Silvia Fre lab
@frelab.bsky.social
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Developmental biologist interested in stem cell fate
Congratulations to Bruno Simoes and Rob Clarke!
#ENBDC
#breastcancer
add a skeleton here at some point
5 days ago
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Thank you so much
@doctoremmerson.bsky.social
for liking our paper! Looking forward to discussing the implications with you!
add a skeleton here at some point
20 days ago
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reposted by
Silvia Fre lab
Robin Journot 🔬| 🎾
about 1 month ago
Our paper is on the cover of
@cp-devcell.bsky.social
. Image: embryonic murine salivary-gland explants stained for fate determinants; p63 (cyan) and HES1 (yellow). Thanks to everyone involved.
doi.org/10.1016/j.de...
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Silvia Fre lab
James Briscoe
about 1 month ago
Mechanical constraints disrupt gastruloid polarisation without changing gene expression - uncouples morphogenesis & patterning Gregor & co use tunable hydrogels to show cell motility, not gene expression, drives axis formation in gastruloids
journals.biologists.com/dev/article/...
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Fine-tuning mechanical constraints reveals uncoupled patterning and gene expression programs in murine gastruloids
Highlighted Article: A bioinert confinement system enables dissection of how stiffness and timing shape gastruloid development, revealing uncoupling between polarization and transcriptional programs.
https://journals.biologists.com/dev/article/152/18/dev204711/369337
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So proud of the exciting story from my PhD student Jakub Sumbal on contractile fibroblasts shaping branching morphogenesis! Fantastic collaboration with the lab of Zuzana Koledova in Prague!
@sumbalovakoledova.bsky.social
It just came out online, check it out here:
rdcu.be/eIIKD
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Contractile fibroblasts form a transient niche for the branching mammary epithelium
Nature Communications - Fibroblasts represent a heterogenous cell population but how their differences reflect their plasticity and origin is not fully understood. Here, the authors map the origin...
https://rdcu.be/eIIKD
about 2 months ago
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Geometry first: how positional cues dictate fate in bilayered epithelia
thenode.biologists.com/geometry-fir...
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Geometry first: how positional cues dictate fate in bilayered epithelia - the Node
Behind the paper story focussed on research on early fate decisions in bilayered epithelia.
https://thenode.biologists.com/geometry-first-how-positional-cues-dictate-fate-in-bilayered-epithelia/research/
2 months ago
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Silvia Fre lab
4 months ago
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Super happy to share the work by my post-doc Candice Merle on breast cancer obtained
@institutcurie.bsky.social
thanks to funding from ARC:
www.fondation-arc.org/actualites/2...
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Pour mieux comprendre la transformation cancéreuse des cellules mammaires
Une exploration des mécanismes moléculaires qui permettent aux cellules mammaires de modifier leur identité donne des éléments fondamentaux pour comprendre certains phénomènes de la transformation can...
https://www.fondation-arc.org/actualites/2025/pour-mieux-comprendre-la-transformation-cancereuse-des-cellules-mammaires
4 months ago
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reposted by
Silvia Fre lab
Robin Journot 🔬| 🎾
5 months ago
🧵Just out ! We reveal how 4 branched epithelia—mammary, lacrimal, salivary & prostate—use a conserved YAP–Notch–p63 circuit to self-organize during development & regeneration. Here’s the story👇
authors.elsevier.com/c/1lM285Sx5g...
Work done in
@frelab.bsky.social
at
@institutcurie.bsky.social
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1000 congrats to Walid
@wtklab.bsky.social
!!! Plenty of success!
add a skeleton here at some point
5 months ago
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Beautiful and insightful review! Congrats to
@sarawickstrom.bsky.social
and
@clemvilleneuve.bsky.social
add a skeleton here at some point
8 months ago
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Dev Bio
@institutcurie.bsky.social
#standupforscience
8 months ago
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reposted by
Silvia Fre lab
c0nc0rdance
9 months ago
This is a room where we turn very modest salaries and budgets (and lots of coffee) into new knowledge, life-saving innovations, and technology that feeds business growth. It's literally the loom that spins hay into gold but these numpties are suddenly worried about the cost of hay.
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Silvia Fre lab
Walid Khaled
10 months ago
JOB ALERT We are seeking a Computational Research Assistant or Research Associate to help drive an ambitious multiomics ageing project part of the NMGN Mouse Ageing Cluster.
www.jobs.cam.ac.uk/job/49939/
@scicambridge.bsky.social
@phar.cam.ac.uk
@cambridgebiosci.bsky.social
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Silvia Fre lab
Financial Times
10 months ago
The man in charge of social media platforms used by billions should show some moral courage, writes
@jemima.bsky.social
www.ft.com/content/682c...
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