1/4 New Paper 🧠🐭 #Neuroscience #Dopamine #FearExtinction #eNeuro Altered Dopamine Signaling in Extinction-Deficient Mice www.eneuro.org/content/12/1...

So functional cell types certainly exist in the spatial system. There is no doubt about this. However, this paper shows that you cannot know that you have found them by just decoding space, or even by showing spatial selectivity! This is a very important thing to tell the field.

"The inevitability and superfluousness of cell types in spatial cognition". Intuitive cell types are found in random artificial networks using the same selection criteria neuroscientists use with actual data. elifesciences.org/reviewed-pre... 1/2

A great intro to academic conferencing. Not sure how I missed this one. scienceforeveryone.science/getting-the-...

We are excited to share our online book and preprint on “Orchestrating Spatial Transcriptomics Analysis with Bioconductor”!

Whether you're new to bioinformatics or a seasoned pro, OSTA covers everything that you need to know about spatial transcriptomics data analysis spanning both sequencing and imaging-based technologies within the Bioconductor framework 👨‍💻🧬 Congrats to all the authors on this huge effort!

Many people hours, calls and messages later: OSTA is now “in (pre)print”, though the real thing lives at bioconductor.org/books/OSTA. Check it out, get in touch. We welcome any feedback, suggestions, wishes (& contributions). It’s been a joy working with you @estellayixingdong.bsky.social!

and there it is. the absolutely massive change in R01s funded multi-year. our perceptions that the new mandate, sorry strong suggestion, has had a dramatic effect on forward funding and therefore success rates is validated.

Learning induces persistent chromatin loops underlying robust gene expression during memory recall www.biorxiv.org/content/10.1...

Locus Coeruleus-Amygdala Circuit Disrupts Prefrontal Control to Impair Fear Extinction. www.biorxiv.org/content/10.1...

Have you wondered which neuron types are conserved across mammals and amygdalar subdivisions? Check out this article from @mictott.bsky.social et al. in Science Advances bit.ly/4pKcbkO #PRF #PapersoftheWeek

Single-cell long-read sequencing of the experience-induced transcriptome www.biorxiv.org/content/10.1...

This was a really fantastic collaboration! Congratulations @mictott.bsky.social Rita Cervera Juanes, @svitlanabach.bsky.social and all co-authors! 🧪🧬💻🧠

Yes, I am on the academic job market looking to start my own lab at the intersection of molecular, computational, and systems neuroscience! If you think my work may be interest to your department, please don't hesitate to reach out. Thank you, Keri!

Congrats Michael! Really appreciate the brilliance & creativity you brought to the analyses and as always, sincere dedication to open science 🧪 🧠 @mictott.bsky.social is on the job market!! Amazing skillset spanning wet lab/computational at molecular, cellular + systems level - and across species!

Very excited to share my second postdoc, now out in Science Advances! We used targeted snRNA-seq to profile four major subnuclei of the primate across three species (including humans). 1/13 www.science.org/doi/10.1126/...

Congratulations to @mictott.bsky.social, Rita Cervera Juanes and @svitlanabach.bsky.social and all co-authors! Really fun collaboration w/labs of @vincentcostaphd.bsky.social and @stephaniehicks.bsky.social to better understand cell type and spatial heterogeneity across amygdala in primate 🧠!

Hot take #3: “BLA subdivisions contain specific subtypes of excitatory and inhibitory neurons. Hot take #4: Genes downregulated in PTSD load mainly onto specific subtypes of inhibitory interneurons that are highly conserved across primates.

Hot take #1: Amygdala neuron types are highly conserved across different primate species. No human specific innovations. Hot take #2: Canonical gene markers identified for murine amygdala neuron types are not especially informative inferring cell type identifies for the primate amygdala.

A spatially resolved transcriptomic atlas of the primate amygdala (human, macaque, and baboon) now out in Science Advances (www.science.org/doi/10.1126/...). The amygdala contains 32 types of neurons with many neuron types specific to particular subdivisions. Lots of updates from the preprint!

(1/10) We’re excited to share our new preprint (doi.org/10.1101/2025...), which uncovers the spatiomolecular landscape of the human nucleus accumbens (NAc), by integrating snRNA-seq with Visium spatial transcriptomics across 10 control donors. 🧠 #NAcLIBD #snRNAseq #10xVisium

Super excited to share this work & accompanying data resources in collab with @martinowk.bsky.social @stephaniehicks.bsky.social @alexisbattle.bsky.social! Congrats to all coauthors and big shout out to @svitlana-bach.bsky.social @prashanthi-ravi.bsky.social for leading this NIDA-funded project.

Beautiful new work from Tugce Tuna, Flavio Mourao, and @stevemaren.bsky.social showing that 8 Hz stimulation of the thalamic nucleus reuniens entrains mPFC-HPC oscillations and facilitates fear extinction! www.biorxiv.org/content/10.1...

Stress-Responsive Neuronal Ensembles and β-Adrenergic Signaling in the Basolateral Amygdala Modulate the Infralimbic Cortical Activity and Govern the Delayed Stress-Induced Fear Extinction Deficit www.jneurosci.org/content/45/3...

Excited to share this huge team effort collaboration supervised by Stephanie Page in Translational Neuroscience @lieberinstitute.bsky.social and @stephaniehicks.bsky.social @jhubiostat.bsky.social to generate a spatio-molecular resource of the hippocampus in human 🧠 www.nature.com/articles/s41...

Happy to see the last bit of data I collected during my PhD out in publication now! Congrats to grad student Tugce Tuna for leading the manuscript, as well as our co-first author Muhammad Badarnee for leading the effort to incorporate fMRI analyses of the human reuniens!

Wow, what a thoughtful care package from @cziscience.bsky.social. Excited to join the Faculty Application Bootcamp to prep for the upcoming job cycle!

Scalable, fast and accurate differential gene expression testing from millions of cells of multiple patients https://www.biorxiv.org/content/10.1101/2025.07.24.666556v1

Congratulations @kinnaryshah.bsky.social @mictott.bsky.social @svitlanabach.bsky.social & all co-authors! Wonderful collab btw @jhubiostat.bsky.social @jhu.edu and @lieberinstitute.bsky.social spatially profiling human dACC 🧠 #TeamScience 🧪 🧬 🖥️ Thank you #NIDA #NIMH for generous funding & support 👏

Check out this awesome new work led by @kinnaryshah.bsky.social uncovering the molecular landscape of the human dACC using both spatial and snRNA-seq! Kinnary used a wide range of analyses to characterize the dACC, as well as compare it to the dlPFC of the same donors.

Latest from the lab using chemogenetics to explore the functions of amygdala-frontal pathways in reward learning, led by Dr Megan Fredericks with Cat Elorette and Jared Boyce. @sinaibrain #braininitiative

Why do we go downstairs when we hear a scary noise at night? New #preprint by postdoc Kati Rothenhoefer shows how novelty seeking & explore-exploit decision making in #macaques resolves curiosity about whether choices will lead to appetitive or aversive outcomes. www.biorxiv.org/content/10.1...

I urge everyone to read Unbreaking’s new page on everything the govt is doing to destroy & diminish medical research funding. It’s the best thing I’ve read on this topic: @lizneeley.bsky.social & co have such done an incredible job. unbreaking.org/issues/medic...

#SpotSweeper is now published! Check our journal club session summary of the pre-print version by @lahuuki.bsky.social The new features @boyiguo.bsky.social + @mictott.bsky.social added in this revised manuscript enhance the use cases for #SpotSweeper: 👀 #VisiumHD data! youtu.be/f72XcXmtkfw?...

Congrats! 🎉 @boyiguo.bsky.social has a deep passion for both statistics and improving the treatment of psychiatric disorders. If any neuroscientists out there are looking for new collaborations in relation to 'omics projects - I would strongly recommend reaching out to him!

Great collaboration motivates methodological and biological innovation! Grateful for the opportunity to work together with @martinowk.bsky.social and @lieberinstitute.bsky.social, investigating the molecular pathology of neuropsychiatric disorder, coming soon! 😉

Excited to announce that I'll start as a tenure-track assistant professor @uofuphs.bsky.social this fall. #BiostatsElevated The #GUOmics lab will focus on developing biologically informed machine learning methods to decode spatial and population-scale omics data. Look forward to exciting colabs!

Quality control matters in spatial transcriptomics. Check out this paper from Guo and colleagues on SpotSweeper that corrects for both local and regional artifacts across diverse technologies. www.nature.com/articles/s41...

🤔Could quality control create more harm than good? We explore this question in the context of #SRT. SpotSweeper is developed to combat implicit selection bias. Led by fellow rising star @mictott.bsky.social and collab with amazing mentor @stephaniehicks.bsky.social 👉: bsky.app/profile/mict...

Very excited to see this important work out led by the talented @mictott.bsky.social @boyiguo.bsky.social @jhubiostat.bsky.social! 🧪🧬🖥️

Important methods development for spatial transcriptomics (ST) data from @mictott.bsky.social @boyiguo.bsky.social @stephaniehicks.bsky.social - congrats! Applying this method to our QC workflow has substantially improved many new ST datasets generated across diverse regions/tissues in the human 🧠

🚨 New paper published in @natmethods.nature.com! We introduce SpotSweeper, the first spatially-aware QC methods for spatial transcriptomics. 📰 Paper : nature.com/articles/s41... 💻 Code: github.com/MicTott/Spot... 📈 Website: mictott.github.io/SpotSweeper/ 🧵👇

Important 'Matters Arising' from @neurome.bsky.social and Zhaoxia Yu discussing false positives due to multiple comparisons in large-scale gene expression data. I applaud Eran and others who consistently raise these issues for discussion in the community. www.nature.com/articles/s41...

Always pseudobulk, always correct for multiple comparisons, and always consult with a biostatistian. www.nature.com/articles/s41...

I have an opportunity to hire a staff scientist for my lab. Looking for someone with outstanding skillset in ML/statistics, genomics applications; interest in mentoring, strong publication record, PD experience required. Email CV to me+cc my assistant (see 'contact' on my website). Ad to follow.

🚨New paper alert! 🚨 Inactivation of the nucleus reuniens causes relapse of extinguished fear. Here we show this “circuit-induced relapse” depends on hippocampal fear memories and is mediated by hippocampal engrams. Congrats to the team!

New paper out! Huge thanks as always to my mentor @drchristineannd.bsky.social and the rest of the team!

Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation. rdcu.be/el18q A short thread follows for those interested. 1/n

➡️ Delighted to contribute to this piece on the mechanisms underlying memory reconsolidation and persistence, together with Hugo Bayer, Cristina Stern and @stevemaren.bsky.social www.sciencedirect.com/science/arti...

Check out this awesome new work by @mouraofg.bsky.social investigating HPC-PFC synchronization underlying context-dependent fear extinction!