3. The paper above looks at the role of "ex ante" peer review process, such as that of research grants, where results are not known at the time of review. The paper below looks at inescapable incentive problems that arise when trying to incentivize both risk and effort.

Very proud of our paper on "scrambling-by-hopping" LADs, which was just published: www.nature.com/articles/s41.... Congrats to Lise Dauban and the rest of the team – this was a real tour-de-force!

New preprint from @apombo1.bsky.social’s lab on gene regulation; insights into super-enhancers and their role in establishing complex regulatory networks of cell-type specific interactions with other enhancers and genes with specialized cellular functions 🧪🧬 www.biorxiv.org/content/10.1...

(1/n) DNA-PAINT imaging inside the nucleus at single antibody resolution using TIRF? Ultrathin sectioning makes it happen! Grateful to share my postdoctoral work introducing “tomographic & kinetically-enhanced DNA-PAINT” or in brief: tkPAINT. Out in @pnas.org! doi.org/10.1073/pnas... 👇🧵

(3/n) Inspired by work by Eric Betzig, @heilemannlab.bsky.social, @apombo1.bsky.social and others, we adopted Tokuyasu cryosectioning to enable TIRF-based DNA-PAINT imaging throughout fixed HeLa cells without range constraint. We started with the nucleus & Pol II to explore tkPAINT’s potential.

1 month to abstract deadline for the first cell biology of the nucleus meeting at @embl.org in many years - organised by the stellar @luskinglab.bsky.social @sarawickstrom.bsky.social Tom Quail & Simone Koehler Tons of open slots, invited and selected speakers all get 20 mins ❤️ #EESNucleus

I’m really happy to present #SCALPEL, a new #Nextflow tool to quantify transcript isoforms at the single-cell level using conventional 3’ scRNA-seq data #scRNA-seq #single-cell #tools #isoforms www.nature.com/articles/s41...

As requested - A Starter Pack of PIs in Biology (or related fields) who are recruiting PHD STUDENTS! If you would like to be added, feel free to ask! go.bsky.app/Bf4DRFm

Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/

The new Department of Functional Genetics at the Max Planck Institute for Molecular Biomedicine is looking for scientists at any level. 👉 mpi-muenster.mpg.de/780013/profil

Postdoc positions available in the Heick Jensen lab in sunny Aarhus. Sorting of good and bad RNAs in mammalian nuclei. Please get in touch for further information and/or use the following link to apply: mbg.au.dk/en/news-and-...

The Chromatin And Development lab are hiring a postdoc! Come join us; we are a happy and hard working team @mrc-lms.bsky.social in London UK. Projects span the intersection of chromatin and transposon biology in dev't and disease. Email/DM for more info. Pls RT! lms.mrc.ac.uk/work/vacanci...

A few months ago, Nature published how-to guide for using ChatGPT to write your peer reviews in 30 minutes. This is, of course, a horrible idea. Here’s my response with @jbakcoleman.bsky.social .

The call just opened! ki.se/en/about-ki/... You can apply to several departments simultaneously, check out which depts better fit your profile! Here is the call for our Department of Medical Biochemistry and Biophysics ki.varbi.com/what:job/job...

How do non-coding variants in enhancers lead to disease? Happy to share our recent work, led by @ewholling.bsky.social, in which we discovered that poised chromatin sensitizes enhancers to aberrant activation by non-coding mutations, contributing to disease. www.biorxiv.org/content/10.1... 1/

Our paper on gene regulatory networks controlling hypothalamic and prethalamic development is now out in Cell Reports./1 www.cell.com/cell-reports...

How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭 Check out our paper - fresh off the press!!! We find widespread functional conservation of enhancers in absence of sequence homology Including: a bioinformatic tool to map sequence-diverged enhancers! rdcu.be/enVDN github.com/tobiaszehnde...

Extensive differences observed in 3D genome structure between homologous heterozygous chromosomes revealed by Genome Architecture Mapping #GAM in the @apombo1.bsky.social lab ➡️ www.embopress.org/doi/full/10....

Big congratulations to Silvia Carvalho for successfully defending her PhD! 🎓 Her thesis focusing on SRRM2 is an exciting contribution to our understanding of gene regulation and early development. We'd like to thank @apombo1.bsky.social for her generous collaboration during this joint supervision.

Interested in chromatin architecture?
 Checkout our new method - PCP - that can map genome organization as multi-way interactions as well as nucleosome footprint and nucleosome spacing at very high resolution. www.biorxiv.org/content/10.1...

Delighted to share the latest preprint from the lab led by Janith Seneviratne We reveal novel roles for #embryonic regulators DPPA2/4 in facilitating a H2AK119Ub primed #chromatin state when aberrantly up-regulated in non-small cell lung #cancers 🧬🔬 (1/6) www.biorxiv.org/content/10.1...

Our institute @iecb.bsky.social is looking for new group leaders. The call is also addressing plant scientists🌱! Join us in the beautiful city of Bordeaux! www.iecb.u-bordeaux.fr/en/news/grou...

Translational Neuroscience division @lieberinstitute.bsky.social has an available Research Assistant position on the Molecular Neuroanatomy team led by @kr-maynard.bsky.social. This position performs single cell & spatial transcriptomics on human 🧠 tissue in a dynamic, team environment.

We have a postdoctoral opening for a researcher with experience in bioinformatics of DNA sequencing and machine learning to work on the development of new methods for cancer diagnostics related to nucleosomes, chromatin and beyond www.jobs.ac.uk/job/DMK060/s.... Application deadline: 21st April 2025

Join us for the 2025 GRC Genome Architecture www.grc.org/genome-archi... @spp2202.bsky.social @jobdekker.bsky.social @metorrespadilla.bsky.social @jopkind.bsky.social @dimplenotani.bsky.social @stanleyqilab.bsky.social @andybelmont.bsky.social @fondufemittendorf.bsky.social @boyanbonev.bsky.social

Attending the Symposium on Physical Genomics on April 25 in Chicago? Submit an abstract for the symposium poster session by April 15 to share your research and network with an international audience of world-class interdisciplinary researchers from academia and industry. #chromatin #microscopy

A friend included this anti-acknowledgement section on her PhD thesis. She also added the proposition: “Systematic bullying and undermining of girls and women in STEM starts early on and is the reason why they do not stay in science and related fields.” Absurd we still need to go through this 🧪👩‍🔬

Interview with me about impact of NIH budget cuts on the American people. It will have ripple effects not only our health but also on state economies across the country. March in support of science tomorrow! apnews.com/article/trum...

Join us for the 2025 GRC Genome Architecture www.grc.org/genome-archi... @spp2202.bsky.social @jobdekker.bsky.social @metorrespadilla.bsky.social @jopkind.bsky.social @dimplenotani.bsky.social @stanleyqilab.bsky.social @andybelmont.bsky.social @fondufemittendorf.bsky.social @boyanbonev.bsky.social

As federal funding for research is uncertain, we need to diversify funding sources for our PhD students. Here is a comprehensive list of >160 PhD fellowships and funding opportunities, mostly from private foundations and scientific societies. Download it here: research.jhu.edu/rdt/funding-...

🚨🚨 MEGA JOB ALERT 🚨🚨 Independent Group Leader Positions in Computational Biology @humantechnopole.bsky.social! Are you ready to start your own lab? Do you know someone who is? Repost this + share with everyone who might want to know about it. Thanks!!! 🙏 More details below... check it out! 🧵 1/3

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

📢 Job Alert! The NOVA Institute for Medical Systems Biology (NIMSB) is hiring 3 Technology Platform Leaders in: 🧬 Genomics (single-cell & spatial) 🧪 Metabolomics/Proteomics 📊 Data Science Join a cutting-edge research environment! Apply by 16 March 2025 👉 nimsb.unl.pt/join-us/ (1/3)

Each cancer is different, and so are the specific treatment options. "Onconaut," an #AI-based tool developed by #mdcBerlin's @al2na.bsky.social and his team, is designed to navigate through the maze of options more efficiently. More: www.mdc-berlin.de/news/news/na... #WorldCancerDay #UnitedByUnique

Together with @smandrup.bsky.social and Minna Kaikkonen we are happy to announce the 3rd Edition of the EMBO Workshop on #Enhancers and #Enhanceropathies. This time we will meet during the beautiful Danish summer (June 16-21). Book the dates and register soon!!! meetings.embo.org/event/25-enh...

Fantastic opportunity: 🚀 Calling early-career scientists! Apply for the 2025 ELISIR Scholar at EPFL. From outstanding PhD straight to group leader. Join an interdisciplinary research community to conduct independent research in any area of #lifesciences in Lausanne, CH 👉 go.epfl.ch/ELISIR

A great opportunity to start your own research group @pasteur.fr in Developmental Biology👇 research.pasteur.fr/fr/call/call...

QMUL Epigenetics Centre (www.qmul.ac.uk/epigenetics/) is looking to recruit a senior lecturer with expertise in Genomics/Epigenomics and/or cell-free DNA. This is an excellent opportunity to join a strong Epigenetics and genomics community. Pl share/apply here qmul-jobs.tal.net/vx/mobile-0/...

Interested in the cell biology of the nucleus? Join us for this unique exciting meeting that covers everything from nuclear biophysics and mechanics to signaling and evolution😍 amazing speaker list and more will be selected from abstracts 🤩

We are hiring! 3-year BBSRC-funded postdoc position available. TEs, epigenetics, pregnancy: if you love one or more of these keywords, apply through the link below. Please spread the word.

Couldn't agree more with Paul Nurse that “Research institutes and units play a unique, beneficial role in the UK’s RDI landscape and this sector should be expanded....” So the MRC should rethink their regressive decision to close MRC Units. www.science.org/content/arti...

Please retweet! Open rank faculty search in the basic sciences at UCLA David School of Medicine. Multiple positions are available - the application deadline is 19th January. Please apply here: recruit.apo.ucla.edu/JPF10062

We are now accepting applications for the spring round of our fully-funded #PhD positions at @mdc-berlin.bsky.social‼️ Apply for your #ScienceCareer in: ▶️ Genes, Cells and Cell-based Medicine ▶️ Molecular Processes and Therapies ▶️ Integrative Biomedicine 👉 www.mdc-berlin.de/phd 👈

Hopkins is recruiting 30 Bloomberg Distinguished Professors in AI + X (X = astrophysics, cancer, neuroscience, genomics, social sciences, etc.) hub.jhu.edu/2024/12/17/d... 22 of these 30 will be organized in clusters that were selected after rigorous external review. The list of clusters is:

Join us at FMI as a Junior Group Leader! A unique opportunity to set up your lab in a vibrant international research institute with world-class research groups and facilities, generous core funding, a collegial and inclusive culture - and great colleagues 🤓!

Excited to share a new algorithm that we have been working on over the last year. 💡 idea is to extend mutual nearest neighbors for #spatial data. We call it spatial mutual nearest neighbors (spatialMNN) 😄 Thank you @haowen-zhou.bsky.social @pratibha-panwar.bsky.social who led this work! 👏 🧬🖥️🧪

Registration is open for the Epigenome Cluster's JHU Chromatin and Chromosomes Workshop on Monday, December 16th. Learn more on their website below: epigenome.jhu.edu/events/

Interested in #singlecell and #spatial #metabolomics? Then book your calendar for December 10th! – Our online, free event will summarize major achievements of the field in 2024. #metabolism #omics #MALDI #EPFL With Giovanni D'Angelo and our #PhD students we prepared for you a fantastic lineup. 🧵 1/5

Dusting off a classic for #FluorescenceFriday: A stunning Blender render by Daniel Stabley of a neuron nucleus I imaged with our colleagues at Janelia. CryoCLEM reveals H3.3 euchromatin (blue) + HP1 heterochromatin (purple), by merging super-res #microscopy with FIB-SEM! #neuroscience #imaging

In September the world lost one of the great biologists of our time: Joe Gall. He bridged the transition from the histology era of cell biology to our molecular present, contributing a remarkable set of insights in his 9 decades 1/n 🧪 rupress.org/jcb/article-...