Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇

Check out 2 papers and a related Perspective on tissue regeneration in @science.org this week Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration | Science www.science.org/doi/10.1126/...

Check out this exciting new study on the role of oyxygen in determining regeneration competence through epigenetics and cell mechanics👇Congratulations Can & team and thank you for including us in this cool project 🤩

Cool discovery how cancer modifies its own niche from the very beginning 🤩 Congratulations Maria and team 🔥

Congratulations @ivaskalab.bsky.social team for this study on the role of vibration in vocal cord cancer! Was a fun collaboration 🎤🎤

Glutamine metabolism gives the immune system precision—quieting inflammation while rebuilding tissue! Proud of my lab team for this exciting work as we venture into immunometabolism to learn how wound cells are fed! www.cell.com/cell-reports...

New preprint @biorxiv-devbio.bsky.social by Harshath Amal and colleagues from our lab @uni-muenster.de shows how a BMP #morphogen gradient is translated into graded junctional permeability by tuning adhesion and actomyosin contractility in #Drosophila See tinyurl.com/yhbwd9xh @sfb1348.bsky.social

Tread -1- EpiSci - I am very proud to share with you our new study that you can access on @biorxivpreprint.bsky.social (see link below) "The Interaction with Nanotopographical Environment regulates nuclear mechanoresponse in mESCs via Histone Demethylase KDM3A. www.biorxiv.org/content/10.6...

Dynamic Cellular #Interfaces reloaded: Join us for the @sfb1348.bsky.social International Meeting on 'Mechanochemical signals at cellular interfaces' in Münster, May 27–29, 2026. Registration is open - Limited spots – first come, first serve! More info: tinyurl.com/ypyzd23w @uni-muenster.de

Exciting and important preprint from @sarawickstrom.bsky.social, @manningresearch.bsky.social and Niessen Labs on the role of mechanical forces and cell mechanical properties on skin epidermis stratification👇! Congratulations @clemvilleneuve.bsky.social and to all authors 👏😀!

Excited to share our work on epithelial multilayering - identifying why stem cell stay in the basal layer and how and why differentiating cells move up. Great collab with @manningresearch.bsky.social and Niessen labs! Check out preprint and great summary below www.biorxiv.org/content/10.6...

@sarawickstrom.bsky.social we are looking forward to your presentation at our #FusionEpigenetics meeting in Portugal this October! Please share this with your followers to let them know you will speaking, and to register & submit today to join us 🔗 bit.ly/4rC6B45

Job alert! 📣 I’m looking for a research assistant to join my new team @idrm.ox.ac.uk Were using #zebrafish to understand gene-environment interactions that shape the heart 🫀generate natural diversity 🐸🐭 and contribute to congenital defects ❤️‍🩹 Full info below, and please share! 🫶🏻 bit.ly/467TO0M

🚨 Job Alert! 🚨 We have an opening at our Microscopy Core Facility in Turku 🇫🇮. If you love imaging 🔬 and helping scientists succeed, we want you! 👇 abo.rekrytointi.com/paikat/index... #Microscopy #ScienceJobs #CoreFacility #Imaging @turkubioscience.bsky.social

Our #FusionEpigenetics speaker line-up is 🔥 Join us in Portugal in October 2026 to hear directly from the scientists shaping the field. See who’s speaking and save your spot here! ➡️ bit.ly/4sq1khf

Apply soon: Full professorship in Systems #Neuroscience @uni-muenster.de See shorturl.at/VczFp

Mark your calendars! The next SFB 1348 International Meeting will take place in #Münster from May 27-29, 2026, with a focus on #Mechanochemical signals at cellular interfaces. Stay tuned for more details and updates at www.uni-muenster.de/SFB1348/en/m...

Peters, @sarawickstrom.bsky.social et al. show that #sphingolipid #metabolism orchestrates establishment of the hair follicle #StemCell compartment. rupress.org/jcb/article/... 📕 From The Year In Cell Biology: rupress.org/jcb/collecti... #CellBio2025

postdocs.yale.edu/posts/2025-1... The Koh Lab is hiring!! Please reach out to join our newly established lab as a postgraduate associate! Come help us write the first exciting chapter of our (hopefully epic) saga! #CraniofacialBM #HSCniche #Vascularbiology #Immunology #YaleStemCellCenter #YaleCMED

Our annual collection highlights 13 of the year's most impactful papers that have garnered exceptional interest from our readership. Explore cutting-edge findings spanning the diverse spectrum of cell biology 👉 rupress.org/jcb/collecti... #CellBio2025 @ascbiology.bsky.social

Registration deadline 20th Dec! We have generous travel grants for early career researchers! April is a beautiful time to visit China!

Launching celldynamicslab.com, the homepage of our new group at EPFL working on cell fragmentation, membrane and cortex mechanics, FLIM imaging, and microfluidics tools. MSc/PhD or postdocs interested in quantitative cell biology are welcome to reach out. We're also hiring a lab manager in 2026!

🙌 Hello from #EESNucleus. The organisers Simone Köhler, Patrick Lusk, Thomas Quail, @sarawickstrom.bsky.social and Karo Wolkersdorfer are welcoming all participants to the four day symposium in Heidelberg.

- A postdoc to work on cancer extravasation (4-year project). - A postdoc help in completing Filopodia-related lab projects (2-year). - Multiple Marie Curie postdoc positions that will open in the fall. - We will open a 5-year position to cover my teaching (70% research and 30% teaching).

I am honnestly a bit worried by the latest fuss about qed (the IA driven review). While the results are indeed quite impressive (it is very good at listing the claim and finding potential improvement), I don't quite see how this will eventually reduce the reviewing burden or help us

Congratulations! In the current call of the European Research Council, Max Planck researchers have secured five Synergy Grants. Together with the University of Cambridge, we are among the top three most successful #research institutions in #Europe ! 🙌 www.mpg.de/25684336/erc... @erc.europa.eu

📣 Read the full news here: www.mpi-muenster.mpg.de/press-releas...

Excited to embark on this scientific journey with Ewa Paluch and Daniel StJohnston to understand fundamentals of epithelial tissue and cell shapes! Thank you to @erc.europa.eu for the support!

Ever wondered how adult organs preserve epithelial barrier integrity while continuously exposed to mechanical stress? We tackled this question in our new preprint – led by our brilliant PhD student Vishnu Krishnakumar! (1/11) 🔗 www.biorxiv.org/content/10.1...

Really excited to present the results of a fantastic collaboration with Jesse Veenvliet @jesseveenvliet.bsky.social @mpi-cbg.de @poldresden.bsky.social 🤩 We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species ➡️ www.biorxiv.org/content/10.1...

@joann-trejo.bsky.social, @marymunson4.bsky.social and I have a commentary in @natcellbio.nature.com on recent attacks on DEI in biomedical research: "If scientific research, especially biomedical research, is meant to serve everyone, then it requires that everyone has an opportunity to participate"

Welcome @shiori-iida.bsky.social , it’s great to have you in the lab! Excited about new directions in chromatin rheology and cell fate 🤓

We are hiring!

So excited to announce lab alumni Dr. Helen Mengze He and Liana Boraas work at @yalecvrc.bsky.social in collaboration with the Kaelyn Sumigray lab @yaleschoolofmed.bsky.social is published today in @natcomms.nature.com and highlighted in Yale News! medicine.yale.edu/news-article...

The @crick.ac.uk is recruiting Early Career Group Leaders - Lab set-up, research costs, salaries for up to 5 researchers - Support for up to 12 years - Access to our core facilities - Competitive salary - Fantastic colleagues - All areas of biology Deadline 27 Nov www.crick.ac.uk/careers-stud...

A recent preprint (Yang et al., doi.org/10.1101/2025...) challenges an article from my lab published in 2024 (Koh et al. 2024, PMID: 39537918). We strongly dispute their claims (please see our comment on bioRXiv). 1/4

Amazing talk today at #CABDseminars by @sarawickstrom.bsky.social! Sara explained work understanding mechanical regulation of cell states. She was hosted by @dariloops.bsky.social & @jrmarmor.bsky.social. Thanks for coming Dr. Wickstrom!

Terribly sad news. Jochen was a pioneer in cell mechanics, a great colleague and a wonderful person. He will be missed.

#CABDseminars "Mechanical regulation of cell states" by Sara Wickström @sarawickstrom.bsky.social, @mpi-muenster.bsky.social 🗓️October 10th ⏰ 12 pm 📍Rosalind Franklin auditorium, CABD Co-hosted by @dariloops.bsky.social & @jrmarmor.bsky.social

Join @jcb.org Scientific Editor Gabriele Stephan at the EMBO | EMBL Symposium “Cell biology of the nucleus” during the lunchtime Meet the Editor talk Nov. 19. www.embl.org/about/info/c... #EESNucleus @events.embl.org

It's online! In this series of perspectives @dev-journal.bsky.social, yours truly talks about the exciting open questions and many things to do in the field of dev bio and neuroscience #DevBio🧪 #PIsOfTomorrow journals.biologists.com/dev/article/...

Elegant new study in our journal by @sarawickstrom.bsky.social @katemiro.bsky.social & co!

💫NEW: @sarawickstrom.bsky.social @katemiro.bsky.social & co show that mechano-osmotic changes in the #nucleus induce general #transcriptional repression and prime #chromatin for cell fate transitions by relieving repression of specific differentiation genes. #pluripotency bit.ly/3VMcyNZ

Third paper to highlight! Here, Lisa Manning, @sarawickstrom.bsky.social, &c olleagues show contractility, pressure, signalling cooperating in vertebrate development, w/thorough combination of expertise in cell biology, signalling, & biophysics. (Open Access) www.nature.com/articles/s41...

We're still accepting submissions for our next special issue: Cell Biology of the Nucleus Guest edited by @abbybuch.bsky.social and Megan King @luskinglab.bsky.social. Submission deadline: 3 November journals.biologists.com/jcs/pages/nu... #cellbiology #nucleus #notforprofit #freetopublish

Nice work from the labs of @katemiro.bsky.social @sarawickstrom.bsky.social Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells www.nature.com/articles/s41...

A landmark study by @sarawickstrom.bsky.social @katemiro.bsky.social and colleagues elucidating the relative contribution of GF and nuclear mechanics on cell fate decisions🤩 !! Many congratulations on this 'tour de force' 👏🎉 (pun on words intended 😉!) !!

Our paper is out in Nature Cell Biology! 🚀 Growth factors, mechanical forces, and osmotic stress work together to guide stem cell differentiation. Delighted to see these discoveries out in the world 🔥

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells @natcellbio.nature.com @sarawickstrom.bsky.social @akistubb.bsky.social www.nature.com/articles/s41... www.nature.com/articles/s41...