Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from? Today, we report the discovery of telomerase homologs in a family of antiviral reverse transcriptases, revealing an unexpected evolutionary origin in bacteria. doi.org/10.1101/2025...

Wonderful opportunity to work with Martin Howard and my group trying to understand how chromatin influences gene transcription and expression. Integration of theory, modelling, and experimentation. Come and join the team! Please repost! jobs.jic.ac.uk/Details.asp?...

We have an open post-doc position in my group to study mRNA cleavage and polyadenylation using biochemical reconstitution and cryoEM. Please get in touch if you are interested in joining this amazing team! 🔬🧬🤩 #RNA #cryoEM

Super excited that this story by @borissieber.bsky.social is now on BioRxiv! For decades, we thought there was no MAPK scaffold for the ERK-like cascade that promotes sexual reproduction in fission yeast ... until Boris found it ! See the thread 👇 and enjoy the paper! doi.org/10.1101/2025...

This may be the most important paper ever published about NIH funded research. www.science.org/doi/10.1126/...

Some (+)ve news to lighten another heavy weekend: our latest preprint (c/o Mattiroli + Ramani labs) is up! www.biorxiv.org/content/10.1... A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)

(1/n) New preprint from @claricehongky.bsky.social Fan Fang Varshini Ramanathan in collab w Jie Liu. Q: How do we get ultra-high-res 3D genome maps? A: New deep learning model, Cleopatra. Cleo trains on Micro-C, fine-tunes on RCMC, and predicts genome-wide 3D maps at ultra-high resolution.

Some truth telling

Hello BlueSky! Inaugural post here from the Sternberg Lab. We're excited to share our latest work, in which we teamed up with the @WiedenheftLab to study how DRT9 reverse transcriptases provide antiviral immunity. Here’s what we found: www.biorxiv.org/content/10.1...

𝐍𝐞𝐰 𝐦𝐞𝐜𝐡𝐚𝐧𝐢𝐬𝐭𝐢𝐜 𝐢𝐧𝐬𝐢𝐠𝐡𝐭𝐬 𝐢𝐧𝐭𝐨 𝐭𝐡𝐞 𝐫𝐞𝐠𝐮𝐥𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐡𝐢𝐬𝐭𝐨𝐧𝐞 𝐬𝐮𝐩𝐩𝐥𝐲! Excited to share our latest collaboration led by tkjeong.bsky.social and ciaranfrater.bsky.social! Structural determination of the histone chaperone ASF1 and its regulator CODANIN-1 uncovers how CODANIN-1 counters ASF1 activity. 🧵👇

Post-doc in fungal molecular cell biology. Seeking person with an understanding of gene expression and phenotypic analysis, who is interested in epigenetic regulation in fungi, to explore mechanisms of antifungal resistance in Zymoseptoria tritici and Schizosaccharomyces pombe. Email me! #ECFG17

The realignment of research in our group @fmiscience.bsky.social is beginning to bear fruit. Proud of our captain @merleskribbe.bsky.social and the whole team! www.sciencedirect.com/science/arti...

𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇

🥳Just published @nature.com. Over 25 years after the discovery of SPO11 as the enzyme responsible for initiating meiotic recombination, we finally succeeded in reconstituting its DNA cleavage activity.🧵 www.nature.com/articles/s41...

Our latest preprint describes methods and tools that enable >99% efficient short homology-dependent genome editing in the human fungal pathogen Cryptococcus neoformans. Congratulations to Matt, Sanjita, and Manning! www.biorxiv.org/content/10.1...

Sounds interesting. If expression levels are equalized across the two alleles not sure it directly accounts for sex determination but I like these examples of genetic compensation.

Sometimes in the heat even the trees are thirsty. Backwaters in Kerala

The Hooghly river drains into the Bay of Bengal. Just an absolutely gorgeous view of waters that nourish eastern India

Street art in Kolkata. The everyday is quite stunning.

At this END of YEAR please check out our new paper on GENE ENDS and a convenient marker of transcription termination: RNAPII CTD T4ph! We think it is relevant to anyone studying human/animal #genes and #genome so put a lot of effort to make it easy to read. #RNABiology and #Epigenetics meet:)

Delighted to share our new preprint on the cell biology and genome of Stentor pyriformis, a giant ciliate that maintains Chlorella endosymbionts in surface-associated microtubule baskets. www.biorxiv.org/content/10.1...

Ever wondered how transcription choreographs histone modifications? Our work reveals the basis of co-transcriptional H3K36me3 by SETD2. We visualize how a histone writer coordinates with the transcription machinery! This is the magnus opus of @jonmarkert.bsky.social! tinyurl.com/setd2

Proofs!

Check out this beautiful representation of our work by @munafomarzia.bsky.social uncovering the molecular bridge between sperm and egg! 🔑🤩 We had lots of fun brainstorming together with Marzia and seeing our discoveries come to life in this artistic rendition 🧵

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

#TEsky Gene acquisition by giant transposons primes eukaryotes for rapid evolution via horizontal gene transfer doi.org/10.1126/scia...

After 60 years, scientists finally know why ginger, calico, and tortoiseshell #cats look the way they do. scim.ag/3BpxRxY

Can a single small molecule rescue the stability of nearly all mutations in a protein? Our new preprint by Taylor Mighell www.biorxiv.org/content/10.1... thread on the other place: x.com/taylor_mighe...

Using biochemical and structural approaches, we show that FIGNL1 forms a ring around RAD51 and removes it from DNA. Mutating key regions of the FIGNL1 ring resulted in loss of RAD51 removal (3/7)

This is just amazing stuff - pmc.ncbi.nlm.nih.gov/articles/PMC... AntiDefenseFinder” – a free open-source tool and web service that detects 156 anti-defense systems Just met with Joseph Bondy-Denomy one of the authors. And am going down a rabbit hole that could occupy me for a long long time

Thrilled to share a new study from the lab revealing an H3K18ub-H3K9me3 crosstalk mechanism, roles for UHRF1 and its E3 ligase activity in regulating a hierarchy of repressive histone methylation signaling, and a strategy for targeting SUV39H1/H2 to improve DNMT1 inhibitor efficacy! #epigenetics

Our paper is out just in time for #EM_Monday! It is about a specialized neuron-specific ER, called the spine apparatus, which is found close to synapses and has a very peculiar shape. If you think neurons are special, the spine apparatus is their🦄 horn! But how does it form?! doi.org/10.1016/j.cu...

PLOS to move away from APC model. PLOS moves designed to make publishing equitable. plos.org/redefining-p... #ScientificPublishing #AcademicSky #AcademicChatter

Postdoc positions in epigenetics! We have several opportunities to investigate big picture questions on (epi)genome function & mechanisms Based @embl.org near Rome (Italy), we offer full scientific support/facilities, training & funding. Also...☀️🏛️🍕🏖️ See👇or contact me for other options. Pls RS

Excited to share the first of 2 new papers diving into functions of UHRF1 ubiquitin ligase activity. Here, a connection to the support of 5mC maintenance in regions of low CpG density. These same regions are prone to 5mC loss in cancer. A potential mechanistic link to PMD formation. #epigenetics

LOL. The cognitive dissonance involved in publishing a paper about the spread of misinformation behind a paywall is something to behold. www.science.org/doi/10.1126/...

In case you did not see it the first time posted. If you are interested in how chromatin-based epimutations mediate resistance in fungi …… read our latest preprint…….

Thrilled to join the amazing community here on Bluesky! 🌟 Kicking off our first post with exciting news: the advanced version of our preprint is now published in Nucleic Acids Research! 🙌 [Read here: academic.oup.com/nar/advance-... Here’s a quick recap of our findings previously shared on X: 👇

400+ years after the "First Thanksgiving" most Americans have no idea that the Wampanoag people are still here. My tribe, the Aquinnah Wampanoag, is on Martha's Vineyard and we're still fighting for our land and rights. We’re also doing some cool stuff. 🧵👇 if you’d like to learn more & support us

The Democrats spent months telling people that the other guy is an authoritarian dictator who will end democracy and they have said nothing about how to stop him now that he has won the election “Leadership”

Yeast ribosomes adapt to glucose starvation by tethering to mitochondria in hibernation. Prolonged depletion halts protein synthesis and remodels ribosomes to create protective ribosome arrays. #ribosomes #RNASky #RNABiology #translation rdcu.be/d1xqj

Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. www.nature.com/articles/s41...

www.embopress.org/doi/full/10.... A non-coding RNA in fission yeast that also promotes longevity in flies.

An Essential Bookmark for Your Web Browser data.fmi.ch/TFexplorer/ 🌐

For my first post here, I am happy to share that our latest paper is out at #NAR. Thanks for the smooth and constructive reviewing process and the highlight #RNAbiology #TEsky #smallRNAs (1/8) doi.org/10.1093/nar/...

Application review starts 11/30! Please share, new Bluesky friends!

I’m thrilled to share a collaborative story from @Mendell_lab and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu. We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation! www.science.org/doi/10.1126/...

🚀 Excited to share that my postdoc work with @adernburg.bsky.social on a Piezo-dependent meiotic checkpoint in C. elegans has just been published in Science doi.org/10.1126/scie... Here's a summary thread, or a “Skydive” (coined by @harmitmalik.bsky.social‬), of the key findings in this work 🧵⬇️1/10

Hello Bluesky community! What a better way to introduce myself and my research team than post our lab’s first paper freshly off press 🥳🍾 We reveal how tubulins regulate the stability of their mRNA via reversible sequestration of TTC5. Bravo A. Batiuk and all coauthors 👏🏻🥂 doi.org/10.1038/s414...