Very happy to share that I just published a new paper from my thesis! 🎉 We analysed 546 species of ant to understand how extreme specialisation into reproductive and non-reproductive roles evolved.  Key discoveries in thread🧵 👇 Full paper here: academic.oup.com/evolut/advan...

An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost! www.biorxiv.org/content/10.6...

📣 Paper alert! I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today! journals.biologists.com/dev/article/...

We are excited to participate this year again in the VBC summer school! If you want to work with me and my amazing student Maria, apply!

It's always special when you find your own paper in the table of contents of the journal 😍 "The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube" -> Now out in its final form www.cell.com/developmenta...

Good to see the peer reviewed version of this in print The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube A global temporal chromatin program operates across the vertebrate nervous system to control neural cell diversity www.cell.com/developmenta...

🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉 Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨ #PhD #3DGenome

Interested in gene regulation during development? Don’t miss the opportunity!

We recently reported that promoter competition can contribute to the robust insulation of gene regulatory domains (www.nature.com/articles/s41...). We now offer a 4-years PhD contract to investigate whether the dirsuption of this regulatory mechanism can lead to congenital defects. More details 👇

#Preprint alert! 📣 We are thrilled to share the work led by Lara Zorro-Shahidian and Lucio di Filippo, in which we show that #MLL2 controls gene expression in both #ESC and upon #differentiation by facilitating the #enhancer like activity of #LINE1 elements www.biorxiv.org/cgi/content/...

This work would not have been possible without the support of @ibbtec.bsky.social @csic.es @erc.europa.eu @ageinves.bsky.social @ec.europa.eu

📕Read the full preprint here: www.biorxiv.org/content/10.1... Special thanks to my great PI and to the @radaiglesiaslab.bsky.social members at IBBTEC, specially to @sanchezgaya.bsky.social, whose work on the bioinformatics part of the project has been truly instrumental 💻📊📉⚡

How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭 Check out our paper - fresh off the press!!! We find widespread functional conservation of enhancers in absence of sequence homology Including: a bioinformatic tool to map sequence-diverged enhancers! rdcu.be/enVDN github.com/tobiaszehnde...

#EMBLChromatin keeps being awesome: fantastic talks, lots of networking and troubleshooting! But guess who is also multitasking? ZIC2! Particularly during neural induction! Come by this afternoon to check poster 158 and I’ll tell you all about it 😉 @radaiglesiaslab.bsky.social

🧵5 Top Free Alternatives to BioRender for Scientific Illustrations! These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs. Save and share the post!

Very happy to share the peer-reviewed version of our paper in which we study the formation and function of pair-wise and multi-way enhancer-promoter interactions in gene regulation (see thread below): www.nature.com/articles/s41...

Really proud of Michaela Bartusel, who initiated this work while being a PhD in our lab. Michaela never gave up and, together with the great guidance of my friend and former colleague Eliezer Calo, made some very interesting findings regarding the genetic basis of orofacial clefting.

I am incredibly proud to share that my work has officially been published in Cell! @cp-cell.bsky.social This work was a product of years of dedication and countless hours of research in the labs of Joanna Wysocka and Dan Jarosz labs @stanfordmedicine.bsky.social www.cell.com/cell/fulltex...

Part 1 and 2 of the Long-read sequencing Special Issues are now live! tinyurl.com/Genome-Res-LRS

Do et al., 2025. Binding domain mutations provide insight into CTCF’s relationship with chromatin and its contribution to gene regulation www.cell.com/cell-genomic...

Excited to share my latest work with @joadelas.bsky.social and @jamesbriscoe.bsky.social Predictable Engineering of Signal-Dependent Cis-Regulatory Elements www.biorxiv.org/content/10.1... 1/11

Do you have an exciting story about #enhancers or #enhanceropathies?. Then submit your abstract to the @embo.org workshop on "Enhancer mechanics and Enhanceropathies" in Denmark before is too late: the deadline for abstract submissions is in two weeks (March 17th)! meetings.embo.org/event/25-enh...

Together with @smandrup.bsky.social and Minna Kaikkonen we are happy to announce the 3rd Edition of the EMBO Workshop on #Enhancers and #Enhanceropathies. This time we will meet during the beautiful Danish summer (June 16-21). Book the dates and register soon!!! meetings.embo.org/event/25-enh...

The administration took down the reproductive rights website that women need access to. So The Skimm bought a url and brought the content back. Pass this on! Go to reproductiverightsdotgov.com

At this END of YEAR please check out our new paper on GENE ENDS and a convenient marker of transcription termination: RNAPII CTD T4ph! We think it is relevant to anyone studying human/animal #genes and #genome so put a lot of effort to make it easy to read. #RNABiology and #Epigenetics meet:)

Fulfilling a family tradition the day before Christmas. Hike to la Picota #Cantabria

Finally! The Hydroxychloroquine study by Gautret et al. has been retracted. I wrote a critical post about it in March 2020, days after it came out. scienceintegritydigest.com/2020/03/24/t...

It has taken more than 4 years but the methodologically poor (doi.org/10.1016/j.th...) and questionable paper (1-day peer review bmcmedresmethodol.bi...) that promoted HCQ for COVID-19 is finally retracted. We've been saying for years it had to be (doi.org/10.1016/j.th...).

FT at San Mamés! Athletic Club 2-1 Real Madrid!! YES!!! After 9 years, 8 months and 27 days, Athletic have finally beaten Madrid in La Liga!! What a performance by our Lions!! Goals by Álex & Guru, with a penalty save by Julen! Goazen Lehoiak!🦁 Lion of the Match:

La garra del Athletic Club es demasiado para el Real Madrid, que cae en La Catedral #LaLiga

Ever wondered how bats develop wings from their hands? 🦇✨ Check out our new preprint and the thread below! 🤓 👏Big applause to our amazing first authors Magdalena Schindler and Christian Feregrino and thanks to all our co-authors for their help! 🥂 www.biorxiv.org/content/10.1...

Great work by @sviatoslavsidorov.bsky.social !

As you make have seen, there is a special issue of JMB on "Controlling Transcription Elongation and Termination: More Than a Means to An End" curated by my colleague here at Pitt Karen Arndt and by Steve Buratowski from Harvard Medical School 🧪🧵 1/ www.sciencedirect.com/science/arti...

Here it is! Congratuations to @jesskelley.bsky.social @edimitrova.bsky.social @neilblackledge.bsky.social @aleksszczurek.bsky.social and the rest of the team (Maciej, Amy, and Hieu). This was a fab collaboration with Arminja Kettenbach. Also see a lovely complementary paper from Fei Chen's group.

I've been meaning to write a lengthy thread about our experiences with DNA methylation editing in mouse ESCs if that would be useful (or interesting?) for a niche audience here. tl;dr: it was frustrating but we learned a lot, and it ended with our shiny new pub (1/17) www.nature.com/articles/s41...

Check out our latest work, scE2G, for mapping the target genes of enhancers from single cell data! www.biorxiv.org/content/10.1... Amazing work led by co-first authors @mayayayas.bsky.social and @613weilin.bsky.social in a great collaboration with @jengreitz.bsky.social's lab See 🧵 by Wei-Lin ⬇️

Thanks @joadelas.bsky.social for visiting us and sharing your exciting projects with us. You , @jcacosta.bsky.social and Silvia Remeseiro did a great job during María’s defense.

REX - a mammalian "range extender" element that can turn short-distance enhancers into long-distance enhancers. New preprint from a collaboration led by Grace Bower and Evgeny Kvon. doi.org/10.1101/2024...