🧵1/14 Preprint thread! Can we predict a cell’s fate based on its dynamics? 🔮 Our new study unveils a framework for watching development unfold in real-time, revealing how a cell's shape and movement encode info about its future fate. 🔬📄 Preprint: tinyurl.com/4shf8v4x

How is developmental speed regulated ? 🪰 Happy to share my PhD story from Schweisguth Lab @devstempasteur.bsky.social. Here we show that cellular NAD+ availability and redox constrain developmental speed in the fly eye. www.biorxiv.org/content/10.1... A big thanks to everyone involved!

⌛1 month left to apply – 2025 PPU call for candidates We invite you to discover 4 Develpmental & Stem Cell Biology projects and 3 Immunology projects👇 🕰️Application deadline: October 20, 2025 📍Program starts: October 2026 Discover all the projects (50+) & apply: www.pasteur.fr/en/education...

We only had a very minor contribution to this story with Alexis, but definitly worth a reading for those interested by patterning, precision and refinment. Nice combining of quantitative live imaging, modeling and optogenetics to dissect vein patterning dynamics www.cell.com/developmenta...

My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...

🚨 The International Developmental Mechanics Zoom Seminar Series is back on Sept 25! 🎤 We have an exciting line-up of speakers this fall. See the image below for details 🌐 Website: sites.google.com/view/devmech... 📝 Interested in presenting? Sign up here: tinyurl.com/2munv5bv

Epithelial crowding drives membrane depolarisation by ENaC/Na+ entry which triggers rapid volume loss, piezo activation and live cell extrusion. Importantly, low intracellular ATP primes cells for live extrusion by preventing the restoring of mb polarisation. www.nature.com/articles/s41...

Interesting changes for the ERC evaluation, including an extension of the eligibility period for StG and CoG (now up to 10 and 15 years post phd respectively). Worth a reading for those intending to apply in the coming years (and nice to see that the council keeps trying to improve the process)

Very happy that the first article from my postdoc work in the Tomancak lab is now published @PNAS! www.pnas.org/doi/10.1073/.... We studied the self-organization of actin in aggregates made from Hydra cells. Thread below (1/9)

Important story dissecting the mechanism of gut cell extrusion using organoids. Local heterogeneity of tension promotes live extrusion and basal relaxation is sufficient to kick the cell out. Nice combination of optogenetics and live imaging to demonstrate this www.science.org/doi/abs/10.1...

New short paper from our lab @currentbiology.bsky.social, in which we discover of a new mode of cell motility for choanoflagellates: flagellar gliding. www.cell.com/current-biol... - A 🧵

We (with @nicolasdray.bsky.social @zenlabpasteur.bsky.social) are happy to release officially FishFeats, our #napari plugin to streamline 3D smFish/RNA quantification! 🎊 Available here: github.com/gletort/Fish... user documentation: gletort.github.io/FishFeats/

Beautiful story that combined mechanobiology, evolution, and the power of fly (opto)genetics to make sense of the cephalic furrow. It was a pleasure writing the News & Views. No doubt this is still just the beginning for the field of mechano-evo-devo! Hats off to all involved

We have a fully funded 3y postdoc position open!!!! Come join us @mpi-cbg.de and @poldresden.bsky.social to understand the role of Membranes in Controlling Biogenic Crystallization :) this is part of our #HFSP funded project with @noemijimenezrojo.bsky.social and @vmonje.bsky.social! Applications👇

🎓 Applications for Institut Pasteur's PhD programs open Sept 1-Oct 20, 2025 for October 2026 entry. Apply to up to 4 projects across 6 programs: PPU, PPU-IMAGINE @institutimagine.bsky.social, [email protected], PPU-EID @upcite.bsky.social & more 🧬 Register now ✍️ www.pasteur.fr/en/education...

Three-Year Funded Postdoctoral Position to study organelle architecture in mammalian oocytes – Terret-Verlhac Lab, CIRB, Collège de France (Starting 2026). For more information, please contact: [email protected]

Summer break prevented me from properly advertising this serie of reviews on the function of cell death during development that I edited. There is still a lot to dig in regarding regulation of apoptosis in vivo ad I hope we managed to illustrate this well www.sciencedirect.com/special-issu...

🚨 Molecular Biology of the Cell – Pasteur Course 🧬 This 4-week course explores the molecular mechanisms of cellular life — from vesicular trafficking and cell division to autophagy, host-pathogen interactions, and tumor invasion. 🕰️Application deadline: Sept 15,2025 👉 Apply: bit.ly/47celmj

✨ How do bird flocks form or diseases emerge? Join the brand-new EMBO | EMBL Symposium #EESCollectivity and explore how collective behaviours arise from fundamental principles across biological systems 🧬🦠🐒 💻 s.embl.org/ees26-01-bl ✒️ Submit your abstract by 18 Nov

FlyBase needs your help! Visit the link below for more information, and please consider donating to help save this amazing resource. wiki.flybase.org/wiki/FlyBase...

We are deeply saddened by the passing of our colleague Catherine Rabouille. Catherine was senior group leader at the Hubrecht Institute, an exceptional cell biologist, a passionate mentor, and a driving force for diversity and inclusion in science. Full tribute: www.hubrecht.eu/in-memoriam-...

🆕🧪‼️ New lab preprint! We study how germ cells (the cells that give rise to gametes, in this case sperm) are supported by somatic (non-germ) cells of the gonad. This matters for our understanding of reproduction - without germ cell development, animals are sterile. www.biorxiv.org/content/10.1...

🔬 The next international Developmental Biology course, organized by Institut Curie with @sorbonne-universite.fr, will focus on "From stem #cells to #morphogenesis". 📅 Apply by: • July 20 (3.5 weeks with hands-on workshop) • Aug 31 (10 days of seminars) 🔗 training.institut-curie.org/courses/deve...

Comment on our @Reproducibility project in @Drosophila immunity. It is a normal that findings—however exciting and important at the time—may later prove to be more complex than initially believed. Re-evaluations is essential to the self-correcting nature of science. www.science.org/content/arti...

This is quite impressive (curious to know if funding agency would support this, for sure they should).

Come and Join our Dpt in Beautiful #Geneva ! We are looking for a #Microscopy & #Image #Analysis expert to help all of us at the Dpt.

Registration is now open! Gastrulation Reloaded: Developing, engineering & evolving the body plan 📅 October 14–17, 2025 📍 Paris, France 🗓️ Abstract & early bird deadline: July 15, 2025 www.gastrulation-reloaded.conferences-pasteur.org/home Exceptional lineup of speakers & many selected talks

Check out my first #preLight on the work of Sokol's team exploring PCP and mechanosensation! It was so much fun to pick a preprint, read it, write about it, and even get to ask the authors questions directly. I have a feeling this is just the beginning of many more preLight posts to come! 🙌

On cell extrusion in the #intestine! After 80 years of observations, we finally took a deeper look thanks to 2D #organoids. We report: 3D #forces, #extrusion still only in the villus even without curvature, #lamellipodia generate 3D force.. and more. Have a look! www.biorxiv.org/content/10.1...

🚨 Hey #gastrulation folks! The early bird registration and the abstract submission are coming up very soon. Please register now for this nice #conference in @pasteur.fr, it will be super cool! 👇👇👇

Excited to share that our work building in vivo biosensors for receptor tyrosine kinases (pYtags!) is now out www.cell.com/cell-reports...

🥇Sham Tlili has been awarded the CNRS 2025 Bronze Medal! She studies how physical forces shape living tissues by using mouse stem cell models known as gastruloids. A unique blend of physics & biology. 🔗 Read more: www.ibdm.univ-amu.fr/sham-tlili-w...

My PhD work is out in Science Advances! We show how DPP drives tissue morphogenesis by encoding local mechanical programs iteratively, unraveling a self-organizing mechanism linking morphogen gradients to tissue dynamics. www.science.org/doi/full/10.... #DevBio #Morphogenesis #Drosophila

Funny that the virtual cell virtually encapsulate everything except....cell biology...(yes, there is a full world of complex behaviour outside the realm of gene expression) 🤷‍♂️

Fully in line with this opinion article on the value of human judgement in peer review. Down the line, reviewing is not about making a good summary, but providing a hierarchy of what is really important and not, weighted by the estimated pain/cost of the requests www.nature.com/articles/d41...

Beautiful!

The Cordero Lab has openings for two post-docs positions. Please contact me if you are interested in doing cross-species research on local and systemic intestinal biology.

Students (Master's/PhD), do not miss this fantastic Developmental Biology course of @sorbonne-universite.fr and @institutcurie.bsky.social - It is FREE and open to international students, however, room and board + travel are not included. training.institut-curie.org/courses/deve...

Very nice piece bringing a lot of food for thought on how to rationalise our practices with fly pushing. It's been a long standing discussion on our side and I am gratefull someone did all the work estimating the impact of various practices.

Very happy to share our latest lab publication! The hard work of @bboumard.bsky.social, Gwenn Le Meur and collaborators! Cell-type-specific nucleotide sharing through gap junctions impacts sensitivity to replication stress in Drosophila: Developmental Cell authors.elsevier.com/a/1lDFi_Yv6z...

🎉 Congratulations to David Bikard @pasteur.fr on his 2025 @embo.org Gold Medal win! 🧬 He's pioneering phage-CRISPR tools to edit gut #bacteria in vivo, reshaping the #microbiome from within and opening the door to targeted therapies. 👉 europa.eu/!HQbHTw 👉 europa.eu/!KtWf33 @dbikard.bsky.social

Flybase lost all of the NIH support overnight - it is a disaster for the community. Please consider donating. I just did! www.philanthropy.cam.ac.uk/give-to-camb...

A new #ScienceSignaling study interrogates crosstalk between mechanical and biochemical signals in epithelial cells, illustrating how mechanical stretching activates a kinase that regulates cell growth, migration, and differentiation.

What is buckling, and why is it relevant in understanding epithelial morphogenesis? 🧐 I am @onenimesa.bsky.social and I will share some papers to understand this aspect of #EpithelialMechanics

🔥 We've already received over a third of pre-registrations! #Mifobio2025 is already shaping up to be a highly attractive event... Don't delay in pre-registering! 👉 imabio-cnrs.fr @cnrs.fr @cnrsbiologie.bsky.social @cnrsingenierie.bsky.social @cnrs-inist.bsky.social

📣Next @devstempasteur.bsky.social Seminar this Friday : Fiona Doetsch from the Biozentrum University of Basel will speak about : Adult Neural Stem Cells: Regulation & Heterogeneity Invited by Shahragim Tajbakhsh

Second preprint from the lab in a week! This time led by Aurelien. Combining live imaging, quantitative image analysis and perturbations, he clarifies the mechanisms leading to primitive induction. 👇

Super excited to share that the final version of our study on the role of Adenylate Kinase 7 (AK7) on centriole maturation is finally out! @devbiol.bsky.social Read the full version here: www.sciencedirect.com/science/arti...

Many cells during development are exposed to caspase activation and yet survive. Why some die and not others ? We found out that the memory of previous caspase activation bias significantly later death comitment and bias death distribution and single cell decision www.biorxiv.org/content/10.1...

🚨📣 New preprint alert! Excited to share my new postdoc work on direct force and mechanical properties measurements in live embryos! A great team effort with A. Chamolly (theory), under the supervision of F. Corson and @jeromegros.bsky.social 📄 www.biorxiv.org/content/10.1... #devbio #mechanics