Silvia Fre lab
@frelab.bsky.social
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Developmental biologist interested in stem cell fate
https://institut-curie.org/team/fre
reposted by
Silvia Fre lab
Anne Grapin-Botton
about 1 month ago
Congratulations to Byung Ho for spearheading this work and our HFSP team! Curious about the formation of networks of thin lumens and some physics behind it? Take a look at the paper. Byung Ho is looking for PI positions and he has amazing ideas and leadership.
www.nature.com/articles/s41...
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Silvia Fre lab
Steffen Rulands
3 months ago
New preprint out now, where we track clonal cancer evolution with barcodes and predict treatment outcome.
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Silvia Fre lab
Levayer Lab
3 months ago
It's been several times that I am pretty sure to witness during reviewer crosscommenting assesment mostly generated by AI (composed of hundred of unnecessary and finicky points that would lead to years of revision). For the human reviewer out there, speak up to editor if you notice this !
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Check out our beautiful story on tumour clonal dynamics with barcodes, performed in the
@frelab.bsky.social
by my super talented post-doc
@candice-merle.bsky.social
and
@ivanditerlizzi.bsky.social
from
@rulands.bsky.social
lab!
#barcodes
#plasticity
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3 months ago
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Thank you
@patrickpla.bsky.social
! I wish I could have been there this year
#FSSCR2025
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3 months ago
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Congratulations to Bruno Simoes and Rob Clarke!
#ENBDC
#breastcancer
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3 months ago
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Thank you so much
@doctoremmerson.bsky.social
for liking our paper! Looking forward to discussing the implications with you!
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4 months ago
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Silvia Fre lab
Robin Journot 🔬| 🎾
5 months ago
Our paper is on the cover of
@cp-devcell.bsky.social
. Image: embryonic murine salivary-gland explants stained for fate determinants; p63 (cyan) and HES1 (yellow). Thanks to everyone involved.
doi.org/10.1016/j.de...
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Silvia Fre lab
James Briscoe
5 months ago
Mechanical constraints disrupt gastruloid polarisation without changing gene expression - uncouples morphogenesis & patterning Gregor & co use tunable hydrogels to show cell motility, not gene expression, drives axis formation in gastruloids
journals.biologists.com/dev/article/...
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Fine-tuning mechanical constraints reveals uncoupled patterning and gene expression programs in murine gastruloids
Highlighted Article: A bioinert confinement system enables dissection of how stiffness and timing shape gastruloid development, revealing uncoupling between polarization and transcriptional programs.
https://journals.biologists.com/dev/article/152/18/dev204711/369337
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So proud of the exciting story from my PhD student Jakub Sumbal on contractile fibroblasts shaping branching morphogenesis! Fantastic collaboration with the lab of Zuzana Koledova in Prague!
@sumbalovakoledova.bsky.social
It just came out online, check it out here:
rdcu.be/eIIKD
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Contractile fibroblasts form a transient niche for the branching mammary epithelium
Nature Communications - Fibroblasts represent a heterogenous cell population but how their differences reflect their plasticity and origin is not fully understood. Here, the authors map the origin...
https://rdcu.be/eIIKD
5 months ago
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Geometry first: how positional cues dictate fate in bilayered epithelia
thenode.biologists.com/geometry-fir...
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Geometry first: how positional cues dictate fate in bilayered epithelia - the Node
Behind the paper story focussed on research on early fate decisions in bilayered epithelia.
https://thenode.biologists.com/geometry-first-how-positional-cues-dictate-fate-in-bilayered-epithelia/research/
6 months ago
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Super happy to share the work by my post-doc Candice Merle on breast cancer obtained
@institutcurie.bsky.social
thanks to funding from ARC:
www.fondation-arc.org/actualites/2...
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Pour mieux comprendre la transformation cancéreuse des cellules mammaires
Une exploration des mécanismes moléculaires qui permettent aux cellules mammaires de modifier leur identité donne des éléments fondamentaux pour comprendre certains phénomènes de la transformation can...
https://www.fondation-arc.org/actualites/2025/pour-mieux-comprendre-la-transformation-cancereuse-des-cellules-mammaires
7 months ago
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reposted by
Silvia Fre lab
Robin Journot 🔬| 🎾
8 months ago
🧵Just out ! We reveal how 4 branched epithelia—mammary, lacrimal, salivary & prostate—use a conserved YAP–Notch–p63 circuit to self-organize during development & regeneration. Here’s the story👇
authors.elsevier.com/c/1lM285Sx5g...
Work done in
@frelab.bsky.social
at
@institutcurie.bsky.social
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1000 congrats to Walid
@wtklab.bsky.social
!!! Plenty of success!
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8 months ago
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Beautiful and insightful review! Congrats to
@sarawickstrom.bsky.social
and
@clemvilleneuve.bsky.social
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12 months ago
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Dev Bio
@institutcurie.bsky.social
#standupforscience
12 months ago
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reposted by
Silvia Fre lab
c0nc0rdance
about 1 year ago
This is a room where we turn very modest salaries and budgets (and lots of coffee) into new knowledge, life-saving innovations, and technology that feeds business growth. It's literally the loom that spins hay into gold but these numpties are suddenly worried about the cost of hay.
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reposted by
Silvia Fre lab
Walid Khaled
about 1 year ago
JOB ALERT We are seeking a Computational Research Assistant or Research Associate to help drive an ambitious multiomics ageing project part of the NMGN Mouse Ageing Cluster.
www.jobs.cam.ac.uk/job/49939/
@scicambridge.bsky.social
@phar.cam.ac.uk
@cambridgebiosci.bsky.social
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Silvia Fre lab
Financial Times
about 1 year ago
The man in charge of social media platforms used by billions should show some moral courage, writes
@jemima.bsky.social
www.ft.com/content/682c...
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