Does every enhancer work with every promoter? With @jengreitz.bsky.social and Will Greenleaf, we revisit this long-debated question and resolve an outstanding contradiction in the field. A tour 🧵👇 www.biorxiv.org/content/10.6...

"the first validated, large-scale framework for judging the quality of life science papers independently of venue, identity, and prestige...Blinded domain-expert professors sided with score three times more often than with journal rank" the-one-percent.qedscience.com 1/n

Gloves are off! TODAY WE RELEASE THE 1% A list of the year’s very best papers 👇 (see thread)

Best news on such a hot day! Congratulations @au-ho-yu.bsky.social and @robklose.bsky.social - an amazing achievement! Alan has done an amazing job and is currently working hard to address the reviewers' concerns! Comments came took 4 months to come back - reviewer 2 doesn't agree with g.e.d!

We looked at 57,455 preprints. No names. No institutions. No reputations. Just the science❕ In 48 hours, we reveal The 1%. #The1Percent #QEDScience #Preprints

This study led by @flavia-con.bsky.social from the Brockdorff lab is finally published at Nature Communications! www.nature.com/articles/s41... Using live-cell and single-molecule imaging, this work dissects how the epigenetic regulator #SMCHD1 interacts with chromatin during X-inactivation.

Yaay! Well done @bluebuleta.bsky.social and team! Great to see this work finally out! Read the paper to see how SETDB1 and HUSH regulate Xist transcription

Unacceptable! Have people started asking for refunds? We don't use Thermo antibodies much but have a couple in the freezer (one I have to admit is good!)

Help please! We need to do some large(ish) cell culture inhibiting E-cadherin with a monoclonal antibody. Does anyone have the DECMA-1 hybridoma cell line so we could purify our own antibody? or a similar monoclonal that would do the job. Any help greatly appreciated, just DM me. Please repost!

Congratulations @robklose.bsky.social for being elected as a Fellow of the Royal Society! royalsociety.org/news/2026/05... great news to have two outstanding scientists, Rob and Colin, from @oxfordbiochemistry.bsky.social joining the Royal society today!

Today we celebrate our colleagues Colin Kleanthous and Rob Klose as they join the Fellowship of the Royal Society, one of the highest honours in the scientific world, in recognition of their impactful contributions to knowledge. Congratulations! 👏 👏 👏 Read more ⬇️

Happy 100th birthday, Sir David Attenborough! 🎂 A legendary broadcaster, natural historian and Clare College alumnus whose voice has inspired generations worldwide for decades. Thank you for a century of curiosity, wonder and unwavering dedication to life on earth.

Very importantly, one of the co-organisers @xrnchew.bsky.social is cycling to the meeting to raise awareness and funds for 'All things small and green' . Please join him or sponsor him! gofund.me/f4068dc3c

Only 1 week left to register for the RNA 3' ends processing meeting, come one, get a wiggle on!! meetings.embo.org/event/26-rna3

Looking forward to hosting Iva Tchasovnikarova @oxfordbiochemistry.bsky.social today for a seminar today! Come along to hear about Fluorogenetic interrogation of epigenetic repression 1 pm Dorothy Crowfoot Hodgkin Building - Seminar Room 2 Department of Biochemistry Oxford

Doing the periodic cleaning of used plasmid miniprep columns and realized in honor of Earth Day it may be worth reminding you molecular biologists: Plasmid miniprep columns can be cleaned and reused essentially indefinitely! Just add 1 M HCl, soak overnight and wash 3x w/ water. Save $ and plastic

I wrote an essay. It’s about gain-of-function mutations. And penguins. Also ion channels, chihuahuas, the film Alien, recycled cardboard, and the Apollonian mind. Oh, and muffins. Thanks to the editors of #GENETICS @genetics-gsa.bsky.social for letting me take some stylistic liberties. 1/2

Just a quick reminder that the first of these Associate Professorships have a closing date for applications of April the 8th. Get your application in now! Please repost

We are excited to be recruiting into 3 Associate Professorship's in @oxfordbiochemistry.bsky.social. Come join us as a colleague and benefit from our vibrant and multidisciplinary environment. Reach out to me if you have any questions. Please repost! (tinyurl.com/48deybuu) (tinyurl.com/4pdvjaft).

We are looking for a Postdoc to join our lab at @oxfordbiochemistry.bsky.social. This is a dry-lab focused post on the computational analysis of long read single-cell sequencing data to understand the role of transposable elements (TEs) in early development. my.corehr.com/pls/uoxrecru... #TEsky

Another fantastic evening celebrating truly inspirational women at the Suffrage Science Awards in Life Sciences 2026. Read about the awardees and what the nominators - previous recipients - had to say about why they nominated these exceptional women: bit.ly/LifeSciences2026

daylight savings in the USA skipped us forward 1 hour, so we might be starting 1 hour earlier for some. Check your time against 9:00 PDT / 12:00 EDT (instead of PST/EST) to ensure you've got the correct start time for tomorrow!

⏰ Calling all chromatin aficionados! We we will be joined by @adelmanlab.bsky.social from @harvardmed.bsky.social for our March 27th webinar 📅 Karen will be sharing her groups work on 'Transcription & RNA Quality Control in Health & Disease' 😷🧬 Register here: us06web.zoom.us/webinar/regi...

meetings.embo.org/event/26-rna3 To all 3' end (and RNA, in general) enthusiasts. I'm organising a great conference in Oxford 7th-11th Sept with @lapassmore.bsky.social and Christine Mayr. The lineup of speakers is brilliant! Registration closes 4th May. Please consider it!

Happy to share our new preprint! 📊 We benchmarked methods for locus-level transposable element quantification in short-read scRNA-seq, using both real datasets and simulations with read-level ground truth. Huge thanks to @catavallejos.bsky.social and @antonio-scialdone.bsky.social! #TEsky

Help needed: I know this has been discussed before - what are people doing now that phase lock tubes have disappeared from the market? Is everyone making their own and that's why companies are not selling them anymore? If so, what is the best vaccum grease you would recommend? 🤷‍♀️

Very nice review by @mileshuseyin.bsky.social and colleagues!

Excited to share @suminkim.bsky.social and @mileshuseyin.bsky.social 's new Current Opinion review on how Polycomb complexes mediate 3D genome interactions including mechanistic models and potential roles in gene regulation: www.sciencedirect.com/science/arti...

1/3 New bioRxiv preprint from the lab: “Minute-scale coupling of chromatin marks and transcriptional bursts”. Led by Xiohui Gao & Chaebeen Ko. bioRxiv : www.biorxiv.org/cgi/content/...

In less than an hour. Will be great!

Come to hear Alan's great new story on SET1/MLL proteins and transcription next Wednesday. @fnucleosome.bsky.social

Come to hear Alan's great new story on SET1/MLL proteins and transcription next Wednesday. @fnucleosome.bsky.social

This was a really fantastic read. Felt like the eras tour albums with one hit unfolding after another!

🧬🎉Join us on Dec 17th for our last session of 2025! 🎉🧬Two fantastic talks on transcriptional regulation: 🔬JB Lalanne on developmental enhancers (and starting a lab in 2025?) 🔬 @rberrens.bsky.social on transposable elements in development 📋Register here: us06web.zoom.us/webinar/regi...

Read Alan's thread below to find out more about the latest work from the Klose lab @au-ho-yu.bsky.social @robklose.bsky.social @aleksszczurek.bsky.social

Also @au-ho-yu.bsky.social probably holds the world record for the most degron-tagged proteins in the same line. Guess how many!

Excited to see the latest from the Klose lab out this morning! Our brilliant PhD student Alan, now Dr Au, has dissected how SET1/MLL complexes shape H3K4me3 and shows they regulate transcription independently of their cat activity. He teamed up with Aleks to explore how. A few surprises!

We have just published a tribute to John Gurdon, reflecting on his scientific legacy and the profound influence he had on generations of developmental biologists. The piece is available open access in Nature Communications: www.nature.com/articles/s41...

Very proud to have our latest work now online in @natsmb.nature.com. A wonderful team effort across the centromere community, across @jansenlab.bsky.social @naltemose.bsky.social @dfachinetti.bsky.social and Giunta labs. Happy reading! 1/4 www.nature.com/articles/s41...

1/8🧵 Excited to share two studies in which I was involved within the Bird Lab📄📄 We have explored how the transcription factor SALL4 assembles and shapes chromatin in embryonic stem cells. @kashyapchhatbar.bsky.social @saragiuliani.bsky.social @drphcb-uoe.bsky.social @edinburghbiology.bsky.social

New method by Davies lab pushing the boundaries of the C-technologies, going down to a single base-pair resolution. Glad we could contribute to the story. Well done, Hangpeng and team!

Awesome stuff James and team! Thanks for giving @edimitrova.bsky.social and I the opportunity to contribute.

Very happy to see our paper published online natcomms.nature.com. Thank you to @wellcometrust.bsky.social for funding this work during my time with @robklose.bsky.social and David Booth! Thanks also to collaborators @garcialabms.bsky.social @alexdemendoza.bsky.social and the other authors!

🚀 Excited to share my latest paper on using SHAP, to predict direct target genes of chromatin-associated factors! Check it out for insights into gene regulation and the power of explainable AI in genomics! #XAI #SHAP #Genomics doi.org/10.1371/jour... Let's break down what we found! 👇

Check out our new story on how broad enhancer inputs are restricted into tissue-specific gene expression 🧬 Hint: Promoter-proximal regions are the key!

What is a promoter? And how does it work? We very happy to share our latest work trying to understand enhancer-promoter compatibility. I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters www.biorxiv.org/content/10.1...

Many of you know, we lost Béla Novák this year. John Tyson, Francis Barr & I tried to capture his wonderful character & great mind so that those that didn't know him can see what a fantastic person he was. Thanks to @jcellsci.bsky.social for publishing. journals.biologists.com/jcs/article/...

Wonderful opportunity to work with Martin Howard and my group trying to understand how chromatin influences gene transcription and expression. Integration of theory, modelling, and experimentation. Come and join the team! Please repost! jobs.jic.ac.uk/Details.asp?...

If you are a computational biologist come, apply and join Howard & Klose lab in a joint Norwich-Oxford collaboration on chromatin dynamics!

Very exciting opportunity for those with a quantitative background and interested in epigenetics / gene regulation. Highly collaborative environment!