New preprint from the Skoklab

February 20th is the deadline - register now for this exciting meeting

• Today’s the day! 🎉 We’re kicking off #chromatin2025 on Zoom at 9:30 AM EST w/ @BiolaMJavierre, @CarrerasIJC, @Javierrelab, @KatieEYost, @Anders_S_Hansen, @kazu_maeshima, @NIG_idenken, @_AnthonySchmitt, & other great speakers! If you haven’t registered yet, there’s still time: See you soon!

Last reminder: We’ll see you bright and early at 9:30 AM EST on the 25th to kick off #chromatin2025! Fantastic lineup of speakers with discussion to follow each talk. Don’t forget to register for this virtual meeting if you haven’t yet: bit.ly/chromatin-2025

• Thanks to @ArimaGenomics for sponsoring #chromatin2025. Don't miss @_AnthonySchmitt and Matija Snuderl’s talk: Detection and characterization of chromosomal rearrangements from FFPE tumors using Hi-C, showcasing rapid 3D genomics for cancer analysis. In case you haven’t registered

What controls how our genes switch on and off across the 3D genome? Dr. Bing Ren from @nygenome will dive deep into transcriptional insulators and the mysteries behind CTCF/Cohesin loop extrusion. Don’t miss his talk, ‘Mechanisms and Modulators of Transcriptional Insulators’ !

The Skok Lab is recruiting an experienced computational scientist to lead single-molecule epigenomic and 3D genome analysis. We integrate long-read sequencing with Hi-C/Hi-ChIP, scmulti-omics, and machine-learning to explore chromatin topology, and gene regulation.

Ever wondered how the 3D shape of DNA influences nucleosome spacing along chromatin? Dr. Vijay Ramani from the Gladstone Institute, will reveal fresh, unpublished insights on this topic, featuring a new method – LASSI – that tracks single-molecule sequence interactions in 3D.

Join @BiolaMJavierre as she unveils the first-ever gene regulatory roadmap of human B cell differentiation – linking chromatin architecture, enhancer activity, and disease risk across nine B cell subtypes.

Speaker Spotlight: Step inside the 3D genome of cancer with Dr. Kathryn Yost (@KatieEYost) from Whitehead Institute! She reveals how enhancer rewiring and genome architecture shape 15 human cancer types – discover tumor archetypes and new pathways hiding in the Cancer Genome Atlas. Don’t miss out:

Explore the ageing human brain with Professor Sheng Zhong (UCSD). Hear about his groundbreaking MUSIC technique for single-cell mapping of chromatin and RNA interactions and discover how brain cells age, interact, and drive disease - all revealed at multiplex resolution! Save your seat:

Speaker Spotlight: Don’t miss @Anders_S_Hansen from MIT as he unpacks the secrets of distal gene regulation in space and time! Learn how enhancers find and activate their target genes—revealing new insights into the selectivity and dynamics of gene control. Reserve your seat:

Excited to share this new preprint from the Sulman and Skok labs

@kazu_maeshima from the Genome Dynamics Laboratory at the National Institute of Genetics (@NIG_idenken) will present groundbreaking research on chromatin organization and behavior in live cells revealed by super-resolution imaging. nyulangone.zoom.us/webinar/regi... #chromatin2025

Excited to share another new preprint from our lab in which we developed a cluster-based phasing strategy using long read nano-NOMe-seq data to link distinct CTCF binding states—captured at the single molecule level—to the transcriptional status of genes: biorxiv.org/content/10.1...

We’re back! Registration is NOW OPEN for the 6th Annual Meeting on Advances in Nuclear Topology & 3D Chromatin Architecture in Cancer. Don’t miss insights from leading experts in the field. Join us online on Nov 25, 2025—register for free: bit.ly/chromatin-2025 #chromatin2025