Amazing work from the Nadler lab 🤩🤩 Congratulations Andre and team 🔥

Very elegant and insightful study on the functional role of tissue architecture and mechanics on tissue dynamics and disease progression in cancer 🤩 !! Many congratulations @katemiro.bsky.social @sarawickstrom.bsky.social and to all authors 🎉👏!!

So proud of this work that @katemiro.bsky.social started with us @helsinki.fi and now completed in her own lab together with the amazing Fabien Bertillot 🤩 @mpi-muenster.bsky.social Check out the preprint and 🧵 on the surprising links between #colorectalcancer architechtures and #stemcell states 👇

Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...

Pathologists have used nuclear & tissue shapes to diagnose #cancer for decades, but what is the molecular basis for this? In our latest work, we develop a computational pipeline to figure this out in #colorectalcancer! Check out 🧵& preprint #mechanobiology #stemcells www.biorxiv.org/content/10.1...

FINALLY! Challenging to publish but we believe it is an important discovery: rdcu.be/eATFz 💚 Thanks to the team ‪@biswashere.bsky.social‬, Omar Muñoz, ✨Q✨ C. Hoege, B. Lorton, R. Nikolay ‪@matthewkraushar.bsky.social‬ @dshechter.bsky.social @gucklab.bsky.social @vasilyzaburdaev.bsky.social‬ 💚

Now published in @natcomms.nature.com! 🥳 👉 rdcu.be/eATn3 We developed image analysis tools to capture the nematic orientation field of 3D tissue surfaces. Tested on epithelial aggregates, zebrafish hearts, myoblasts on spheres & micro-vessels, we combined soft matter physics with exp. biology.

Very proud of this work performed by the super talented Fabien Bertillot with essential support from @sol-herve.bsky.social and our amazing collaborators, especially Toni Seppälä and @sarawickstrom.bsky.social. Grateful for support from @mpi-muenster.bsky.social, NIH, and @helsinki.fi

Collectively, our work supports a model where disruption of tissue architecture & stromal cues initiate a co-evolutionary feed forward loop that drives disease aggression & suggests that quantitative analysis of tumor heterogeneity with architecture as proxy may be the key to diagnostic precision

Interestingly, while epithelial-to-mesenchymal transition states were also enriched in fragmented architectures, mechanical confinement was not sufficient to trigger #EMT. Combination of compression & soluble signals from the stroma drove further separation of regenerative stem cell and EMT states.

To figure out causation we turned to patient derived #organoids. Together with our #bioengineering colleagues in the Lutolf lab we generated topographies that mimic poor prognosis architectures. Indeed, regenerative stem cell states emerged in response to mechanical constraints and compression

Analyzing single patient biopsies with heterogeneous architectures showed that cell states and architectures co-evolve, and we can predict likely tissue shape transitions based on the transcriptional signatures! So now the chicken & egg question: which comes first – abnormal shapes or cell states?

Intriguingly, nuclear shapes correspond with tissue architectures, both independently predicting patient survival. Overlaying this with #spatialtranscriptomics revealed that fragmented architectures associate with regenerative stem cell states that have been shown to drive metastasis.

So proud of this work that @katemiro.bsky.social started with us @helsinki.fi and now completed in her own lab together with the amazing Fabien Bertillot 🤩 @mpi-muenster.bsky.social Check out the preprint and 🧵 on the surprising links between #colorectalcancer architechtures and #stemcell states 👇

🔬 Speakers: CarenNorden nordenlab.bsky.social and Carl Modes @nicolettapetridou.bsky.social and zenahadjivasiliou.bsky.social Yonit Maroudas-Sacks and Marko Popović Vasudha Srivastava and Asa Kalish www.isscr.org/upcoming-pro... #ISSCR #StemCells #Biophysics #Mechanobiology #ScienceSpotlight

Don’t miss the exciting ISSCR Digital Webinar: Integrating Biophysics into Stem Cell Biology on October 14,2025! Together with Windie Höfs we have organized this webinar that features paired tandem talks of experimentalists and theorists working at the interface of stem cell biology and biophysics!

Our institution has given a generous donation as well as our fly labs. Convince yours to do so as well!

Colorectal cancer heterogeneity co-evolves with tumor architecture to determine disease outcome https://www.biorxiv.org/content/10.1101/2025.08.11.669722v1

What better way to launch our new account with the publication of @jmstein.bsky.social latest paper from the lab! 🧪 Check out the 🧵 below to learn more about tkPAINT and how we use it to image proteins, DNA, and RNA in the nucleus using DNA-PAINT.

Check out this exciting meeting and register! Fantastic line-up of speakers on cell biology of the nucleus and a great venue 🔥

Want to acquire #ExM images like this and help us understand the true extent of cytoskeletal diversity across the tree of life? This position might be for you! embl.wd103.myworkdayjobs.com/en-US/EMBL/j... With @dudinlab.bsky.social @embl.org @biology-unige.bsky.social @moorefound.bsky.social

Very happy to see our preprint on how the mechanosensitive ion channel Piezo1 controls intercellular junction maturation by balancing cortex and membrane tension now published in @jcellsci.bsky.social Congratulations to Ahsan & team! journals.biologists.com/jcs/article/...

Thrilled to bits to see our latest work online in Dev Cell! 🥳 We wanted to know how cells build functional organs with precision🫀🫁📏 Here we show how coupling of cell shape and organ function fine tunes the form and contractile power of the developing #zebrafish heart 1/n tinyurl.com/cell-stretch

Very happy to see our preprint on how the mechanosensitive ion channel Piezo1 controls intercellular junction maturation by balancing cortex and membrane tension now published in @jcellsci.bsky.social Congratulations to Ahsan & team! journals.biologists.com/jcs/article/...

The video was adapted from movie 3 in the accepted manuscript "Piezo1 balances membrane and cortex tension to stabilize intercellular junctions and maintain epithelial barrier " by @sarawickstrom.bsky.social doi.org/10.1242/jcs.... The article also features our membrane tension probe Flipper-TR!

Our Live cell actin probe SPY650-FastAct efficiently labels primary keratinocytes isolated from mice.

Meet the 2025 ASCB Award Winners—trailblazing scientists honored for research, mentoring, education, and innovation. Celebrate excellence across all career stages in cell biology. Read more: www.ascb.org/society-news...