Anna Nordin
@annanordin.bsky.social
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📥 476
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Postdoc in Rasmus Siersbæk's Group | PhD in the Cantù lab | Avid CUT&RUN-er 🥼🧬🇺🇸🇸🇪
Very excited to present some of my PhD work from the
@claudiocantu81.bsky.social
Cantù lab tomorrow!
add a skeleton here at some point
about 1 month ago
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reposted by
Anna Nordin
Claudio Cantù
about 1 month ago
Hepatoblastoma is a nasty childhood liver cancer driven by mutant β-catenin How tumor cells get different and more or less aggressive? We found this out w Peng & Thomas from the Princess Maxima Center for Pediatric Oncology &
@annanordin.bsky.social
@liu.se
@pnas.org
www.pnas.org/doi/10.1073/...
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Differential Wnt/β-catenin signaling via TCF7L2/LEF1 binding specificity shapes cellular and tumor phenotypes | PNAS
The mechanisms by which Wnt/β-catenin signaling regulates gene expression in a tissue- and context-specific manner remain poorly understood, limiti...
https://www.pnas.org/doi/10.1073/pnas.2528450123
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2 years of work packed into 2 little figures. When it finally worked, it 𝘸𝘰𝘳𝘬𝘦𝘥, beyond my wildest dreams. Try it out!
add a skeleton here at some point
7 months ago
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reposted by
Anna Nordin
Claudio Cantù
11 months ago
SOX2 and NR2F1 cooperate to make
#neurons
in the
#Thalamus
for visual input from the
#retina
#DevBio
journals.biologists.com/bio/article/...
@biologyopen.bsky.social
In collab w Sara Mercurio and Silvia Nicolis
@btbsunimib.bsky.social
Driven by Linda Serra and
@annanordin.bsky.social
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SOX2 and NR2F1 coordinate the gene expression program of the early postnatal visual thalamus
Summary: The transcriptional regulators SOX2 and NR2F1 drive the development of the visual thalamus. Mutations in these genes cause visual impairment in humans.
https://journals.biologists.com/bio/article/14/8/bio062014/368747/SOX2-and-NR2F1-coordinate-the-gene-expression
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reposted by
Anna Nordin
Claudio Cantù
about 1 year ago
A 6-year long study from the Lab is finally out
@genomeresearch.bsky.social
Mastered by
@annanordin.bsky.social
in collaboration with Chaitali Chakraborty from
@remeseiro-lab.bsky.social
Why is our work Important? Discover it in the quick Bluetorial 👇
genome.cshlp.org/content/earl...
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Wnt signaling activation induces CTCF binding and loop formation at cis-regulatory elements of target genes
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms
https://genome.cshlp.org/content/early/2025/07/13/gr.279684.124.full.pdf+html
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reposted by
Anna Nordin
Claudio Cantù
about 1 year ago
We had previously shown that TBX3 and
#WNT
cooperate in limb
#DevBio
We now have a shocking finding, just published in
@pnas.org
TBX3 physically engages with β-catenin to drive metastasis genes in
#ColorectalCancer
(CRC)
www.pnas.org/doi/epub/10....
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The developmental factor TBX3 engages with the Wnt/β-catenin transcriptional complex in colorectal cancer to regulate metastasis genes
https://www.pnas.org/doi/epub/10.1073/pnas.2419691122
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reposted by
Anna Nordin
Development
over 1 year ago
Construction of an atlas of transcription factor binding during mouse development identifies popular regulatory regions Read this Techniques & Resources Article by
@annanordin.bsky.social
@gianlucazamba.bsky.social
@claudiocantu81.bsky.social
& co.:
doi.org/10.1242/dev....
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reposted by
Anna Nordin
Claudio Cantù
over 1 year ago
Our first release in the attempt to build the Transcription Factor Binding (TFB)-OMICS during
#DevBio
is now out in Development
@dev-journal.bsky.social
doi.org/10.1242/dev....
👉We hope many will use our data, and some will want to help mapping their beloved gene regulators in their favorite tissue
add a skeleton here at some point
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